Found 22 hits for monomerid = 29135 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
TRAR1
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| Article PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation
Curated by PDSP Ki Database
| |
Proc Natl Acad Sci U S A 98: 8966-71 (2001)
Article DOI: 10.1073/pnas.151105198 BindingDB Entry DOI: 10.7270/Q2G15ZD5 |
More data for this Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | GoogleScholar
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| Article PubMed
| 72.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIH
Curated by PDSP Ki Database
| |
Synapse 39: 32-41 (2001)
Article DOI: 10.1002/1098-2396(20010101)39:1 BindingDB Entry DOI: 10.7270/Q2NV9GT3 |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 106 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIH
Curated by PDSP Ki Database
| |
Synapse 39: 32-41 (2001)
Article DOI: 10.1002/1098-2396(20010101)39:1 BindingDB Entry DOI: 10.7270/Q2NV9GT3 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
Reactome pathway KEGG
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| 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIH
Curated by PDSP Ki Database
| |
Synapse 39: 32-41 (2001)
Article DOI: 10.1002/1098-2396(20010101)39:1 BindingDB Entry DOI: 10.7270/Q2NV9GT3 |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 13: 454-73 (1977)
BindingDB Entry DOI: 10.7270/Q2TT4PFZ |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
Reactome pathway KEGG
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| Article
| >1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptor |
Bioorg Med Chem Lett 7: 1207-1212 (1997)
Article DOI: 10.1016/S0960-894X(97)00194-7 BindingDB Entry DOI: 10.7270/Q2CJ8F0Z |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Mol Pharmacol 13: 454-73 (1977)
BindingDB Entry DOI: 10.7270/Q2TT4PFZ |
More data for this Ligand-Target Pair | |
D(4) dopamine receptor
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| Article
| >3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptor |
Bioorg Med Chem Lett 7: 1207-1212 (1997)
Article DOI: 10.1016/S0960-894X(97)00194-7 BindingDB Entry DOI: 10.7270/Q2CJ8F0Z |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
Reactome pathway KEGG
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| Article PubMed
| 1.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin
Curated by ChEMBL
| Assay Description Affinity towards Dopamine receptor D2 |
J Med Chem 41: 4385-99 (1998)
Article DOI: 10.1021/jm9800292 BindingDB Entry DOI: 10.7270/Q2R21227 |
More data for this Ligand-Target Pair | |
Phenylethanolamine N-methyltransferase
(Bos taurus (bovine)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
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| Article PubMed
| 2.94E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by ChEMBL
| Assay Description The compound was tested for In vitro inhibitory activity against Phenylethanolamine N-Methyltransferase (PNMT) |
J Med Chem 32: 478-86 (1989)
Article DOI: 10.1021/jm00122a032 BindingDB Entry DOI: 10.7270/Q2P55P32 |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
Reactome pathway KEGG
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| Article PubMed
| 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas at Austin
Curated by ChEMBL
| Assay Description Affinity towards Dopamine receptor D1 |
J Med Chem 41: 4385-99 (1998)
Article DOI: 10.1021/jm9800292 BindingDB Entry DOI: 10.7270/Q2R21227 |
More data for this Ligand-Target Pair | |
Trace amine-associated receptor 1 (TAAR1)
(Rattus norvegicus (Rat)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by ChEMBL
| Assay Description Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr |
J Med Chem 60: 2605-2628 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00085 BindingDB Entry DOI: 10.7270/Q2DJ5HWM |
More data for this Ligand-Target Pair | |
Opioid receptor
(Rattus norvegicus (rat)-RAT) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of specifically bound [3H]naloxone from rat brain homogenate, in the absence of NaCl |
J Med Chem 23: 1113-22 (1980)
Article DOI: 10.1021/jm00184a010 BindingDB Entry DOI: 10.7270/Q2639RX4 |
More data for this Ligand-Target Pair | |
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)
(RAT) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor |
J Med Chem 23: 990-4 (1980)
Article DOI: 10.1021/jm00183a006 BindingDB Entry DOI: 10.7270/Q2668FCW |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a |
Howard Hughes Medical Institute
Curated by ChEMBL
| Assay Description Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay |
Nature 450: 553-556 (2007)
Article DOI: 10.1038/nature05991 BindingDB Entry DOI: 10.7270/Q2833SXW |
More data for this Ligand-Target Pair | |
trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 731 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal... |
Bioorg Med Chem 16: 7415-23 (2008)
Article DOI: 10.1016/j.bmc.2008.06.009 BindingDB Entry DOI: 10.7270/Q2DR2V92 |
More data for this Ligand-Target Pair | |
TyR1
(Chilo suppressalis) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | n/a | n/a | 369 | n/a | n/a | n/a | n/a |
Zhejiang University
Curated by ChEMBL
| Assay Description Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced ... |
Pest Manag Sci 69: 126-34 (2013)
Article DOI: 10.1002/ps.3378 BindingDB Entry DOI: 10.7270/Q2T43X0R |
More data for this Ligand-Target Pair | |
G-protein subunit alpha-16
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway
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| PCBioAssay
| n/a | n/a | >2.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
| |
PubChem Bioassay (2013)
BindingDB Entry DOI: 10.7270/Q2QZ28KG |
More data for this Ligand-Target Pair | |
trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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| PCBioAssay
| n/a | n/a | n/a | n/a | 178 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
| |
PubChem Bioassay (2013)
BindingDB Entry DOI: 10.7270/Q24748HT |
More data for this Ligand-Target Pair | |
trace amine-associated receptor 1
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway KEGG
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Patents
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| PCBioAssay
| n/a | n/a | 882 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
| |
PubChem Bioassay (2013)
BindingDB Entry DOI: 10.7270/Q280517J |
More data for this Ligand-Target Pair | |
G-protein subunit alpha-16
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | Reactome pathway
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| PCBioAssay
| n/a | n/a | n/a | n/a | >2.99E+4 | n/a | n/a | n/a | n/a |
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
| |
PubChem Bioassay (2013)
BindingDB Entry DOI: 10.7270/Q2CN72J7 |
More data for this Ligand-Target Pair | |
Beta-secretase 1
(Homo sapiens (Human)) | BDBM29135
(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)Show InChI InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | PDB MMDB
Reactome pathway KEGG
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| MMDB PDB Article PubMed
| n/a | n/a | n/a | 2.00E+6 | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by ChEMBL
| Assay Description Binding affinity to BACE1 by surface plasmon resonance method |
Bioorg Med Chem Lett 18: 1304-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.032 BindingDB Entry DOI: 10.7270/Q2Z60PW9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |