BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 51480532 Oc1c(O)c2C(=O)c3ccccc3C(=O)c2cc1S([O-])(=O)=O InChI=1S/C14H8O7S/c15-11-6-3-1-2-4-7(6)12(16)10-8(11)5-9(22(19,20)21)13(17)14(10)18/h1-5,17-18H,(H,19,20,21)/p-1 JKYKXTRKURYNGW-UHFFFAOYSA-M 50143419 Sodium; 3,4-dihydroxy-9,10-dioxo-9,10-dihydro-anthracene-2-sulfonate::CHEMBL175336 Pyruvate kinase PKLR Homo sapiens 200 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143419&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 3863551 104032613 CHEMBL175336 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480533 OC(=O)CNS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O InChI=1S/C16H11NO8S/c18-11(19)6-17-26(24,25)10-5-9-12(16(23)15(10)22)14(21)8-4-2-1-3-7(8)13(9)20/h1-5,17,22-23H,6H2,(H,18,19) XAPQQYQERZCOIC-UHFFFAOYSA-N 50596751 CHEMBL5176753 Pyruvate kinase PKLR Homo sapiens 200 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596751&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168273114 482607603 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480534 c1ccc2c(c1)C(=O)c3cc(c(c(c3C2=O)O)O)S(=O)(=O)NCCC(=O)O InChI=1S/C17H13NO8S/c19-12(20)5-6-18-27(25,26)11-7-10-13(17(24)16(11)23)15(22)9-4-2-1-3-8(9)14(10)21/h1-4,7,18,23-24H,5-6H2,(H,19,20) TVGDFUTTWNAYMD-UHFFFAOYSA-N 50596752 CHEMBL5172682 Pyruvate kinase PKLR Homo sapiens 5800 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596752&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search I9Q 5SDT 162678542 482607604 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480535 OC(=O)CCCNS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O InChI=1S/C18H15NO8S/c20-13(21)6-3-7-19-28(26,27)12-8-11-14(18(25)17(12)24)16(23)10-5-2-1-4-9(10)15(11)22/h1-2,4-5,8,19,24-25H,3,6-7H2,(H,20,21) IIKPOAWOQXFKOA-UHFFFAOYSA-N 50596753 CHEMBL5209293 Pyruvate kinase PKLR Homo sapiens 7500 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596753&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168295517 482607605 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480536 c1ccc2c(c1)C(=O)c3cc(c(c(c3C2=O)O)O)S(=O)(=O)NCCCCC(=O)O InChI=1S/C19H17NO8S/c21-14(22)7-3-4-8-20-29(27,28)13-9-12-15(19(26)18(13)25)17(24)11-6-2-1-5-10(11)16(12)23/h1-2,5-6,9,20,25-26H,3-4,7-8H2,(H,21,22) QKSBODUPEIWERR-UHFFFAOYSA-N 50596754 CHEMBL5188932 Pyruvate kinase PKLR Homo sapiens 19000 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596754&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search E6K 5SC8 162678531 482607606 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480537 OC[C@H](NS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O |r| InChI=1S/C17H13NO9S/c19-6-10(17(24)25)18-28(26,27)11-5-9-12(16(23)15(11)22)14(21)8-4-2-1-3-7(8)13(9)20/h1-5,10,18-19,22-23H,6H2,(H,24,25) ABRGLDHFMGSAGG-UHFFFAOYSA-N 50596755 CHEMBL5183208 Pyruvate kinase PKLR Homo sapiens 900 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596755&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168278474 482607607 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480538 COC[C@H](NS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O |r| InChI=1S/C18H15NO9S/c1-28-7-11(18(24)25)19-29(26,27)12-6-10-13(17(23)16(12)22)15(21)9-5-3-2-4-8(9)14(10)20/h2-6,11,19,22-23H,7H2,1H3,(H,24,25) LTERDQPAPZBVNO-UHFFFAOYSA-N 50596756 CHEMBL5186564 Pyruvate kinase PKLR Homo sapiens 1200 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596756&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168278184 482607608 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480539 CSCCC(NS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O InChI=1S/C19H17NO8S2/c1-29-7-6-12(19(25)26)20-30(27,28)13-8-11-14(18(24)17(13)23)16(22)10-5-3-2-4-9(10)15(11)21/h2-5,8,12,20,23-24H,6-7H2,1H3,(H,25,26) XONKGDIAVYIUIF-UHFFFAOYSA-N 50596757 CHEMBL5186706 Pyruvate kinase PKLR Homo sapiens 1400 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596757&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168281066 482607609 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480540 OC(=O)CNC(=O)CNS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O InChI=1S/C18H14N2O9S/c21-12(19-7-13(22)23)6-20-30(28,29)11-5-10-14(18(27)17(11)26)16(25)9-4-2-1-3-8(9)15(10)24/h1-5,20,26-27H,6-7H2,(H,19,21)(H,22,23) KXQNRTCNXMVTJL-UHFFFAOYSA-N 50596758 CHEMBL5172724 Pyruvate kinase PKLR Homo sapiens 4100 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596758&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168270356 482607610 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480541 OC(=O)CNC(=O)CNC(=O)CNS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O InChI=1S/C20H17N3O10S/c24-13(22-8-15(26)27)6-21-14(25)7-23-34(32,33)12-5-11-16(20(31)19(12)30)18(29)10-4-2-1-3-9(10)17(11)28/h1-5,23,30-31H,6-8H2,(H,21,25)(H,22,24)(H,26,27) ZODQXYMGQOTJON-UHFFFAOYSA-N 50596759 CHEMBL5188496 Pyruvate kinase PKLR Homo sapiens 700 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596759&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168281121 482607611 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480542 OC(=O)Cc1ccc(CNS(=O)(=O)c2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1C(O)=O InChI=1S/C24H17NO10S/c26-18(27)8-12-6-5-11(7-15(12)24(32)33)10-25-36(34,35)17-9-16-19(23(31)22(17)30)21(29)14-4-2-1-3-13(14)20(16)28/h1-7,9,25,30-31H,8,10H2,(H,26,27)(H,32,33) APZGIAKOKFDDCJ-UHFFFAOYSA-N 50596760 CHEMBL5181251 Pyruvate kinase PKLR Homo sapiens 300 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596760&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168274745 482607612 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480543 OC(=O)C1CCCN(C1)S(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O InChI=1S/C20H17NO8S/c22-16-11-5-1-2-6-12(11)17(23)15-13(16)8-14(18(24)19(15)25)30(28,29)21-7-3-4-10(9-21)20(26)27/h1-2,5-6,8,10,24-25H,3-4,7,9H2,(H,26,27) COKUEECTCYPUSI-UHFFFAOYSA-N 50596761 CHEMBL5209097 Pyruvate kinase PKLR Homo sapiens 160 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596761&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168295032 482607613 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480544 c1ccc2c(c1)C(=O)c3cc(c(c(c3C2=O)O)O)S(=O)(=O)N4CCC(CC4)C(=O)O InChI=1S/C20H17NO8S/c22-16-11-3-1-2-4-12(11)17(23)15-13(16)9-14(18(24)19(15)25)30(28,29)21-7-5-10(6-8-21)20(26)27/h1-4,9-10,24-25H,5-8H2,(H,26,27) GAZMUVGYYAVFHP-UHFFFAOYSA-N 50596762 CHEMBL5170819 Pyruvate kinase PKLR Homo sapiens 4800 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596762&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search I7K 5SC9 162678532 482607614 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480545 OC(=O)C[C@H](NC(=O)C1CCCN(C1)S(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O |r| InChI=1S/C24H22N2O11S/c27-17(28)9-15(24(34)35)25-23(33)11-4-3-7-26(10-11)38(36,37)16-8-14-18(22(32)21(16)31)20(30)13-6-2-1-5-12(13)19(14)29/h1-2,5-6,8,11,15,31-32H,3-4,7,9-10H2,(H,25,33)(H,27,28)(H,34,35) HWQZQOYBMBRIAX-UHFFFAOYSA-N 50596763 CHEMBL5198643 Pyruvate kinase PKLR Homo sapiens 1900 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596763&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168286018 482607615 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480546 OC(=O)CC[C@H](NC(=O)C1CCCN(C1)S(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O |r| InChI=1S/C25H24N2O11S/c28-18(29)8-7-16(25(35)36)26-24(34)12-4-3-9-27(11-12)39(37,38)17-10-15-19(23(33)22(17)32)21(31)14-6-2-1-5-13(14)20(15)30/h1-2,5-6,10,12,16,32-33H,3-4,7-9,11H2,(H,26,34)(H,28,29)(H,35,36) OEXQBYGKYFTFIN-UHFFFAOYSA-N 50596764 CHEMBL5206382 Pyruvate kinase PKLR Homo sapiens 1300 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596764&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168296762 482607616 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480547 c1ccc2c(c1)C(=O)c3cc(c(c(c3C2=O)O)O)S(=O)(=O)N4CCNCC4 InChI=1S/C18H16N2O6S/c21-15-10-3-1-2-4-11(10)16(22)14-12(15)9-13(17(23)18(14)24)27(25,26)20-7-5-19-6-8-20/h1-4,9,19,23-24H,5-8H2 LUICJQQAUHLELI-UHFFFAOYSA-N 50596765 CHEMBL5204170 Pyruvate kinase PKLR Homo sapiens 150 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596765&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search I9N 5SCK 162678541 482607617 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480548 OC(=O)CC[C@H](NC(=O)N1CCN(CC1)S(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O |r| InChI=1S/C24H23N3O11S/c28-17(29)6-5-15(23(34)35)25-24(36)26-7-9-27(10-8-26)39(37,38)16-11-14-18(22(33)21(16)32)20(31)13-4-2-1-3-12(13)19(14)30/h1-4,11,15,32-33H,5-10H2,(H,25,36)(H,28,29)(H,34,35) SSAQUUNBXCJABL-UHFFFAOYSA-N 50596766 CHEMBL5204537 Pyruvate kinase PKLR Homo sapiens 550 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596766&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168294804 482607618 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480549 OC(=O)Cc1ccc(CNC(=O)N2CCN(CC2)S(=O)(=O)c2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1C(O)=O InChI=1S/C29H25N3O11S/c33-22(34)12-16-6-5-15(11-19(16)28(39)40)14-30-29(41)31-7-9-32(10-8-31)44(42,43)21-13-20-23(27(38)26(21)37)25(36)18-4-2-1-3-17(18)24(20)35/h1-6,11,13,37-38H,7-10,12,14H2,(H,30,41)(H,33,34)(H,39,40) CNIGWNHYMRJFCQ-UHFFFAOYSA-N 50596767 CHEMBL5176181 Pyruvate kinase PKLR Homo sapiens 290 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596767&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168272106 482607619 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480550 OC(=O)CC(O)(CC(=O)N1CCN(CC1)S(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O InChI=1S/C24H22N2O12S/c27-16(10-24(36,23(34)35)11-17(28)29)25-5-7-26(8-6-25)39(37,38)15-9-14-18(22(33)21(15)32)20(31)13-4-2-1-3-12(13)19(14)30/h1-4,9,32-33,36H,5-8,10-11H2,(H,28,29)(H,34,35) PYHLNZSMOIJZLQ-UHFFFAOYSA-N 50596768 CHEMBL5208105 Pyruvate kinase PKLR Homo sapiens 200 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596768&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168294676 482607620 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480551 Oc1cc(cc2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O InChI=1S/C14H8O6S/c15-11-6-7(21(18,19)20)5-10-12(11)14(17)9-4-2-1-3-8(9)13(10)16/h1-6,15H,(H,18,19,20)/p-1 PAMDWDSSKCYOML-UHFFFAOYSA-M 50596769 CHEMBL5193313 Pyruvate kinase PKLR Homo sapiens 7300 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596769&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 23696251 482607621 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480552 Oc1cc2C(=O)c3ccccc3C(=O)c2cc1S([O-])(=O)=O InChI=1S/C14H8O6S/c15-11-5-9-10(6-12(11)21(18,19)20)14(17)8-4-2-1-3-7(8)13(9)16/h1-6,15H,(H,18,19,20)/p-1 PHPXXDWAMNINMC-UHFFFAOYSA-M 50596770 CHEMBL5170574 Pyruvate kinase PKLR Homo sapiens 3400 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596770&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 23663361 482607622 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480553 Oc1c(O)c2C(=O)c3ccccc3C(=O)c2cc1C([O-])=O InChI=1S/C15H8O6/c16-11-6-3-1-2-4-7(6)12(17)10-8(11)5-9(15(20)21)13(18)14(10)19/h1-5,18-19H,(H,20,21)/p-1 WVNZRIIMWFMRKM-UHFFFAOYSA-M 50596771 CHEMBL5181273 Pyruvate kinase PKLR Homo sapiens 1400 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596771&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168277183 482607623 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480554 OC(=O)Cc1ccc(CNC(=O)Nc2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1C(O)=O InChI=1S/C25H18N2O9/c28-18(29)8-12-6-5-11(7-15(12)24(34)35)10-26-25(36)27-17-9-16-19(23(33)22(17)32)21(31)14-4-2-1-3-13(14)20(16)30/h1-7,9,32-33H,8,10H2,(H,28,29)(H,34,35)(H2,26,27,36) XARRCYVPCCGREF-UHFFFAOYSA-N 50596772 CHEMBL5200212 Pyruvate kinase PKLR Homo sapiens 1700 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596772&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168291245 482607624 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480555 OC(=O)Cc1ccc(CNc2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1C(O)=O InChI=1S/C24H17NO8/c26-18(27)8-12-6-5-11(7-15(12)24(32)33)10-25-17-9-16-19(23(31)22(17)30)21(29)14-4-2-1-3-13(14)20(16)28/h1-7,9,25,30-31H,8,10H2,(H,26,27)(H,32,33) FAVOAKBENZCWLQ-UHFFFAOYSA-N 50596773 CHEMBL5195754 Pyruvate kinase PKLR Homo sapiens 1300 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596773&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168284330 482607625 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480556 OC(=O)CC(Nc1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O)C(O)=O InChI=1S/C18H13NO8/c20-12(21)6-11(18(26)27)19-10-5-9-13(17(25)16(10)24)15(23)8-4-2-1-3-7(8)14(9)22/h1-5,11,19,24-25H,6H2,(H,20,21)(H,26,27) JVFYYXJPKLKCMJ-UHFFFAOYSA-N 50596774 CHEMBL5177546 Pyruvate kinase PKLR Homo sapiens 2500 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596774&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168275453 482607626 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973 51480557 OC(=O)Cc1ccc(CNc2cc3C(=O)c4ccccc4C(=O)c3c(O)c2O)cc1 InChI=1S/C23H17NO6/c25-18(26)9-12-5-7-13(8-6-12)11-24-17-10-16-19(23(30)22(17)29)21(28)15-4-2-1-3-14(15)20(16)27/h1-8,10,24,29-30H,9,11H2,(H,25,26) RXQXULCJAATEQI-UHFFFAOYSA-N 50596775 CHEMBL5169856 Pyruvate kinase PKLR Homo sapiens 3800 ChEMBL 10.7270/Q2VX0MJ9 35290845 Nain-Perez, A; Foller Füchtbauer, A; Håversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grøtli, M 4/15/2022 6/22/2023 University of Gothenburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006714&target=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596775&enzyme=Pyruvate+kinase+PKLR&column=ki&startPg=0&Increment=50&submit=Search 168268863 482607627 1 MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS 8XFD,2VGB,8TBU,8TBT,8TBS,9R3O,9R3M,9R3L,9R3I,9R3H,7QZU,7QDN,7FSD,7FSC,7FSB,7FSA,7FS9 Pyruvate kinase PKLR KPYR_HUMAN P30613 O75758 P11973