Query String: TRIFLUOPERAZINE
Trifluperazine TRIFLUOPERAZINE DIHYDROCHLORIDE TRIFLUOPERAZINE 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride SMR000059133 cid_5566 cid_2913535 BDBM79181 MLS001146870 US11542290, Compound Trifluoperazine 10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride
BDBM50001886 TRIFLUOPERAZINE (trifluoperazine)10-[3-(4-Methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine 10-[3-(4-Methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine ( Trifluoperazine) Stelazine Trifluoperazin trifluroperazine 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE 10-[3-(4-Methyl-piperazin-1-yl)-propyl]-2-trifluoromethyl-10H-phenothiazine (Trifluoperazine) CHEMBL422 10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine trifluoroperazine
- ChEMBL_1576538 (CHEMBL3803978) Displacement of [3H]trifluoperazine from bovine brain CaM in presence of calcium
- ChEMBL_1833057 (CHEMBL4333065) Inhibition of UGT1A4 in human liver microsomes assessed as reduction in trifluoperazine N-glucuronidation by tandem mass spectrometry analysis
- Fluorescence Polarization Assay The competition binding assay was performed in a 384-well plate format and in 20 μl reactions. Serial dilutions (0.001-100 μM) of a test compound were incubated with CaM in the presence of 16B05 at room temperature for 30 min. The final binding reagent contained 50 nM of CaM and 5 nM of 16B05 in the assay buffer (50 mM HEPES pH 7.5, 0.01% (w/v) Triton X-100 and 100 μM CaCl2). Each plate contained two types of control wells, containing either 5 nM fluorescent probe bound to 50 nM CaM (bound state, maximum read) or 5 nM unbound probe alone (free state, minimum read) in the assay buffer. Reference compounds Trifluoperazine (CP-Chengdu, Barcode 20008599), A-3 hydrochloride (Sigma, Cat. No. A1980), and A-7 (Tocris Bioscience, Cat. No. 0378) were also included. Upon completion of the incubation, fluorescence polarization degrees (excitation at 531 nm, emission at 595 nm) were measured on the EnVision Microplate Reader (PerkinElmer). Data analysis was performed according to Audran et al., Biochim Biophys Acta. 1833 (2013) 1720-1731. Fluorescence decay was plotted against log concentration of the compound and half maximal inhibitory concentration (IC50) was calculated by XLfit version 4.3.1 (ID Business Solutions) with a 4-parameter logistic model or sigmoidal dose-response model.