BindingDB PrimarySearch

BDBM50026472 (CH3)2SO::(methanesulfinyl)methanedimethyl sulfoxide::CHEMBL504::DIMETHYL SULFOXIDE::Dimethylsulfoxid::S(O)Me2::dimethyl sulfur oxide::dimethyl sulphoxide::dmso::methylsulfinylmethane::sulfinylbis(methane)

SMILES: CS(C)=O

InChI Key: InChIKey=IAZDPXIOMUYVGZ-UHFFFAOYSA-N

Data: 6 KI 2 IC50 7 Kd

PDB links: 3213 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50026472
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	1.07E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein cereblon (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.37E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	5.70E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform by FRET assay				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	1.10E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Competitive binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST ba...				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Choline Acetyltransferase (RAT)	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.50E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)				J Med Chem 28: 1309-13 (1985) Article DOI: 10.1021/jm00147a033 BindingDB Entry DOI: 10.7270/Q26W994C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.37E+8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Competitive binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by FRET assay				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair
Protein cereblon (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.64E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence by MS...				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair
Cereblon isoform 4 (Magnetospirillum gryphiswaldense)	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	2.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
Max Planck Institute for Developmental Biology Curated by ChEMBL					Assay Description Binding affinity to Magnetospirillum gryphiswaldense cereblon isoform 4 by measuring baseline corrected normalized fluorescence by MST based assay				ACS Med Chem Lett 12: 74-81 (2021)
					More data for this Ligand-Target Pair				3D Structure (crystal)
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	6.48E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue Y50				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.41E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue L73				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	6.50E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue S85				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	7.19E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in BS binding to Insulin-like growth factor binding protein 5 at the residue K91				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	6.10E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue L81				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	7.83E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue Y86				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Insulin-like growth factor binding protein 5 (Homo sapiens (Human))	BDBM50026472 ((CH3)2SO \| (methanesulfinyl)methanedimethyl sulfox...) Show SMILES CS(C)=O Show InChI InChI=1S/C2H6OS/c1-4(2)3/h1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	9.21E+8	n/a	n/a	n/a	n/a	n/a
Institute for Biochemistry Curated by ChEMBL					Assay Description Dissociation constant of the compound in binding to Insulin-like growth factor binding protein 5 at the residue R87				J Med Chem 45: 5655-60 (2002) Article DOI: 10.1021/jm0208828 BindingDB Entry DOI: 10.7270/Q2QV3KV4
Institute for Biochemistry Curated by ChEMBL					More data for this Ligand-Target Pair