BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 237001 Cc1ccccc1-c1nnc(S)o1 InChI=1S/C9H8N2OS/c1-6-4-2-3-5-7(6)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13) HNFIJWNVPWXSOL-UHFFFAOYSA-N 42577 SMR000009336::cid_774385::5-(2-methylphenyl)-3H-1,3,4-oxadiazole-2-thione::MLS000029608::5-o-Tolyl-3H-[1,3,4]oxadiazole-2-thione::5-(o-tolyl)-3H-1,3,4-oxadiazole-2-thione Major prion protein Homo sapiens 5752 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42577&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 774385 252623271 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237002 Cc1ccc(cc1)C1C(C#N)C(=N)SC(=N)C1C#N InChI=1S/C14H12N4S/c1-8-2-4-9(5-3-8)12-10(6-15)13(17)19-14(18)11(12)7-16/h2-5,10-12,17-18H,1H3 XLSJDNOPRJQIAQ-UHFFFAOYSA-N 114305 2,6-bis(azanyl)-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile::cid_600799::MLS000072491::SMR000010366::2,6-diamino-4-(4-methylphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-Diamino-4-p-tolyl-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(p-tolyl)-4H-thiopyran-3,5-dicarbonitrile Major prion protein Homo sapiens 1863 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114305&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899713 252663811 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237003 OC(=O)CSc1ccc2ccccc2n1 InChI=1S/C11H9NO2S/c13-11(14)7-15-10-6-5-8-3-1-2-4-9(8)12-10/h1-6H,7H2,(H,13,14) WOZJGFBFMIWEGN-UHFFFAOYSA-N 42597 2-(2-quinolinylthio)acetic acid::(Quinolin-2-ylsulfanyl)-acetic acid::cid_408543::2-quinolin-2-ylsulfanylethanoic acid::SMR000009740::2-quinolin-2-ylsulfanylacetic acid::MLS000029205::2-(2-quinolylthio)acetic acid Major prion protein Homo sapiens 6886 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42597&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 408543 252623290 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237004 COC(=O)CSc1nc(nc2ccccc12)C(C)C InChI=1S/C14H16N2O2S/c1-9(2)13-15-11-7-5-4-6-10(11)14(16-13)19-8-12(17)18-3/h4-7,9H,8H2,1-3H3 RXCTXYJPRWUXHX-UHFFFAOYSA-N 40943 SMR000006837::(2-Isopropyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester::cid_652110::MLS000074241::methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoate::2-[(2-propan-2-yl-4-quinazolinyl)thio]acetic acid methyl ester::methyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetate::2-[(2-isopropylquinazolin-4-yl)thio]acetic acid methyl ester Major prion protein Homo sapiens 910 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40943&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 652110 252621724 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237005 COc1ccc2c(Cl)c(sc2c1)C(N)=O InChI=1S/C10H8ClNO2S/c1-14-5-2-3-6-7(4-5)15-9(8(6)11)10(12)13/h2-4H,1H3,(H2,12,13) IWPCUYGXTLHCHD-UHFFFAOYSA-N 37876 SMR000012987::MLS000075717::3-Chloro-6-methoxy-benzo[b]thiophene-2-carboxylic acid amide::3-chloro-6-methoxy-1-benzothiophene-2-carboxamide::cid_652152::3-chloranyl-6-methoxy-1-benzothiophene-2-carboxamide::3-chloro-6-methoxy-benzothiophene-2-carboxamide Major prion protein Homo sapiens 2464 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37876&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 652152 252618834 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237006 CCCc1nc(SCC(=O)Nc2cc(C)on2)c2ccccc2n1 InChI=1S/C17H18N4O2S/c1-3-6-14-18-13-8-5-4-7-12(13)17(20-14)24-10-16(22)19-15-9-11(2)23-21-15/h4-5,7-9H,3,6,10H2,1-2H3,(H,19,21,22) MQSYQADINVVTLN-UHFFFAOYSA-N 42605 SMR000006835::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanylacetamide::N-(5-methyl-3-isoxazolyl)-2-[(2-propyl-4-quinazolinyl)thio]acetamide::cid_653552::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanyl-ethanamide::N-(5-Methyl-isoxazol-3-yl)-2-(2-propyl-quinazolin-4-ylsulfanyl)-acetamide::MLS000073796::N-(5-methylisoxazol-3-yl)-2-[(2-propylquinazolin-4-yl)thio]acetamide Major prion protein Homo sapiens 1005 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42605&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 653552 252623298 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237007 CCOC(=O)CSc1nc(CC)nc2ccccc12 InChI=1S/C14H16N2O2S/c1-3-12-15-11-8-6-5-7-10(11)14(16-12)19-9-13(17)18-4-2/h5-8H,3-4,9H2,1-2H3 GYWWQCMUVOLXSR-UHFFFAOYSA-N 114306 ethyl 2-(2-ethylquinazolin-4-yl)sulfanylethanoate::MLS000072840::cid_654420::2-[(2-ethyl-4-quinazolinyl)thio]acetic acid ethyl ester::ethyl 2-(2-ethylquinazolin-4-yl)sulfanylacetate::(2-Ethyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester::SMR000003743::2-[(2-ethylquinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 1078 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114306&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 654420 252663812 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237008 CSCCC(Nc1ncnc2ccc(Br)cc12)C(O)=O InChI=1S/C13H14BrN3O2S/c1-20-5-4-11(13(18)19)17-12-9-6-8(14)2-3-10(9)15-7-16-12/h2-3,6-7,11H,4-5H2,1H3,(H,18,19)(H,15,16,17) IUHZVPMVQBUAIR-UHFFFAOYSA-N 42607 SMR000011110::2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid;hydrochloride::MLS000032173::cid_2787398::2-(6-Bromo-quinazolin-4-ylamino)-4-methylsulfanyl-butyric acid::2-[(6-bromanylquinazolin-4-yl)amino]-4-methylsulfanyl-butanoic acid;hydrochloride::2-[(6-bromoquinazolin-4-yl)amino]-4-methylsulfanylbutanoic acid;hydrochloride::2-[(6-bromoquinazolin-4-yl)amino]-4-(methylthio)butyric acid;hydrochloride Major prion protein Homo sapiens 1907 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42607&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 655842 252623300 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237009 NC(=O)c1ccc(o1)-c1ccc(Br)cc1 InChI=1S/C11H8BrNO2/c12-8-3-1-7(2-4-8)9-5-6-10(15-9)11(13)14/h1-6H,(H2,13,14) XXLMIQGREFEHPT-UHFFFAOYSA-N 114307 SMR000039735::5-(4-bromophenyl)furan-2-carboxamide::cid_658747::MLS000079797::5-(4-bromophenyl)-2-furancarboxamide::5-(4-bromophenyl)-2-furamide Major prion protein Homo sapiens 7425 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114307&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 658747 252663813 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237010 Brc1cc(Br)c2ncnc(N3CCCCC3)c2c1 InChI=1S/C13H13Br2N3/c14-9-6-10-12(11(15)7-9)16-8-17-13(10)18-4-2-1-3-5-18/h6-8H,1-5H2 VRGCZRLDXAZCCX-UHFFFAOYSA-N 66153 6,8-dibromo-4-(1-piperidinyl)quinazoline::MLS000038796::cid_659524::6,8-dibromo-4-piperidin-1-ylquinazoline::SMR000040604::6,8-bis(bromanyl)-4-piperidin-1-yl-quinazoline::6,8-dibromo-4-piperidino-quinazoline Major prion protein Homo sapiens 1382 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66153&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 659524 252644482 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237011 COc1ccccc1-c1n[nH]c(=S)n1-c1ccccc1 InChI=1S/C15H13N3OS/c1-19-13-10-6-5-9-12(13)14-16-17-15(20)18(14)11-7-3-2-4-8-11/h2-10H,1H3,(H,17,20) QFYMYTCWMJUZSY-UHFFFAOYSA-N 47052 SMR000059294::cid_660816::MLS000077671::3-(2-methoxyphenyl)-4-phenyl-1H-1,2,4-triazole-5-thione Major prion protein Homo sapiens 7184 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47052&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 660816 252627574 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237012 CCc1c([nH]c2ccc(Br)cc12)C(O)=O InChI=1S/C11H10BrNO2/c1-2-7-8-5-6(12)3-4-9(8)13-10(7)11(14)15/h3-5,13H,2H2,1H3,(H,14,15) VDWBOEDWXSJGGH-UHFFFAOYSA-N 66155 5-bromanyl-3-ethyl-1H-indole-2-carboxylic acid::MLS000036715::SMR000041962::cid_661296::5-bromo-3-ethyl-1H-indole-2-carboxylic acid Major prion protein Homo sapiens 5952 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66155&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 661296 252644484 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237013 CC(Sc1ccc2ccccc2n1)C(O)=O InChI=1S/C12H11NO2S/c1-8(12(14)15)16-11-7-6-9-4-2-3-5-10(9)13-11/h2-8H,1H3,(H,14,15) JLYPYACZXPBHLU-UHFFFAOYSA-N 42635 SMR000042099::MLS000036607::2-quinolin-2-ylsulfanylpropanoic acid::cid_661441::2-(2-quinolinylthio)propanoic acid::2-(2-quinolylthio)propionic acid Major prion protein Homo sapiens 1558 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42635 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42635&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 661441 252623327 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237014 OC(=O)CCSc1ccc2ccccc2n1 InChI=1S/C12H11NO2S/c14-12(15)7-8-16-11-6-5-9-3-1-2-4-10(9)13-11/h1-6H,7-8H2,(H,14,15) QKYKAHGSVSTGFP-UHFFFAOYSA-N 42636 3-quinolin-2-ylsulfanylpropanoic acid::cid_661670::SMR000042255::3-(2-quinolinylthio)propanoic acid::MLS000077859::3-(2-quinolylthio)propionic acid Major prion protein Homo sapiens 3186 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42636&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 661670 252623328 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237015 Cn1c(nc2n(C)c(=O)n(Cc3cccc(Br)c3)c(=O)c12)N1CCC(CC1)C(N)=O InChI=1S/C20H23BrN6O3/c1-24-15-17(23-19(24)26-8-6-13(7-9-26)16(22)28)25(2)20(30)27(18(15)29)11-12-4-3-5-14(21)10-12/h3-5,10,13H,6-9,11H2,1-2H3,(H2,22,28) GYPCOXPCDHSNDK-UHFFFAOYSA-N 114308 cid_662346::SMR000042978::MLS000082096::1-[1-[(3-bromophenyl)methyl]-3,7-dimethyl-2,6-bis(oxidanylidene)purin-8-yl]piperidine-4-carboxamide::1-[1-[(3-bromophenyl)methyl]-3,7-dimethyl-2,6-dioxopurin-8-yl]piperidine-4-carboxamide::1-[1-[(3-bromophenyl)methyl]-3,7-dimethyl-2,6-dioxo-8-purinyl]-4-piperidinecarboxamide::1-[1-(3-bromobenzyl)-2,6-diketo-3,7-dimethyl-purin-8-yl]isonipecotamide Major prion protein Homo sapiens 8380 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114308&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 662346 252663814 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237016 CC(=NCc1cccnc1)c1c(O)n(-c2ccc(C)cc2)c(=O)[nH]c1=O |w:2.2| InChI=1S/C19H18N4O3/c1-12-5-7-15(8-6-12)23-18(25)16(17(24)22-19(23)26)13(2)21-11-14-4-3-9-20-10-14/h3-10,25H,11H2,1-2H3,(H,22,24,26) SIYDBMUOFNOSKX-UHFFFAOYSA-N 114309 (5E)-1-(4-methylphenyl)-5-[1-(pyridin-3-ylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione::SMR000043385::MLS000041292::(5E)-1-(4-methylphenyl)-5-[1-(3-pyridinylmethylamino)ethylidene]-1,3-diazinane-2,4,6-trione::cid_5389570::(5E)-1-(p-tolyl)-5-[1-(3-pyridylmethylamino)ethylidene]barbituric acid Major prion protein Homo sapiens 10211 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114309&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5389570 252663815 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237017 Brc1ccc(o1)-c1nn2c(nnc2s1)-c1ccco1 InChI=1S/C11H5BrN4O2S/c12-8-4-3-7(18-8)10-15-16-9(6-2-1-5-17-6)13-14-11(16)19-10/h1-5H SMGFRJZXRIDDIV-UHFFFAOYSA-N 42643 6-(5-bromofuran-2-yl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(5-bromo-2-furanyl)-3-(2-furanyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::MLS000041402::SMR000043609::6-(5-bromanylfuran-2-yl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::cid_662886::6-(5-bromo-2-furyl)-3-(2-furyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Major prion protein Homo sapiens 4141 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42643 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42643&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 662886 252623335 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237018 OC\C=C(\CS(=O)(=O)c1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C16H16O5S2/c17-12-11-16(23(20,21)15-9-5-2-6-10-15)13-22(18,19)14-7-3-1-4-8-14/h1-11,17H,12-13H2 AIAKDUWZCKEZRU-UHFFFAOYSA-N 36923 (Z)-3,4-bis(benzenesulfonyl)but-2-en-1-ol::cid_5389617::(Z)-3,4-bis(benzenesulfonyl)-2-buten-1-ol::MLS000080860::SMR000043655::(Z)-3,4-bis(phenylsulfonyl)but-2-en-1-ol::(Z)-3,4-dibesylbut-2-en-1-ol Major prion protein Homo sapiens 9140 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36923&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5389617 252617895 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237019 COc1ccc(cc1OC)-c1nnc(o1)-c1ccc(Br)o1 InChI=1S/C14H11BrN2O4/c1-18-9-4-3-8(7-11(9)19-2)13-16-17-14(21-13)10-5-6-12(15)20-10/h3-7H,1-2H3 CAJCHFLRAUBNQL-UHFFFAOYSA-N 39607 2-(5-bromo-2-furanyl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::2-(5-bromofuran-2-yl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::SMR000064578::cid_1219876::2-(5-bromanylfuran-2-yl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::MLS000056595::2-(5-bromo-2-furyl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole Major prion protein Homo sapiens 4587 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39607&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1219876 252620496 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237020 O=C(CSc1ncnc2ccccc12)NCc1ccco1 InChI=1S/C15H13N3O2S/c19-14(16-8-11-4-3-7-20-11)9-21-15-12-5-1-2-6-13(12)17-10-18-15/h1-7,10H,8-9H2,(H,16,19) OPWCBBCTBKTILK-UHFFFAOYSA-N 87650 N-(furan-2-ylmethyl)-2-quinazolin-4-ylsulfanylacetamide::MLS000048928::N-(furan-2-ylmethyl)-2-quinazolin-4-ylsulfanyl-ethanamide::SMR000061736::cid_2396077::N-(2-furanylmethyl)-2-(4-quinazolinylthio)acetamide::N-(2-furfuryl)-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 6831 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87650&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2396077 252660022 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237021 Cn1c(=O)c(C(=O)CSc2nncs2)c(N)n(Cc2ccccc2)c1=O InChI=1S/C16H15N5O3S2/c1-20-14(23)12(11(22)8-25-15-19-18-9-26-15)13(17)21(16(20)24)7-10-5-3-2-4-6-10/h2-6,9H,7-8,17H2,1H3 XYXTWTYKQHBETE-UHFFFAOYSA-N 114310 MLS000057265::6-amino-1-benzyl-3-methyl-5-[2-(1,3,4-thiadiazol-2-ylsulfanyl)acetyl]pyrimidine-2,4-dione::6-azanyl-3-methyl-1-(phenylmethyl)-5-[2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanoyl]pyrimidine-2,4-dione::SMR000065173::cid_2532080::6-amino-3-methyl-5-[1-oxo-2-(1,3,4-thiadiazol-2-ylthio)ethyl]-1-(phenylmethyl)pyrimidine-2,4-dione::6-amino-1-benzyl-3-methyl-5-[2-(1,3,4-thiadiazol-2-ylthio)acetyl]pyrimidine-2,4-quinone Major prion protein Homo sapiens 8528 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114310 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114310&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2532080 252663816 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237022 CCC(Sc1ccc2nnc(-c3ccc(F)cc3)n2n1)C(O)=O InChI=1S/C15H13FN4O2S/c1-2-11(15(21)22)23-13-8-7-12-17-18-14(20(12)19-13)9-3-5-10(16)6-4-9/h3-8,11H,2H2,1H3,(H,21,22) NPZNJYWZTLCDLC-UHFFFAOYSA-N 68498 2-[[3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio]butanoic acid::SMR000028953::2-{[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio}butanoic acid::cid_3239288::MLS000093332::2-[[3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]sulfanyl]butanoic acid::2-[[3-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]thio]butyric acid Major prion protein Homo sapiens 13006 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68498&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3239288 252646674 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237023 CC(=O)c1nnn(c1C)-c1nc(N)nc(n1)N(c1ccccc1)c1ccccc1 InChI=1S/C20H18N8O/c1-13-17(14(2)29)25-26-28(13)20-23-18(21)22-19(24-20)27(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12H,1-2H3,(H2,21,22,23,24) BXKPXOLOHHWWCM-UHFFFAOYSA-N 114311 cid_1510815::MLS000045653::1-{1-[4-amino-6-(diphenylamino)-1,3,5-triazin-2-yl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone::1-[1-[4-azanyl-6-(diphenylamino)-1,3,5-triazin-2-yl]-5-methyl-1,2,3-triazol-4-yl]ethanone::1-[1-[4-amino-6-(N-phenylanilino)-1,3,5-triazin-2-yl]-5-methyl-4-triazolyl]ethanone::SMR000027610::1-[1-[4-amino-6-(N-phenylanilino)-1,3,5-triazin-2-yl]-5-methyltriazol-4-yl]ethanone::1-[1-[4-amino-6-(N-phenylanilino)-s-triazin-2-yl]-5-methyl-triazol-4-yl]ethanone Major prion protein Homo sapiens 1923 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114311&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1510815 252663817 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237024 Clc1cccc(NC(=O)CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)c1 InChI=1S/C17H11ClN4O3S/c18-10-3-1-4-11(7-10)20-14(23)9-26-17-21-15(13-5-2-6-25-13)12(8-19)16(24)22-17/h1-7H,9H2,(H,20,23)(H,21,22,24) GZZLHIZFGQDPLE-UHFFFAOYSA-N 42714 N-(3-chlorophenyl)-2-{[5-cyano-4-(2-furyl)-6-oxo-1,6-dihydropyrimidin-2-yl]thio}acetamide::cid_3240275::MLS000089894::N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidin-2-yl]sulfanyl]ethanamide::N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furanyl)-4-oxo-1H-pyrimidin-2-yl]thio]acetamide::N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxo-1H-pyrimidin-2-yl]sulfanyl]acetamide::SMR000024512::N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furyl)-4-keto-1H-pyrimidin-2-yl]thio]acetamide Major prion protein Homo sapiens 1691 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42714&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3240275 252623406 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237025 CC(C(O)=O)n1nc(C)c2sc3ccccc3c2c1=O InChI=1S/C14H12N2O3S/c1-7-12-11(9-5-3-4-6-10(9)20-12)13(17)16(15-7)8(2)14(18)19/h3-6,8H,1-2H3,(H,18,19) OSERJAMIDNURES-UHFFFAOYSA-N 42732 SMR000031388::MLS000095840::cid_3242118::2-(4-methyl-1-oxo[1]benzothieno[2,3-d]pyridazin-2(1H)-yl)propanoic acid::2-(4-methyl-1-oxidanylidene-[1]benzothiolo[2,3-d]pyridazin-2-yl)propanoic acid::2-(4-methyl-1-oxo-[1]benzothiolo[2,3-d]pyridazin-2-yl)propanoic acid::2-(1-keto-4-methyl-benzothiopheno[2,3-d]pyridazin-2-yl)propionic acid Major prion protein Homo sapiens 8452 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42732&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3242118 252623424 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237026 Fc1ccc(CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)cc1 InChI=1S/C16H10FN3O2S/c17-11-5-3-10(4-6-11)9-23-16-19-14(13-2-1-7-22-13)12(8-18)15(21)20-16/h1-7H,9H2,(H,19,20,21) DXRLBFPEYLCEPQ-UHFFFAOYSA-N 42791 cid_974019::2-[(4-fluorophenyl)methylthio]-6-(2-furanyl)-4-oxo-1H-pyrimidine-5-carbonitrile::2-[(4-fluorobenzyl)thio]-4-(2-furyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile::SMR000078436::MLS000065058::2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile::2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidine-5-carbonitrile::2-[(4-fluorobenzyl)thio]-6-(2-furyl)-4-keto-1H-pyrimidine-5-carbonitrile Major prion protein Homo sapiens 1025 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42791&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 974019 252623482 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237027 COC(=O)c1sccc1NC(=O)C1CC=CCC1C(O)=O |c:15| InChI=1S/C14H15NO5S/c1-20-14(19)11-10(6-7-21-11)15-12(16)8-4-2-3-5-9(8)13(17)18/h2-3,6-9H,4-5H2,1H3,(H,15,16)(H,17,18) NCLPSSAAUMRJND-UHFFFAOYSA-N 42805 6-[[(2-methoxycarbonyl-3-thiophenyl)amino]-oxomethyl]-1-cyclohex-3-enecarboxylic acid::6-({[2-(methoxycarbonyl)-3-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid::cid_2931382::6-[(2-methoxycarbonylthiophen-3-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid::MLS000088394::SMR000071767::6-[(2-carbomethoxy-3-thienyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid Major prion protein Homo sapiens 2478 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42805&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2931382 252623495 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237028 COc1ccc(Cl)cc1-c1nnc(S)o1 InChI=1S/C9H7ClN2O2S/c1-13-7-3-2-5(10)4-6(7)8-11-12-9(15)14-8/h2-4H,1H3,(H,12,15) FOBNNSSNVSMNMG-UHFFFAOYSA-N 42817 MLS000061371::5-(5-chloro-2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione::SMR000070630::5-(5-chloranyl-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione::5-(5-chloro-2-methoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione::cid_701063::5-(5-chloro-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione Major prion protein Homo sapiens 2085 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42817&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 701063 252623507 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237029 Cc1cc(NC(=O)CSc2nc(-c3ccccc3)c(C#N)c(=O)[nH]2)no1 InChI=1S/C17H13N5O3S/c1-10-7-13(22-25-10)19-14(23)9-26-17-20-15(11-5-3-2-4-6-11)12(8-18)16(24)21-17/h2-7H,9H2,1H3,(H,19,22,23)(H,20,21,24) NUBDDNLQWTWUOY-UHFFFAOYSA-N 43247 2-[(5-cyano-4-oxidanylidene-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)ethanamide::MLS000089197::cid_1081542::SMR000072926::2-[(5-cyano-6-oxo-4-phenyl-1,6-dihydro-2-pyrimidinyl)thio]-N-(5-methyl-3-isoxazolyl)acetamide::2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-(5-methyl-1,2-oxazol-3-yl)acetamide::2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]-N-(5-methyl-3-isoxazolyl)acetamide::2-[(5-cyano-4-keto-6-phenyl-1H-pyrimidin-2-yl)thio]-N-(5-methylisoxazol-3-yl)acetamide Major prion protein Homo sapiens 7139 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43247&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1081542 252623928 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237030 Brc1cc2[nH]cnc2c2ccccc12 InChI=1S/C11H7BrN2/c12-9-5-10-11(14-6-13-10)8-4-2-1-3-7(8)9/h1-6H,(H,13,14) NOQABCGGRDYROW-UHFFFAOYSA-N 54967 MLS000064822::5-bromo-1H-naphtho[1,2-d]imidazole::SMR000077719::cid_972961::5-bromanyl-3H-benzo[e]benzimidazole::5-bromo-3H-benzo[e]benzimidazole Major prion protein Homo sapiens 5962 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54967&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 972961 252634977 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237031 Cc1nc(SCCC(O)=O)c2ccccc2n1 InChI=1S/C12H12N2O2S/c1-8-13-10-5-3-2-4-9(10)12(14-8)17-7-6-11(15)16/h2-5H,6-7H2,1H3,(H,15,16) BWOVZKBKWYSBAR-UHFFFAOYSA-N 42858 MLS000112624::3-[(2-methyl-4-quinazolinyl)thio]propanoic acid::cid_588806::3-(2-methylquinazolin-4-yl)sulfanylpropanoic acid::SMR000108535::3-[(2-methylquinazolin-4-yl)thio]propionic acid Major prion protein Homo sapiens 915 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42858&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 588806 252623548 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237032 Cc1cccc2c(C)cc(SCCC(O)=O)nc12 InChI=1S/C14H15NO2S/c1-9-4-3-5-11-10(2)8-12(15-14(9)11)18-7-6-13(16)17/h3-5,8H,6-7H2,1-2H3,(H,16,17) UKJHYMDKFLEBCX-UHFFFAOYSA-N 114312 MLS000068584::3-(4,8-dimethylquinolin-2-yl)sulfanylpropanoic acid::SMR000122963::3-(4,8-Dimethyl-quinolin-2-ylsulfanyl)-propionic acid::cid_744542::3-[(4,8-dimethyl-2-quinolinyl)thio]propanoic acid::3-[(4,8-dimethyl-2-quinolyl)thio]propionic acid Major prion protein Homo sapiens 4671 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114312&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 744542 252663818 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237033 CCOC(=O)CSc1nc(nc2ccccc12)C(C)C InChI=1S/C15H18N2O2S/c1-4-19-13(18)9-20-15-11-7-5-6-8-12(11)16-14(17-15)10(2)3/h5-8,10H,4,9H2,1-3H3 JGEMVBAKEOFYDZ-UHFFFAOYSA-N 41000 ethyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoate::SMR000122408::ethyl 2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetate::MLS000067789::(2-Isopropyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester::cid_1451311::2-[(2-propan-2-yl-4-quinazolinyl)thio]acetic acid ethyl ester::2-[(2-isopropylquinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 1079 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41000&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1451311 252621778 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237034 CC(C)c1nc(SCC(=O)Nc2cc(C)on2)c2ccccc2n1 InChI=1S/C17H18N4O2S/c1-10(2)16-18-13-7-5-4-6-12(13)17(20-16)24-9-15(22)19-14-8-11(3)23-21-14/h4-8,10H,9H2,1-3H3,(H,19,21,22) MGDZMXRQAZCEAN-UHFFFAOYSA-N 41001 N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide::MLS000067840::cid_1442803::N-(5-methyl-3-isoxazolyl)-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide::SMR000122414::2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(5-methyl-isoxazol-3-yl)-acetamide::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide::2-[(2-isopropylquinazolin-4-yl)thio]-N-(5-methylisoxazol-3-yl)acetamide Major prion protein Homo sapiens 936 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41001&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442803 252621779 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237035 Cc1nc2c(Br)cc(Br)cc2cc1O InChI=1S/C10H7Br2NO/c1-5-9(14)3-6-2-7(11)4-8(12)10(6)13-5/h2-4,14H,1H3 CFQPLIFZQANEHN-UHFFFAOYSA-N 54184 SMR000126686::6,8-bis(bromanyl)-2-methyl-quinolin-3-ol::6,8-dibromo-2-methylquinolin-3-ol::6,8-dibromo-2-methyl-3-quinolinol::cid_1472973::MLS000544929::6,8-dibromo-2-methyl-quinolin-3-ol Major prion protein Homo sapiens 1364 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54184&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1472973 252634215 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237036 CCCCOc1ccc(C(=O)C2C(N(Cc3cccnc3)C(=O)C2=O)c2ccncc2)c(C)c1 InChI=1S/C27H27N3O4/c1-3-4-14-34-21-7-8-22(18(2)15-21)25(31)23-24(20-9-12-28-13-10-20)30(27(33)26(23)32)17-19-6-5-11-29-16-19/h5-13,15-16,23-24H,3-4,14,17H2,1-2H3 QRHNZWXQDCLALU-UHFFFAOYSA-N 114313 (4Z)-4-[(4-butoxy-2-methylphenyl)-hydroxymethylidene]-5-pyridin-4-yl-1-(3-pyridinylmethyl)pyrrolidine-2,3-dione::cid_9550006::MLS000556301::SMR000147618::4-(4-Butoxy-2-methyl-benzoyl)-3-hydroxy-5-pyridin-4-yl-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one::(4Z)-4-[(4-butoxy-2-methyl-phenyl)-oxidanyl-methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione::(4Z)-4-[(4-butoxy-2-methylphenyl)-hydroxymethylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione::(4Z)-4-[(4-butoxy-2-methyl-phenyl)-hydroxy-methylene]-5-(4-pyridyl)-1-(3-pyridylmethyl)pyrrolidine-2,3-quinone Major prion protein Homo sapiens 4207 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114313&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899714 252663819 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237037 COc1cc2cc(Br)cc(Br)c2nc1C InChI=1S/C11H9Br2NO/c1-6-10(15-2)4-7-3-8(12)5-9(13)11(7)14-6/h3-5H,1-2H3 FCFSZNPPKZCVRS-UHFFFAOYSA-N 114314 6,8-bis(bromanyl)-3-methoxy-2-methyl-quinoline::6,8-dibromo-3-methoxy-2-methylquinoline::SMR000126214::cid_1473006::MLS000541356::6,8-dibromo-3-methoxy-2-methyl-quinoline Major prion protein Homo sapiens 4511 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114314&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1473006 252663820 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237038 CCC(Sc1ncnc2sc(C)c(C)c12)C(=O)OC InChI=1S/C13H16N2O2S2/c1-5-9(13(16)17-4)19-12-10-7(2)8(3)18-11(10)14-6-15-12/h6,9H,5H2,1-4H3 OOUKYFUUFDBBHO-UHFFFAOYSA-N 48470 2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]butanoic acid methyl ester::SMR000142763::MLS000535327::methyl 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbutanoate::cid_2922139::methyl 2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio]butanoate::2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio]butyric acid methyl ester Major prion protein Homo sapiens 2460 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=48470 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=48470&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2922139 252628763 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237039 COc1cccc2s\c(=N/C(=O)c3ccc(Br)s3)n(CC#C)c12 InChI=1S/C16H11BrN2O2S2/c1-3-9-19-14-10(21-2)5-4-6-11(14)23-16(19)18-15(20)12-7-8-13(17)22-12/h1,4-8H,9H2,2H3 DTRVITGVFDLNCO-UHFFFAOYSA-N 114315 5-bromanyl-N-(4-methoxy-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)thiophene-2-carboxamide::5-bromo-N-(4-methoxy-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)-2-thiophenecarboxamide::5-bromo-N-(4-methoxy-3-prop-2-ynyl-1,3-benzothiazol-2-ylidene)thiophene-2-carboxamide::SMR000127141::cid_2151361::MLS000530125::5-bromo-N-(4-methoxy-3-propargyl-1,3-benzothiazol-2-ylidene)thiophene-2-carboxamide Major prion protein Homo sapiens 2604 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114315&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2151361 252663821 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237040 CC1CCC\C=C\C2CC(O)CC2C(O)\C=C\C(=O)O1 |t:5,16| InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3 KQNZDYYTLMIZCT-UHFFFAOYSA-N 114316 MLS000534571::SMR000142008::1,13-dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one::cid_5362868::(2E,10E)-7-methyl-12,15-bis(oxidanyl)-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one::(2E,10E)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one Major prion protein Homo sapiens 3427 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114316&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5362868 252663822 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237041 Cc1cc2cc(CNC(=O)c3ccc(cc3)S(=O)(=O)N3CCCC3)ccc2n1C InChI=1S/C22H25N3O3S/c1-16-13-19-14-17(5-10-21(19)24(16)2)15-23-22(26)18-6-8-20(9-7-18)29(27,28)25-11-3-4-12-25/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H,23,26) HINARVISCHQVBB-UHFFFAOYSA-N 114317 N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidin-1-ylsulfonylbenzamide::N-[(1,2-dimethyl-5-indolyl)methyl]-4-(1-pyrrolidinylsulfonyl)benzamide::cid_5101824::N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidin-1-ylsulfonyl-benzamide::SMR000127185::MLS000529721::N-[(1,2-dimethylindol-5-yl)methyl]-4-pyrrolidinosulfonyl-benzamide Major prion protein Homo sapiens 21542 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114317&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5101824 252663823 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237042 FC(F)(F)C1(N=C(CCc2ccccc2)Nc2c1c(=O)[nH]c(=O)n2Cc1ccco1)C(F)(F)F |t:5| InChI=1S/C21H16F6N4O3/c22-20(23,24)19(21(25,26)27)15-16(28-14(30-19)9-8-12-5-2-1-3-6-12)31(18(33)29-17(15)32)11-13-7-4-10-34-13/h1-7,10H,8-9,11H2,(H,28,30)(H,29,32,33) BULKAXQESNZYGS-UHFFFAOYSA-N 114318 SMR000144409::1-(2-furylmethyl)-7-(2-phenylethyl)-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione::cid_2304541::1-(2-furanylmethyl)-7-(2-phenylethyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione::MLS000538372::1-(furan-2-ylmethyl)-7-(2-phenylethyl)-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-dione::1-(2-furfuryl)-7-phenethyl-5,5-bis(trifluoromethyl)-8H-pyrimido[4,5-d]pyrimidine-2,4-quinone Major prion protein Homo sapiens 8507 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114318&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2304541 252663824 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237043 CC(Sc1ccc2ccccc2n1)C([O-])=O InChI=1S/C12H11NO2S/c1-8(12(14)15)16-11-7-6-9-4-2-3-5-10(9)13-11/h2-8H,1H3,(H,14,15)/p-1 JLYPYACZXPBHLU-UHFFFAOYSA-M 114319 Sodium; 2-(quinolin-2-ylsulfanyl)-propionate::cid_23663723::SMR000147147::MLS000555430::sodium;2-(2-quinolinylthio)propanoate::sodium;2-quinolin-2-ylsulfanylpropanoate::sodium;2-(2-quinolylthio)propionate Major prion protein Homo sapiens 1876 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114319&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5225434 252663825 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237044 CCN(CC)C(=O)CSc1nc(O)c(Cc2ccccc2)c(=O)n1-c1ccccc1 InChI=1S/C23H25N3O3S/c1-3-25(4-2)20(27)16-30-23-24-21(28)19(15-17-11-7-5-8-12-17)22(29)26(23)18-13-9-6-10-14-18/h5-14,28H,3-4,15-16H2,1-2H3 FMGQSNGHLIFPAY-UHFFFAOYSA-N 114320 N,N-diethyl-2-[6-oxidanyl-4-oxidanylidene-1-phenyl-5-(phenylmethyl)pyrimidin-2-yl]sulfanyl-ethanamide::N,N-diethyl-2-[[6-hydroxy-4-oxo-1-phenyl-5-(phenylmethyl)-2-pyrimidinyl]thio]acetamide::2-(5-benzyl-6-hydroxy-4-oxo-1-phenylpyrimidin-2-yl)sulfanyl-N,N-diethylacetamide::SMR000147409::2-(5-Benzyl-4-hydroxy-6-oxo-1-phenyl-1,6-dihydro-pyrimidin-2-ylsulfanyl)-N,N-diethyl-acetamide::cid_1415442::MLS000555892::2-[(5-benzyl-6-hydroxy-4-keto-1-phenyl-pyrimidin-2-yl)thio]-N,N-diethyl-acetamide Major prion protein Homo sapiens 14606 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114320 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114320&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1415442 252663826 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237045 CC(=O)c1ccc(CCCCCCCCCC(O)=O)s1 InChI=1S/C16H24O3S/c1-13(17)15-12-11-14(20-15)9-7-5-3-2-4-6-8-10-16(18)19/h11-12H,2-10H2,1H3,(H,18,19) HDTZBTOOXZUCLB-UHFFFAOYSA-N 114321 10-(5-acetylthiophen-2-yl)decanoic acid::10-(5-ethanoylthiophen-2-yl)decanoic acid::10-(5-acetyl-2-thiophenyl)decanoic acid::SMR000145174::MLS000551248::10-(5-Acetyl-thiophen-2-yl)-decanoic acid::cid_1914729::10-(5-acetyl-2-thienyl)capric acid Major prion protein Homo sapiens 5711 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114321&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1914729 252663827 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237046 Cc1sc2nc(C)nc(SC3CCOC3=O)c2c1C InChI=1S/C13H14N2O2S2/c1-6-7(2)18-11-10(6)12(15-8(3)14-11)19-9-4-5-17-13(9)16/h9H,4-5H2,1-3H3 DRTFKGMFRMJVSK-UHFFFAOYSA-N 114322 MLS000566711::3-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanyloxolan-2-one::cid_4881170::3-[(2,5,6-trimethyl-4-thieno[2,3-d]pyrimidinyl)thio]-2-oxolanone::SMR000153614::3-[(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)thio]tetrahydrofuran-2-one Major prion protein Homo sapiens 1927 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114322&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4881170 252663828 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237047 [#6]-[#6](=O)-[#7]-c1ccc2nc(-[#6])c(-[#6]\[#6]=[#6](\Cl)Cl)c(-[#8])c2c1 InChI=1S/C15H3Cl2N2O2/c1-8-11(4-6-14(16)17)15(21)12-7-10(19-9(2)20)3-5-13(12)18-8/h3,5,7H WBFHTGQBIWENOS-UHFFFAOYSA-N 44947 cid_870388::N-[3-(3,3-dichloro-2-propen-1-yl)-4-hydroxy-2-methyl-6-quinolinyl]acetamide::MLS000530452::N-[3-(3,3-dichloroprop-2-enyl)-2-methyl-4-oxo-1H-quinolin-6-yl]acetamide::N-[3-[3,3-bis(chloranyl)prop-2-enyl]-2-methyl-4-oxidanylidene-1H-quinolin-6-yl]ethanamide::SMR000135430::N-[3-(3,3-dichloroallyl)-4-keto-2-methyl-1H-quinolin-6-yl]acetamide Major prion protein Homo sapiens 10204 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44947&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 870388 252625550 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237048 COc1ccc2c(C)cc(SCc3c(C)noc3C)nc2c1 InChI=1S/C17H18N2O2S/c1-10-7-17(22-9-15-11(2)19-21-12(15)3)18-16-8-13(20-4)5-6-14(10)16/h5-8H,9H2,1-4H3 YEBZZBFCHJNCKE-UHFFFAOYSA-N 89942 SMR000152651::4-[(7-methoxy-4-methyl-quinolin-2-yl)sulfanylmethyl]-3,5-dimethyl-1,2-oxazole::MLS000565375::4-[[(7-methoxy-4-methyl-2-quinolinyl)thio]methyl]-3,5-dimethylisoxazole::4-[(7-methoxy-4-methylquinolin-2-yl)sulfanylmethyl]-3,5-dimethyl-1,2-oxazole::cid_727693::4-[[(7-methoxy-4-methyl-2-quinolyl)thio]methyl]-3,5-dimethyl-isoxazole Major prion protein Homo sapiens 4313 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=89942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=89942&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 727693 252661512 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237049 CC1CCCN(C1)C(=O)CSc1cnc2ccccc2n1 InChI=1S/C16H19N3OS/c1-12-5-4-8-19(10-12)16(20)11-21-15-9-17-13-6-2-3-7-14(13)18-15/h2-3,6-7,9,12H,4-5,8,10-11H2,1H3 OOAPYKLARLJPAY-UHFFFAOYSA-N 114323 1-(3-methylpiperidin-1-yl)-2-quinoxalin-2-ylsulfanyl-ethanone::1-(3-methyl-1-piperidinyl)-2-(2-quinoxalinylthio)ethanone::cid_4134237::1-(3-methylpiperidin-1-yl)-2-quinoxalin-2-ylsulfanylethanone::SMR000152016::MLS000564811::1-(3-methylpiperidino)-2-(quinoxalin-2-ylthio)ethanone Major prion protein Homo sapiens 5873 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114323&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4134237 252663829 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237050 Cc1n(nc2c1c(C)n[nH]c2=S)-c1ccc(C)cc1 InChI=1S/C14H14N4S/c1-8-4-6-11(7-5-8)18-10(3)12-9(2)15-16-14(19)13(12)17-18/h4-7H,1-3H3,(H,16,19) KCGYRJGFRLIWJP-UHFFFAOYSA-N 95259 3,4-dimethyl-2-(4-methylphenyl)-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione::MLS000325312::SMR000161327::3,4-dimethyl-2-(4-methylphenyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione::cid_1234246::3,4-dimethyl-2-(p-tolyl)-6H-pyrazolo[3,4-d]pyridazine-7-thione Major prion protein Homo sapiens 142.56 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95259&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234246 164036503 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237051 Cc1n(nc2c1c(C)n[nH]c2=S)-c1ccccc1F InChI=1S/C13H11FN4S/c1-7-11-8(2)18(10-6-4-3-5-9(10)14)17-12(11)13(19)16-15-7/h3-6H,1-2H3,(H,16,19) JUHZXNZQUIPTPX-UHFFFAOYSA-N 114324 cid_1234241::MLS000325321::2-(2-fluorophenyl)-3,4-dimethyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione::SMR000161325::2-(2-fluorophenyl)-3,4-dimethyl-6H-pyrazolo[3,4-d]pyridazine-7-thione Major prion protein Homo sapiens 8710 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114324&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234241 252663830 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237052 Cc1n(nc2c1c(C)n[nH]c2=S)-c1cccc(Cl)c1 InChI=1S/C13H11ClN4S/c1-7-11-8(2)18(10-5-3-4-9(14)6-10)17-12(11)13(19)16-15-7/h3-6H,1-2H3,(H,16,19) JWGNZMYQNRMNMN-UHFFFAOYSA-N 52335 MLS000325322::2-(3-chlorophenyl)-3,4-dimethyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione::cid_1234240::SMR000161324::2-(3-chlorophenyl)-3,4-dimethyl-6H-pyrazolo[3,4-d]pyridazine-7-thione Major prion protein Homo sapiens 5526 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52335 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52335&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234240 252632478 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237053 CCOC(=O)COc1cc(Br)c(CN=Nc2ccccc2)cc1OC |w:14.14| InChI=1S/C18H19BrN2O4/c1-3-24-18(22)12-25-17-10-15(19)13(9-16(17)23-2)11-20-21-14-7-5-4-6-8-14/h4-10H,3,11-12H2,1-2H3 PEBSOCBUAIYABE-UHFFFAOYSA-N 114325 SMR000159639::cid_9679773::ethyl [5-bromo-2-methoxy-4-(2-phenylcarbohydrazonoyl)phenoxy]acetate::ethyl 2-[5-bromo-2-methoxy-4-[(E)-(phenylhydrazinylidene)methyl]phenoxy]acetate::2-[5-bromo-2-methoxy-4-[(E)-(phenylhydrazinylidene)methyl]phenoxy]acetic acid ethyl ester::MLS000544297::ethyl 2-[5-bromanyl-2-methoxy-4-[(E)-(phenylhydrazinylidene)methyl]phenoxy]ethanoate::2-[5-bromo-2-methoxy-4-[(E)-(phenylhydrazono)methyl]phenoxy]acetic acid ethyl ester Major prion protein Homo sapiens 16418 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114325&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899715 252663831 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237054 CC(C)c1nc(SCC(=O)Nc2nnc(C)s2)c2ccccc2n1 InChI=1S/C16H17N5OS2/c1-9(2)14-17-12-7-5-4-6-11(12)15(19-14)23-8-13(22)18-16-21-20-10(3)24-16/h4-7,9H,8H2,1-3H3,(H,18,21,22) UDTGGEHYKCUCGD-UHFFFAOYSA-N 41062 2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(5-methyl-[1,3,4]thiadiazol-2-yl)-acetamide::N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide::SMR000173439::N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide::cid_1442817::MLS000556711::N-(5-methyl-1,3,4-thiadiazol-2-yl)-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide::2-[(2-isopropylquinazolin-4-yl)thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide Major prion protein Homo sapiens 1826 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41062&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442817 252621839 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237055 COC(=O)CSc1nc(nc2ccc(F)cc12)-c1ccccc1 InChI=1S/C17H13FN2O2S/c1-22-15(21)10-23-17-13-9-12(18)7-8-14(13)19-16(20-17)11-5-3-2-4-6-11/h2-9H,10H2,1H3 PMNCDEVNRMCBHT-UHFFFAOYSA-N 114326 cid_865077::methyl 2-(6-fluoranyl-2-phenyl-quinazolin-4-yl)sulfanylethanoate::MLS000551204::methyl 2-(6-fluoro-2-phenylquinazolin-4-yl)sulfanylacetate::2-[(6-fluoro-2-phenyl-4-quinazolinyl)thio]acetic acid methyl ester::(6-Fluoro-2-phenyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester::SMR000172514::2-[(6-fluoro-2-phenyl-quinazolin-4-yl)thio]acetic acid methyl ester Major prion protein Homo sapiens 2555 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114326&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 865077 252663832 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237056 CC(C)c1nc(SCC(=O)Nc2nc3CCCCc3s2)c2ccccc2n1 InChI=1S/C20H22N4OS2/c1-12(2)18-21-14-8-4-3-7-13(14)19(24-18)26-11-17(25)23-20-22-15-9-5-6-10-16(15)27-20/h3-4,7-8,12H,5-6,9-11H2,1-2H3,(H,22,23,25) APKUCKKHQWGBDN-UHFFFAOYSA-N 114327 cid_1442808::2-[(2-propan-2-yl-4-quinazolinyl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide::MLS000556707::SMR000173437::2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide::2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide::2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)ethanamide::2-[(2-isopropylquinazolin-4-yl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide Major prion protein Homo sapiens 5968 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114327&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442808 252663833 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237057 CCc1nc(SCC(=O)Nc2nc3CCCCc3s2)c2ccccc2n1 InChI=1S/C19H20N4OS2/c1-2-16-20-13-8-4-3-7-12(13)18(22-16)25-11-17(24)23-19-21-14-9-5-6-10-15(14)26-19/h3-4,7-8H,2,5-6,9-11H2,1H3,(H,21,23,24) GZIFDVNAKHXPJD-UHFFFAOYSA-N 114328 2-(2-ethylquinazolin-4-yl)sulfanyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)ethanamide::2-(2-Ethyl-quinazolin-4-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide::2-[(2-ethyl-4-quinazolinyl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide::SMR000172942::MLS000556136::cid_1435022::2-(2-ethylquinazolin-4-yl)sulfanyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide::2-[(2-ethylquinazolin-4-yl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide Major prion protein Homo sapiens 6971 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114328&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1435022 252663834 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237058 CCc1nc(SCC(=O)NNC(=O)C2CCCCC2)c2ccccc2n1 InChI=1S/C19H24N4O2S/c1-2-16-20-15-11-7-6-10-14(15)19(21-16)26-12-17(24)22-23-18(25)13-8-4-3-5-9-13/h6-7,10-11,13H,2-5,8-9,12H2,1H3,(H,22,24)(H,23,25) GKWDCDIUUPYSEC-UHFFFAOYSA-N 41064 MLS000556663::SMR000172939::Cyclohexanecarboxylic acid N'-[2-(2-ethyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::cid_1435013::N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]cyclohexanecarbohydrazide::N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]cyclohexanecarbohydrazide::N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]cyclohexanecarbohydrazide::N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]cyclohexanecarbohydrazide Major prion protein Homo sapiens 1181 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41064&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1435013 252621841 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237059 CCCc1nc(SCC(=O)NNC(=O)C2CCCCC2)c2ccccc2n1 InChI=1S/C20H26N4O2S/c1-2-8-17-21-16-12-7-6-11-15(16)20(22-17)27-13-18(25)23-24-19(26)14-9-4-3-5-10-14/h6-7,11-12,14H,2-5,8-10,13H2,1H3,(H,23,25)(H,24,26) YAAOJFKWOGDMQD-UHFFFAOYSA-N 114329 SMR000173429::Cyclohexanecarboxylic acid N'-[2-(2-propyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::MLS000556674::N'-[2-(2-propylquinazolin-4-yl)sulfanylacetyl]cyclohexanecarbohydrazide::cid_1442626::N'-[1-oxo-2-[(2-propyl-4-quinazolinyl)thio]ethyl]cyclohexanecarbohydrazide::N'-[2-(2-propylquinazolin-4-yl)sulfanylethanoyl]cyclohexanecarbohydrazide::N'-[2-[(2-propylquinazolin-4-yl)thio]acetyl]cyclohexanecarbohydrazide Major prion protein Homo sapiens 896.07 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114329&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442626 252663835 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237060 CCOC(=O)CSc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C18H16N2O2S/c1-2-22-16(21)12-23-18-14-10-6-7-11-15(14)19-17(20-18)13-8-4-3-5-9-13/h3-11H,2,12H2,1H3 LDEHPRNCJJXOFE-UHFFFAOYSA-N 114330 ethyl 2-(2-phenylquinazolin-4-yl)sulfanylacetate::MLS000552024::(2-Phenyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester::SMR000172513::ethyl 2-(2-phenylquinazolin-4-yl)sulfanylethanoate::2-[(2-phenyl-4-quinazolinyl)thio]acetic acid ethyl ester::cid_865072::2-[(2-phenylquinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 1728 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114330&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 865072 252663836 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237061 CCc1nc(SCC(=O)N2c3ccccc3Sc3ccccc23)c2ccccc2n1 InChI=1S/C24H19N3OS2/c1-2-22-25-17-10-4-3-9-16(17)24(26-22)29-15-23(28)27-18-11-5-7-13-20(18)30-21-14-8-6-12-19(21)27/h3-14H,2,15H2,1H3 HMROKRSPIQUEHJ-UHFFFAOYSA-N 114331 2-(2-ethylquinazolin-4-yl)sulfanyl-1-phenothiazin-10-ylethanone::2-(2-ethylquinazolin-4-yl)sulfanyl-1-phenothiazin-10-yl-ethanone::MLS000555763::2-[(2-ethyl-4-quinazolinyl)thio]-1-(10-phenothiazinyl)ethanone::2-(2-Ethyl-quinazolin-4-ylsulfanyl)-1-phenothiazin-10-yl-ethanone::SMR000172945::cid_1435033::2-[(2-ethylquinazolin-4-yl)thio]-1-phenothiazin-10-yl-ethanone Major prion protein Homo sapiens 1843 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114331&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1435033 252663837 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237062 O=C(CSc1nc(Cc2ccccc2)nc2ccccc12)Nc1ccc2OCCOc2c1 InChI=1S/C25H21N3O3S/c29-24(26-18-10-11-21-22(15-18)31-13-12-30-21)16-32-25-19-8-4-5-9-20(19)27-23(28-25)14-17-6-2-1-3-7-17/h1-11,15H,12-14,16H2,(H,26,29) XXRWMPPSAVOZBW-UHFFFAOYSA-N 87783 cid_1442514::MLS000556790::2-(2-Benzyl-quinazolin-4-ylsulfanyl)-N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-acetamide::SMR000173426::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[2-(phenylmethyl)quinazolin-4-yl]sulfanyl-ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[[2-(phenylmethyl)-4-quinazolinyl]thio]acetamide::2-(2-benzylquinazolin-4-yl)sulfanyl-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::2-[(2-benzylquinazolin-4-yl)thio]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide Major prion protein Homo sapiens 5395 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=87783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=87783&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442514 252660082 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237063 CCc1nc(SCC(=O)NNC(=O)C(C)C)c2ccccc2n1 InChI=1S/C16H20N4O2S/c1-4-13-17-12-8-6-5-7-11(12)16(18-13)23-9-14(21)19-20-15(22)10(2)3/h5-8,10H,4,9H2,1-3H3,(H,19,21)(H,20,22) RANCGPUEMGNWHP-UHFFFAOYSA-N 114332 MLS000556743::Isobutyric acid N'-[2-(2-ethyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]-2-methylpropanehydrazide::N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]-2-methylpropanehydrazide::cid_3192185::SMR000172943::N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]-2-methyl-propanehydrazide::N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]-2-methyl-propionohydrazide Major prion protein Homo sapiens 1931 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114332&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3192185 252663838 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237064 CCOC(=O)CSc1nc(nc2ccc(F)cc12)-c1ccccc1 InChI=1S/C18H15FN2O2S/c1-2-23-16(22)11-24-18-14-10-13(19)8-9-15(14)20-17(21-18)12-6-4-3-5-7-12/h3-10H,2,11H2,1H3 CFIRJSLELXCDRH-UHFFFAOYSA-N 114333 cid_865078::2-[(6-fluoro-2-phenyl-4-quinazolinyl)thio]acetic acid ethyl ester::(6-Fluoro-2-phenyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester::ethyl 2-(6-fluoro-2-phenylquinazolin-4-yl)sulfanylacetate::MLS000551976::ethyl 2-(6-fluoranyl-2-phenyl-quinazolin-4-yl)sulfanylethanoate::SMR000172515::2-[(6-fluoro-2-phenyl-quinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 1971 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114333&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 865078 252663839 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237065 CCc1cc2cccc(C)c2nc1SCC(=O)NNC(=O)c1ccco1 InChI=1S/C19H19N3O3S/c1-3-13-10-14-7-4-6-12(2)17(14)20-19(13)26-11-16(23)21-22-18(24)15-8-5-9-25-15/h4-10H,3,11H2,1-2H3,(H,21,23)(H,22,24) UUHNULKSYOXUNI-UHFFFAOYSA-N 114334 Furan-2-carboxylic acid N'-[2-(3-ethyl-8-methyl-quinolin-2-ylsulfanyl)-acetyl]-hydrazide::MLS000555407::N'-[2-(3-ethyl-8-methyl-quinolin-2-yl)sulfanylethanoyl]furan-2-carbohydrazide::N'-[2-(3-ethyl-8-methylquinolin-2-yl)sulfanylacetyl]furan-2-carbohydrazide::cid_3207963::SMR000173151::N'-[2-[(3-ethyl-8-methyl-2-quinolinyl)thio]-1-oxoethyl]-2-furancarbohydrazide::N'-[2-[(3-ethyl-8-methyl-2-quinolyl)thio]acetyl]-2-furohydrazide Major prion protein Homo sapiens 3733 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114334 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114334&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3207963 252663840 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237066 CNc1ncc(s1)C(=O)c1ccc(Cl)cc1 InChI=1S/C11H9ClN2OS/c1-13-11-14-6-9(16-11)10(15)7-2-4-8(12)5-3-7/h2-6H,1H3,(H,13,14) CIWPDPHKRCENFN-UHFFFAOYSA-N 114335 (4-chlorophenyl)-[2-(methylamino)-1,3-thiazol-5-yl]methanone::(4-chlorophenyl)-[2-(methylamino)-5-thiazolyl]methanone::MLS000543208::(4-chlorophenyl)[2-(methylamino)-1,3-thiazol-5-yl]methanone::SMR000169177::cid_1485897::(4-chlorophenyl)-[2-(methylamino)thiazol-5-yl]methanone Major prion protein Homo sapiens 6924 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114335 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114335&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1485897 252663841 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237067 Cn1nc(c(\C=N\OC(=O)c2ccccc2Cl)c1SCc1ccccc1Cl)C(F)(F)F InChI=1S/C20H14Cl2F3N3O2S/c1-28-18(31-11-12-6-2-4-8-15(12)21)14(17(27-28)20(23,24)25)10-26-30-19(29)13-7-3-5-9-16(13)22/h2-10H,11H2,1H3 OQOHQEKEDCTRRA-UHFFFAOYSA-N 114336 cid_9659462::4-({[(2-chlorobenzoyl)oxy]imino}methyl)-5-[(2-chlorobenzyl)sulfanyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole::SMR000169321::[(E)-[5-[(2-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylideneamino] 2-chlorobenzoate::MLS000543352::[(E)-[5-[(2-chlorophenyl)methylsulfanyl]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methylideneamino] 2-chloranylbenzoate::2-chlorobenzoic acid [(E)-[5-[(2-chlorophenyl)methylthio]-1-methyl-3-(trifluoromethyl)-4-pyrazolyl]methylideneamino] ester::2-chlorobenzoic acid [(E)-[5-[(2-chlorobenzyl)thio]-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]methyleneamino] ester Major prion protein Homo sapiens 4679 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114336&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 9659462 252663842 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237068 S=c1[nH]cnc2c3ccccc3[nH]c12 InChI=1S/C10H7N3S/c14-10-9-8(11-5-12-10)6-3-1-2-4-7(6)13-9/h1-5,13H,(H,11,12,14) YMNTVDMKBNZRJH-UHFFFAOYSA-N 78637 1,5-dihydropyrimido[5,4-b]indole-4-thione::cid_814519::9H-2,4,9-Triaza-fluorene-1-thiol::MLS000551996::SMR000174931::1,5-dihydropyrimid[5,4-b]indole-4-thione Major prion protein Homo sapiens 1502 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=78637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=78637&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 814519 252655381 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237069 C(c1ccccc1)c1nnc(Sc2ccccc2)c2ccccc12 InChI=1S/C21H16N2S/c1-3-9-16(10-4-1)15-20-18-13-7-8-14-19(18)21(23-22-20)24-17-11-5-2-6-12-17/h1-14H,15H2 PFCZWSUYQWSCDQ-UHFFFAOYSA-N 114337 1-benzyl-4-phenylsulfanylphthalazine::SMR000169797::cid_6404569::1-(phenylmethyl)-4-phenylsulfanyl-phthalazine::1-benzyl-4-(phenylsulfanyl)phthalazine::MLS000325800::1-(phenylmethyl)-4-(phenylthio)phthalazine::1-benzyl-4-(phenylthio)phthalazine Major prion protein Homo sapiens 6507 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114337&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 6404569 252663843 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237070 Cc1ccc(NS(=O)(=O)c2cc(ccc2Cl)C(=O)NCc2ccccn2)cc1C InChI=1S/C21H20ClN3O3S/c1-14-6-8-17(11-15(14)2)25-29(27,28)20-12-16(7-9-19(20)22)21(26)24-13-18-5-3-4-10-23-18/h3-12,25H,13H2,1-2H3,(H,24,26) IONLGROWVAPKLI-UHFFFAOYSA-N 114338 4-chloro-3-[(3,4-dimethylphenyl)sulfamoyl]-N-(2-pyridinylmethyl)benzamide::SMR000201608::4-chloranyl-3-[(3,4-dimethylphenyl)sulfamoyl]-N-(pyridin-2-ylmethyl)benzamide::4-chloro-3-[(3,4-dimethylphenyl)sulfamoyl]-N-(pyridin-2-ylmethyl)benzamide::4-chloro-3-{[(3,4-dimethylphenyl)amino]sulfonyl}-N-(2-pyridinylmethyl)benzamide::MLS000582903::cid_2238869::4-chloro-3-[(3,4-dimethylphenyl)sulfamoyl]-N-(2-pyridylmethyl)benzamide Major prion protein Homo sapiens 12966 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114338&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2238869 252663844 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237071 COc1cccc(c1)-c1cc2c([nH]c(=S)n(-c3ccccc3)c2=O)s1 InChI=1S/C19H14N2O2S2/c1-23-14-9-5-6-12(10-14)16-11-15-17(25-16)20-19(24)21(18(15)22)13-7-3-2-4-8-13/h2-11H,1H3,(H,20,24) ISDMPOJYBIUHNC-UHFFFAOYSA-N 114339 cid_1327115::6-(3-methoxyphenyl)-3-phenyl-2-sulfanylidene-1H-thieno[2,3-d]pyrimidin-4-one::2-mercapto-6-(3-methoxyphenyl)-3-phenylthieno[2,3-d]pyrimidin-4(3H)-one::MLS000575857::SMR000196892::6-(3-methoxyphenyl)-3-phenyl-2-thioxo-1H-thieno[2,3-d]pyrimidin-4-one Major prion protein Homo sapiens 6337 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114339&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1327115 252663845 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237072 Clc1cccc(Nc2ncnc3ccc(Br)cc23)c1 InChI=1S/C14H9BrClN3/c15-9-4-5-13-12(6-9)14(18-8-17-13)19-11-3-1-2-10(16)7-11/h1-8H,(H,17,18,19) LYKXFKUSOXETGV-UHFFFAOYSA-N 50311887 CHEMBL1079374::cid_720635::6-bromo-N-(3-chlorophenyl)quinazolin-4-amine Major prion protein Homo sapiens 6275 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311887&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 720635 104146248 CHEMBL1079374 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237073 Cc1cc(Br)c2nc3CCCCCc3c(C(O)=O)c2c1 InChI=1S/C16H16BrNO2/c1-9-7-11-14(16(19)20)10-5-3-2-4-6-13(10)18-15(11)12(17)8-9/h7-8H,2-6H2,1H3,(H,19,20) SMLFVHZWGKWRSD-UHFFFAOYSA-N 47242 MLS000579904::SMR000199143::4-bromanyl-2-methyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylic acid::cid_975392::4-bromo-2-methyl-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylic acid Major prion protein Homo sapiens 141.33 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47242&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 975392 252627646 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237074 COc1ccc(NC(=O)CCSc2ccc3ccccc3n2)cc1 InChI=1S/C19H18N2O2S/c1-23-16-9-7-15(8-10-16)20-18(22)12-13-24-19-11-6-14-4-2-3-5-17(14)21-19/h2-11H,12-13H2,1H3,(H,20,22) RZTVCDUNPJLVNF-UHFFFAOYSA-N 114340 cid_890011::N-(4-methoxyphenyl)-3-(2-quinolinylthio)propanamide::N-(4-methoxyphenyl)-3-quinolin-2-ylsulfanyl-propanamide::MLS000578394::SMR000198295::N-(4-methoxyphenyl)-3-quinolin-2-ylsulfanylpropanamide::N-(4-methoxyphenyl)-3-(2-quinolylthio)propionamide Major prion protein Homo sapiens 4516 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114340 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114340&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 890011 252663846 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237075 OC(=O)CC(NC(=O)c1sc2ccccc2c1Cl)c1ccc(F)cc1 InChI=1S/C18H13ClFNO3S/c19-16-12-3-1-2-4-14(12)25-17(16)18(24)21-13(9-15(22)23)10-5-7-11(20)8-6-10/h1-8,13H,9H2,(H,21,24)(H,22,23) MJEFZJLSMDPVDN-UHFFFAOYSA-N 114341 SMR000208075::MLS000586696::3-[[(3-chloro-1-benzothiophen-2-yl)-oxomethyl]amino]-3-(4-fluorophenyl)propanoic acid::3-[(3-chloranyl-1-benzothiophen-2-yl)carbonylamino]-3-(4-fluorophenyl)propanoic acid::3-{[(3-chloro-1-benzothien-2-yl)carbonyl]amino}-3-(4-fluorophenyl)propanoic acid::cid_3613213::3-[(3-chloro-1-benzothiophene-2-carbonyl)amino]-3-(4-fluorophenyl)propanoic acid::3-[(3-chlorobenzothiophene-2-carbonyl)amino]-3-(4-fluorophenyl)propionic acid Major prion protein Homo sapiens 7662 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114341 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114341&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3613213 252663847 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237076 NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2sc3ccccc3c2Cl)cc1 InChI=1S/C17H14ClN5O3S3/c18-13-11-3-1-2-4-12(11)28-14(13)15(24)22-17(27)21-9-5-7-10(8-6-9)29(25,26)23-16(19)20/h1-8H,(H4,19,20,23)(H2,21,22,24,27) OVSBAFVCQFKIIW-UHFFFAOYSA-N 114342 3-chloro-N-[[4-(diaminomethylideneamino)sulfonylanilino]-sulfanylidenemethyl]-1-benzothiophene-2-carboxamide::3-chloro-N-[[4-(diaminomethylideneamino)sulfonylphenyl]carbamothioyl]-1-benzothiophene-2-carboxamide::MLS000553448::SMR000171334::cid_3100477::N-[[4-[bis(azanyl)methylideneamino]sulfonylphenyl]carbamothioyl]-3-chloranyl-1-benzothiophene-2-carboxamide::3-chloro-N-[(4-guanidinosulfonylphenyl)thiocarbamoyl]benzothiophene-2-carboxamide Major prion protein Homo sapiens 5536 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114342 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114342&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3100477 252663848 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237077 CCOc1ccc(NC(=O)CCSc2ccc3ccccc3n2)cc1 InChI=1S/C20H20N2O2S/c1-2-24-17-10-8-16(9-11-17)21-19(23)13-14-25-20-12-7-15-5-3-4-6-18(15)22-20/h3-12H,2,13-14H2,1H3,(H,21,23) PRUHHAYOXKDWML-UHFFFAOYSA-N 114343 cid_2241313::N-(4-ethoxyphenyl)-3-quinolin-2-ylsulfanylpropanamide::N-(4-ethoxyphenyl)-3-(quinolin-2-ylthio)propanamide::SMR000204187::N-(4-ethoxyphenyl)-3-quinolin-2-ylsulfanyl-propanamide::N-(4-ethoxyphenyl)-3-(2-quinolinylthio)propanamide::MLS000585624::N-p-phenetyl-3-(2-quinolylthio)propionamide Major prion protein Homo sapiens 9013 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114343 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114343&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2241313 252663849 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237078 COc1cccc(NC(=O)CCSc2ccc3ccccc3n2)c1 InChI=1S/C19H18N2O2S/c1-23-16-7-4-6-15(13-16)20-18(22)11-12-24-19-10-9-14-5-2-3-8-17(14)21-19/h2-10,13H,11-12H2,1H3,(H,20,22) YBRVASRWDNJOIV-UHFFFAOYSA-N 114344 N-(3-methoxyphenyl)-3-quinolin-2-ylsulfanyl-propanamide::cid_2241315::N-(3-methoxyphenyl)-3-quinolin-2-ylsulfanylpropanamide::N-(3-methoxyphenyl)-3-(quinolin-2-ylthio)propanamide::N-(3-methoxyphenyl)-3-(2-quinolinylthio)propanamide::SMR000204188::MLS000585625::N-(3-methoxyphenyl)-3-(2-quinolylthio)propionamide Major prion protein Homo sapiens 3968 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114344 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114344&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2241315 252663850 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237079 CCc1c(C)nc2c(Br)cccc2c1SCCC#N InChI=1S/C15H15BrN2S/c1-3-11-10(2)18-14-12(6-4-7-13(14)16)15(11)19-9-5-8-17/h4,6-7H,3,5,9H2,1-2H3 VYVDAGILFVOBKB-UHFFFAOYSA-N 114345 MLS000591728::3-[(8-bromo-3-ethyl-2-methyl-4-quinolinyl)thio]propanenitrile::SMR000218749::3-(8-Bromo-3-ethyl-2-methyl-quinolin-4-ylsulfanyl)-propionitrile::3-(8-bromanyl-3-ethyl-2-methyl-quinolin-4-yl)sulfanylpropanenitrile::3-(8-bromo-3-ethyl-2-methylquinolin-4-yl)sulfanylpropanenitrile::cid_1952926::3-[(8-bromo-3-ethyl-2-methyl-4-quinolyl)thio]propionitrile Major prion protein Homo sapiens 2521 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114345 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114345&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1952926 252663851 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237080 Fc1ccc(Cn2cc(C(=O)c3ccc(F)cc3)c(=O)c3cc4OCCOc4cc23)cc1 InChI=1S/C25H17F2NO4/c26-17-5-1-15(2-6-17)13-28-14-20(24(29)16-3-7-18(27)8-4-16)25(30)19-11-22-23(12-21(19)28)32-10-9-31-22/h1-8,11-12,14H,9-10,13H2 CICLIYILJWEQET-UHFFFAOYSA-N 114346 6-[(4-fluorophenyl)methyl]-8-[(4-fluorophenyl)-oxomethyl]-2,3-dihydro-[1,4]dioxino[2,3-g]quinolin-9-one::cid_2136283::MLS000724765::8-(4-fluorobenzoyl)-6-[(4-fluorophenyl)methyl]-2,3-dihydro-[1,4]dioxino[2,3-g]quinolin-9-one::SMR000237573::8-(4-fluorophenyl)carbonyl-6-[(4-fluorophenyl)methyl]-2,3-dihydro-[1,4]dioxino[2,3-g]quinolin-9-one::8-(4-fluorobenzoyl)-6-(4-fluorobenzyl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinolin-9-one Major prion protein Homo sapiens 3029 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114346 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114346&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2136283 252663852 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237081 COc1ccc(\C=C/C(=O)NCc2ccc3n(C)c(C)cc3c2)cc1OC InChI=1S/C22H24N2O3/c1-15-11-18-12-17(5-8-19(18)24(15)2)14-23-22(25)10-7-16-6-9-20(26-3)21(13-16)27-4/h5-13H,14H2,1-4H3,(H,23,25) KVOCEKQRMUEHDD-UHFFFAOYSA-N 114347 MLS000724665::cid_12005929::(Z)-3-(3,4-dimethoxyphenyl)-N-[(1,2-dimethylindol-5-yl)methyl]prop-2-enamide::(Z)-3-(3,4-dimethoxyphenyl)-N-[(1,2-dimethyl-5-indolyl)methyl]-2-propenamide::SMR000237473::(Z)-3-(3,4-dimethoxyphenyl)-N-[(1,2-dimethylindol-5-yl)methyl]acrylamide Major prion protein Homo sapiens 40319 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114347&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 12005929 252663853 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237082 COc1ccc2nc(Nc3nc4cc5OCCOc5cc4s3)sc2c1 InChI=1S/C17H13N3O3S2/c1-21-9-2-3-10-14(6-9)24-16(18-10)20-17-19-11-7-12-13(8-15(11)25-17)23-5-4-22-12/h2-3,6-8H,4-5H2,1H3,(H,18,19,20) ZQLQTFWSMINSMH-UHFFFAOYSA-N 76477 SMR000236243::MLS000720419::cid_7110103::N-(6-methoxy-1,3-benzothiazol-2-yl)-6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-amine::6,7-dihydro-[1,4]dioxino[2,3-f][1,3]benzothiazol-2-yl-(6-methoxy-1,3-benzothiazol-2-yl)amine Major prion protein Homo sapiens 7318 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=76477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=76477&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 7110103 252653655 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237083 CCOC(=O)c1sc(NC(=S)NC(=O)C2CCCC2)cc1C InChI=1S/C15H20N2O3S2/c1-3-20-14(19)12-9(2)8-11(22-12)16-15(21)17-13(18)10-6-4-5-7-10/h8,10H,3-7H2,1-2H3,(H2,16,17,18,21) KMPSGVKDKZXFMM-UHFFFAOYSA-N 54973 MLS000392613::SMR000261518::ethyl 5-(cyclopentanecarbonylcarbamothioylamino)-3-methylthiophene-2-carboxylate::5-[[[[cyclopentyl(oxo)methyl]amino]-sulfanylidenemethyl]amino]-3-methyl-2-thiophenecarboxylic acid ethyl ester::ethyl 5-(cyclopentylcarbonylcarbamothioylamino)-3-methyl-thiophene-2-carboxylate::cid_2375640::5-(cyclopentanecarbonylthiocarbamoylamino)-3-methyl-thiophene-2-carboxylic acid ethyl ester Major prion protein Homo sapiens 5290 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54973&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2375640 252634983 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237084 CCOc1cc(C2Nc3ccccc3C(=O)N2c2ccccc2)c(Br)cc1OCC(O)=O InChI=1S/C24H21BrN2O5/c1-2-31-20-12-17(18(25)13-21(20)32-14-22(28)29)23-26-19-11-7-6-10-16(19)24(30)27(23)15-8-4-3-5-9-15/h3-13,23,26H,2,14H2,1H3,(H,28,29) XPCNPNMAMZQASS-UHFFFAOYSA-N 114348 MLS000704897::cid_4231295::SMR000231545::[5-bromo-2-ethoxy-4-(4-oxo-3-phenyl-1,2,3,4-tetrahydro-2-quinazolinyl)phenoxy]acetic acid::2-[5-bromo-2-ethoxy-4-(4-oxo-3-phenyl-1,2-dihydroquinazolin-2-yl)phenoxy]acetic acid::2-[5-bromanyl-2-ethoxy-4-(4-oxidanylidene-3-phenyl-1,2-dihydroquinazolin-2-yl)phenoxy]ethanoic acid::2-[5-bromo-2-ethoxy-4-(4-keto-3-phenyl-1,2-dihydroquinazolin-2-yl)phenoxy]acetic acid Major prion protein Homo sapiens 10113 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114348 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114348&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4231295 252663854 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237085 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)Nc1nc2ccccc2s1 InChI=1S/C20H22N4O3S2/c1-23(2)29(26,27)14-9-10-17(24-11-5-6-12-24)15(13-14)19(25)22-20-21-16-7-3-4-8-18(16)28-20/h3-4,7-10,13H,5-6,11-12H2,1-2H3,(H,21,22,25) YMKBDADQLTWAOA-UHFFFAOYSA-N 114349 N-(1,3-benzothiazol-2-yl)-5-(dimethylsulfamoyl)-2-(1-pyrrolidinyl)benzamide::SMR000247618::N-(1,3-benzothiazol-2-yl)-5-(dimethylsulfamoyl)-2-pyrrolidin-1-yl-benzamide::cid_2529879::MLS000409355::N-(1,3-benzothiazol-2-yl)-5-(dimethylsulfamoyl)-2-pyrrolidin-1-ylbenzamide::N-(1,3-benzothiazol-2-yl)-5-(dimethylsulfamoyl)-2-pyrrolidino-benzamide Major prion protein Homo sapiens 10403 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114349 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114349&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2529879 252663855 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237086 Fc1cccc2sc(Nc3nc4c(F)cccc4s3)nc12 InChI=1S/C14H7F2N3S2/c15-7-3-1-5-9-11(7)17-13(20-9)19-14-18-12-8(16)4-2-6-10(12)21-14/h1-6H,(H,17,18,19) XWIBJZAZVONZEX-UHFFFAOYSA-N 114350 4-fluoro-N-(4-fluoro-1,3-benzothiazol-2-yl)-1,3-benzothiazol-2-amine::SMR000236224::cid_7109977::4-fluoranyl-N-(4-fluoranyl-1,3-benzothiazol-2-yl)-1,3-benzothiazol-2-amine::MLS000720337::bis(4-fluoro-1,3-benzothiazol-2-yl)amine Major prion protein Homo sapiens 8315 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114350 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114350&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 7109977 252663856 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237087 CCN(CC)S(=O)(=O)c1ccc(NC(=O)CSc2ncnc3ccccc23)cc1 InChI=1S/C20H22N4O3S2/c1-3-24(4-2)29(26,27)16-11-9-15(10-12-16)23-19(25)13-28-20-17-7-5-6-8-18(17)21-14-22-20/h5-12,14H,3-4,13H2,1-2H3,(H,23,25) XJKKSBPFVAILDI-UHFFFAOYSA-N 44055 SMR000243688::N-[4-(diethylsulfamoyl)phenyl]-2-(4-quinazolinylthio)acetamide::N-[4-(diethylsulfamoyl)phenyl]-2-quinazolin-4-ylsulfanylacetamide::cid_2389378::MLS000393282::N-[4-(diethylsulfamoyl)phenyl]-2-quinazolin-4-ylsulfanyl-ethanamide::N-[4-(diethylsulfamoyl)phenyl]-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 7175 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44055&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2389378 252624682 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237088 Cc1ccc(cc1NC(=O)CSc1ncnc2ccccc12)S(=O)(=O)N1CCCCC1 InChI=1S/C22H24N4O3S2/c1-16-9-10-17(31(28,29)26-11-5-2-6-12-26)13-20(16)25-21(27)14-30-22-18-7-3-4-8-19(18)23-15-24-22/h3-4,7-10,13,15H,2,5-6,11-12,14H2,1H3,(H,25,27) DGAKDVIAOVPIHJ-UHFFFAOYSA-N 114351 MLS000417683::N-(2-methyl-5-piperidin-1-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide::SMR000242756::N-(2-methyl-5-piperidin-1-ylsulfonyl-phenyl)-2-quinazolin-4-ylsulfanyl-ethanamide::cid_5110655::N-[2-methyl-5-(1-piperidinylsulfonyl)phenyl]-2-(4-quinazolinylthio)acetamide::N-(2-methyl-5-piperidinosulfonyl-phenyl)-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 5596 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114351 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114351&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5110655 252663857 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237089 C1Oc2cc3nc(Nc4nc5ccccc5s4)sc3cc2O1 InChI=1S/C15H9N3O2S2/c1-2-4-12-8(3-1)16-14(21-12)18-15-17-9-5-10-11(20-7-19-10)6-13(9)22-15/h1-6H,7H2,(H,16,17,18) JJXVDMDKAYLNFO-UHFFFAOYSA-N 114352 N-(1,3-benzothiazol-2-yl)-[1,3]dioxolo[4,5-f][1,3]benzothiazol-6-amine::cid_7110078::MLS000720359::SMR000236237::1,3-benzothiazol-2-yl([1,3]dioxolo[4,5-f][1,3]benzothiazol-6-yl)amine Major prion protein Homo sapiens 8565 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114352 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114352&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 7110078 252663858 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237090 OCc1cccc(NC(=S)NC(=O)COc2ccc3ccccc3c2Br)c1 InChI=1S/C20H17BrN2O3S/c21-19-16-7-2-1-5-14(16)8-9-17(19)26-12-18(25)23-20(27)22-15-6-3-4-13(10-15)11-24/h1-10,24H,11-12H2,(H2,22,23,25,27) NXAUFCFMFZUBMQ-UHFFFAOYSA-N 114353 2-(1-bromanylnaphthalen-2-yl)oxy-N-[[3-(hydroxymethyl)phenyl]carbamothioyl]ethanamide::cid_1014465::SMR000228792::N-{[(1-bromo-2-naphthyl)oxy]acetyl}-N'-[3-(hydroxymethyl)phenyl]thiourea::2-[(1-bromo-2-naphthalenyl)oxy]-N-[[3-(hydroxymethyl)anilino]-sulfanylidenemethyl]acetamide::2-(1-bromonaphthalen-2-yl)oxy-N-[[3-(hydroxymethyl)phenyl]carbamothioyl]acetamide::MLS000705929::2-(1-bromo-2-naphthoxy)-N-[(3-methylolphenyl)thiocarbamoyl]acetamide Major prion protein Homo sapiens 9987 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114353 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114353&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1014465 252663859 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237091 CN(C)S(=O)(=O)c1ccc(NC(=O)CSc2ncnc3ccccc23)cc1 InChI=1S/C18H18N4O3S2/c1-22(2)27(24,25)14-9-7-13(8-10-14)21-17(23)11-26-18-15-5-3-4-6-16(15)19-12-20-18/h3-10,12H,11H2,1-2H3,(H,21,23) VKJXOMLBPBWAKW-UHFFFAOYSA-N 44072 MLS000394067::N-[4-(dimethylsulfamoyl)phenyl]-2-quinazolin-4-ylsulfanyl-ethanamide::cid_2607891::N-[4-(dimethylsulfamoyl)phenyl]-2-quinazolin-4-ylsulfanylacetamide::N-[4-(dimethylsulfamoyl)phenyl]-2-(4-quinazolinylthio)acetamide::SMR000247733::N-[4-(dimethylsulfamoyl)phenyl]-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 16494 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44072&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2607891 252624699 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237092 Cc1n(nc2c(SCCN3CCOCC3)nnc(C)c12)-c1ccc(C)cc1 InChI=1S/C20H25N5OS/c1-14-4-6-17(7-5-14)25-16(3)18-15(2)21-22-20(19(18)23-25)27-13-10-24-8-11-26-12-9-24/h4-7H,8-13H2,1-3H3 APXBKTFOSOPGRD-UHFFFAOYSA-N 114354 SMR000229573::MLS000698466::3,4-dimethyl-2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyridazin-7-yl 2-(4-morpholinyl)ethyl sulfide::cid_990451::4-[2-[3,4-dimethyl-2-(4-methylphenyl)pyrazolo[3,4-d]pyridazin-7-yl]sulfanylethyl]morpholine::4-[2-[[3,4-dimethyl-2-(4-methylphenyl)-7-pyrazolo[3,4-d]pyridazinyl]thio]ethyl]morpholine::4-[2-[[3,4-dimethyl-2-(p-tolyl)pyrazolo[3,4-d]pyridazin-7-yl]thio]ethyl]morpholine Major prion protein Homo sapiens 12802 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114354&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 990451 252663860 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237093 CCOc1ccc(cc1)-n1nc2c(c1C)c(C)n[nH]c2=S InChI=1S/C15H16N4OS/c1-4-20-12-7-5-11(6-8-12)19-10(3)13-9(2)16-17-15(21)14(13)18-19/h5-8H,4H2,1-3H3,(H,17,21) SSSYEWMEKZAAPX-UHFFFAOYSA-N 114355 SMR000229593::MLS000701189::cid_1234242::2-(4-ethoxyphenyl)-3,4-dimethyl-6H-pyrazolo[3,4-d]pyridazine-7-thione::2-(4-ethoxyphenyl)-3,4-dimethyl-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazine-7-thione::3,4-dimethyl-2-p-phenetyl-6H-pyrazolo[3,4-d]pyridazine-7-thione Major prion protein Homo sapiens 320.71 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114355&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234242 252663861 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237094 Cc1ccc(Sc2c(O)c3ccccc3n(C)c2=O)cc1 InChI=1S/C17H15NO2S/c1-11-7-9-12(10-8-11)21-16-15(19)13-5-3-4-6-14(13)18(2)17(16)20/h3-10,19H,1-2H3 HGINECSUHNZQGL-UHFFFAOYSA-N 114356 1-methyl-3-(4-methylphenyl)sulfanyl-4-oxidanyl-quinolin-2-one::4-hydroxy-1-methyl-3-(4-methylphenyl)sulfanylquinolin-2-one::4-hydroxy-1-methyl-3-[(4-methylphenyl)thio]-2-quinolinone::4-hydroxy-1-methyl-3-[(4-methylphenyl)sulfanyl]-2(1H)-quinolinone::MLS000699512::SMR000226666::cid_54710218::4-hydroxy-1-methyl-3-(p-tolylthio)carbostyril Major prion protein Homo sapiens 7120 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114356&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 54710218 252663862 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237095 O=C(CSc1ncnc2ccccc12)NCCc1ccccc1 InChI=1S/C18H17N3OS/c22-17(19-11-10-14-6-2-1-3-7-14)12-23-18-15-8-4-5-9-16(15)20-13-21-18/h1-9,13H,10-12H2,(H,19,22) ZZALUHFYWNYDSY-UHFFFAOYSA-N 114357 cid_2595072::N-(2-phenylethyl)-2-quinazolin-4-ylsulfanyl-ethanamide::N-(2-phenylethyl)-2-quinazolin-4-ylsulfanylacetamide::SMR000323265::N-(2-phenylethyl)-2-(4-quinazolinylthio)acetamide::MLS000684753::N-phenethyl-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 6695 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114357 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114357&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2595072 252663863 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237096 [O-]C(=O)c1cc(nc2ccc(Br)cc12)-c1cccnc1 InChI=1S/C15H9BrN2O2/c16-10-3-4-13-11(6-10)12(15(19)20)7-14(18-13)9-2-1-5-17-8-9/h1-8H,(H,19,20)/p-1 AVLAIBAXSCQGEN-UHFFFAOYSA-M 66176 SMR000306271::cid_23679856::potassium;6-bromanyl-2-pyridin-3-yl-quinoline-4-carboxylate::MLS000727574::potassium;6-bromo-2-(3-pyridinyl)-4-quinolinecarboxylate::potassium;6-bromo-2-pyridin-3-ylquinoline-4-carboxylate::potassium;6-bromo-2-(3-pyridyl)cinchoninate Major prion protein Homo sapiens 13832 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66176&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4220296 252644504 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237097 CC(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1 InChI=1S/C12H9N3O2S2/c1-7(16)6-19-12-14-10(9-3-2-4-18-9)8(5-13)11(17)15-12/h2-4H,6H2,1H3,(H,14,15,17) HDOKKTADSWPMGL-UHFFFAOYSA-N 47295 4-oxidanylidene-2-(2-oxidanylidenepropylsulfanyl)-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::4-oxo-2-(2-oxopropylsulfanyl)-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::cid_1234392::SMR000231785::6-oxo-2-[(2-oxopropyl)sulfanyl]-4-(2-thienyl)-1,6-dihydro-5-pyrimidinecarbonitrile::4-oxo-2-(2-oxopropylthio)-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::MLS000705355::2-(acetonylthio)-4-keto-6-(2-thienyl)-1H-pyrimidine-5-carbonitrile Major prion protein Homo sapiens 2273 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47295&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234392 252627664 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237098 CCOC(=O)C(CC)Sc1cc(C)nc2ccc(OC)cc12 InChI=1S/C17H21NO3S/c1-5-15(17(19)21-6-2)22-16-9-11(3)18-14-8-7-12(20-4)10-13(14)16/h7-10,15H,5-6H2,1-4H3 FMWVPFGUKCGOAF-UHFFFAOYSA-N 114358 MLS000706222::SMR000288274::cid_3168484::ethyl 2-(6-methoxy-2-methylquinolin-4-yl)sulfanylbutanoate::2-[(6-methoxy-2-methyl-4-quinolinyl)thio]butanoic acid ethyl ester::ethyl 2-(6-methoxy-2-methyl-quinolin-4-yl)sulfanylbutanoate::2-[(6-methoxy-2-methyl-4-quinolyl)thio]butyric acid ethyl ester Major prion protein Homo sapiens 5287 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114358 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114358&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3168484 252663864 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237099 CCc1nc(SCC(=O)OC(C)C)c2ccccc2n1 InChI=1S/C15H18N2O2S/c1-4-13-16-12-8-6-5-7-11(12)15(17-13)20-9-14(18)19-10(2)3/h5-8,10H,4,9H2,1-3H3 LCOIGHVHYKDELE-UHFFFAOYSA-N 114359 SMR000286138::2-[(2-ethyl-4-quinazolinyl)thio]acetic acid propan-2-yl ester::MLS000677310::propan-2-yl 2-(2-ethylquinazolin-4-yl)sulfanylacetate::propan-2-yl 2-(2-ethylquinazolin-4-yl)sulfanylethanoate::cid_1434993::2-[(2-ethylquinazolin-4-yl)thio]acetic acid isopropyl ester Major prion protein Homo sapiens 2377 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114359 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114359&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1434993 252663865 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237100 CCOC(=O)c1c(N)scc1-c1ccc(C)s1 InChI=1S/C12H13NO2S2/c1-3-15-12(14)10-8(6-16-11(10)13)9-5-4-7(2)17-9/h4-6H,3,13H2,1-2H3 OCXFDSDTIGSDOV-UHFFFAOYSA-N 34856 MLS000676163::ethyl 5'-amino-5-methyl-2,3'-bithiophene-4'-carboxylate::ethyl 2-amino-4-(5-methylthiophen-2-yl)thiophene-3-carboxylate::SMR000271900::ethyl 2-azanyl-4-(5-methylthiophen-2-yl)thiophene-3-carboxylate::2-amino-4-(5-methyl-2-thiophenyl)-3-thiophenecarboxylic acid ethyl ester::cid_711175::2-amino-4-(5-methyl-2-thienyl)thiophene-3-carboxylic acid ethyl ester Major prion protein Homo sapiens 104237 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34856&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 711175 252617502 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237101 COc1ccc(Nc2nnc(-c3ccc(O)cc3)c3ccccc23)cc1C(N)=O InChI=1S/C22H18N4O3/c1-29-19-11-8-14(12-18(19)21(23)28)24-22-17-5-3-2-4-16(17)20(25-26-22)13-6-9-15(27)10-7-13/h2-12,27H,1H3,(H2,23,28)(H,24,26) LGIAETWKSXMAPI-UHFFFAOYSA-N 114360 MLS000714775::2-methoxy-5-[[4-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-phthalazin-1-yl]amino]benzamide::2-methoxy-5-[[4-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)-3H-phthalazin-1-yl]amino]benzamide::cid_5438298::SMR000274754::2-methoxy-5-[[4-(4-oxo-1-cyclohexa-2,5-dienylidene)-3H-phthalazin-1-yl]amino]benzamide::5-[[4-(4-ketocyclohexa-2,5-dien-1-ylidene)-3H-phthalazin-1-yl]amino]-2-methoxy-benzamide Major prion protein Homo sapiens 759.13 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114360 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114360&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5438298 252663866 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237102 COc1ccc2[nH]c3c(nc[nH]c3=S)c2c1 InChI=1S/C11H9N3OS/c1-15-6-2-3-8-7(4-6)9-10(14-8)11(16)13-5-12-9/h2-5,14H,1H3,(H,12,13,16) NRHNFEIOZFBUID-UHFFFAOYSA-N 95270 8-methoxy-1,5-dihydropyrimido[5,4-b]indole-4-thione::MLS000711893::cid_744304::SMR000281660::8-methoxy-1,5-dihydropyrimid[5,4-b]indole-4-thione Major prion protein Homo sapiens 5912 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95270&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 744304 164036514 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237103 CCc1nc(SCC(=O)NNC(=O)c2ccc(OC)cc2)c2ccccc2n1 InChI=1S/C20H20N4O3S/c1-3-17-21-16-7-5-4-6-15(16)20(22-17)28-12-18(25)23-24-19(26)13-8-10-14(27-2)11-9-13/h4-11H,3,12H2,1-2H3,(H,23,25)(H,24,26) ZAQWDOVEFXKWFO-UHFFFAOYSA-N 114361 SMR000286107::MLS000677348::N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]-4-methoxybenzohydrazide::N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]-4-methoxybenzohydrazide::cid_1435001::N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]-4-methoxy-benzohydrazide::N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]-4-methoxy-benzohydrazide Major prion protein Homo sapiens 1722 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114361&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1435001 252663867 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237104 NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C16H15N5O5S2/c17-15(18)21-28(23,24)11-4-2-10(3-5-11)19-16(27)20-14(22)9-1-6-12-13(7-9)26-8-25-12/h1-7H,8H2,(H4,17,18,21)(H2,19,20,22,27) QHYNODSDBUNAIJ-UHFFFAOYSA-N 43259 N-[[4-(diaminomethylideneamino)sulfonylphenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide::MLS000621545::SMR000299720::cid_1991728::N-({[4-({[amino(imino)methyl]amino}sulfonyl)phenyl]amino}carbonothioyl)-1,3-benzodioxole-5-carboxamide::N-[[4-[bis(azanyl)methylideneamino]sulfonylphenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide::N-[[4-(diaminomethylideneamino)sulfonylanilino]-sulfanylidenemethyl]-1,3-benzodioxole-5-carboxamide::N-[(4-guanidinosulfonylphenyl)thiocarbamoyl]-piperonylamide Major prion protein Homo sapiens 15091 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43259&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1991728 252623940 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237105 NC(=NOC(=O)COc1ccc2ccccc2c1Br)c1ccccn1 |w:2.2| InChI=1S/C18H14BrN3O3/c19-17-13-6-2-1-5-12(13)8-9-15(17)24-11-16(23)25-22-18(20)14-7-3-4-10-21-14/h1-10H,11H2,(H2,20,22) ZSYCLUQOZFJIIU-UHFFFAOYSA-N 114362 N'-({2-[(1-bromo-2-naphthyl)oxy]acetyl}oxy)-2-pyridinecarboximidamide::MLS000624736::[(Z)-[azanyl(pyridin-2-yl)methylidene]amino] 2-(1-bromanylnaphthalen-2-yl)oxyethanoate::cid_9587840::[(Z)-[amino(pyridin-2-yl)methylidene]amino] 2-(1-bromonaphthalen-2-yl)oxyacetate::2-[(1-bromo-2-naphthalenyl)oxy]acetic acid [(Z)-[amino(2-pyridinyl)methylidene]amino] ester::SMR000294955::2-(1-bromo-2-naphthoxy)acetic acid [(Z)-[amino(2-pyridyl)methylene]amino] ester Major prion protein Homo sapiens 4710 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114362&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 9587840 252663868 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237106 CC(C)(C)C(=O)NNC(=O)COc1ccc2ccccc2c1Br InChI=1S/C17H19BrN2O3/c1-17(2,3)16(22)20-19-14(21)10-23-13-9-8-11-6-4-5-7-12(11)15(13)18/h4-9H,10H2,1-3H3,(H,19,21)(H,20,22) UBDRJHGRSGICKV-UHFFFAOYSA-N 114363 N'-{[(1-bromo-2-naphthyl)oxy]acetyl}-2,2-dimethylpropanohydrazide::MLS000679836::N'-[2-(1-bromonaphthalen-2-yl)oxyacetyl]-2,2-dimethylpropanehydrazide::SMR000296707::N'-[2-(1-bromanylnaphthalen-2-yl)oxyethanoyl]-2,2-dimethyl-propanehydrazide::N'-[2-[(1-bromo-2-naphthalenyl)oxy]-1-oxoethyl]-2,2-dimethylpropanehydrazide::cid_2980985::N'-[2-(1-bromo-2-naphthoxy)acetyl]-2,2-dimethyl-propionohydrazide Major prion protein Homo sapiens 4912 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114363&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2980985 252663869 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237107 OCCNC(=S)NC(=O)c1sc2ccccc2c1Cl InChI=1S/C12H11ClN2O2S2/c13-9-7-3-1-2-4-8(7)19-10(9)11(17)15-12(18)14-5-6-16/h1-4,16H,5-6H2,(H2,14,15,17,18) HSHMSTBUBANAQF-UHFFFAOYSA-N 114364 3-chloro-N-[(2-hydroxyethylamino)-sulfanylidenemethyl]-1-benzothiophene-2-carboxamide::3-chloranyl-N-(2-hydroxyethylcarbamothioyl)-1-benzothiophene-2-carboxamide::MLS000679871::cid_2237594::3-chloro-N-(2-hydroxyethylcarbamothioyl)-1-benzothiophene-2-carboxamide::SMR000296739::3-chloro-N-{[(2-hydroxyethyl)amino]carbonothioyl}-1-benzothiophene-2-carboxamide::3-chloro-N-(2-hydroxyethylthiocarbamoyl)benzothiophene-2-carboxamide Major prion protein Homo sapiens 3396 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114364&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2237594 252663870 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237108 CNC(=O)NC(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1 InChI=1S/C13H11N5O3S2/c1-15-12(21)16-9(19)6-23-13-17-10(8-3-2-4-22-8)7(5-14)11(20)18-13/h2-4H,6H2,1H3,(H,17,18,20)(H2,15,16,19,21) MWXYCXHXADPYIF-UHFFFAOYSA-N 47306 2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)thio]-N-(methylcarbamoyl)acetamide::MLS000705748::cid_1817440::SMR000231787::2-[(5-cyano-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)ethanamide::N-({[5-cyano-6-oxo-4-(2-thienyl)-1,6-dihydro-2-pyrimidinyl]sulfanyl}acetyl)-N'-methylurea::2-[(5-cyano-4-oxo-6-thiophen-2-yl-1H-pyrimidin-2-yl)sulfanyl]-N-(methylcarbamoyl)acetamide::2-[[5-cyano-4-keto-6-(2-thienyl)-1H-pyrimidin-2-yl]thio]-N-(methylcarbamoyl)acetamide Major prion protein Homo sapiens 875.59 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47306&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1817440 252627670 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237109 CCOC(=O)CSc1nc(Cc2ccccc2)nc2ccccc12 InChI=1S/C19H18N2O2S/c1-2-23-18(22)13-24-19-15-10-6-7-11-16(15)20-17(21-19)12-14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3 YRAOHSZYMMTKQT-UHFFFAOYSA-N 114365 ethyl 2-(2-benzylquinazolin-4-yl)sulfanylacetate::ethyl 2-[2-(phenylmethyl)quinazolin-4-yl]sulfanylethanoate::SMR000286711::cid_1442565::MLS000764906::2-[[2-(phenylmethyl)-4-quinazolinyl]thio]acetic acid ethyl ester::2-[(2-benzylquinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 4306 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114365&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442565 252663871 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237110 CC(C)OC(=O)CSc1nc(Cc2ccccc2)nc2ccccc12 InChI=1S/C20H20N2O2S/c1-14(2)24-19(23)13-25-20-16-10-6-7-11-17(16)21-18(22-20)12-15-8-4-3-5-9-15/h3-11,14H,12-13H2,1-2H3 PMWUBZNMXMPBQR-UHFFFAOYSA-N 114366 propan-2-yl 2-[2-(phenylmethyl)quinazolin-4-yl]sulfanylethanoate::propan-2-yl 2-(2-benzylquinazolin-4-yl)sulfanylacetate::SMR000287000::MLS000709833::2-[[2-(phenylmethyl)-4-quinazolinyl]thio]acetic acid propan-2-yl ester::cid_1442567::2-[(2-benzylquinazolin-4-yl)thio]acetic acid isopropyl ester Major prion protein Homo sapiens 4452 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114366&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442567 252663872 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237111 CCOC(=O)CSc1nc(nc2ccccc12)C(C)(C)C InChI=1S/C16H20N2O2S/c1-5-20-13(19)10-21-14-11-8-6-7-9-12(11)17-15(18-14)16(2,3)4/h6-9H,5,10H2,1-4H3 KBCUNRKOHQPPAP-UHFFFAOYSA-N 114367 ethyl 2-(2-tert-butylquinazolin-4-yl)sulfanylacetate::MLS000709831::SMR000286998::ethyl 2-(2-tert-butylquinazolin-4-yl)sulfanylethanoate::cid_1442473::2-[(2-tert-butyl-4-quinazolinyl)thio]acetic acid ethyl ester::2-[(2-tert-butylquinazolin-4-yl)thio]acetic acid ethyl ester Major prion protein Homo sapiens 6981 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114367&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442473 252663873 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237112 OC(=O)CCC(=O)NNC(=O)COc1ccc2ccccc2c1Br InChI=1S/C16H15BrN2O5/c17-16-11-4-2-1-3-10(11)5-6-12(16)24-9-14(21)19-18-13(20)7-8-15(22)23/h1-6H,7-9H2,(H,18,20)(H,19,21)(H,22,23) UJRZEIOSYLWMKO-UHFFFAOYSA-N 114368 4-[2-[2-(1-bromanylnaphthalen-2-yl)oxyethanoyl]hydrazinyl]-4-oxidanylidene-butanoic acid::MLS000704315::cid_1632391::SMR000231431::4-(2-{[(1-bromo-2-naphthyl)oxy]acetyl}hydrazino)-4-oxobutanoic acid::4-[2-[2-(1-bromonaphthalen-2-yl)oxyacetyl]hydrazinyl]-4-oxobutanoic acid::4-[[2-[(1-bromo-2-naphthalenyl)oxy]-1-oxoethyl]hydrazo]-4-oxobutanoic acid::4-[N'-[2-(1-bromo-2-naphthoxy)acetyl]hydrazino]-4-keto-butyric acid Major prion protein Homo sapiens 4454 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114368&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1632391 252663874 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237113 COC(=O)CSc1nc(Cc2ccccc2)nc2ccccc12 InChI=1S/C18H16N2O2S/c1-22-17(21)12-23-18-14-9-5-6-10-15(14)19-16(20-18)11-13-7-3-2-4-8-13/h2-10H,11-12H2,1H3 KFQPLDGBOHNNAC-UHFFFAOYSA-N 114369 2-[[2-(phenylmethyl)-4-quinazolinyl]thio]acetic acid methyl ester::MLS000709832::SMR000286999::methyl 2-(2-benzylquinazolin-4-yl)sulfanylacetate::methyl 2-[2-(phenylmethyl)quinazolin-4-yl]sulfanylethanoate::cid_1442564::2-[(2-benzylquinazolin-4-yl)thio]acetic acid methyl ester Major prion protein Homo sapiens 3293 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114369&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442564 252663875 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237114 Clc1ccc(CSc2nc(-c3cccs3)c(C#N)c(=O)[nH]2)cc1 InChI=1S/C16H10ClN3OS2/c17-11-5-3-10(4-6-11)9-23-16-19-14(13-2-1-7-22-13)12(8-18)15(21)20-16/h1-7H,9H2,(H,19,20,21) JQXFFLCVJXGBDY-UHFFFAOYSA-N 47311 MLS000705749::2-[(4-chlorophenyl)methylthio]-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::SMR000231786::cid_1234393::2-[(4-chlorobenzyl)sulfanyl]-6-oxo-4-(2-thienyl)-1,6-dihydro-5-pyrimidinecarbonitrile::2-[(4-chlorophenyl)methylsulfanyl]-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-[(4-chlorophenyl)methylsulfanyl]-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-[(4-chlorobenzyl)thio]-4-keto-6-(2-thienyl)-1H-pyrimidine-5-carbonitrile Major prion protein Homo sapiens 1048 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47311&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1234393 252627673 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237115 OC(=O)CSc1ncnc2sc3CCCCc3c12 InChI=1S/C12H12N2O2S2/c15-9(16)5-17-11-10-7-3-1-2-4-8(7)18-12(10)14-6-13-11/h6H,1-5H2,(H,15,16) GFFWEDHEGYCZHG-UHFFFAOYSA-N 114370 cid_746456::MLS000715131::2-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)ethanoic acid::SMR000275110::2-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylthio)acetic acid::2-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylsulfanyl)acetic acid::2-(5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-4-ylthio)acetic acid Major prion protein Homo sapiens 8489 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114370&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 746456 252663876 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237116 CC(Sc1cc(C)c2ccccc2n1)C(O)=O InChI=1S/C13H13NO2S/c1-8-7-12(17-9(2)13(15)16)14-11-6-4-3-5-10(8)11/h3-7,9H,1-2H3,(H,15,16) PZYFRXRGRLCMPV-UHFFFAOYSA-N 114371 2-[(4-methyl-2-quinolinyl)thio]propanoic acid::cid_2939635::2-(4-methylquinolin-2-yl)sulfanylpropanoic acid::SMR000274741::MLS000714762::2-[(4-methyl-2-quinolyl)thio]propionic acid Major prion protein Homo sapiens 8846 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114371&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2939635 252663877 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237117 COc1cccc(c1)-n1cc(O)c(c1N)-c1nc2ccccc2s1 InChI=1S/C18H15N3O2S/c1-23-12-6-4-5-11(9-12)21-10-14(22)16(17(21)19)18-20-13-7-2-3-8-15(13)24-18/h2-10,22H,19H2,1H3 ZGUSHZWMNURFRB-UHFFFAOYSA-N 114372 5-amino-4-(1,3-benzothiazol-2-yl)-1-(3-methoxyphenyl)-2H-pyrrol-3-one::cid_725168::SMR000284241::MLS000688054::5-azanyl-4-(1,3-benzothiazol-2-yl)-1-(3-methoxyphenyl)-2H-pyrrol-3-one::5-amino-4-(1,3-benzothiazol-2-yl)-1-(3-methoxyphenyl)-2-pyrrolin-3-one Major prion protein Homo sapiens 5106 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114372&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899716 252663878 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237118 COC(=O)CSc1ncnc2scc(-c3ccccc3)c12 InChI=1S/C15H12N2O2S2/c1-19-12(18)8-21-15-13-11(10-5-3-2-4-6-10)7-20-14(13)16-9-17-15/h2-7,9H,8H2,1H3 GSJZDBNDELCNEI-UHFFFAOYSA-N 114373 methyl 2-(5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetate::2-[(5-phenyl-4-thieno[2,3-d]pyrimidinyl)thio]acetic acid methyl ester::cid_856427::MLS000678230::methyl 2-(5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanoate::SMR000285213::2-[(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid methyl ester Major prion protein Homo sapiens 5595 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114373&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 856427 252663879 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237119 CCc1nc(SCC(=O)Nc2ccc(cc2)N(C)C)c2ccccc2n1 InChI=1S/C20H22N4OS/c1-4-18-22-17-8-6-5-7-16(17)20(23-18)26-13-19(25)21-14-9-11-15(12-10-14)24(2)3/h5-12H,4,13H2,1-3H3,(H,21,25) OLEVNZWKVOAFRW-UHFFFAOYSA-N 114374 N-[4-(dimethylamino)phenyl]-2-(2-ethylquinazolin-4-yl)sulfanyl-ethanamide::SMR000285519::cid_1435045::N-[4-(dimethylamino)phenyl]-2-(2-ethylquinazolin-4-yl)sulfanylacetamide::MLS000693575::N-[4-(dimethylamino)phenyl]-2-[(2-ethyl-4-quinazolinyl)thio]acetamide::N-[4-(dimethylamino)phenyl]-2-[(2-ethylquinazolin-4-yl)thio]acetamide Major prion protein Homo sapiens 4471 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114374&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1435045 252663880 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237120 CCOC(=O)CNC(=O)CSc1nc2c(C)cccc2cc1CC InChI=1S/C18H22N2O3S/c1-4-13-9-14-8-6-7-12(3)17(14)20-18(13)24-11-15(21)19-10-16(22)23-5-2/h6-9H,4-5,10-11H2,1-3H3,(H,19,21) NUNBAOSRSNHECU-UHFFFAOYSA-N 114375 MLS000692883::cid_3207945::SMR000285556::ethyl 2-[[2-(3-ethyl-8-methylquinolin-2-yl)sulfanylacetyl]amino]acetate::ethyl 2-[2-(3-ethyl-8-methyl-quinolin-2-yl)sulfanylethanoylamino]ethanoate::2-[[2-[(3-ethyl-8-methyl-2-quinolinyl)thio]-1-oxoethyl]amino]acetic acid ethyl ester::2-[[2-[(3-ethyl-8-methyl-2-quinolyl)thio]acetyl]amino]acetic acid ethyl ester Major prion protein Homo sapiens 2762 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114375&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3207945 252663881 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237121 CCOC(=O)CSc1ccc2ccccc2n1 InChI=1S/C13H13NO2S/c1-2-16-13(15)9-17-12-8-7-10-5-3-4-6-11(10)14-12/h3-8H,2,9H2,1H3 AIHOCXBKNMJTLF-UHFFFAOYSA-N 114376 2-(2-quinolinylthio)acetic acid ethyl ester::SMR000283235::cid_737004::ethyl 2-quinolin-2-ylsulfanylethanoate::MLS000689202::ethyl 2-quinolin-2-ylsulfanylacetate::2-(2-quinolylthio)acetic acid ethyl ester Major prion protein Homo sapiens 9536 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114376&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 737004 252663882 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237122 CC(=O)Nc1ccc(cc1)-c1ccnc(n1)-c1ccc(NC(C)=O)cc1 InChI=1S/C20H18N4O2/c1-13(25)22-17-7-3-15(4-8-17)19-11-12-21-20(24-19)16-5-9-18(10-6-16)23-14(2)26/h3-12H,1-2H3,(H,22,25)(H,23,26) SXGAJAPFZZVVFL-UHFFFAOYSA-N 114377 SMR000283830::MLS000688185::N-[4-[2-(4-acetamidophenyl)pyrimidin-4-yl]phenyl]ethanamide::cid_540833::N-[4-[2-(4-acetamidophenyl)-4-pyrimidinyl]phenyl]acetamide::N-[4-[2-(4-acetamidophenyl)pyrimidin-4-yl]phenyl]acetamide Major prion protein Homo sapiens 26659 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114377&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 540833 252663883 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237123 CC(C)c1nc(SCC(=O)N2CC(=O)Nc3ccccc23)c2ccccc2n1 InChI=1S/C21H20N4O2S/c1-13(2)20-23-15-8-4-3-7-14(15)21(24-20)28-12-19(27)25-11-18(26)22-16-9-5-6-10-17(16)25/h3-10,13H,11-12H2,1-2H3,(H,22,26) BBDFSDPMFNFYKL-UHFFFAOYSA-N 114378 MLS000709663::cid_1442861::SMR000286530::4-[1-oxo-2-[(2-propan-2-yl-4-quinazolinyl)thio]ethyl]-1,3-dihydroquinoxalin-2-one::4-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoyl]-1,3-dihydroquinoxalin-2-one::4-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetyl]-1,3-dihydroquinoxalin-2-one::4-[2-[(2-isopropylquinazolin-4-yl)thio]acetyl]-1,3-dihydroquinoxalin-2-one Major prion protein Homo sapiens 2412 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114378&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442861 252663884 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237124 COC(=O)CSc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C17H14N2O2S/c1-21-15(20)11-22-17-13-9-5-6-10-14(13)18-16(19-17)12-7-3-2-4-8-12/h2-10H,11H2,1H3 ICTBRAWGEXCUJI-UHFFFAOYSA-N 114379 MLS000688435::2-[(2-phenyl-4-quinazolinyl)thio]acetic acid methyl ester::methyl 2-(2-phenylquinazolin-4-yl)sulfanylethanoate::methyl 2-(2-phenylquinazolin-4-yl)sulfanylacetate::SMR000284369::cid_865071::2-[(2-phenylquinazolin-4-yl)thio]acetic acid methyl ester Major prion protein Homo sapiens 1312 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114379&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 865071 252663885 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237125 CCCCNC(=O)CSc1nc(CCC)nc2ccccc12 InChI=1S/C17H23N3OS/c1-3-5-11-18-16(21)12-22-17-13-9-6-7-10-14(13)19-15(20-17)8-4-2/h6-7,9-10H,3-5,8,11-12H2,1-2H3,(H,18,21) MNVBWFKNPKNXLH-UHFFFAOYSA-N 114380 N-butyl-2-(2-propylquinazolin-4-yl)sulfanyl-ethanamide::MLS000855965::cid_3221482::N-butyl-2-[(2-propyl-4-quinazolinyl)thio]acetamide::SMR000286410::N-butyl-2-(2-propylquinazolin-4-yl)sulfanylacetamide::N-butyl-2-[(2-propylquinazolin-4-yl)thio]acetamide Major prion protein Homo sapiens 14653 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114380&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3221482 252663886 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237126 CCCc1nc(SCC(=O)NNC(=O)c2ccc(OC)cc2)c2ccccc2n1 InChI=1S/C21H22N4O3S/c1-3-6-18-22-17-8-5-4-7-16(17)21(23-18)29-13-19(26)24-25-20(27)14-9-11-15(28-2)12-10-14/h4-5,7-12H,3,6,13H2,1-2H3,(H,24,26)(H,25,27) IMJYWUVLQTYIEI-UHFFFAOYSA-N 114381 4-methoxy-N'-[2-(2-propylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide::4-methoxy-N'-[1-oxo-2-[(2-propyl-4-quinazolinyl)thio]ethyl]benzohydrazide::4-methoxy-N'-[2-(2-propylquinazolin-4-yl)sulfanylacetyl]benzohydrazide::cid_1442627::MLS000855976::SMR000286421::4-methoxy-N'-[2-[(2-propylquinazolin-4-yl)thio]acetyl]benzohydrazide Major prion protein Homo sapiens 1519 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114381&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442627 252663887 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237127 Cc1cc2cccc(C)c2nc1SCC(=O)NNC(=O)c1ccco1 InChI=1S/C18H17N3O3S/c1-11-5-3-6-13-9-12(2)18(19-16(11)13)25-10-15(22)20-21-17(23)14-7-4-8-24-14/h3-9H,10H2,1-2H3,(H,20,22)(H,21,23) AUSKUINCLGCDKS-UHFFFAOYSA-N 114382 N'-[2-(3,8-dimethylquinolin-2-yl)sulfanylethanoyl]furan-2-carbohydrazide::N'-[2-(3,8-dimethylquinolin-2-yl)sulfanylacetyl]furan-2-carbohydrazide::cid_1176113::N'-[2-[(3,8-dimethyl-2-quinolinyl)thio]-1-oxoethyl]-2-furancarbohydrazide::MLS000688165::SMR000283817::N'-[2-[(3,8-dimethyl-2-quinolyl)thio]acetyl]-2-furohydrazide Major prion protein Homo sapiens 7042 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114382&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1176113 252663888 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237128 Cc1cc(C)nc(NS(=O)(=O)c2ccc(NC(=O)CSc3nc(-c4ccccc4)c(C#N)c(=O)[nH]3)cc2)n1 InChI=1S/C25H21N7O4S2/c1-15-12-16(2)28-24(27-15)32-38(35,36)19-10-8-18(9-11-19)29-21(33)14-37-25-30-22(17-6-4-3-5-7-17)20(13-26)23(34)31-25/h3-12H,14H2,1-2H3,(H,29,33)(H,27,28,32)(H,30,31,34) IUJPONXESIYPRV-UHFFFAOYSA-N 114383 2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]-N-[4-[(4,6-dimethyl-2-pyrimidinyl)sulfamoyl]phenyl]acetamide::2-[(5-cyano-4-oxidanylidene-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]ethanamide::cid_3635365::SMR000313009::2-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanyl]-N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide::MLS000682926::2-[(5-cyano-6-oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)thio]-N-(4-{[(4,6-dimethylpyrimidin-2-yl)amino]sulfonyl}phenyl)acetamide::2-[(5-cyano-4-keto-6-phenyl-1H-pyrimidin-2-yl)thio]-N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide Major prion protein Homo sapiens 6282 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114383&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3635365 252663889 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237129 [O-][N+](=O)c1ccc2nccc(Nc3ccc(C(=O)Nc4ccc(Nc5ccncc5)cc4)c(c3)[N+]([O-])=O)c2c1 InChI=1S/C27H19N7O5/c35-27(32-18-3-1-17(2-4-18)30-19-9-12-28-13-10-19)22-7-5-20(15-26(22)34(38)39)31-25-11-14-29-24-8-6-21(33(36)37)16-23(24)25/h1-16H,(H,28,30)(H,29,31)(H,32,35) YUOOWNPVFAMPNZ-UHFFFAOYSA-N 50649 cid_5236119::2-nitro-4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide::MLS000756458::SMR000528741::2-nitro-4-[(6-nitro-4-quinolinyl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide::2-nitro-4-[(6-nitro-4-quinolyl)amino]-N-[4-(4-pyridylamino)phenyl]benzamide Major prion protein Homo sapiens 9031 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50649&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5236119 252630906 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237130 CCOC(=O)C(C)Sc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C19H18N2O2S/c1-3-23-19(22)13(2)24-18-15-11-7-8-12-16(15)20-17(21-18)14-9-5-4-6-10-14/h4-13H,3H2,1-2H3 QKVPTJMGYXIZKW-UHFFFAOYSA-N 114384 cid_3167727::2-[(2-phenyl-4-quinazolinyl)thio]propanoic acid ethyl ester::MLS000687054::ethyl 2-(2-phenylquinazolin-4-yl)sulfanylpropanoate::SMR000284159::2-[(2-phenylquinazolin-4-yl)thio]propionic acid ethyl ester Major prion protein Homo sapiens 1835 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114384&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3167727 252663890 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237131 CC(C)c1nc(SCC(=O)Nc2ccc(cc2)N(C)C)c2ccccc2n1 InChI=1S/C21H24N4OS/c1-14(2)20-23-18-8-6-5-7-17(18)21(24-20)27-13-19(26)22-15-9-11-16(12-10-15)25(3)4/h5-12,14H,13H2,1-4H3,(H,22,26) YQWMYZGJQBXBMT-UHFFFAOYSA-N 114385 N-[4-(dimethylamino)phenyl]-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide::MLS000856169::N-[4-(dimethylamino)phenyl]-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide::SMR000286614::cid_1442821::N-[4-(dimethylamino)phenyl]-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide::N-[4-(dimethylamino)phenyl]-2-[(2-isopropylquinazolin-4-yl)thio]acetamide Major prion protein Homo sapiens 2944 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114385&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442821 252663891 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237132 Clc1ccc(Cc2nc3ccccc3c(=S)[nH]2)cc1 InChI=1S/C15H11ClN2S/c16-11-7-5-10(6-8-11)9-14-17-13-4-2-1-3-12(13)15(19)18-14/h1-8H,9H2,(H,17,18,19) UIYZWJVIMFVNSO-UHFFFAOYSA-N 114386 2-(4-chlorobenzyl)-4-quinazolinethiol::cid_2766814::2-[(4-chlorophenyl)methyl]-1H-quinazoline-4-thione::MLS000696299::SMR000333405::2-(4-chlorobenzyl)-1H-quinazoline-4-thione Major prion protein Homo sapiens 7465 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114386&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2766814 252663892 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237133 CN(Cc1cn(C)nc1C)C(=O)c1cc(nc2ccc(Br)cc12)-c1ccccc1 InChI=1S/C23H21BrN4O/c1-15-17(14-28(3)26-15)13-27(2)23(29)20-12-22(16-7-5-4-6-8-16)25-21-10-9-18(24)11-19(20)21/h4-12,14H,13H2,1-3H3 AGHSRUDOCZHHSV-UHFFFAOYSA-N 114387 MLS000727578::cid_5048043::SMR000306275::6-bromo-N-[(1,3-dimethylpyrazol-4-yl)methyl]-N-methyl-2-phenylquinoline-4-carboxamide::6-bromanyl-N-[(1,3-dimethylpyrazol-4-yl)methyl]-N-methyl-2-phenyl-quinoline-4-carboxamide::6-bromo-N-[(1,3-dimethyl-4-pyrazolyl)methyl]-N-methyl-2-phenyl-4-quinolinecarboxamide::6-bromo-N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-methyl-2-phenylquinoline-4-carboxamide::6-bromo-N-[(1,3-dimethylpyrazol-4-yl)methyl]-N-methyl-2-phenyl-cinchoninamide Major prion protein Homo sapiens 6118 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114387&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5048043 252663893 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237134 Cc1cc(C)c2nc(SC3CCOC3=O)cc(C)c2c1 InChI=1S/C16H17NO2S/c1-9-6-11(3)15-12(7-9)10(2)8-14(17-15)20-13-4-5-19-16(13)18/h6-8,13H,4-5H2,1-3H3 AVUUKLPJAUFQCC-UHFFFAOYSA-N 114388 SMR000353852::3-(4,6,8-trimethylquinolin-2-yl)sulfanyloxolan-2-one::MLS001017594::cid_5135882::3-[(4,6,8-trimethyl-2-quinolinyl)thio]-2-oxolanone::3-[(4,6,8-trimethyl-2-quinolyl)thio]tetrahydrofuran-2-one Major prion protein Homo sapiens 3663 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114388&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5135882 252663894 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237135 Brc1c(SCC(=O)OCC(=O)NC2CC2)ccc2ccccc12 InChI=1S/C17H16BrNO3S/c18-17-13-4-2-1-3-11(13)5-8-14(17)23-10-16(21)22-9-15(20)19-12-6-7-12/h1-5,8,12H,6-7,9-10H2,(H,19,20) CNXAOEHBFALPJE-UHFFFAOYSA-N 114389 cid_2334933::SMR000353952::[2-(cyclopropylamino)-2-oxoethyl] 2-(1-bromonaphthalen-2-yl)sulfanylacetate::MLS001017694::[2-(cyclopropylamino)-2-oxidanylidene-ethyl] 2-(1-bromanylnaphthalen-2-yl)sulfanylethanoate::2-[(1-bromo-2-naphthalenyl)thio]acetic acid [2-(cyclopropylamino)-2-oxoethyl] ester::2-[(1-bromo-2-naphthyl)thio]acetic acid [2-(cyclopropylamino)-2-keto-ethyl] ester Major prion protein Homo sapiens 4724 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114389&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2334933 252663895 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237136 CCOC(=O)NC(=O)CSc1cc(C)c2cc(C)cc(C)c2n1 InChI=1S/C17H20N2O3S/c1-5-22-17(21)18-14(20)9-23-15-8-11(3)13-7-10(2)6-12(4)16(13)19-15/h6-8H,5,9H2,1-4H3,(H,18,20,21) OGSSRTMFGCDQKC-UHFFFAOYSA-N 114390 N-[1-oxo-2-[(4,6,8-trimethyl-2-quinolinyl)thio]ethyl]carbamic acid ethyl ester::ethyl N-[2-(4,6,8-trimethylquinolin-2-yl)sulfanylacetyl]carbamate::cid_2552154::MLS001007750::ethyl N-[2-(4,6,8-trimethylquinolin-2-yl)sulfanylethanoyl]carbamate::SMR000384838::N-[2-[(4,6,8-trimethyl-2-quinolyl)thio]acetyl]carbamic acid ethyl ester Major prion protein Homo sapiens 9396 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114390&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2552154 252663896 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237137 O=C(CSc1ncnc2ccccc12)NCc1ccc2OCOc2c1 InChI=1S/C18H15N3O3S/c22-17(19-8-12-5-6-15-16(7-12)24-11-23-15)9-25-18-13-3-1-2-4-14(13)20-10-21-18/h1-7,10H,8-9,11H2,(H,19,22) JPRKDBZDQPRAEN-UHFFFAOYSA-N 114391 SMR000385443::N-(1,3-benzodioxol-5-ylmethyl)-2-quinazolin-4-ylsulfanylacetamide::N-(1,3-benzodioxol-5-ylmethyl)-2-(4-quinazolinylthio)acetamide::cid_2371304::MLS001033104::N-(1,3-benzodioxol-5-ylmethyl)-2-quinazolin-4-ylsulfanyl-ethanamide::N-piperonyl-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 7376 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114391&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2371304 252663897 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237138 Cc1sc2ncnc(Sc3ccccc3C(O)=O)c2c1C InChI=1S/C15H12N2O2S2/c1-8-9(2)20-13-12(8)14(17-7-16-13)21-11-6-4-3-5-10(11)15(18)19/h3-7H,1-2H3,(H,18,19) TZPXEPYUAQIFRO-UHFFFAOYSA-N 114392 cid_2384232::2-[(5,6-dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]benzoic acid::SMR000364244::2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylbenzoic acid::MLS000773492::2-[(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)thio]benzoic acid Major prion protein Homo sapiens 908 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114392&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search A1A5C 2384232 252663898 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237139 OC(=O)c1ccccc1Sc1ncnc2sc3CCCc3c12 InChI=1S/C16H12N2O2S2/c19-16(20)10-4-1-2-6-12(10)22-15-13-9-5-3-7-11(9)21-14(13)17-8-18-15/h1-2,4,6,8H,3,5,7H2,(H,19,20) QFTBUYQYYPLHDV-UHFFFAOYSA-N 43230 cid_2415319::MLS000774547::SMR000372028::2-(7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-d]pyrimidin-1-ylsulfanyl)benzoic acid::2-(7,8-dihydro-6H-cyclopenta[2,3]thieno[2,4-d]pyrimidin-1-ylthio)benzoic acid Major prion protein Homo sapiens 7047 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43230&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2415319 252623914 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237140 O=C(CSc1ncnc2ccccc12)Nc1cccc(c1)S(=O)(=O)N1CCOCC1 InChI=1S/C20H20N4O4S2/c25-19(13-29-20-17-6-1-2-7-18(17)21-14-22-20)23-15-4-3-5-16(12-15)30(26,27)24-8-10-28-11-9-24/h1-7,12,14H,8-11,13H2,(H,23,25) LUSKRKQRUDKTJV-UHFFFAOYSA-N 114393 N-(3-morpholin-4-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanyl-ethanamide::MLS000775831::SMR000370945::cid_5198374::N-[3-(4-morpholinylsulfonyl)phenyl]-2-(4-quinazolinylthio)acetamide::N-(3-morpholin-4-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide::N-(3-morpholinosulfonylphenyl)-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 9121 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114393&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5198374 252663899 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237141 COc1ccc(cc1NC(=O)CSc1ncnc2ccccc12)S(=O)(=O)N1CCOCC1 InChI=1S/C21H22N4O5S2/c1-29-19-7-6-15(32(27,28)25-8-10-30-11-9-25)12-18(19)24-20(26)13-31-21-16-4-2-3-5-17(16)22-14-23-21/h2-7,12,14H,8-11,13H2,1H3,(H,24,26) PPYXMSMSXRUXNC-UHFFFAOYSA-N 114394 N-(2-methoxy-5-morpholin-4-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide::cid_4648816::MLS000775904::SMR000371023::N-(2-methoxy-5-morpholin-4-ylsulfonyl-phenyl)-2-quinazolin-4-ylsulfanyl-ethanamide::N-[2-methoxy-5-(4-morpholinylsulfonyl)phenyl]-2-(4-quinazolinylthio)acetamide::N-(2-methoxy-5-morpholinosulfonyl-phenyl)-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 2663 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114394&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4648816 252663900 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237142 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1O InChI=1S/C16H14O6/c17-10-2-1-8-13-9-4-12(19)11(18)3-7(9)5-16(13,21)6-22-15(8)14(10)20/h1-4,13,17-21H,5-6H2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 114395 MLS000876743::7,11b-dihydro-6H-indeno[2,1-c][1]benzopyran-3,4,6a,9,10-pentol::SMR000440556::cid_10603::7,11b-dihydro-6H-indeno[2,1-c]chromene-3,4,6a,9,10-pentol Major prion protein Homo sapiens 13956 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114395 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114395&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 10603 252663901 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237143 CN(C(=O)CSc1cc(C(=O)c2nccn2C)c2ccccc2n1)c1ccccc1 InChI=1S/C23H20N4O2S/c1-26-13-12-24-23(26)22(29)18-14-20(25-19-11-7-6-10-17(18)19)30-15-21(28)27(2)16-8-4-3-5-9-16/h3-14H,15H2,1-2H3 UVXRRTUPOSDVOC-UHFFFAOYSA-N 114396 MLS001004873::cid_5008348::N-methyl-2-[4-(1-methylimidazol-2-yl)carbonylquinolin-2-yl]sulfanyl-N-phenyl-ethanamide::SMR000348420::N-methyl-2-[4-(1-methylimidazole-2-carbonyl)quinolin-2-yl]sulfanyl-N-phenylacetamide::N-methyl-2-[[4-[(1-methyl-2-imidazolyl)-oxomethyl]-2-quinolinyl]thio]-N-phenylacetamide::N-methyl-2-[[4-(1-methylimidazole-2-carbonyl)-2-quinolyl]thio]-N-phenyl-acetamide Major prion protein Homo sapiens 11427 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114396&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5008348 252663902 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237144 Cc1sc2nc(C)nc(SCC(=O)Nc3cc(cc(c3)C(N)=O)C(N)=O)c2c1C InChI=1S/C19H19N5O3S2/c1-8-9(2)29-19-15(8)18(22-10(3)23-19)28-7-14(25)24-13-5-11(16(20)26)4-12(6-13)17(21)27/h4-6H,7H2,1-3H3,(H2,20,26)(H2,21,27)(H,24,25) PLSOPAWTQWKQOO-UHFFFAOYSA-N 94734 cid_2548636::5-[[1-oxo-2-[(2,5,6-trimethyl-4-thieno[2,3-d]pyrimidinyl)thio]ethyl]amino]benzene-1,3-dicarboxamide::MLS001007073::5-[2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanoylamino]benzene-1,3-dicarboxamide::5-[[2-(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]amino]benzene-1,3-dicarboxamide::SMR000384470::5-[[2-[(2,5,6-trimethylthieno[2,3-d]pyrimidin-4-yl)thio]acetyl]amino]isophthalamide Major prion protein Homo sapiens 11589 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=94734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=94734&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2548636 164035978 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237145 CC(=O)NC(CSc1cc(C)nc2ccc(Br)cc12)C(O)=O InChI=1S/C15H15BrN2O3S/c1-8-5-14(11-6-10(16)3-4-12(11)17-8)22-7-13(15(20)21)18-9(2)19/h3-6,13H,7H2,1-2H3,(H,18,19)(H,20,21) LAJAYRAKHFWSGO-UHFFFAOYSA-N 114397 MLS000778540::2-acetamido-3-(6-bromo-2-methylquinolin-4-yl)sulfanylpropanoic acid::2-acetamido-3-[(6-bromo-2-methyl-4-quinolinyl)thio]propanoic acid::2-Acetylamino-3-(6-bromo-2-methyl-quinolin-4-ylsulfanyl)-propionic acid::cid_3279901::SMR000415334::2-acetamido-3-(6-bromanyl-2-methyl-quinolin-4-yl)sulfanyl-propanoic acid::2-acetamido-3-[(6-bromo-2-methyl-4-quinolyl)thio]propionic acid Major prion protein Homo sapiens 4479 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114397&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3279901 252663903 C02847 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237146 Nc1nnc(SCc2nc3scc(-c4ccccc4)c3c(=O)[nH]2)s1 InChI=1S/C15H11N5OS3/c16-14-19-20-15(24-14)23-7-10-17-12(21)11-9(6-22-13(11)18-10)8-4-2-1-3-5-8/h1-6H,7H2,(H2,16,19)(H,17,18,21) GTCVVJLHMBTZRI-UHFFFAOYSA-N 88933 SMR000365178::2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one::2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one::MLS000774073::cid_2469491::2-[[(5-amino-1,3,4-thiadiazol-2-yl)thio]methyl]-5-phenyl-3H-thieno[2,3-d]pyrimidin-4-one Major prion protein Homo sapiens 12167 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=88933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=88933&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2469491 252660549 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237147 OC(=O)CSc1ncnc2scc(-c3ccccc3)c12 InChI=1S/C14H10N2O2S2/c17-11(18)7-20-14-12-10(9-4-2-1-3-5-9)6-19-13(12)15-8-16-14/h1-6,8H,7H2,(H,17,18) NHKGPOMUILRMLW-UHFFFAOYSA-N 114398 2-[(5-phenyl-4-thieno[2,3-d]pyrimidinyl)thio]acetic acid::2-(5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid::2-(5-phenylthieno[2,3-d]pyrimidin-4-yl)sulfanylethanoic acid::SMR000413519::MLS000777123::cid_724891::(5-Phenyl-thieno[2,3-d]pyrimidin-4-ylsulfanyl)-acetic acid::2-[(5-phenylthieno[2,3-d]pyrimidin-4-yl)thio]acetic acid Major prion protein Homo sapiens 5044 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114398&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 724891 252663904 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237148 CCN1C(=O)C2(C(C(=O)c3cc4ccccc4o3)C(=O)C(=O)N2CCCN2CCOCC2)c2ccccc12 InChI=1S/C29H29N3O6/c1-2-31-21-10-5-4-9-20(21)29(28(31)36)24(25(33)23-18-19-8-3-6-11-22(19)38-23)26(34)27(35)32(29)13-7-12-30-14-16-37-17-15-30/h3-6,8-11,18,24H,2,7,12-17H2,1H3 OAOILMMXPXJGST-UHFFFAOYSA-N 114399 cid_3363660::SMR000438209::MLS000762609::4'-[2-benzofuranyl(oxo)methyl]-1-ethyl-3'-hydroxy-1'-[3-(4-morpholinyl)propyl]spiro[indole-3,5'-pyrrole]-2,2'-dione::4'-(1-benzofuran-2-ylcarbonyl)-1-ethyl-1'-(3-morpholin-4-ylpropyl)-3'-oxidanyl-spiro[indole-3,5'-pyrrole]-2,2'-dione::4'-(1-benzofuran-2-carbonyl)-1-ethyl-3'-hydroxy-1'-(3-morpholin-4-ylpropyl)spiro[indole-3,5'-pyrrole]-2,2'-dione::4-(benzofuran-2-carbonyl)-1'-ethyl-3-hydroxy-1-(3-morpholinopropyl)spiro[3-pyrroline-5,3'-indoline]-2,2'-quinone Major prion protein Homo sapiens 2084 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114399&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899717 252663905 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237149 Cc1cc(OCc2ccccc2)ccc1C(=O)C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccncc1 InChI=1S/C30H25N3O4/c1-20-16-24(37-19-21-6-3-2-4-7-21)9-10-25(20)28(34)26-27(23-11-14-31-15-12-23)33(30(36)29(26)35)18-22-8-5-13-32-17-22/h2-17,26-27H,18-19H2,1H3 YEWCSAJABWMCBZ-UHFFFAOYSA-N 114400 MLS000769299::cid_6254504::4-(4-Benzyloxy-2-methyl-benzoyl)-3-hydroxy-5-pyridin-4-yl-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one::SMR000434033::(4Z)-4-[hydroxy-(2-methyl-4-phenylmethoxyphenyl)methylidene]-5-pyridin-4-yl-1-(3-pyridinylmethyl)pyrrolidine-2,3-dione::(4Z)-4-[(2-methyl-4-phenylmethoxy-phenyl)-oxidanyl-methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione::(4Z)-4-[hydroxy-(2-methyl-4-phenylmethoxyphenyl)methylidene]-5-pyridin-4-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione::(4Z)-4-[(4-benzoxy-2-methyl-phenyl)-hydroxy-methylene]-5-(4-pyridyl)-1-(3-pyridylmethyl)pyrrolidine-2,3-quinone Major prion protein Homo sapiens 12491 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114400&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899718 252663906 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237150 CCc1cc2cccc(C)c2nc1SCC(=O)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C23H25N3O3S/c1-3-17-14-18-7-4-6-16(2)21(18)24-22(17)30-15-20(27)25-9-11-26(12-10-25)23(28)19-8-5-13-29-19/h4-8,13-14H,3,9-12,15H2,1-2H3 GSYJNCHTJBPSSQ-UHFFFAOYSA-N 114401 MLS000882485::cid_647243::SMR000004816::2-(3-Ethyl-8-methyl-quinolin-2-ylsulfanyl)-1-[4-(furan-2-carbonyl)-piperazin-1-yl]-ethanone::2-(3-ethyl-8-methyl-quinolin-2-yl)sulfanyl-1-[4-(furan-2-ylcarbonyl)piperazin-1-yl]ethanone::2-[(3-ethyl-8-methyl-2-quinolinyl)thio]-1-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]ethanone::2-(3-ethyl-8-methylquinolin-2-yl)sulfanyl-1-[4-(furan-2-carbonyl)piperazin-1-yl]ethanone::2-[(3-ethyl-8-methyl-2-quinolyl)thio]-1-[4-(2-furoyl)piperazino]ethanone Major prion protein Homo sapiens 10692 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114401&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 647243 252663907 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237151 Cc1cc(NC(=O)CSc2nc(CCC3CCCC3)nc3ccccc23)no1 InChI=1S/C21H24N4O2S/c1-14-12-19(25-27-14)23-20(26)13-28-21-16-8-4-5-9-17(16)22-18(24-21)11-10-15-6-2-3-7-15/h4-5,8-9,12,15H,2-3,6-7,10-11,13H2,1H3,(H,23,25,26) BGSNRDWFRRFRDX-UHFFFAOYSA-N 114402 2-[2-(2-Cyclopentyl-ethyl)-quinazolin-4-ylsulfanyl]-N-(5-methyl-isoxazol-3-yl)-acetamide::SMR000006838::MLS000880443::2-[2-(2-cyclopentylethyl)quinazolin-4-yl]sulfanyl-N-(5-methyl-1,2-oxazol-3-yl)ethanamide::cid_651643::2-[2-(2-cyclopentylethyl)quinazolin-4-yl]sulfanyl-N-(5-methyl-1,2-oxazol-3-yl)acetamide::2-[[2-(2-cyclopentylethyl)-4-quinazolinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide::2-[[2-(2-cyclopentylethyl)quinazolin-4-yl]thio]-N-(5-methylisoxazol-3-yl)acetamide Major prion protein Homo sapiens 9420 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114402&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 651643 252663908 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237152 Cc1ccc(NC(=O)CSc2ncnc3ccccc23)cc1S(=O)(=O)N1CCOCC1 InChI=1S/C21H22N4O4S2/c1-15-6-7-16(12-19(15)31(27,28)25-8-10-29-11-9-25)24-20(26)13-30-21-17-4-2-3-5-18(17)22-14-23-21/h2-7,12,14H,8-11,13H2,1H3,(H,24,26) UJHQQCCOBPSWSI-UHFFFAOYSA-N 78909 SMR000371303::N-(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)-2-quinazolin-4-ylsulfanyl-ethanamide::MLS000776292::cid_3616560::N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide::N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-2-(4-quinazolinylthio)acetamide::N-(4-methyl-3-morpholinosulfonyl-phenyl)-2-(quinazolin-4-ylthio)acetamide Major prion protein Homo sapiens 8722 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=78909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=78909&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3616560 252655633 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237153 Oc1ccc2[C@H](c3c(O)c4ccccc4oc3=O)c3c(Oc2c1)c1ccccc1oc3=O InChI=1S/C25H14O7/c26-12-9-10-13-18(11-12)30-23-15-6-2-4-8-17(15)32-25(29)21(23)19(13)20-22(27)14-5-1-3-7-16(14)31-24(20)28/h1-11,19,26-27H AFUYGYGEPFCEIX-UHFFFAOYSA-N 66067 (7R)-10-hydroxy-7-(2-hydroxy-4-oxo-1-benzopyran-3-yl)-7H-[1]benzopyrano[3,2-c][1]benzopyran-6-one::(7R)-10-hydroxy-7-(4-hydroxy-2-keto-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one::(7R)-10-hydroxy-7-(2-hydroxy-4-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one::cid_16745841::10-Hydroxy-7-(4-hydroxy-2-oxo-2H-chromen-3-yl)-7H-chromeno[4,3-b]chromen-6-one::SMR000415059::MLS001043278::(7R)-10-oxidanyl-7-(2-oxidanyl-4-oxidanylidene-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one::(7R)-10-hydroxy-7-(2-hydroxy-4-keto-chromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one Major prion protein Homo sapiens 9011 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66067&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 54677747 252644396 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237154 OC1(N=C(C(C#N)C(C1[n+]1ccccc1)c1cccs1)[C-](C#N)C#N)c1ccccc1 |c:2| InChI=1S/C24H17N5OS/c25-14-17(15-26)22-19(16-27)21(20-10-7-13-31-20)23(29-11-5-2-6-12-29)24(30,28-22)18-8-3-1-4-9-18/h1-13,19,21,23,30H QFSLEXXAYHTFTQ-UHFFFAOYSA-N 114404 MLS001029990::[2-cyano-2-(5-cyano-2-oxidanyl-2-phenyl-3-pyridin-1-ium-1-yl-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl)ethenylidene]azanide::[2-cyano-2-[5-cyano-2-hydroxy-2-phenyl-3-(1-pyridin-1-iumyl)-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl]ethenylidene]azanide::cid_3714754::SMR000427193::[2-cyano-2-(5-cyano-2-hydroxy-2-phenyl-3-pyridin-1-ium-1-yl-4-thiophen-2-yl-3,4-dihydro-1H-pyridin-6-yl)ethenylidene]azanide::[2-cyano-2-[5-cyano-2-hydroxy-2-phenyl-3-pyridin-1-ium-1-yl-4-(2-thienyl)-3,4-dihydro-1H-pyridin-6-yl]ethenylidene]azanide Major prion protein Homo sapiens 9735 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114404&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899719 252663909 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237155 Cc1cc(NC(=O)CCC(=O)N(C(C(=O)NC2CCCC2)c2cccs2)c2ccccc2)no1 InChI=1S/C25H28N4O4S/c1-17-16-21(28-33-17)27-22(30)13-14-23(31)29(19-10-3-2-4-11-19)24(20-12-7-15-34-20)25(32)26-18-8-5-6-9-18/h2-4,7,10-12,15-16,18,24H,5-6,8-9,13-14H2,1H3,(H,26,32)(H,27,28,30) KNBSSVMGTJJRMN-UHFFFAOYSA-N 114405 N'-[2-(cyclopentylamino)-2-oxo-1-thiophen-2-ylethyl]-N-(5-methyl-3-isoxazolyl)-N'-phenylbutanediamide::N'-[2-(cyclopentylamino)-2-oxidanylidene-1-thiophen-2-yl-ethyl]-N-(5-methyl-1,2-oxazol-3-yl)-N'-phenyl-butanediamide::SMR000005122::N-(Cyclopentylcarbamoyl-thiophen-2-yl-methyl)-N'-(5-methyl-isoxazol-3-yl)-N-phenyl-succinamide::MLS000888340::cid_645511::N'-[2-(cyclopentylamino)-2-oxo-1-thiophen-2-ylethyl]-N-(5-methyl-1,2-oxazol-3-yl)-N'-phenylbutanediamide::N'-[2-(cyclopentylamino)-2-keto-1-(2-thienyl)ethyl]-N-(5-methylisoxazol-3-yl)-N'-phenyl-succinamide Major prion protein Homo sapiens 16202 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114405 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114405&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 645511 252663910 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237156 CC(=O)c1sccc1NC(=O)c1ccccc1C([O-])=O InChI=1S/C14H11NO4S/c1-8(16)12-11(6-7-20-12)15-13(17)9-4-2-3-5-10(9)14(18)19/h2-7H,1H3,(H,15,17)(H,18,19)/p-1 JBPSIUJQSLGDHC-UHFFFAOYSA-M 50266510 2-(2-acetylthiophen-3-ylcarbamoyl)benzoate::cid_2808378 Major prion protein Homo sapiens 3087 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266510&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 25273008 104113853 C06374 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237157 CC(C)N1CCc2c(C1)sc(NC(=O)c1ccc3ccccc3c1)c2C(N)=O InChI=1S/C22H23N3O2S/c1-13(2)25-10-9-17-18(12-25)28-22(19(17)20(23)26)24-21(27)16-8-7-14-5-3-4-6-15(14)11-16/h3-8,11,13H,9-10,12H2,1-2H3,(H2,23,26)(H,24,27) QDEMEVNHYSHEOG-UHFFFAOYSA-N 53368 SMR000805783::MLS001167736::2-[[2-naphthalenyl(oxo)methyl]amino]-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride::cid_16806297::2-(naphthalen-2-ylcarbonylamino)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride::2-(naphthalene-2-carbonylamino)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride::6-isopropyl-2-(2-naphthoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride Major prion protein Homo sapiens 12487 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53368&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3534318 252633500 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237158 COc1ccc2[nH]c(cc2c1)C(=O)Nc1ccc(C)c(F)c1 InChI=1S/C17H15FN2O2/c1-10-3-4-12(9-14(10)18)19-17(21)16-8-11-7-13(22-2)5-6-15(11)20-16/h3-9,20H,1-2H3,(H,19,21) CMXUKKOQMOIOGB-UHFFFAOYSA-N 114406 cid_2742889::MLS000859319::SMR000461196::N-(3-fluoranyl-4-methyl-phenyl)-5-methoxy-1H-indole-2-carboxamide::N-(3-fluoro-4-methylphenyl)-5-methoxy-1H-indole-2-carboxamide::N-(3-fluoro-4-methyl-phenyl)-5-methoxy-1H-indole-2-carboxamide Major prion protein Homo sapiens 10459 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114406&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2742889 252663911 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237159 COC(=O)CSc1ccnc2cc(Cl)ccc12 InChI=1S/C12H10ClNO2S/c1-16-12(15)7-17-11-4-5-14-10-6-8(13)2-3-9(10)11/h2-6H,7H2,1H3 KXWTYTYYOMNTAN-UHFFFAOYSA-N 114407 MLS000860910::cid_2823604::methyl 2-[(7-chloroquinolin-4-yl)thio]acetate::2-[(7-chloro-4-quinolinyl)thio]acetic acid methyl ester::methyl 2-(7-chloroquinolin-4-yl)sulfanylacetate::SMR000459694::methyl 2-(7-chloranylquinolin-4-yl)sulfanylethanoate::2-[(7-chloro-4-quinolyl)thio]acetic acid methyl ester Major prion protein Homo sapiens 5160 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114407 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114407&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2823604 252663912 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237160 CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1 InChI=1S/C10H7N3OS2/c1-15-10-12-8(7-3-2-4-16-7)6(5-11)9(14)13-10/h2-4H,1H3,(H,12,13,14) VDPMRMLCAJPWSP-UHFFFAOYSA-N 69582 MLS000849828::2-(methylthio)-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-(methylthio)-6-oxo-4-(2-thienyl)-1,6-dihydropyrimidine-5-carbonitrile::SMR000455846::2-methylsulfanyl-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::cid_2802193::2-methylsulfanyl-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::4-keto-2-(methylthio)-6-(2-thienyl)-1H-pyrimidine-5-carbonitrile Major prion protein Homo sapiens 3218 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=69582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=69582&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2802193 252647748 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237161 OC(=O)CSc1ccnc2cc(Cl)ccc12 InChI=1S/C11H8ClNO2S/c12-7-1-2-8-9(5-7)13-4-3-10(8)16-6-11(14)15/h1-5H,6H2,(H,14,15) YFWVKWISZZSPFR-UHFFFAOYSA-N 114408 MLS000850622::2-[(7-chloro-4-quinolinyl)thio]acetic acid::cid_224672::2-(7-chloranylquinolin-4-yl)sulfanylethanoic acid::2-(7-chloroquinolin-4-yl)sulfanylacetic acid::2-[(7-chloro-4-quinolinyl)sulfanyl]acetic acid::SMR000456640::2-[(7-chloro-4-quinolyl)thio]acetic acid Major prion protein Homo sapiens 4040 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114408 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114408&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 224672 252663913 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237162 Brc1ccc(cc1)C(=O)CSc1nc(-c2cccs2)c(C#N)c(=O)[nH]1 InChI=1S/C17H10BrN3O2S2/c18-11-5-3-10(4-6-11)13(22)9-25-17-20-15(14-2-1-7-24-14)12(8-19)16(23)21-17/h1-7H,9H2,(H,20,21,23) GZYOIVQDBARMEH-UHFFFAOYSA-N 54150 MLS000850710::2-{[2-(4-bromophenyl)-2-oxoethyl]thio}-6-oxo-4-(2-thienyl)-1,6-dihydropyrimidine-5-carbonitrile::cid_2727374::SMR000456727::2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-[2-(4-bromophenyl)-2-oxidanylidene-ethyl]sulfanyl-4-oxidanylidene-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-[[2-(4-bromophenyl)-2-oxoethyl]thio]-4-oxo-6-thiophen-2-yl-1H-pyrimidine-5-carbonitrile::2-[[2-(4-bromophenyl)-2-keto-ethyl]thio]-4-keto-6-(2-thienyl)-1H-pyrimidine-5-carbonitrile Major prion protein Homo sapiens 6128 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54150&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2727374 252634182 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237163 CC(C)C1Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12 InChI=1S/C15H16N2OS/c1-8(2)11-7-9-5-3-4-6-10(9)13-12(11)14(18)17-15(19)16-13/h3-6,8,11H,7H2,1-2H3,(H2,16,17,18,19) JSCHTMXWJLGDCJ-UHFFFAOYSA-N 66185 MLS001076058::5-isopropyl-2-thioxo-2,3,5,6-tetrahydrobenzo[h]quinazolin-4(1H)-one::cid_2835304::SMR000473141::5-propan-2-yl-2-sulfanylidene-5,6-dihydro-1H-benzo[h]quinazolin-4-one::5-isopropyl-2-thioxo-5,6-dihydro-1H-benzo[h]quinazolin-4-one Major prion protein Homo sapiens 4873 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66185&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2835304 252644512 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237164 COc1nc(-c2ccccc2)c2cc(Br)ccc2n1 InChI=1S/C15H11BrN2O/c1-19-15-17-13-8-7-11(16)9-12(13)14(18-15)10-5-3-2-4-6-10/h2-9H,1H3 TTZQZJSCZVKQIG-UHFFFAOYSA-N 63928 MLS001178487::cid_746070::6-bromo-2-methoxy-4-phenylquinazoline::6-bromo-2-(methyloxy)-4-phenylquinazoline::6-bromanyl-2-methoxy-4-phenyl-quinazoline::SMR000476286::6-bromo-2-methoxy-4-phenyl-quinazoline Major prion protein Homo sapiens 5533 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=63928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=63928&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 746070 252643027 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237165 CCC1(CC)Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12 InChI=1S/C16H18N2OS/c1-3-16(4-2)9-10-7-5-6-8-11(10)13-12(16)14(19)18-15(20)17-13/h5-8H,3-4,9H2,1-2H3,(H2,17,18,19,20) YLYIABHKKTUWPT-UHFFFAOYSA-N 114409 SMR000476470::5,5-diethyl-2-sulfanylidene-1,6-dihydrobenzo[h]quinazolin-4-one::5,5-diethyl-2-thioxo-2,3,5,6-tetrahydrobenzo[h]quinazolin-4(1H)-one::MLS001179574::cid_899350::5,5-diethyl-2-thioxo-1,6-dihydrobenzo[h]quinazolin-4-one Major prion protein Homo sapiens 3084 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114409&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 899350 252663914 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237166 CCC1(C)Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12 InChI=1S/C15H16N2OS/c1-3-15(2)8-9-6-4-5-7-10(9)12-11(15)13(18)17-14(19)16-12/h4-7H,3,8H2,1-2H3,(H2,16,17,18,19) ODCHTCODQLEAGG-UHFFFAOYSA-N 66186 5-ethyl-5-methyl-2-sulfanylidene-1,6-dihydrobenzo[h]quinazolin-4-one::SMR000515069::5-Ethyl-5-methyl-2-thioxo-2,3,5,6-tetrahydro-1H-benzo[h]quinazolin-4-one::cid_2835302::MLS001204926::5-ethyl-5-methyl-2-thioxo-1,6-dihydrobenzo[h]quinazolin-4-one Major prion protein Homo sapiens 2930 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66186&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2835302 252644513 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237167 COC(=O)CSc1nc(COc2ccccc2)nc2ccccc12 InChI=1S/C18H16N2O3S/c1-22-17(21)12-24-18-14-9-5-6-10-15(14)19-16(20-18)11-23-13-7-3-2-4-8-13/h2-10H,11-12H2,1H3 HZNMMECHTLICIS-UHFFFAOYSA-N 114410 SMR000504662::cid_24746879::2-[[2-(phenoxymethyl)-4-quinazolinyl]thio]acetic acid methyl ester::(2-Phenoxymethyl-quinazolin-4-ylsulfanyl)-acetic acid methyl ester::methyl 2-[2-(phenoxymethyl)quinazolin-4-yl]sulfanylacetate::MLS001205954::methyl 2-[2-(phenoxymethyl)quinazolin-4-yl]sulfanylethanoate::2-[[2-(phenoxymethyl)quinazolin-4-yl]thio]acetic acid methyl ester Major prion protein Homo sapiens 8484 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114410 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114410&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24746879 252663915 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237168 COc1ccc(OC)c(c1)C1NC(=O)N(C)C(C)=C1C(=O)OCc1ccccc1 |c:18| InChI=1S/C22H24N2O5/c1-14-19(21(25)29-13-15-8-6-5-7-9-15)20(23-22(26)24(14)2)17-12-16(27-3)10-11-18(17)28-4/h5-12,20H,13H2,1-4H3,(H,23,26) MAPCGPXHRYCHSI-UHFFFAOYSA-N 114411 SMR000515049::6-(2,5-dimethoxyphenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylic acid (phenylmethyl) ester::cid_3115457::4-(2,5-Dimethoxy-phenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid benzyl ester::(phenylmethyl) 6-(2,5-dimethoxyphenyl)-3,4-dimethyl-2-oxidanylidene-1,6-dihydropyrimidine-5-carboxylate::MLS001209719::benzyl 6-(2,5-dimethoxyphenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate::6-(2,5-dimethoxyphenyl)-2-keto-3,4-dimethyl-1,6-dihydropyrimidine-5-carboxylic acid benzyl ester Major prion protein Homo sapiens 6038 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114411 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114411&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3115457 252663916 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237169 COc1cc(cc(OC)c1OC)C(=O)Nc1scc(c1C(O)=O)-c1ccc(C)cc1 InChI=1S/C22H21NO6S/c1-12-5-7-13(8-6-12)15-11-30-21(18(15)22(25)26)23-20(24)14-9-16(27-2)19(29-4)17(10-14)28-3/h5-11H,1-4H3,(H,23,24)(H,25,26) KYAWUDLEPXHMHZ-UHFFFAOYSA-N 114412 4-(4-methylphenyl)-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid::cid_1082733::4-(4-methylphenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylic acid::4-p-Tolyl-2-(3,4,5-trimethoxy-benzoylamino)-thiophene-3-carboxylic acid::4-(4-methylphenyl)-2-[(3,4,5-trimethoxyphenyl)carbonylamino]thiophene-3-carboxylic acid::SMR000523517::MLS001207050::4-(p-tolyl)-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thenoic acid Major prion protein Homo sapiens 4398 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114412 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114412&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1082733 252663917 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237170 COc1cc(cc(OC)c1OC)C(=O)Nc1ccc2n(C)cnc2c1 InChI=1S/C18H19N3O4/c1-21-10-19-13-9-12(5-6-14(13)21)20-18(22)11-7-15(23-2)17(25-4)16(8-11)24-3/h5-10H,1-4H3,(H,20,22) IVDMIURLYGNWDG-UHFFFAOYSA-N 114413 MLS001207034::SMR000523155::cid_929513::3,4,5-Trimethoxy-N-(1-methyl-1H-benzoimidazol-5-yl)-benzamide::3,4,5-trimethoxy-N-(1-methyl-5-benzimidazolyl)benzamide::3,4,5-trimethoxy-N-(1-methylbenzimidazol-5-yl)benzamide Major prion protein Homo sapiens 6229 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114413 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114413&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 929513 252663918 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237171 CCOC(=O)CSc1nc(COc2ccccc2)nc2ccccc12 InChI=1S/C19H18N2O3S/c1-2-23-18(22)13-25-19-15-10-6-7-11-16(15)20-17(21-19)12-24-14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3 XTFGHZTYASUYTO-UHFFFAOYSA-N 114414 cid_1451421::MLS001212808::(2-Phenoxymethyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester::2-[[2-(phenoxymethyl)-4-quinazolinyl]thio]acetic acid ethyl ester::SMR000503906::ethyl 2-[2-(phenoxymethyl)quinazolin-4-yl]sulfanylacetate::ethyl 2-[2-(phenoxymethyl)quinazolin-4-yl]sulfanylethanoate::2-[[2-(phenoxymethyl)quinazolin-4-yl]thio]acetic acid ethyl ester Major prion protein Homo sapiens 8249 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114414&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1451421 252663919 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237172 CC1(C)Cc2ccccc2-c2[nH]c(=S)[nH]c(=O)c12 InChI=1S/C14H14N2OS/c1-14(2)7-8-5-3-4-6-9(8)11-10(14)12(17)16-13(18)15-11/h3-6H,7H2,1-2H3,(H2,15,16,17,18) XMYDQZMDMBKIEW-UHFFFAOYSA-N 66187 MLS001211957::SMR000505168::5,5-dimethyl-2-sulfanylidene-1,6-dihydrobenzo[h]quinazolin-4-one::5,5-Dimethyl-2-thioxo-2,3,5,6-tetrahydro-1H-benzo[h]quinazolin-4-one::cid_713572::5,5-dimethyl-2-thioxo-1,6-dihydrobenzo[h]quinazolin-4-one Major prion protein Homo sapiens 4555 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66187&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 713572 252644514 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237173 CC(C)CSc1nnc2c(n1)n(C)c1ccccc21 InChI=1S/C14H16N4S/c1-9(2)8-19-14-15-13-12(16-17-14)10-6-4-5-7-11(10)18(13)3/h4-7,9H,8H2,1-3H3 HTRLSZXIYYGSGR-UHFFFAOYSA-N 114415 cid_3153154::5-methyl-3-(2-methylpropylthio)-[1,2,4]triazino[5,6-b]indole::2-Isobutylsulfanyl-9-methyl-9H-1,3,4,9-tetraaza-fluorene::MLS001204432::5-methyl-3-(2-methylpropylsulfanyl)-[1,2,4]triazino[5,6-b]indole::SMR000523457::3-(isobutylthio)-5-methyl-[1,2,4]triazin[5,6-b]indole Major prion protein Homo sapiens 4374 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114415&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3153154 252663920 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237174 Cc1nc2ccc(Br)cc2c(-c2ccccc2)c1C(O)=O InChI=1S/C17H12BrNO2/c1-10-15(17(20)21)16(11-5-3-2-4-6-11)13-9-12(18)7-8-14(13)19-10/h2-9H,1H3,(H,20,21) DLRRYGJBGBBQBK-UHFFFAOYSA-N 66188 MLS001173402::SMR000538992::6-bromanyl-2-methyl-4-phenyl-quinoline-3-carboxylic acid::6-bromo-2-methyl-4-phenyl-3-quinolinecarboxylic acid::6-bromo-2-methyl-4-phenylquinoline-3-carboxylic acid::cid_757946::6-bromo-2-methyl-4-phenyl-quinoline-3-carboxylic acid Major prion protein Homo sapiens 5466 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66188&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 757946 252644515 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237175 CCc1cc2c(occ(-c3ccc4OCOc4c3)c2=O)c(CN(C)C)c1O InChI=1S/C21H21NO5/c1-4-12-7-14-20(24)16(13-5-6-17-18(8-13)27-11-26-17)10-25-21(14)15(19(12)23)9-22(2)3/h5-8,10,23H,4,9,11H2,1-3H3 GYQXMQJFFWCMNS-UHFFFAOYSA-N 114416 SMR000539645::3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxychromen-4-one::MLS001164289::3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-oxidanyl-chromen-4-one::3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxy-1-benzopyran-4-one::cid_1181832::3-(1,3-benzodioxol-5-yl)-8-[(dimethylamino)methyl]-6-ethyl-7-hydroxy-chromone Major prion protein Homo sapiens 2070 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114416&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1181832 252663921 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237176 COc1cc(cc(OC)c1OC)C(=O)Nc1scc(c1C(O)=O)-c1ccc(Br)cc1 InChI=1S/C21H18BrNO6S/c1-27-15-8-12(9-16(28-2)18(15)29-3)19(24)23-20-17(21(25)26)14(10-30-20)11-4-6-13(22)7-5-11/h4-10H,1-3H3,(H,23,24)(H,25,26) WRMKKPCGARQORO-UHFFFAOYSA-N 54422 4-(4-bromophenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]thiophene-3-carboxylic acid::4-(4-bromophenyl)-2-[(3,4,5-trimethoxyphenyl)carbonylamino]thiophene-3-carboxylic acid::MLS001164606::SMR000539809::cid_1332923::4-(4-bromophenyl)-2-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-3-thiophenecarboxylic acid::4-(4-bromophenyl)-2-[(3,4,5-trimethoxybenzoyl)amino]-3-thenoic acid::US20230364057, Compound 189 Major prion protein Homo sapiens 5712 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=54422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=54422&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1332923 252634449 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237177 CCc1ccc(s1)-c1nc2ccc(Br)cc2c(C(O)=O)c1C InChI=1S/C17H14BrNO2S/c1-3-11-5-7-14(22-11)16-9(2)15(17(20)21)12-8-10(18)4-6-13(12)19-16/h4-8H,3H2,1-2H3,(H,20,21) NNZWCNMLHBFTKG-UHFFFAOYSA-N 114417 6-bromo-2-(5-ethylthiophen-2-yl)-3-methylquinoline-4-carboxylic acid::6-bromo-2-(5-ethylthien-2-yl)-3-methylquinoline-4-carboxylic acid::6-bromanyl-2-(5-ethylthiophen-2-yl)-3-methyl-quinoline-4-carboxylic acid::MLS001195884::SMR000558711::6-bromo-2-(5-ethyl-2-thiophenyl)-3-methyl-4-quinolinecarboxylic acid::cid_995260::6-bromo-2-(5-ethyl-2-thienyl)-3-methyl-cinchoninic acid Major prion protein Homo sapiens 1245 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114417&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 995260 252663922 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237178 CCCOc1ccc(cc1C)C(=O)C1C(N(C(=O)C1=O)c1ccccn1)c1ccccc1F InChI=1S/C26H23FN2O4/c1-3-14-33-20-12-11-17(15-16(20)2)24(30)22-23(18-8-4-5-9-19(18)27)29(26(32)25(22)31)21-10-6-7-13-28-21/h4-13,15,22-23H,3,14H2,1-2H3 WNKWISZWKYVYBA-UHFFFAOYSA-N 55052 5-(2-fluorophenyl)-3-hydroxy-4-(3-methyl-4-propoxybenzoyl)-1-pyridin-2-yl-1,5-dihydro-2H-pyrrol-2-one::SMR000556023::(4E)-5-(2-fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-(2-pyridinyl)pyrrolidine-2,3-dione::(4E)-5-(2-fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxyphenyl)methylidene]-1-pyridin-2-ylpyrrolidine-2,3-dione::cid_6060654::MLS001196677::(4E)-5-(2-fluorophenyl)-4-[(3-methyl-4-propoxy-phenyl)-oxidanyl-methylidene]-1-pyridin-2-yl-pyrrolidine-2,3-dione::(4E)-5-(2-fluorophenyl)-4-[hydroxy-(3-methyl-4-propoxy-phenyl)methylene]-1-(2-pyridyl)pyrrolidine-2,3-quinone Major prion protein Homo sapiens 2956 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=55052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=55052&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91897199 252635059 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237179 NC(=O)CSc1nc(nc2ccccc12)-c1ccccc1 InChI=1S/C16H13N3OS/c17-14(20)10-21-16-12-8-4-5-9-13(12)18-15(19-16)11-6-2-1-3-7-11/h1-9H,10H2,(H2,17,20) XAEZEADAVHOKLK-UHFFFAOYSA-N 114418 SMR000517719::2-(2-Phenyl-quinazolin-4-ylsulfanyl)-acetamide::cid_865075::2-(2-phenylquinazolin-4-yl)sulfanylacetamide::2-[(2-phenyl-4-quinazolinyl)thio]acetamide::2-(2-phenylquinazolin-4-yl)sulfanylethanamide::MLS001210458::2-[(2-phenylquinazolin-4-yl)thio]acetamide Major prion protein Homo sapiens 6234 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114418&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 865075 252663923 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237180 Brc1cc(Br)c2nc3CCCc3cc2c1 InChI=1S/C12H9Br2N/c13-9-5-8-4-7-2-1-3-11(7)15-12(8)10(14)6-9/h4-6H,1-3H2 DAHMUJBHSOWVNQ-UHFFFAOYSA-N 114419 MLS001166000::5,7-bis(bromanyl)-2,3-dihydro-1H-cyclopenta[b]quinoline::SMR000550258::cid_3705005::5,7-dibromo-2,3-dihydro-1H-cyclopenta[b]quinoline Major prion protein Homo sapiens 5892 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114419&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3705005 252663924 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237181 Nc1nc(C(C#N)C#N)c(C#N)c(-c2ccccc2)c1C#N InChI=1S/C16H8N6/c17-6-11(7-18)15-12(8-19)14(10-4-2-1-3-5-10)13(9-20)16(21)22-15/h1-5,11H,(H2,21,22) YOKGAZCODZPKKU-UHFFFAOYSA-N 66190 cid_910973::2-azanyl-6-(dicyanomethylidene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile::2-amino-6-(dicyanomethylidene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile::SMR000539348::MLS001163959::2-amino-6-(dicyanomethylene)-4-phenyl-1H-pyridine-3,5-dicarbonitrile Major prion protein Homo sapiens 1919 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66190&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 12930835 252644517 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237182 CCOC(=O)c1c(oc2cc(Br)c(O)cc12)-c1ccccc1 InChI=1S/C17H13BrO4/c1-2-21-17(20)15-11-8-13(19)12(18)9-14(11)22-16(15)10-6-4-3-5-7-10/h3-9,19H,2H2,1H3 LZAQEGWNAMGRAA-UHFFFAOYSA-N 78382 ethyl 6-bromo-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate::6-bromo-5-hydroxy-2-phenyl-3-benzofurancarboxylic acid ethyl ester::SMR000555502::MLS001197117::cid_979431::ethyl 6-bromanyl-5-oxidanyl-2-phenyl-1-benzofuran-3-carboxylate::6-bromo-5-hydroxy-2-phenyl-benzofuran-3-carboxylic acid ethyl ester Major prion protein Homo sapiens 1441 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=78382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=78382&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 979431 252655138 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237183 COc1ccccc1Cn1c(=S)[nH]c2ccccc2c1=O InChI=1S/C16H14N2O2S/c1-20-14-9-5-2-6-11(14)10-18-15(19)12-7-3-4-8-13(12)17-16(18)21/h2-9H,10H2,1H3,(H,17,21) VACPJKGZPPGKRO-UHFFFAOYSA-N 114420 3-[(2-methoxyphenyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one::MLS001201096::SMR000564203::3-(2-methoxybenzyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one::cid_866360::3-o-anisyl-2-thioxo-1H-quinazolin-4-one::US20240366606, Compound C9-5 Major prion protein Homo sapiens 3492 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114420&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 866360 252663925 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237184 COc1ccccc1Cn1c(=S)[nH]c2ccc(F)cc2c1=O InChI=1S/C16H13FN2O2S/c1-21-14-5-3-2-4-10(14)9-19-15(20)12-8-11(17)6-7-13(12)18-16(19)22/h2-8H,9H2,1H3,(H,18,22) JOZDVNMNPRLODN-UHFFFAOYSA-N 95288 6-fluoro-3-(2-methoxybenzyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one::cid_4191572::6-fluoranyl-3-[(2-methoxyphenyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one::SMR000564262::MLS001201090::6-fluoro-3-[(2-methoxyphenyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one::6-fluoro-3-o-anisyl-2-thioxo-1H-quinazolin-4-one Major prion protein Homo sapiens 412.1 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95288&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 4191572 164036532 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237185 CCOc1ccc(C(=O)C2C(N(C(=O)C2=O)c2ccccn2)c2ccc(F)cc2)c(C)c1 InChI=1S/C25H21FN2O4/c1-3-32-18-11-12-19(15(2)14-18)23(29)21-22(16-7-9-17(26)10-8-16)28(25(31)24(21)30)20-6-4-5-13-27-20/h4-14,21-22H,3H2,1-2H3 LXCQVSBHUXSNQV-UHFFFAOYSA-N 114421 SMR000556025::MLS001196701::(4Z)-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-(2-pyridinyl)pyrrolidine-2,3-dione::4-(4-ethoxy-2-methylbenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-pyridin-2-yl-1,5-dihydro-2H-pyrrol-2-one::cid_23933133::(4Z)-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(4-fluorophenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione::(4Z)-4-[(4-ethoxy-2-methyl-phenyl)-oxidanyl-methylidene]-5-(4-fluorophenyl)-1-pyridin-2-yl-pyrrolidine-2,3-dione::(4Z)-4-[(4-ethoxy-2-methyl-phenyl)-hydroxy-methylene]-5-(4-fluorophenyl)-1-(2-pyridyl)pyrrolidine-2,3-quinone Major prion protein Homo sapiens 12957 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114421&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899721 252663926 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237186 Cc1c(sc2ccccc12)C(=O)c1ccccc1C(O)=O InChI=1S/C17H12O3S/c1-10-11-6-4-5-9-14(11)21-16(10)15(18)12-7-2-3-8-13(12)17(19)20/h2-9H,1H3,(H,19,20) VDVUQDXJGUWTNV-UHFFFAOYSA-N 66788 SMR000567813::MLS001182112::2-[(3-methyl-1-benzothiophen-2-yl)-oxomethyl]benzoic acid::2-[(3-methyl-1-benzothiophen-2-yl)carbonyl]benzoic acid::2-(3-methyl-1-benzothiophene-2-carbonyl)benzoic acid::cid_2779879::2-(3-methylbenzothiophene-2-carbonyl)benzoic acid Major prion protein Homo sapiens 8209 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66788&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2779879 252645106 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237187 OC(=O)c1cc(nc2ccc(Br)cc12)-c1cccs1 InChI=1S/C14H8BrNO2S/c15-8-3-4-11-9(6-8)10(14(17)18)7-12(16-11)13-2-1-5-19-13/h1-7H,(H,17,18) KYHKYEUYJZTRCP-UHFFFAOYSA-N 66192 6-bromo-2-thiophen-2-ylquinoline-4-carboxylic acid::SMR000567820::MLS001182077::cid_755656::6-bromanyl-2-thiophen-2-yl-quinoline-4-carboxylic acid::6-bromo-2-thiophen-2-yl-4-quinolinecarboxylic acid::6-bromo-2-(2-thienyl)cinchoninic acid Major prion protein Homo sapiens 1410 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66192&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 755656 252644519 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237188 OC(=O)c1ccccc1SCc1csc(n1)-c1ccccc1 InChI=1S/C17H13NO2S2/c19-17(20)14-8-4-5-9-15(14)21-10-13-11-22-16(18-13)12-6-2-1-3-7-12/h1-9,11H,10H2,(H,19,20) XYEXJJDMMULNNX-UHFFFAOYSA-N 73939 2-[(2-phenyl-4-thiazolyl)methylthio]benzoic acid::cid_2353244::2-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]benzoic acid::SMR000591271::MLS001172667::2-[(2-phenylthiazol-4-yl)methylthio]benzoic acid Major prion protein Homo sapiens 6487 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=73939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=73939&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2353244 252651176 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237189 S=c1[nH]nc2n1c1ccccc1[nH]c2=S InChI=1S/C9H6N4S2/c14-8-7-11-12-9(15)13(7)6-4-2-1-3-5(6)10-8/h1-4H,(H,10,14)(H,12,15) FYTBEPMFYXFJKF-UHFFFAOYSA-N 53214 MLS001199640::[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dithiol::SMR000560114::cid_5300057::2,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1,4-dithione Major prion protein Homo sapiens 1703 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53214&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5300057 252633346 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237190 CC1Cc2cc(ccc2N1C(C)=O)S(=O)(=O)N1CCCC(C1)C(=O)Nc1cc(C)cc(C)c1 InChI=1S/C25H31N3O4S/c1-16-10-17(2)12-22(11-16)26-25(30)20-6-5-9-27(15-20)33(31,32)23-7-8-24-21(14-23)13-18(3)28(24)19(4)29/h7-8,10-12,14,18,20H,5-6,9,13,15H2,1-4H3,(H,26,30) ZNOAYIBUHQKWSP-UHFFFAOYSA-N 114422 1-[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]-N-(3,5-dimethylphenyl)-3-piperidinecarboxamide::MLS001122629::1-[(1-acetyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]-N-(3,5-dimethylphenyl)piperidine-3-carboxamide::cid_20901978::N-(3,5-dimethylphenyl)-1-[(1-ethanoyl-2-methyl-2,3-dihydroindol-5-yl)sulfonyl]piperidine-3-carboxamide::SMR000628409::1-(1-acetyl-2-methyl-indolin-5-yl)sulfonyl-N-(3,5-dimethylphenyl)nipecotamide Major prion protein Homo sapiens 10357 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114422&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 20901978 252663927 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237191 CN1C(=O)C(C)(C)c2cc(ccc12)S(=O)(=O)N1CCCC(C1)C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H26ClN3O4S/c1-23(2)19-13-18(10-11-20(19)26(3)22(23)29)32(30,31)27-12-4-5-15(14-27)21(28)25-17-8-6-16(24)7-9-17/h6-11,13,15H,4-5,12,14H2,1-3H3,(H,25,28) GBFAZCSCJCEJFF-UHFFFAOYSA-N 114423 N-(4-chlorophenyl)-1-[(1,3,3-trimethyl-2-oxo-5-indolyl)sulfonyl]-3-piperidinecarboxamide::N-(4-chlorophenyl)-1-(1,3,3-trimethyl-2-oxidanylidene-indol-5-yl)sulfonyl-piperidine-3-carboxamide::N-(4-chlorophenyl)-1-(1,3,3-trimethyl-2-oxoindol-5-yl)sulfonylpiperidine-3-carboxamide::SMR000628232::MLS001122861::cid_20900935::N-(4-chlorophenyl)-1-(2-keto-1,3,3-trimethyl-indolin-5-yl)sulfonyl-nipecotamide Major prion protein Homo sapiens 5863 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114423&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 20900935 252663928 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237192 CCOc1ccc(cc1)-c1cc(C(=O)NCCCn2ccnc2)c2cc(Br)ccc2n1 InChI=1S/C24H23BrN4O2/c1-2-31-19-7-4-17(5-8-19)23-15-21(20-14-18(25)6-9-22(20)28-23)24(30)27-10-3-12-29-13-11-26-16-29/h4-9,11,13-16H,2-3,10,12H2,1H3,(H,27,30) MJRQQIMEMIMUAP-UHFFFAOYSA-N 66143 6-bromanyl-2-(4-ethoxyphenyl)-N-(3-imidazol-1-ylpropyl)quinoline-4-carboxamide::MLS001125204::6-bromo-2-(4-ethoxyphenyl)-N-(3-imidazol-1-ylpropyl)quinoline-4-carboxamide::cid_2965534::6-bromo-2-(4-ethoxyphenyl)-N-[3-(1-imidazolyl)propyl]-4-quinolinecarboxamide::SMR000668827::6-bromo-N-(3-imidazol-1-ylpropyl)-2-p-phenetyl-cinchoninamide Major prion protein Homo sapiens 4384 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66143&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2965534 252644472 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237193 CC(C)c1nc(SCC(=O)Nc2nccs2)c2ccccc2n1 InChI=1S/C16H16N4OS2/c1-10(2)14-18-12-6-4-3-5-11(12)15(20-14)23-9-13(21)19-16-17-7-8-22-16/h3-8,10H,9H2,1-2H3,(H,17,19,21) HEUDEZJRXQYWFL-UHFFFAOYSA-N 114424 2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-N-(1,3-thiazol-2-yl)acetamide::2-[(2-propan-2-yl-4-quinazolinyl)thio]-N-(2-thiazolyl)acetamide::cid_1442829::MLS001221918::2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-N-(1,3-thiazol-2-yl)ethanamide::SMR000601898::2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-thiazol-2-yl-acetamide::2-[(2-isopropylquinazolin-4-yl)thio]-N-thiazol-2-yl-acetamide Major prion protein Homo sapiens 2396 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114424&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442829 252663929 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237194 CCc1nc(SCC(=O)NNC(=O)c2ccc(C)cc2)c2ccccc2n1 InChI=1S/C20H20N4O2S/c1-3-17-21-16-7-5-4-6-15(16)20(22-17)27-12-18(25)23-24-19(26)14-10-8-13(2)9-11-14/h4-11H,3,12H2,1-2H3,(H,23,25)(H,24,26) NRQMBTHVPQQMRC-UHFFFAOYSA-N 114425 MLS001222925::N'-[2-(2-ethylquinazolin-4-yl)sulfanylethanoyl]-4-methyl-benzohydrazide::N'-[2-[(2-ethyl-4-quinazolinyl)thio]-1-oxoethyl]-4-methylbenzohydrazide::SMR000606954::cid_24792443::N'-[2-(2-ethylquinazolin-4-yl)sulfanylacetyl]-4-methylbenzohydrazide::4-Methyl-benzoic acid N'-[2-(2-ethyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::N'-[2-[(2-ethylquinazolin-4-yl)thio]acetyl]-4-methyl-benzohydrazide Major prion protein Homo sapiens 1362 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114425&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24792443 252663930 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237195 CC(C)(C)c1nc(SCC(=O)NNC(=O)c2ccccc2)c2ccccc2n1 InChI=1S/C21H22N4O2S/c1-21(2,3)20-22-16-12-8-7-11-15(16)19(23-20)28-13-17(26)24-25-18(27)14-9-5-4-6-10-14/h4-12H,13H2,1-3H3,(H,24,26)(H,25,27) KUUJHMPVWPOXRN-UHFFFAOYSA-N 114426 cid_24792486::SMR000607288::N'-[2-(2-tert-butylquinazolin-4-yl)sulfanylacetyl]benzohydrazide::Benzoic acid N'-[2-(2-tert-butyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::N'-[2-[(2-tert-butyl-4-quinazolinyl)thio]-1-oxoethyl]benzohydrazide::MLS001225442::N'-[2-(2-tert-butylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide::N'-[2-[(2-tert-butylquinazolin-4-yl)thio]acetyl]benzohydrazide Major prion protein Homo sapiens 5462 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114426&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24792486 252663931 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237196 CCCN(c1ccc(OCC)cc1)S(=O)(=O)c1ccc2OCC(=O)Nc2c1 InChI=1S/C19H22N2O5S/c1-3-11-21(14-5-7-15(8-6-14)25-4-2)27(23,24)16-9-10-18-17(12-16)20-19(22)13-26-18/h5-10,12H,3-4,11,13H2,1-2H3,(H,20,22) ZPSACFKWOWSMII-UHFFFAOYSA-N 114427 SMR000627232::N-(4-ethoxyphenyl)-3-oxidanylidene-N-propyl-4H-1,4-benzoxazine-6-sulfonamide::cid_22548306::N-(4-ethoxyphenyl)-3-oxo-N-propyl-4H-1,4-benzoxazine-6-sulfonamide::MLS001116972::3-keto-N-p-phenetyl-N-propyl-4H-1,4-benzoxazine-6-sulfonamide Major prion protein Homo sapiens 13082 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114427&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 22548306 252663932 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237197 Brc1c(OCC(=O)Nc2ccncc2)ccc2ccccc12 InChI=1S/C17H13BrN2O2/c18-17-14-4-2-1-3-12(14)5-6-15(17)22-11-16(21)20-13-7-9-19-10-8-13/h1-10H,11H2,(H,19,20,21) GSRWLRFSCHYKJZ-UHFFFAOYSA-N 114428 2-(1-bromanylnaphthalen-2-yl)oxy-N-pyridin-4-yl-ethanamide::2-(1-bromonaphthalen-2-yl)oxy-N-pyridin-4-ylacetamide::MLS001125513::2-[(1-bromo-2-naphthalenyl)oxy]-N-pyridin-4-ylacetamide::SMR000668628::cid_1301702::2-(1-bromo-2-naphthoxy)-N-(4-pyridyl)acetamide Major prion protein Homo sapiens 10388 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114428&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1301702 252663933 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237198 COc1ccc(cc1)C(=O)NNC(=O)CSc1nc(nc2ccccc12)C(C)C InChI=1S/C21H22N4O3S/c1-13(2)19-22-17-7-5-4-6-16(17)21(23-19)29-12-18(26)24-25-20(27)14-8-10-15(28-3)11-9-14/h4-11,13H,12H2,1-3H3,(H,24,26)(H,25,27) JOLWOBRENLKKFU-UHFFFAOYSA-N 114429 4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide::SMR000607289::4-Methoxy-benzoic acid N'-[2-(2-isopropyl-quinazolin-4-ylsulfanyl)-acetyl]-hydrazide::4-methoxy-N'-[1-oxo-2-[(2-propan-2-yl-4-quinazolinyl)thio]ethyl]benzohydrazide::cid_24793479::MLS001221823::4-methoxy-N'-[2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetyl]benzohydrazide::N'-[2-[(2-isopropylquinazolin-4-yl)thio]acetyl]-4-methoxy-benzohydrazide Major prion protein Homo sapiens 1980 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114429 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114429&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24793479 252663934 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237199 CC(C)c1nc(SCC(=O)Nc2nc(C)cs2)c2ccccc2n1 InChI=1S/C17H18N4OS2/c1-10(2)15-19-13-7-5-4-6-12(13)16(21-15)23-9-14(22)20-17-18-11(3)8-24-17/h4-8,10H,9H2,1-3H3,(H,18,20,22) OEJSGWNYBKFOOU-UHFFFAOYSA-N 114430 N-(4-methyl-1,3-thiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanylacetamide::MLS001221905::SMR000601897::2-(2-Isopropyl-quinazolin-4-ylsulfanyl)-N-(4-methyl-thiazol-2-yl)-acetamide::N-(4-methyl-2-thiazolyl)-2-[(2-propan-2-yl-4-quinazolinyl)thio]acetamide::N-(4-methyl-1,3-thiazol-2-yl)-2-(2-propan-2-ylquinazolin-4-yl)sulfanyl-ethanamide::cid_1442810::2-[(2-isopropylquinazolin-4-yl)thio]-N-(4-methylthiazol-2-yl)acetamide Major prion protein Homo sapiens 2046 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114430 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114430&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1442810 252663935 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237200 Brc1c(OCC(=O)Nc2cccnc2)ccc2ccccc12 InChI=1S/C17H13BrN2O2/c18-17-14-6-2-1-4-12(14)7-8-15(17)22-11-16(21)20-13-5-3-9-19-10-13/h1-10H,11H2,(H,20,21) WLLRAGBPCSOJNH-UHFFFAOYSA-N 97255 2-[(1-bromo-2-naphthalenyl)oxy]-N-(3-pyridinyl)acetamide::cid_1301094::2-(1-bromanylnaphthalen-2-yl)oxy-N-pyridin-3-yl-ethanamide::2-(1-bromonaphthalen-2-yl)oxy-N-pyridin-3-ylacetamide::SMR000668603::MLS001125494::2-(1-bromo-2-naphthoxy)-N-(3-pyridyl)acetamide Major prion protein Homo sapiens 5812 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97255&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1301094 164038499 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237201 Cc1onc(c1C(=O)Nc1nnc(s1)C(F)(F)F)-c1c(F)cccc1Cl |(11.89,2.65,;12.05,1.12,;13.38,.35,;13.06,-1.16,;11.53,-1.32,;10.9,.09,;9.4,.41,;8.36,-.73,;8.92,1.88,;7.41,2.2,;6.27,1.16,;4.93,1.93,;5.26,3.44,;6.79,3.6,;4.22,4.59,;3.19,5.73,;3.08,3.56,;5.37,5.62,;10.76,-2.65,;12.09,-3.42,;13.43,-2.65,;12.09,-4.96,;10.76,-5.73,;9.42,-4.96,;9.42,-3.42,;8.09,-2.65,)| InChI=1S/C14H7ClF4N4O2S/c1-5-8(10(23-25-5)9-6(15)3-2-4-7(9)16)11(24)20-13-22-21-12(26-13)14(17,18)19/h2-4H,1H3,(H,20,22,24) HYWUHVSQTNXIMZ-UHFFFAOYSA-N 66201 MLS001035723::cid_1247739::3-(2-chloro-6-fluorophenyl)-5-methyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,2-oxazole-4-carboxamide::SMR000669181::3-(2-chloro-6-fluorophenyl)-5-methyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-4-isoxazolecarboxamide::3-(2-chloranyl-6-fluoranyl-phenyl)-5-methyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,2-oxazole-4-carboxamide::3-(2-chloro-6-fluoro-phenyl)-5-methyl-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]isoxazole-4-carboxamide Major prion protein Homo sapiens 2788 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66201&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 1247739 252644528 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237202 COC(=O)c1sc(NC(=S)NNC(=O)c2c(Br)c(C)nn2C)c(C(=O)OC)c1C InChI=1S/C16H18BrN5O5S2/c1-6-8(14(24)26-4)13(29-11(6)15(25)27-5)18-16(28)20-19-12(23)10-9(17)7(2)21-22(10)3/h1-5H3,(H,19,23)(H2,18,20,28) HYVJKDVHTPBYQF-UHFFFAOYSA-N 114431 MLS001035785::cid_2205361::SMR000666341::dimethyl 5-[[(4-bromo-2,5-dimethylpyrazole-3-carbonyl)amino]carbamothioylamino]-3-methylthiophene-2,4-dicarboxylate::5-[[[[(4-bromo-2,5-dimethyl-3-pyrazolyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]amino]-3-methylthiophene-2,4-dicarboxylic acid dimethyl ester::dimethyl 5-[[(4-bromanyl-2,5-dimethyl-pyrazol-3-yl)carbonylamino]carbamothioylamino]-3-methyl-thiophene-2,4-dicarboxylate::5-[[(4-bromo-2,5-dimethyl-pyrazole-3-carbonyl)amino]thiocarbamoylamino]-3-methyl-thiophene-2,4-dicarboxylic acid dimethyl ester Major prion protein Homo sapiens 1160 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114431&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2205361 252663936 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237203 Fc1cccc(c1)C1C(C(=O)c2cc3ccccc3o2)C(=O)C(=O)N1CCN1CCOCC1 InChI=1S/C25H23FN2O5/c26-18-6-3-5-17(14-18)22-21(23(29)20-15-16-4-1-2-7-19(16)33-20)24(30)25(31)28(22)9-8-27-10-12-32-13-11-27/h1-7,14-15,21-22H,8-13H2 GVCDJZJNQAPHSQ-UHFFFAOYSA-N 66203 SMR000646795::3-(1-benzofuran-2-carbonyl)-2-(3-fluorophenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one::3-[2-benzofuranyl(oxo)methyl]-2-(3-fluorophenyl)-4-hydroxy-1-[2-(4-morpholinyl)ethyl]-2H-pyrrol-5-one::MLS001146374::3-(1-benzofuran-2-ylcarbonyl)-2-(3-fluorophenyl)-1-(2-morpholin-4-ylethyl)-4-oxidanyl-2H-pyrrol-5-one::cid_4342649::4-(benzofuran-2-carbonyl)-5-(3-fluorophenyl)-3-hydroxy-1-(2-morpholinoethyl)-3-pyrrolin-2-one Major prion protein Homo sapiens 6769 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66203&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91897629 252644530 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237204 [H][C@]12CN(C[C@]([H])(C1)c1cccc(=O)n1C2)C(=O)COc1ccc2c(C)c(Br)c(=O)oc2c1 |TLB:9:8:7:3.2.4| InChI=1S/C23H21BrN2O5/c1-13-17-6-5-16(8-19(17)31-23(29)22(13)24)30-12-21(28)25-9-14-7-15(11-25)18-3-2-4-20(27)26(18)10-14/h2-6,8,14-15H,7,9-12H2,1H3 KQAZJQXFNDOORW-UHFFFAOYSA-N 114432 SMR000653126::MLS001160002::cid_16406841 Major prion protein Homo sapiens 8340 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114432&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 16406841 242053897 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237205 Cc1cccc2c1oc(NC(=O)c1ccco1)c(-c1ccc3OCOc3c1)c2=O InChI=1S/C22H15NO6/c1-12-4-2-5-14-19(24)18(13-7-8-15-17(10-13)28-11-27-15)22(29-20(12)14)23-21(25)16-6-3-9-26-16/h2-10H,11H2,1H3,(H,23,25) VUBLYIOCWZPNRJ-UHFFFAOYSA-N 114433 N-[3-(1,3-benzodioxol-5-yl)-8-methyl-4-oxidanylidene-chromen-2-yl]furan-2-carboxamide::N-[3-(1,3-benzodioxol-5-yl)-8-methyl-4-oxo-1-benzopyran-2-yl]-2-furancarboxamide::cid_7693217::MLS001158920::N-[3-(1,3-benzodioxol-5-yl)-8-methyl-4-oxochromen-2-yl]furan-2-carboxamide::SMR000651713::N-[3-(1,3-benzodioxol-5-yl)-4-keto-8-methyl-chromen-2-yl]-2-furamide Major prion protein Homo sapiens 9571 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114433&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 7693217 252663937 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237206 COc1ccc(NC(=O)NNC(=O)COc2ccc3cc(Br)ccc3c2)cc1OC InChI=1S/C21H20BrN3O5/c1-28-18-8-6-16(11-19(18)29-2)23-21(27)25-24-20(26)12-30-17-7-4-13-9-15(22)5-3-14(13)10-17/h3-11H,12H2,1-2H3,(H,24,26)(H2,23,25,27) WAHRXJHRNQYLBW-UHFFFAOYSA-N 114434 MLS001229860::1-[2-(6-bromanylnaphthalen-2-yl)oxyethanoylamino]-3-(3,4-dimethoxyphenyl)urea::cid_24818595::1-[[2-(6-bromonaphthalen-2-yl)oxyacetyl]amino]-3-(3,4-dimethoxyphenyl)urea::1-[[2-[(6-bromo-2-naphthalenyl)oxy]-1-oxoethyl]amino]-3-(3,4-dimethoxyphenyl)urea::SMR000679269::1-[[2-(6-bromo-2-naphthoxy)acetyl]amino]-3-(3,4-dimethoxyphenyl)urea Major prion protein Homo sapiens 5333 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114434&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24818595 252663938 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237207 CCc1nonc1NC(=O)c1oc2cc(Br)ccc2c1C InChI=1S/C14H12BrN3O3/c1-3-10-13(18-21-17-10)16-14(19)12-7(2)9-5-4-8(15)6-11(9)20-12/h4-6H,3H2,1-2H3,(H,16,18,19) DDPCWWPIKCJUKD-UHFFFAOYSA-N 114435 6-bromo-N-(4-ethyl-1,2,5-oxadiazol-3-yl)-3-methyl-2-benzofurancarboxamide::6-bromanyl-N-(4-ethyl-1,2,5-oxadiazol-3-yl)-3-methyl-1-benzofuran-2-carboxamide::cid_16438048::MLS001116336::6-bromo-N-(4-ethyl-1,2,5-oxadiazol-3-yl)-3-methyl-1-benzofuran-2-carboxamide::SMR000625678::6-bromo-N-(4-ethylfurazan-3-yl)-3-methyl-coumarilamide Major prion protein Homo sapiens 3555 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114435 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114435&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 16438048 252663939 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237208 CCOC(=O)N1CCN(CC1)C(=O)COc1ccc2ccccc2c1Br InChI=1S/C19H21BrN2O4/c1-2-25-19(24)22-11-9-21(10-12-22)17(23)13-26-16-8-7-14-5-3-4-6-15(14)18(16)20/h3-8H,2,9-13H2,1H3 FDWRHXOLHGWWBR-UHFFFAOYSA-N 114436 SMR000668543::MLS001123887::cid_2959558::ethyl 4-[2-(1-bromanylnaphthalen-2-yl)oxyethanoyl]piperazine-1-carboxylate::ethyl 4-[2-(1-bromonaphthalen-2-yl)oxyacetyl]piperazine-1-carboxylate::4-[2-[(1-bromo-2-naphthalenyl)oxy]-1-oxoethyl]-1-piperazinecarboxylic acid ethyl ester::4-[2-(1-bromo-2-naphthoxy)acetyl]piperazine-1-carboxylic acid ethyl ester Major prion protein Homo sapiens 6282 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114436&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2959558 252663940 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237209 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)Nc1ccc(C)c(F)c1 InChI=1S/C20H24FN3O3S/c1-14-6-7-15(12-18(14)21)22-20(25)17-13-16(28(26,27)23(2)3)8-9-19(17)24-10-4-5-11-24/h6-9,12-13H,4-5,10-11H2,1-3H3,(H,22,25) YDMCKWRFJWZPHV-UHFFFAOYSA-N 114437 cid_24819918::5-(dimethylsulfamoyl)-N-(3-fluoro-4-methylphenyl)-2-pyrrolidin-1-ylbenzamide::5-(dimethylsulfamoyl)-N-(3-fluoranyl-4-methyl-phenyl)-2-pyrrolidin-1-yl-benzamide::SMR000717647::MLS001150547::5-(dimethylsulfamoyl)-N-(3-fluoro-4-methylphenyl)-2-(1-pyrrolidinyl)benzamide::5-(dimethylsulfamoyl)-N-(3-fluoro-4-methyl-phenyl)-2-pyrrolidino-benzamide Major prion protein Homo sapiens 9919 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114437&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24819918 252663941 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237210 Brc1cccc(c1)C1C(C(=O)c2cc3ccccc3o2)C(=O)C(=O)N1CCN1CCOCC1 InChI=1S/C25H23BrN2O5/c26-18-6-3-5-17(14-18)22-21(23(29)20-15-16-4-1-2-7-19(16)33-20)24(30)25(31)28(22)9-8-27-10-12-32-13-11-27/h1-7,14-15,21-22H,8-13H2 ZSSBHGILLLWBMK-UHFFFAOYSA-N 66213 3-(1-benzofuran-2-carbonyl)-2-(3-bromophenyl)-4-hydroxy-1-(2-morpholin-4-ylethyl)-2H-pyrrol-5-one::SMR000646798::cid_3802907::MLS001146404::3-(1-benzofuran-2-ylcarbonyl)-2-(3-bromophenyl)-1-(2-morpholin-4-ylethyl)-4-oxidanyl-2H-pyrrol-5-one::3-[2-benzofuranyl(oxo)methyl]-2-(3-bromophenyl)-4-hydroxy-1-[2-(4-morpholinyl)ethyl]-2H-pyrrol-5-one::4-(benzofuran-2-carbonyl)-5-(3-bromophenyl)-3-hydroxy-1-(2-morpholinoethyl)-3-pyrrolin-2-one Major prion protein Homo sapiens 3216 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=66213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=66213&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91897638 252644540 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237211 CCOc1ccc(cc1OCC)C1C(C#N)C(=N)SC(=N)C1C#N InChI=1S/C17H18N4O2S/c1-3-22-13-6-5-10(7-14(13)23-4-2)15-11(8-18)16(20)24-17(21)12(15)9-19/h5-7,11-12,15,20-21H,3-4H2,1-2H3 JJNWAPOGCBYIBZ-UHFFFAOYSA-N 114438 MLS001385164::cid_646863::2,6-Diamino-4-(3,4-diethoxy-phenyl)-4H-thiopyran-3,5-dicarbonitrile::SMR000014498::2,6-bis(azanyl)-4-(3,4-diethoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(3,4-diethoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile Major prion protein Homo sapiens 2318 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114438&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899722 252663942 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237212 O=C1CC(c2cccs2)C(C#N)=C2SCN(Cc3ccccc3)CN12 |t:12| InChI=1S/C19H17N3OS2/c20-10-16-15(17-7-4-8-24-17)9-18(23)22-12-21(13-25-19(16)22)11-14-5-2-1-3-6-14/h1-8,15H,9,11-13H2 BXISOPKQRATYMT-UHFFFAOYSA-N 47134 cid_5308895::MLS000117264::6-oxo-3-(phenylmethyl)-8-thiophen-2-yl-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile::3-benzyl-6-oxo-8-thiophen-2-yl-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile::6-oxidanylidene-3-(phenylmethyl)-8-thiophen-2-yl-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile::SMR000094216::3-benzyl-6-keto-8-(2-thienyl)-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile Major prion protein Homo sapiens 137972 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47134&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5308895 252627593 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237213 CC1CCC(CC1)NC(=O)c1cc2CCCCc2s1 |(16.57,-.77,;15.03,-.77,;14.26,-2.1,;12.72,-2.1,;11.95,-.77,;12.72,.56,;14.26,.56,;10.41,-.77,;9.64,.56,;10.41,1.9,;8.1,.56,;7.2,1.8,;5.75,1.33,;4.41,2.1,;3.08,1.33,;3.08,-.21,;4.41,-.98,;5.75,-.21,;7.2,-.68,)| InChI=1S/C16H23NOS/c1-11-6-8-13(9-7-11)17-16(18)15-10-12-4-2-3-5-14(12)19-15/h10-11,13H,2-9H2,1H3,(H,17,18) KUYAAMCAMQHADE-UHFFFAOYSA-N 114439 MLS001129648::N-(4-methylcyclohexyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::cid_24979973::SMR000710535::N-(4-methylcyclohexyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Major prion protein Homo sapiens 4391 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114439&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 24979973 252663943 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237214 C[C@H]1CCC\C=C\[C@@H]2C[C@H](O)C[C@H]2[C@H](O)\C=C\C(=O)O1 |t:5,16| InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3 KQNZDYYTLMIZCT-UHFFFAOYSA-N 97307 MLS001074108::cid_5287620::Bredfeldin A::Ascotoxin::(1S,2E,7S,10E,12R,13R,15S)-7-methyl-12,15-bis(oxidanyl)-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one::SMR000653527::(1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one Major prion protein Homo sapiens 3505 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97307&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 5287620 164038551 DB07348 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237215 CC(Sc1nc(nc2ccccc12)-c1cccs1)C(=O)Nc1cc(C)on1 InChI=1S/C19H16N4O2S2/c1-11-10-16(23-25-11)21-18(24)12(2)27-19-13-6-3-4-7-14(13)20-17(22-19)15-8-5-9-26-15/h3-10,12H,1-2H3,(H,21,23,24) PARFDVYQHIXUOZ-UHFFFAOYSA-N 114440 N-(5-methyl-1,2-oxazol-3-yl)-2-(2-thiophen-2-ylquinazolin-4-yl)sulfanyl-propanamide::SMR001247998::MLS002165637::N-(5-methyl-3-isoxazolyl)-2-[(2-thiophen-2-yl-4-quinazolinyl)thio]propanamide::cid_16332572::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-thiophen-2-ylquinazolin-4-yl)sulfanylpropanamide::N-(5-methylisoxazol-3-yl)-2-[[2-(2-thienyl)quinazolin-4-yl]thio]propionamide Major prion protein Homo sapiens 1703 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114440&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 16332572 252663944 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237216 CCCn1c(N)c(C(=O)CSc2nncs2)c(=O)[nH]c1=O InChI=1S/C11H13N5O3S2/c1-2-3-16-8(12)7(9(18)14-10(16)19)6(17)4-20-11-15-13-5-21-11/h5H,2-4,12H2,1H3,(H,14,18,19) BWFZWDIHYGGGSU-UHFFFAOYSA-N 114441 cid_8302969::SMR001240024::6-amino-1-propyl-5-[2-(1,3,4-thiadiazol-2-ylsulfanyl)acetyl]pyrimidine-2,4-dione::MLS002157535::6-azanyl-1-propyl-5-[2-(1,3,4-thiadiazol-2-ylsulfanyl)ethanoyl]pyrimidine-2,4-dione::6-amino-5-[1-oxo-2-(1,3,4-thiadiazol-2-ylthio)ethyl]-1-propylpyrimidine-2,4-dione::6-amino-1-propyl-5-[2-(1,3,4-thiadiazol-2-ylthio)acetyl]pyrimidine-2,4-quinone Major prion protein Homo sapiens 5883 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114441 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114441&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 8302969 252663945 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237217 Cc1cc(NC(=O)CSc2nc(nc3ccccc23)-c2cccs2)no1 InChI=1S/C18H14N4O2S2/c1-11-9-15(22-24-11)20-16(23)10-26-18-12-5-2-3-6-13(12)19-17(21-18)14-7-4-8-25-14/h2-9H,10H2,1H3,(H,20,22,23) VFGXSZFSAGZFAN-UHFFFAOYSA-N 114442 SMR001240262::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-thiophen-2-ylquinazolin-4-yl)sulfanylacetamide::N-(5-methyl-3-isoxazolyl)-2-[(2-thiophen-2-yl-4-quinazolinyl)thio]acetamide::MLS002157776::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-thiophen-2-ylquinazolin-4-yl)sulfanyl-ethanamide::cid_2567379::N-(5-methylisoxazol-3-yl)-2-[[2-(2-thienyl)quinazolin-4-yl]thio]acetamide Major prion protein Homo sapiens 2151 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114442&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2567379 252663946 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237218 Cc1cc(NC(=O)COc2ccc3ccccc3c2Br)no1 InChI=1S/C16H13BrN2O3/c1-10-8-14(19-22-10)18-15(20)9-21-13-7-6-11-4-2-3-5-12(11)16(13)17/h2-8H,9H2,1H3,(H,18,19,20) WGMUUKPZKHZDIR-UHFFFAOYSA-N 114443 MLS002251153::2-(1-bromanylnaphthalen-2-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)ethanamide::SMR000835091::2-[(1-bromo-2-naphthalenyl)oxy]-N-(5-methyl-3-isoxazolyl)acetamide::cid_2565490::2-(1-bromonaphthalen-2-yl)oxy-N-(5-methyl-1,2-oxazol-3-yl)acetamide::2-(1-bromo-2-naphthoxy)-N-(5-methylisoxazol-3-yl)acetamide Major prion protein Homo sapiens 1392 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114443&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 2565490 252663947 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237219 Cc1nc(SCC(=O)NNC(=O)c2ccc(F)cc2)c2ccccc2n1 InChI=1S/C18H15FN4O2S/c1-11-20-15-5-3-2-4-14(15)18(21-11)26-10-16(24)22-23-17(25)12-6-8-13(19)9-7-12/h2-9H,10H2,1H3,(H,22,24)(H,23,25) NPEZGZQPAWZULK-UHFFFAOYSA-N 114444 SMR001315228::cid_9207942::MLS002252894::4-fluoro-N'-[2-[(2-methyl-4-quinazolinyl)thio]-1-oxoethyl]benzohydrazide::4-fluoranyl-N'-[2-(2-methylquinazolin-4-yl)sulfanylethanoyl]benzohydrazide::4-fluoro-N'-[2-(2-methylquinazolin-4-yl)sulfanylacetyl]benzohydrazide::4-fluoro-N'-[2-[(2-methylquinazolin-4-yl)thio]acetyl]benzohydrazide Major prion protein Homo sapiens 2262 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114444&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 9207942 252663948 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237220 CN(C)S(=O)(=O)c1ccc(N2CCCC2)c(c1)C(=O)Nc1nccs1 InChI=1S/C16H20N4O3S2/c1-19(2)25(22,23)12-5-6-14(20-8-3-4-9-20)13(11-12)15(21)18-16-17-7-10-24-16/h5-7,10-11H,3-4,8-9H2,1-2H3,(H,17,18,21) TUFPXVPLOXZIMZ-UHFFFAOYSA-N 114445 5-(dimethylsulfamoyl)-2-(1-pyrrolidinyl)-N-(2-thiazolyl)benzamide::SMR001315276::MLS002252943::cid_8762613::5-(dimethylsulfamoyl)-2-pyrrolidin-1-yl-N-(1,3-thiazol-2-yl)benzamide::5-(dimethylsulfamoyl)-2-pyrrolidino-N-thiazol-2-yl-benzamide Major prion protein Homo sapiens 14809 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114445 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114445&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 8762613 252663949 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237221 Cc1cnc(s1)NC(=O)c2cc(ccc2N3CCCC3)S(=O)(=O)N(C)C InChI=1S/C17H22N4O3S2/c1-12-11-18-17(25-12)19-16(22)14-10-13(26(23,24)20(2)3)6-7-15(14)21-8-4-5-9-21/h6-7,10-11H,4-5,8-9H2,1-3H3,(H,18,19,22) QPKGRLIYJGBKJL-UHFFFAOYSA-N 114446 cid_2519269::SMR001315774::5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-yl-benzamide::5-(dimethylsulfamoyl)-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide::MLS002248299::5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide::5-(dimethylsulfamoyl)-N-(5-methylthiazol-2-yl)-2-pyrrolidino-benzamide Major prion protein Homo sapiens 2873 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114446 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114446&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search ZXT 8PN9 2519269 252663950 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237222 Cc1ccc(cc1)S(=O)(=O)N(CCCN1CCCC1=O)Cc1cc2c(C)ccc(C)c2[nH]c1=O InChI=1S/C26H31N3O4S/c1-18-7-11-22(12-8-18)34(32,33)29(15-5-14-28-13-4-6-24(28)30)17-21-16-23-19(2)9-10-20(3)25(23)27-26(21)31/h7-12,16H,4-6,13-15,17H2,1-3H3,(H,27,31) NZOJWVJZJBDPDD-UHFFFAOYSA-N 52224 N-[(5,8-dimethyl-2-oxidanylidene-1H-quinolin-3-yl)methyl]-4-methyl-N-[3-(2-oxidanylidenepyrrolidin-1-yl)propyl]benzenesulfonamide::cid_3203401::MLS000523368::N-(5,8-Dimethyl-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-4-methyl-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzenesulfonamide::SMR000123346::N-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-4-methyl-N-[3-(2-oxopyrrolidin-1-yl)propyl]benzenesulfonamide::N-[(5,8-dimethyl-2-oxo-1H-quinolin-3-yl)methyl]-4-methyl-N-[3-(2-oxo-1-pyrrolidinyl)propyl]benzenesulfonamide::N-[(2-keto-5,8-dimethyl-1H-quinolin-3-yl)methyl]-N-[3-(2-ketopyrrolidino)propyl]-4-methyl-benzenesulfonamide Major prion protein Homo sapiens 4168 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=52224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=52224&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 3203401 252632374 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237223 OC(=O)c1ccccc1C(=O)c1cccc2c(Br)cccc12 InChI=1S/C18H11BrO3/c19-16-10-4-7-11-12(16)8-3-9-13(11)17(20)14-5-1-2-6-15(14)18(21)22/h1-10H,(H,21,22) CLKBMCKEDALDRQ-UHFFFAOYSA-N 114447 MLS002639261::cid_232079::2-(5-bromonaphthalene-1-carbonyl)benzoic acid::2-[(5-bromo-1-naphthalenyl)-oxomethyl]benzoic acid::2-(5-bromanylnaphthalen-1-yl)carbonylbenzoic acid::SMR001548707::2-(5-bromo-1-naphthoyl)benzoic acid Major prion protein Homo sapiens 1571 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114447 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114447&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 232079 252663951 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237224 Cn1c2c(ccc3ccccc23)sc1=S InChI=1S/C12H9NS2/c1-13-11-9-5-3-2-4-8(9)6-7-10(11)15-12(13)14/h2-7H,1H3 NPDUDUAXKVYXFJ-UHFFFAOYSA-N 114448 1-methyl-2-benzo[e][1,3]benzothiazolethione::cid_274146::SMR001574355::MLS002706959::1-methylbenzo[e][1,3]benzothiazole-2-thione Major prion protein Homo sapiens 6250 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114448 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114448&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 274146 252663952 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237225 COc1ccc2C3=C(Br)C(=O)CC3(C)CCc2c1 |c:6| InChI=1S/C15H15BrO2/c1-15-6-5-9-7-10(18-2)3-4-11(9)13(15)14(16)12(17)8-15/h3-4,7H,5-6,8H2,1-2H3 UOCPVWVHJRUTEM-UHFFFAOYSA-N 114449 1-bromanyl-7-methoxy-3a-methyl-4,5-dihydro-3H-cyclopenta[a]naphthalen-2-one::MLS003115317::1-bromo-7-methoxy-3a-methyl-4,5-dihydro-3H-cyclopenta[a]naphthalen-2-one::SMR001830897::1-BORMO-3,3A,4,5-TETRAHYDRO-7-METHOXY-3A-METHYL-2H-BENZ[E]INDEN-2-ONE::cid_317824::1-bromo-7-methoxy-3a-methyl-4,5-dihydro-3H-benz[e]inden-2-one Major prion protein Homo sapiens 3209 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114449&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 317824 252663953 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237226 CCOc1ccc(C(=O)C2C(N(C(=O)C2=O)c2ccccn2)c2ccccc2F)c(C)c1 InChI=1S/C25H21FN2O4/c1-3-32-16-11-12-17(15(2)14-16)23(29)21-22(18-8-4-5-9-19(18)26)28(25(31)24(21)30)20-10-6-7-13-27-20/h4-14,21-22H,3H2,1-2H3 OXNOCHTZUYOFDF-UHFFFAOYSA-N 114450 MLS001210000::(4E)-4-[(4-ethoxy-2-methyl-phenyl)-oxidanyl-methylidene]-5-(2-fluorophenyl)-1-pyridin-2-yl-pyrrolidine-2,3-dione::(4E)-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(2-fluorophenyl)-1-pyridin-2-ylpyrrolidine-2,3-dione::(4E)-4-[(4-ethoxy-2-methylphenyl)-hydroxymethylidene]-5-(2-fluorophenyl)-1-(2-pyridinyl)pyrrolidine-2,3-dione::4-(4-Ethoxy-2-methyl-benzoyl)-5-(2-fluoro-phenyl)-3-hydroxy-1-pyridin-2-yl-1,5-dihydro-pyrrol-2-one::cid_5767849::SMR000518614::(4E)-4-[(4-ethoxy-2-methyl-phenyl)-hydroxy-methylene]-5-(2-fluorophenyl)-1-(2-pyridyl)pyrrolidine-2,3-quinone Major prion protein Homo sapiens 5580 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114450&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 91899723 252663954 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237227 NC(=O)CSc1nnc2n(-c3ccccc3)c(=O)c3c4CCCCCc4sc3n12 InChI=1S/C20H19N5O2S2/c21-15(26)11-28-20-23-22-19-24(12-7-3-1-4-8-12)17(27)16-13-9-5-2-6-10-14(13)29-18(16)25(19)20/h1,3-4,7-8H,2,5-6,9-11H2,(H2,21,26) ILNZPCHQXNINAG-UHFFFAOYSA-N 53489 SMR000039328::MLS000030459::cid_658507 Major prion protein Homo sapiens 4664 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=53489 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=53489&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 658507 242053241 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237228 Cc1ccc(Cc2c(nc3c(C)cc(Br)cn23)-c2ccco2)cc1 InChI=1S/C20H17BrN2O/c1-13-5-7-15(8-6-13)11-17-19(18-4-3-9-24-18)22-20-14(2)10-16(21)12-23(17)20/h3-10,12H,11H2,1-2H3 FPWBEULRPXCFKB-UHFFFAOYSA-N 114451 MLS003222320::cid_51359042::SMR001906875::6-bromo-2-(furan-2-yl)-8-methyl-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::6-bromo-2-(2-furanyl)-8-methyl-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::6-bromanyl-2-(furan-2-yl)-8-methyl-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::6-bromo-2-(2-furyl)-8-methyl-3-(4-methylbenzyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 9948 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114451 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114451&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51359042 252663955 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237229 Cc1cc(Br)cn2c(Cc3cccc(F)c3)c(nc12)-c1ccco1 InChI=1S/C19H14BrFN2O/c1-12-8-14(20)11-23-16(10-13-4-2-5-15(21)9-13)18(22-19(12)23)17-6-3-7-24-17/h2-9,11H,10H2,1H3 PNXALFFESWHVFX-UHFFFAOYSA-N 114452 SMR001913527::MLS003230962::6-bromo-3-[(3-fluorophenyl)methyl]-2-(furan-2-yl)-8-methylimidazo[1,2-a]pyridine::cid_51359977::6-bromanyl-3-[(3-fluorophenyl)methyl]-2-(furan-2-yl)-8-methyl-imidazo[1,2-a]pyridine::6-bromo-3-[(3-fluorophenyl)methyl]-2-(2-furanyl)-8-methylimidazo[1,2-a]pyridine::6-bromo-3-(3-fluorobenzyl)-2-(2-furyl)-8-methyl-imidazo[1,2-a]pyridine Major prion protein Homo sapiens 7364 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114452&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51359977 252663956 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237230 COc1ccc(cc1OC)-c1nc2c(C)cc(Br)cn2c1Cc1cccc(Cl)c1 InChI=1S/C23H20BrClN2O2/c1-14-9-17(24)13-27-19(11-15-5-4-6-18(25)10-15)22(26-23(14)27)16-7-8-20(28-2)21(12-16)29-3/h4-10,12-13H,11H2,1-3H3 UNUFWWAVLIELIK-UHFFFAOYSA-N 114453 SMR001913572::6-bromanyl-3-[(3-chlorophenyl)methyl]-2-(3,4-dimethoxyphenyl)-8-methyl-imidazo[1,2-a]pyridine::MLS003231007::cid_51360010::6-bromo-3-[(3-chlorophenyl)methyl]-2-(3,4-dimethoxyphenyl)-8-methylimidazo[1,2-a]pyridine::6-bromo-3-(3-chlorobenzyl)-2-(3,4-dimethoxyphenyl)-8-methyl-imidazo[1,2-a]pyridine Major prion protein Homo sapiens 7520 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114453&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51360010 252663957 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237231 Brc1ccc2nc(-c3ccco3)c(Cc3ccccc3)n2c1 InChI=1S/C18H13BrN2O/c19-14-8-9-17-20-18(16-7-4-10-22-16)15(21(17)12-14)11-13-5-2-1-3-6-13/h1-10,12H,11H2 IBYSEKUNBGPWKD-UHFFFAOYSA-N 114454 6-bromo-2-(2-furanyl)-3-(phenylmethyl)imidazo[1,2-a]pyridine::cid_51360068::MLS003269858::SMR001950255::6-bromanyl-2-(furan-2-yl)-3-(phenylmethyl)imidazo[1,2-a]pyridine::3-benzyl-6-bromo-2-(furan-2-yl)imidazo[1,2-a]pyridine::3-benzyl-6-bromo-2-(2-furyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 6665 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114454&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51360068 252663958 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237232 Cc1ccc(Cc2c(nc3ccc(Br)cn23)-c2ccco2)cc1 InChI=1S/C19H15BrN2O/c1-13-4-6-14(7-5-13)11-16-19(17-3-2-10-23-17)21-18-9-8-15(20)12-22(16)18/h2-10,12H,11H2,1H3 PQIQXZGXMYRBJD-UHFFFAOYSA-N 114455 SMR001950258::MLS003269861::6-bromanyl-2-(furan-2-yl)-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::6-bromo-2-(furan-2-yl)-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::cid_51360071::6-bromo-2-(2-furanyl)-3-[(4-methylphenyl)methyl]imidazo[1,2-a]pyridine::6-bromo-2-(2-furyl)-3-(4-methylbenzyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 8496 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114455&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51360071 252663959 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237233 Fc1cccc(Cc2c(nc3ccc(Br)cn23)-c2ccc(cc2)C#N)c1 InChI=1S/C21H13BrFN3/c22-17-8-9-20-25-21(16-6-4-14(12-24)5-7-16)19(26(20)13-17)11-15-2-1-3-18(23)10-15/h1-10,13H,11H2 QDKIGNDDRBWHDU-UHFFFAOYSA-N 114456 4-[6-bromo-3-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyridin-2-yl]benzonitrile::4-[6-bromo-3-[(3-fluorophenyl)methyl]-2-imidazo[1,2-a]pyridinyl]benzonitrile::cid_51360082::4-[6-bromanyl-3-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyridin-2-yl]benzenecarbonitrile::MLS003269876::SMR001950269::4-[6-bromo-3-(3-fluorobenzyl)imidazo[1,2-a]pyridin-2-yl]benzonitrile Major prion protein Homo sapiens 2981 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114456&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51360082 252663960 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237234 COc1ccc(cc1OC)-c1nc2ccc(Br)cn2c1Cc1cccc(F)c1 InChI=1S/C22H18BrFN2O2/c1-27-19-8-6-15(12-20(19)28-2)22-18(11-14-4-3-5-17(24)10-14)26-13-16(23)7-9-21(26)25-22/h3-10,12-13H,11H2,1-2H3 VIXDNGWKINORNJ-UHFFFAOYSA-N 114457 6-bromo-2-(3,4-dimethoxyphenyl)-3-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyridine::6-bromanyl-2-(3,4-dimethoxyphenyl)-3-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyridine::SMR001950313::cid_51361243::MLS003269924::6-bromo-2-(3,4-dimethoxyphenyl)-3-(3-fluorobenzyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 6960 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114457&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51361243 252663961 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237235 Fc1cccc(Cc2c(nc3ccc(Br)cn23)-c2ccco2)c1 InChI=1S/C18H12BrFN2O/c19-13-6-7-17-21-18(16-5-2-8-23-16)15(22(17)11-13)10-12-3-1-4-14(20)9-12/h1-9,11H,10H2 NEHLOOXQKNFLIO-UHFFFAOYSA-N 114458 6-bromo-3-[(3-fluorophenyl)methyl]-2-(furan-2-yl)imidazo[1,2-a]pyridine::6-bromanyl-3-[(3-fluorophenyl)methyl]-2-(furan-2-yl)imidazo[1,2-a]pyridine::6-bromo-3-[(3-fluorophenyl)methyl]-2-(2-furanyl)imidazo[1,2-a]pyridine::SMR001950314::MLS003269925::cid_51361244::6-bromo-3-(3-fluorobenzyl)-2-(2-furyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 6293 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114458&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51361244 252663962 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237236 COc1ccc(cc1OC)-c1nc2ccc(Br)cn2c1Cc1cccc(Cl)c1 InChI=1S/C22H18BrClN2O2/c1-27-19-8-6-15(12-20(19)28-2)22-18(11-14-4-3-5-17(24)10-14)26-13-16(23)7-9-21(26)25-22/h3-10,12-13H,11H2,1-2H3 SFDUEAGVBUDCMI-UHFFFAOYSA-N 114459 cid_51361306::MLS003269989::6-bromo-3-[(3-chlorophenyl)methyl]-2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine::SMR001950378::6-bromanyl-3-[(3-chlorophenyl)methyl]-2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine::6-bromo-3-(3-chlorobenzyl)-2-(3,4-dimethoxyphenyl)imidazo[1,2-a]pyridine Major prion protein Homo sapiens 5351 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114459&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51361306 252663963 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237237 Cc1cc(Br)cn2c(Cc3cccc(Cl)c3)c(nc12)-c1ccco1 InChI=1S/C19H14BrClN2O/c1-12-8-14(20)11-23-16(10-13-4-2-5-15(21)9-13)18(22-19(12)23)17-6-3-7-24-17/h2-9,11H,10H2,1H3 JESMIUAIFXBPCA-UHFFFAOYSA-N 97190 SMR001913570::6-bromo-3-[(3-chlorophenyl)methyl]-2-(furan-2-yl)-8-methylimidazo[1,2-a]pyridine::6-bromo-3-[(3-chlorophenyl)methyl]-2-(2-furanyl)-8-methylimidazo[1,2-a]pyridine::6-bromanyl-3-[(3-chlorophenyl)methyl]-2-(furan-2-yl)-8-methyl-imidazo[1,2-a]pyridine::MLS003231005::cid_53299527::6-bromo-3-(3-chlorobenzyl)-2-(2-furyl)-8-methyl-imidazo[1,2-a]pyridine Major prion protein Homo sapiens 10527 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97190&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 53299527 164038434 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237238 Brc1ccc2nc(-c3ccc(CN4CCC5(CNc6ccccc56)CC4)cc3)c(nc2c1)-c1ccccc1 InChI=1S/C33H29BrN4/c34-26-14-15-29-30(20-26)37-31(24-6-2-1-3-7-24)32(36-29)25-12-10-23(11-13-25)21-38-18-16-33(17-19-38)22-35-28-9-5-4-8-27(28)33/h1-15,20,35H,16-19,21-22H2 ZAYDEHXHLVKNBW-UHFFFAOYSA-N 114460 cid_56588074::SMR002157955::1'-[[4-(6-bromo-3-phenylquinoxalin-2-yl)phenyl]methyl]spiro[1,2-dihydroindole-3,4'-piperidine];2,2,2-trifluoroacetic acid::1'-[[4-(6-bromo-3-phenyl-2-quinoxalinyl)phenyl]methyl]spiro[1,2-dihydroindole-3,4'-piperidine];2,2,2-trifluoroacetic acid::MLS003510221::1'-(4-(6-bromo-3-phenylquinoxalin-2-yl)benzyl)spiro[indoline-3,4'-piperidine]::1'-[[4-(6-bromanyl-3-phenyl-quinoxalin-2-yl)phenyl]methyl]spiro[1,2-dihydroindole-3,4'-piperidine];2,2,2-tris(fluoranyl)ethanoic acid::1'-[4-(6-bromo-3-phenyl-quinoxalin-2-yl)benzyl]spiro[indoline-3,4'-piperidine];2,2,2-trifluoroacetic acid Major prion protein Homo sapiens 7835 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114460&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 51049789 252663964 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237239 O=C(Nc1cc(ccc1N1CCCC1)S(=O)(=O)N1CCOCC1)c1cc2CCCCc2s1 InChI=1S/C23H29N3O4S2/c27-23(22-15-17-5-1-2-6-21(17)31-22)24-19-16-18(7-8-20(19)25-9-3-4-10-25)32(28,29)26-11-13-30-14-12-26/h7-8,15-16H,1-6,9-14H2,(H,24,27) PODUXAQFLMUPKS-UHFFFAOYSA-N 68315 cid_17460708::N-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-yl-phenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::MLS-0435541.0001::N-[5-(4-morpholinylsulfonyl)-2-(1-pyrrolidinyl)phenyl]-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide::N-(5-morpholinosulfonyl-2-pyrrolidino-phenyl)-4,5,6,7-tetrahydrobenzothiophene-2-carboxamide Major prion protein Homo sapiens 5472 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=68315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=68315&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 17460708 252646503 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237240 Nc1nc2ccc(Cl)cc2cc1C(=O)NCc1ccccc1Br InChI=1S/C17H13BrClN3O/c18-14-4-2-1-3-10(14)9-21-17(23)13-8-11-7-12(19)5-6-15(11)22-16(13)20/h1-8H,9H2,(H2,20,22)(H,21,23) OLGKZNGMUYFEID-UHFFFAOYSA-N 114461 MLS003986996::2-amino-N-[(2-bromophenyl)methyl]-6-chloroquinoline-3-carboxamide::cid_60157876::SMR002721971::2-amino-N-(2-bromobenzyl)-6-chloroquinoline-3-carboxamide::2-azanyl-N-[(2-bromophenyl)methyl]-6-chloranyl-quinoline-3-carboxamide::2-amino-N-[(2-bromophenyl)methyl]-6-chloro-3-quinolinecarboxamide::2-amino-N-(2-bromobenzyl)-6-chloro-quinoline-3-carboxamide Major prion protein Homo sapiens 7351 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114461&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 60157876 252663965 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237241 C[C@H]1COc2n1nc1cc(I)ccc21 InChI=1S/C10H9IN2O/c1-6-5-14-10-8-3-2-7(11)4-9(8)12-13(6)10/h2-4,6H,5H2,1H3 WXEAUHXARNLYSO-UHFFFAOYSA-N 114462 SMR003242809::cid_60159077::(3S)-7-iodo-3-methyl-2,3-dihydrooxazolo[3,2-b]indazole::MLS004428894::(3S)-7-iodanyl-3-methyl-2,3-dihydro-[1,3]oxazolo[3,2-b]indazole::(3S)-7-iodo-3-methyl-2,3-dihydro-[1,3]oxazolo[3,2-b]indazole::(3S)-7-iodo-3-methyl-2,3-dihydrooxazol[3,2-b]indazole Major prion protein Homo sapiens 3611 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114462&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 60159077 252663966 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19 237242 COC(=O)[C@H](CC1(C(=O)Nc2ccccc12)c1cn(c2ccccc12)S(=O)(=O)CC[Si](C)(C)C)NC(=O)OC(C)(C)C InChI=1S/C30H39N3O7SSi/c1-29(2,3)40-28(36)32-24(26(34)39-4)18-30(21-13-9-10-14-23(21)31-27(30)35)22-19-33(25-15-11-8-12-20(22)25)41(37,38)16-17-42(5,6)7/h8-15,19,24H,16-18H2,1-7H3,(H,31,35)(H,32,36) WFALMCYURNLZBJ-UHFFFAOYSA-N 114463 methyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[2-oxo-3-[1-(2-trimethylsilylethylsulfonyl)indol-3-yl]-1H-indol-3-yl]propanoate::MLS004682191::methyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-[2-oxidanylidene-3-[1-(2-trimethylsilylethylsulfonyl)indol-3-yl]-1H-indol-3-yl]propanoate::SMR003453341::cid_70680043::(2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-3-[2-oxo-3-[1-(2-trimethylsilylethylsulfonyl)-3-indolyl]-1H-indol-3-yl]propanoic acid methyl ester::(2S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2-oxo-3-(1-((2-(trimethylsilyl)ethyl)sulfonyl)-1H-indol-3-yl)indolin-3-yl)propanoate::(2S)-2-(tert-butoxycarbonylamino)-3-[2-keto-3-[1-(2-trimethylsilylethylsulfonyl)indol-3-yl]indolin-3-yl]propionic acid methyl ester Major prion protein Homo sapiens 11665 PubChem 10.7270/Q2HM573M aid743453 PubChem, PC 4/11/2014 8/8/2014 The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001025&target=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114463&enzyme=Major+prion+protein&column=ki&startPg=0&Increment=50&submit=Search 70680043 252663967 1 MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG 6LNI,4KML,4N9O,2LSB,2LV1,2LEJ,5YJ5,2LFT,1FO7,1FKC,3HJ5,3HAF,6DU9,3HEQ,3HES,2K1D,2KUN,5L6R,4YX2,2W9E,1QM3,1QM2,4DGI,7RL4,1I4M,2JOH,1HJN,1HJM,1XYU,2K5O,1XYX,3O79,6UUR,1M25,1G04,2RMV,2IV5,2IV6,7YAT,2IV4 Major prion protein PRIO_HUMAN P04156 O60489 P78446 Q15216 Q15221 Q27H91 Q5QPB4 Q8TBG0 Q96E70 Q9UP19