Query String: VINCRISTINE
BDBM50139772 vincristine 22-oxovincaleukoblastine leurocristine
VINCRISTINE SULFATE SMR000058540 BDBM38872 MLS000069706 cid_5388992
- ChEMBL_838301 (CHEMBL2076249) TP_TRANSPORTER: drug resistance (vincristine) in AML-2/D100 cells
- ChEMBL_1587231 (CHEMBL3826047) Inhibition of ABCB1 in human KBVIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 8 uM after 72 hrs by SRB assay (Rvb = 2867.34 +/- 142.36 nM)
- ChEMBL_1587232 (CHEMBL3826048) Inhibition of ABCB1 in human KBVIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 2867.34 +/- 142.36 nM)
- ChEMBL_1625368 (CHEMBL3867837) Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 50 nM after 72 hrs by MTT assay (Rvb = 277.68 +/- 56.61 nM)
- ChEMBL_1625369 (CHEMBL3867838) Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 100 nM after 72 hrs by MTT assay (Rvb = 277.68 +/- 56.61 nM)
- ChEMBL_1625370 (CHEMBL3867839) Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 200 nM after 72 hrs by MTT assay (Rvb = 277.68 +/- 56.61 nM)
- ChEMBL_1625371 (CHEMBL3867840) Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 500 nM after 72 hrs by MTT assay (Rvb = 277.68 +/- 56.61 nM)
- ChEMBL_1625372 (CHEMBL3867841) Inhibition of human ABCB1 expressed in KBV1 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 1000 nM after 72 hrs by MTT assay (Rvb = 277.68 +/- 56.61 nM)
- ChEMBL_2089945 (CHEMBL4771208) Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 6 +/- 0.2 nM)
- ChEMBL_2089946 (CHEMBL4771209) Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 6 +/- 0.2 nM)
- ChEMBL_1792901 (CHEMBL4264820) Inhibition of MDR1 in human KB/VCR cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 25 uM after 72 hrs by Western blot analysis (Rvb = 4.21 +/- 0.33 uM)
- ChEMBL_2089957 (CHEMBL4771220) Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 4.55 +/- 0.28 nM)
- ChEMBL_2089958 (CHEMBL4771221) Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 4.55 +/- 0.28 nM)
- ChEMBL_2089963 (CHEMBL4771226) Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 2867 +/- 142 nM)
- ChEMBL_2089964 (CHEMBL4771227) Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 2867 +/- 142 nM)
- ChEMBL_2111358 (CHEMBL4820208) Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by MTT assay
- ChEMBL_2111359 (CHEMBL4820209) Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by measuring vincristine IC50 at 10 uM measured after 72 hrs by MTT assay
- ChEMBL_1625411 (CHEMBL3867880) Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 50 nM after 72 hrs by MTT assay (Rvb = 3714.80 +/- 383.58 nM)
- ChEMBL_1625412 (CHEMBL3867881) Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 100 nM after 72 hrs by MTT assay (Rvb = 3714.80 +/- 383.58 nM)
- ChEMBL_1625413 (CHEMBL3867882) Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 200 nM after 72 hrs by MTT assay (Rvb = 3714.80 +/- 383.58 nM)
- ChEMBL_1625414 (CHEMBL3867883) Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 500 nM after 72 hrs by MTT assay (Rvb = 3714.80 +/- 383.58 nM)
- ChEMBL_1625415 (CHEMBL3867884) Inhibition of human ABCB1 expressed in NCI-ADR-RES cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 1000 nM after 72 hrs by MTT assay (Rvb = 3714.80 +/- 383.58 nM)
- ChEMBL_2111362 (CHEMBL4820212) Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by MTT assay
- ChEMBL_2111363 (CHEMBL4820213) Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity by measuring vincristine IC50 at 10 uM measured after 72 hrs by MTT assay
- ChEMBL_1587214 (CHEMBL3825950) Inhibition of full length human ABCB1 expressed in Flp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 8 uM after 72 hrs by SRB assay (Rvb = 823.13 +/- 15.79 nM)
- ChEMBL_1587215 (CHEMBL3825951) Inhibition of full length human ABCB1 expressed in Flp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 823.13 +/- 15.79 nM)
- ChEMBL_1862984 (CHEMBL4363840) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM after 72 hrs by MTT assay (Rvb = 2.92 +/- 0.31 nM)
- ChEMBL_1862985 (CHEMBL4363841) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 2.92 +/- 0.31 nM)
- ChEMBL_2089951 (CHEMBL4771214) Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 823 +/- 16 nM)
- ChEMBL_2089952 (CHEMBL4771215) Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 823 +/- 16 nM)
- ChEMBL_2103480 (CHEMBL4811983) Reversal of P-gp-mediated multidrug resistance in human KB/VCR cells assessed as potentiation of vincristine-induced antiproliferative activity by measuring vincristine IC50 at 20 uM measured after 72 hrs by CCK8 assay (Rvb = 0.78 uM)
- ChEMBL_2103482 (CHEMBL4811985) Reversal of P-gp-mediated multidrug resistance in human KB/VCR cells assessed as potentiation of vincristine-induced antiproliferative activity by measuring vincristine IC50 at 2 uM measured after 72 hrs by CCK8 assay (Rvb = 0.51 uM)
- ChEBML_151382 Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine
- ChEMBL_1500058 (CHEMBL3584172) Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival after 5 days by MTS assay
- ChEMBL_151382 (CHEMBL758145) Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine
- ChEMBL_151383 (CHEMBL758146) Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the presence of 10 nM vincristine