BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 453991 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H27N5O2/c1-19(2,3)26-18(25)24-9-12-7-14(8-13(12)10-24)23(4)17-15-5-6-20-16(15)21-11-22-17/h5-6,11-14H,7-10H2,1-4H3,(H,20,21,22) NZHSLDWIEHMESB-UHFFFAOYSA-N 260452 US9527851, 5::US9527851, example 5::US10428074, Example 5 Tyrosine-protein kinase JAK1 Homo sapiens 30 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260452&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622026 350085136 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453992 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H21N5O2/c1-20(16-13-2-3-17-15(13)18-9-19-16)12-4-10-6-21(14(23)8-22)7-11(10)5-12/h2-3,9-12,22H,4-8H2,1H3,(H,17,18,19) CLHWMUKWBSGCJU-UHFFFAOYSA-N 260453 US9527851, 6::US9527851, example 112::US10428074, Example 6 Tyrosine-protein kinase JAK1 Homo sapiens 5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260453&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71598725 350085137 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453993 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N6O/c1-22(17-14-3-5-19-16(14)20-10-21-17)13-6-11-8-23(9-12(11)7-13)15(24)2-4-18/h3,5,10-13H,2,6-9H2,1H3,(H,19,20,21) UNUNDLREFQLZKK-UHFFFAOYSA-N 260454 US9527851, 8::US9527851, example 8::US10428074, Example 8 Tyrosine-protein kinase JAK1 Homo sapiens 32 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260454&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663998 350085138 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453994 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(C)=O)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H21N5O/c1-10(22)21-7-11-5-13(6-12(11)8-21)20(2)16-14-3-4-17-15(14)18-9-19-16/h3-4,9,11-13H,5-8H2,1-2H3,(H,17,18,19) LZNJEOZXHXMPFY-UHFFFAOYSA-N 260455 US9527851, 11::US9527851, example 11::US10428074, Example 11 Tyrosine-protein kinase JAK1 Homo sapiens 33 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260455&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622164 350085139 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453995 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H23N5O/c1-22(17-15-4-5-19-16(15)20-10-21-17)14-6-12-8-23(9-13(12)7-14)18(24)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,19,20,21) MIBUNWWGWVHSBE-UHFFFAOYSA-N 260456 US9527851, 13::US9527851, example 13::US10428074, Example 13 Tyrosine-protein kinase JAK1 Homo sapiens 30 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260456&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622165 350085140 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453996 CN([C@@H]1C[C@H]2CN(C[C@@]2(C)C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-17-6-12(5-11(17)7-22(9-17)14(24)8-23)21(2)16-13-3-4-18-15(13)19-10-20-16/h3-4,10-12,23H,5-9H2,1-2H3,(H,18,19,20) WAFFPCVUEMWXCM-UHFFFAOYSA-N 260457 US9527851, 14 Tyrosine-protein kinase JAK1 Homo sapiens 30 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260457&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89664010 350085141 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453997 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)S(=O)(=O)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2S/c1-21(17-15-4-5-18-16(15)19-10-20-17)13-6-11-8-22(9-12(11)7-13)25(23,24)14-2-3-14/h4-5,10-14H,2-3,6-9H2,1H3,(H,18,19,20) VVSRXURBCPALRE-UHFFFAOYSA-N 260458 US9527851, 15::US9527851, example 15::US10428074, Example 15 Tyrosine-protein kinase JAK1 Homo sapiens 80 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260458&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622166 350085142 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453998 C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260459 US9527851, 17::US9527851, example 17::US10428074, Example 17 Tyrosine-protein kinase JAK1 Homo sapiens 0.2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260459&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622168 350085143 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 453999 COCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(17-14-3-4-18-16(14)19-10-20-17)13-5-11-7-22(8-12(11)6-13)15(23)9-24-2/h3-4,10-13H,5-9H2,1-2H3,(H,18,19,20) GJOIVZIGZBMCIC-UHFFFAOYSA-N 260460 US9527851, 18::US9527851, example 18::US10428074, Example 18 Tyrosine-protein kinase JAK1 Homo sapiens 49 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260460&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663955 350085144 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454000 C[C@@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260461 US9527851, 19::US9527851, example 19::US10428074, Example 19 Tyrosine-protein kinase JAK1 Homo sapiens 48 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260461&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663954 350085145 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454001 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H]2CN(C(=O)CNS(C)(=O)=O)C[C@@H]2C1 InChI=1S/C17H24N6O3S/c1-22(17-14-3-4-18-16(14)19-10-20-17)13-5-11-8-23(9-12(11)6-13)15(24)7-21-27(2,25)26/h3-4,10-13,21H,5-9H2,1-2H3,(H,18,19,20) SLAGBUNQIUBDQL-UHFFFAOYSA-N 260462 US9527851, 21::US9527851, example 21::US10428074, Example 21 Tyrosine-protein kinase JAK1 Homo sapiens 17 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260462&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622297 350085146 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454002 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-4-6-20-17(15)21-11-22-18)14-7-12-9-24(10-13(12)8-14)16(25)3-2-5-19/h4,6,11-14H,2-3,7-10H2,1H3,(H,20,21,22) AVTGDSQGKFZTQR-UHFFFAOYSA-N 260463 US9527851, 22::US9527851, example 22::US10428074, Example 22 Tyrosine-protein kinase JAK1 Homo sapiens 16 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260463&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71623000 350085147 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454003 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H21N5O2/c1-20(16-13-2-3-17-15(13)18-9-19-16)12-4-10-6-21(14(23)8-22)7-11(10)5-12/h2-3,9-12,22H,4-8H2,1H3,(H,17,18,19) CLHWMUKWBSGCJU-UHFFFAOYSA-N 260464 US9527851, 23::US10428074, Example 23 Tyrosine-protein kinase JAK1 Homo sapiens 21 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260464 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260464&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71598725 350085148 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454004 COC(=O)CN1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(17-14-3-4-18-16(14)19-10-20-17)13-5-11-7-22(8-12(11)6-13)9-15(23)24-2/h3-4,10-13H,5-9H2,1-2H3,(H,18,19,20) OEZLLEKHYIIGCT-UHFFFAOYSA-N 260465 US9527851, 24::US9527851, example 24::US10428074, Example 24 Tyrosine-protein kinase JAK1 Homo sapiens 13 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260465&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89664090 350085149 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454005 CN([C@@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20) VNVPUFSPTOLWEW-UHFFFAOYSA-N 260466 US9527851, 26::US9527851, example 26::US10428074, Example 26 Tyrosine-protein kinase JAK1 Homo sapiens 46 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260466 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260466&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622028 350085150 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454006 CN([C@@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H22N6/c1-22(17-15-3-5-19-16(15)20-11-21-17)14-7-12-9-23(6-2-4-18)10-13(12)8-14/h3,5,11-14H,2,6-10H2,1H3,(H,19,20,21) XPIZAVXMVAKCMR-UHFFFAOYSA-N 260467 US9527851, 27::US9527851, example 27::US10428074, Example 27 Tyrosine-protein kinase JAK1 Homo sapiens 30 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260467 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260467&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663968 350085151 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454007 COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27) DNBCBAXDWNDRNO-UHFFFAOYSA-N 260469 US9527851, 34::US9527851, example 34::US10428074, Example 34 Tyrosine-protein kinase JAK1 Homo sapiens 2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260469 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260469&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622431 350085153 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454008 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O/c1-11(23)22-6-4-12-7-14(8-13(12)9-22)21(2)17-15-3-5-18-16(15)19-10-20-17/h3,5,10,12-14H,4,6-9H2,1-2H3,(H,18,19,20) HAFYTSOEALROHE-UHFFFAOYSA-N 260470 US9527851, 35::US10428074, Example 35 Tyrosine-protein kinase JAK1 Homo sapiens 3 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260470 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260470&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622432 350085154 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454009 COC(=O)N1CC[C@H]2CC(C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(16-14-3-5-18-15(14)19-10-20-16)13-7-11-4-6-22(17(23)24-2)9-12(11)8-13/h3,5,10-13H,4,6-9H2,1-2H3,(H,18,19,20) QCBFFVVAONXLHM-UHFFFAOYSA-N 260471 US9527851, 36::US10428074, Example 36 Tyrosine-protein kinase JAK1 Homo sapiens 25 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260471 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260471&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664377 350085155 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454010 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(17-14-2-4-18-16(14)19-10-20-17)13-6-11-3-5-22(15(24)9-23)8-12(11)7-13/h2,4,10-13,23H,3,5-9H2,1H3,(H,18,19,20) VOFSAPSQHCBZQQ-UHFFFAOYSA-N 260472 US9527851, 37::US9527851, example 37::US10428074, Example 37 Tyrosine-protein kinase JAK1 Homo sapiens 50 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260472&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89664002 350085156 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454011 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-3-6-20-17(15)21-11-22-18)14-8-12-4-7-24(10-13(12)9-14)16(25)2-5-19/h3,6,11-14H,2,4,7-10H2,1H3,(H,20,21,22) NRMPNHBYSBGAQE-UHFFFAOYSA-N 260474 US9527851, 39::US9527851, example 39::US10428074, Example 39 Tyrosine-protein kinase JAK1 Homo sapiens 34 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260474 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260474&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663971 350085158 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454012 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK1 Homo sapiens 98 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454013 CN(c1ncnc2[nH]ccc12)[C@@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260476 US9527851, 41::US9527851, example 41::US10428074, Example 41 Tyrosine-protein kinase JAK1 Homo sapiens 80 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260476 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260476&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663981 350085160 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454014 CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) DUPYAJLEYKVLNZ-UHFFFAOYSA-N 260477 US9527851, 48::US9527851, 121::US9527851, example 48::US10428074, Example 121 Tyrosine-protein kinase JAK1 Homo sapiens 1 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260477&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663982 350085161 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454015 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK1 Homo sapiens 0.2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454016 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8O2S/c1-25(16-13-2-3-19-15(13)20-9-21-16)12-4-10-6-26(7-11(10)5-12)18(28)23-17-22-14(8-27)24-29-17/h2-3,9-12,27H,4-8H2,1H3,(H,19,20,21)(H,22,23,24,28) XLPLHVMZOYBIBG-UHFFFAOYSA-N 260479 US9527851, 50 Tyrosine-protein kinase JAK1 Homo sapiens 0.5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260479 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260479&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622575 350085163 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454017 CN(C1C[C@H]2CN(C[C@H]2C1)S(C)(=O)=O)c1ncnc2[nH]ccc12 |r| InChI=1S/C15H21N5O2S/c1-19(15-13-3-4-16-14(13)17-9-18-15)12-5-10-7-20(23(2,21)22)8-11(10)6-12/h3-4,9-12H,5-8H2,1-2H3,(H,16,17,18) YAOHTFWFQGFDDQ-UHFFFAOYSA-N 260480 US9527851, 51::US9527851, example 51 Tyrosine-protein kinase JAK1 Homo sapiens 100 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260480 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260480&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622712 350085164 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454018 CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20F3N5/c1-23(15-13-2-3-20-14(13)21-9-22-15)12-4-10-6-24(7-11(10)5-12)8-16(17,18)19/h2-3,9-12H,4-8H2,1H3,(H,20,21,22) GMUIAVNHQPVDNZ-UHFFFAOYSA-N 260481 US9527851, 56::US9527851, example 56::US10428074, Example 56 Tyrosine-protein kinase JAK1 Homo sapiens 11 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260481 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260481&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622854 350085165 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454019 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)no1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H21N7O/c1-10-21-17(25-22-10)24-7-11-5-13(6-12(11)8-24)23(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9,11-13H,5-8H2,1-2H3,(H,18,19,20) RVEKSRYFIDXWBN-UHFFFAOYSA-N 260482 US9527851, 61::US9527851, example 61::US10428074, Example 61 Tyrosine-protein kinase JAK1 Homo sapiens 128 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260482 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260482&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622858 350085166 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454020 CN(C1C[C@H]2CN(C[C@H]2C1)c1nc(C)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H21N7S/c1-10-21-17(25-22-10)24-7-11-5-13(6-12(11)8-24)23(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9,11-13H,5-8H2,1-2H3,(H,18,19,20) ZZEBVMRIKZWBTE-UHFFFAOYSA-N 260483 US9527851, 65 Tyrosine-protein kinase JAK1 Homo sapiens 50 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260483 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260483&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622859 350085167 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454021 CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H22N6/c1-22(17-15-3-5-19-16(15)20-11-21-17)14-7-12-9-23(6-2-4-18)10-13(12)8-14/h3,5,11-14H,2,6-10H2,1H3,(H,19,20,21) XPIZAVXMVAKCMR-UHFFFAOYSA-N 260484 US9527851, 68::US9527851, example 68::US10428074, Example 68 Tyrosine-protein kinase JAK1 Homo sapiens 17 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260484 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260484&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663968 350085168 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454022 CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20) VNVPUFSPTOLWEW-UHFFFAOYSA-N 260485 US9527851, 69::US9527851, example 69::US10428074, Example 69 Tyrosine-protein kinase JAK1 Homo sapiens 5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260485 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260485&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622028 350085169 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454023 C[C@H](O)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260486 US9527851, 71::US9527851, example 71::US10428074, Example 71 Tyrosine-protein kinase JAK1 Homo sapiens 36 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260486 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260486&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622168 350085170 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454024 C[C@@H](O)C(=O)N1C[C@@H]2C[C@@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260487 US9527851, 72::US9527851, example 72::US10428074, Example 72 Tyrosine-protein kinase JAK1 Homo sapiens 42 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260487 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260487&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663954 350085171 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454025 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8OS/c1-24(15-13-2-3-18-14(13)19-8-20-15)12-4-10-6-25(7-11(10)5-12)17(26)22-16-23-21-9-27-16/h2-3,8-12H,4-7H2,1H3,(H,18,19,20)(H,22,23,26) XXMRXZSCYMAWAX-UHFFFAOYSA-N 260488 US9527851, 73::US9527851, example 73::US10428074, Example 73 Tyrosine-protein kinase JAK1 Homo sapiens 75 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260488 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260488&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620801 350085172 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454026 COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27) DNBCBAXDWNDRNO-UHFFFAOYSA-N 260489 US9527851, 74::US9527851, example 74::US10428074, Example 74 Tyrosine-protein kinase JAK1 Homo sapiens 4 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260489 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260489&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622431 350085173 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454027 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-4-6-20-17(15)21-11-22-18)14-7-12-9-24(10-13(12)8-14)16(25)3-2-5-19/h4,6,11-14H,2-3,7-10H2,1H3,(H,20,21,22) AVTGDSQGKFZTQR-UHFFFAOYSA-N 260490 US9527851, 75::US9527851, example 75::US10428074, Example 75 Tyrosine-protein kinase JAK1 Homo sapiens 46 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260490 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260490&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71623000 350085174 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454028 CNC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H22N6O/c1-17-16(23)22-7-10-5-12(6-11(10)8-22)21(2)15-13-3-4-18-14(13)19-9-20-15/h3-4,9-12H,5-8H2,1-2H3,(H,17,23)(H,18,19,20) NUZLERKAEBNCHE-UHFFFAOYSA-N 260491 US9527851, 80::US9527851, example 80::US10428074, Example 80 Tyrosine-protein kinase JAK1 Homo sapiens 127 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260491 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260491&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620797 350085175 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454029 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)c1ccccc1)c1ncnc2[nH]ccc12 |r| InChI=1S/C22H25N5O2/c1-26(21-18-7-8-23-20(18)24-13-25-21)17-9-15-11-27(12-16(15)10-17)22(29)19(28)14-5-3-2-4-6-14/h2-8,13,15-17,19,28H,9-12H2,1H3,(H,23,24,25) HGADDVYOWHODOT-UHFFFAOYSA-N 260492 US9527851, 81::US9527851, example 81::US10428074, Example 81 Tyrosine-protein kinase JAK1 Homo sapiens 113 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260492 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260492&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620798 350085176 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454030 CC(C#N)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-11(7-19)18(25)24-8-12-5-14(6-13(12)9-24)23(2)17-15-3-4-20-16(15)21-10-22-17/h3-4,10-14H,5-6,8-9H2,1-2H3,(H,20,21,22) KQYSLSWBRXNMSV-UHFFFAOYSA-N 260493 US9527851, 82::US9527851, example 82::US10428074, Example 82 Tyrosine-protein kinase JAK1 Homo sapiens 49 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260493&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664403 350085177 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454031 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C(C)(C)O)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H25N5O2/c1-18(2,25)17(24)23-8-11-6-13(7-12(11)9-23)22(3)16-14-4-5-19-15(14)20-10-21-16/h4-5,10-13,25H,6-9H2,1-3H3,(H,19,20,21) ODLUWOUQFWZMKZ-UHFFFAOYSA-N 260494 US9527851, 83::US9527851, example 83::US10428074, Example 83 Tyrosine-protein kinase JAK1 Homo sapiens 50 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260494&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620799 350085178 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454032 CCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O/c1-3-15(23)22-8-11-6-13(7-12(11)9-22)21(2)17-14-4-5-18-16(14)19-10-20-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,18,19,20) MNUAUENNCLYYAM-UHFFFAOYSA-N 260495 US9527851, 84::US9527851, example 84::US10428074, Example 84 Tyrosine-protein kinase JAK1 Homo sapiens 73 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260495&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89664107 350085179 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454033 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@@H]2CN(C(=O)Cc3nn[nH]n3)C[C@@H]2C1 InChI=1S/C17H21N9O/c1-25(17-13-2-3-18-16(13)19-9-20-17)12-4-10-7-26(8-11(10)5-12)15(27)6-14-21-23-24-22-14/h2-3,9-12H,4-8H2,1H3,(H,18,19,20)(H,21,22,23,24) QDBOCSLEIBBQTH-UHFFFAOYSA-N 260496 US9527851, 85::US9527851, example 85::US10428074, Example 85 Tyrosine-protein kinase JAK1 Homo sapiens 80 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260496&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620800 350085180 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454034 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8OS/c1-24(15-13-2-3-18-14(13)19-8-20-15)12-4-10-6-25(7-11(10)5-12)17(26)22-16-23-21-9-27-16/h2-3,8-12H,4-7H2,1H3,(H,18,19,20)(H,22,23,26) XXMRXZSCYMAWAX-UHFFFAOYSA-N 260497 US9527851, 86::US9527851, example 86::US10428074, Example 86 Tyrosine-protein kinase JAK1 Homo sapiens 10 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260497&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620801 350085181 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454035 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O3/c1-21(16-13-2-3-18-15(13)19-9-20-16)12-4-10-6-22(7-11(10)5-12)17(25)14(24)8-23/h2-3,9-12,14,23-24H,4-8H2,1H3,(H,18,19,20) OZSJWTSKFVWRDI-UHFFFAOYSA-N 260498 US9527851, 92::US9527851, example 92::US10428074, Example 92 Tyrosine-protein kinase JAK1 Homo sapiens 131 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260498&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664374 350085182 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454036 CC[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H25N5O2/c1-3-15(24)18(25)23-8-11-6-13(7-12(11)9-23)22(2)17-14-4-5-19-16(14)20-10-21-17/h4-5,10-13,15,24H,3,6-9H2,1-2H3,(H,19,20,21) FIVILVSKVOGTKW-UHFFFAOYSA-N 260499 US9527851, 93::US9527851, example 93::US10428074, Example 93 Tyrosine-protein kinase JAK1 Homo sapiens 70 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260499&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71620955 350085183 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454037 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)C(F)(F)F)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20F3N5O2/c1-24(15-12-2-3-21-14(12)22-8-23-15)11-4-9-6-25(7-10(9)5-11)16(27)13(26)17(18,19)20/h2-3,8-11,13,26H,4-7H2,1H3,(H,21,22,23) VHEXBZQPDPLHEY-UHFFFAOYSA-N 260500 US9527851, 94::US9527851, example 94::US10428074, Example 94 Tyrosine-protein kinase JAK1 Homo sapiens 45 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260500&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664722 350085184 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454038 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C21H28N8O3S/c1-21(2,31)10-32-18-25-19(33-27-18)26-20(30)29-8-12-6-14(7-13(12)9-29)28(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,31H,6-10H2,1-3H3,(H,22,23,24)(H,25,26,27,30) NFXSQEWDYUCEGU-UHFFFAOYSA-N 260502 US9527851, 99 Tyrosine-protein kinase JAK1 Homo sapiens 0.3 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260502&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621112 350085186 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454039 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1ccn(C)n1)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H24N8O/c1-25-6-4-16(24-25)23-19(28)27-9-12-7-14(8-13(12)10-27)26(2)18-15-3-5-20-17(15)21-11-22-18/h3-6,11-14H,7-10H2,1-2H3,(H,20,21,22)(H,23,24,28) GVHHFMXXJVNLQR-UHFFFAOYSA-N 260503 US9527851, 104::US9527851, example 104::US10428074, Example 104 Tyrosine-protein kinase JAK1 Homo sapiens 109 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260503&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621272 350085187 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454040 COc1cncc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)c1 |r| InChI=1S/C21H25N7O2/c1-27(20-18-3-4-23-19(18)24-12-25-20)16-5-13-10-28(11-14(13)6-16)21(29)26-15-7-17(30-2)9-22-8-15/h3-4,7-9,12-14,16H,5-6,10-11H2,1-2H3,(H,26,29)(H,23,24,25) VOSKEUBOYCKUIS-UHFFFAOYSA-N 260504 US9527851, 109::US9527851, example 109::US10428074, Example 109 Tyrosine-protein kinase JAK1 Homo sapiens 15 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260504&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621275 350085188 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454041 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20F3N5O2/c1-24(15-13-2-3-21-14(13)22-9-23-15)12-4-10-6-25(7-11(10)5-12)16(26)27-8-17(18,19)20/h2-3,9-12H,4-8H2,1H3,(H,21,22,23) IBQMTPXNTWEHOG-UHFFFAOYSA-N 260505 US9527851, 111::US9527851, example 111::US10428074, Example 111 Tyrosine-protein kinase JAK1 Homo sapiens 96 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260505&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664504 350085189 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454042 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ccnc2[nH]ccc12 |r| InChI=1S/C17H22N4O2/c1-20(15-3-5-19-17-14(15)2-4-18-17)13-6-11-8-21(16(23)10-22)9-12(11)7-13/h2-5,11-13,22H,6-10H2,1H3,(H,18,19) HCNHXHKICFVHAT-UHFFFAOYSA-N 260506 US9527851, 112::US10428074, Example 112 Tyrosine-protein kinase JAK1 Homo sapiens 96 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260506&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664625 350085190 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454043 COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1 |r| InChI=1S/C19H23N7O2S/c1-25(15-4-6-21-16-14(15)3-5-20-16)13-7-11-9-26(10-12(11)8-13)19(27)23-18-22-17(28-2)24-29-18/h3-6,11-13H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27) QZZCHXWNBVIWLJ-UHFFFAOYSA-N 260507 US9527851, 113::US9527851, example 113 Tyrosine-protein kinase JAK1 Homo sapiens 23 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260507&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664531 350085191 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454044 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r| InChI=1S/C19H23N7OS/c1-11-22-18(28-24-11)23-19(27)26-9-12-7-14(8-13(12)10-26)25(2)16-4-6-21-17-15(16)3-5-20-17/h3-6,12-14H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27) WWBABDLTQYBIOH-UHFFFAOYSA-N 260508 US9527851, 114::US9527851, example 114::US10428074, Example 114 Tyrosine-protein kinase JAK1 Homo sapiens 2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260508&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664651 350085192 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454045 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1ncc(C)s1)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H23N7OS/c1-11-7-21-18(28-11)24-19(27)26-8-12-5-14(6-13(12)9-26)25(2)17-15-3-4-20-16(15)22-10-23-17/h3-4,7,10,12-14H,5-6,8-9H2,1-2H3,(H,20,22,23)(H,21,24,27) FDHDRPONTSJJEV-UHFFFAOYSA-N 260509 US9527851, 117::US9527851, example 117::US10428074, Example 117 Tyrosine-protein kinase JAK1 Homo sapiens 95 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260509&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664546 350085193 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454046 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1cc(C)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H23N7OS/c1-11-5-16(28-24-11)23-19(27)26-8-12-6-14(7-13(12)9-26)25(2)18-15-3-4-20-17(15)21-10-22-18/h3-5,10,12-14H,6-9H2,1-2H3,(H,23,27)(H,20,21,22) XMCHONPILHYMKN-UHFFFAOYSA-N 260510 US9527851, 119::US9527851, example 119::US10428074, Example 119 Tyrosine-protein kinase JAK1 Homo sapiens 48 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260510&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664459 350085194 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454047 CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) DUPYAJLEYKVLNZ-UHFFFAOYSA-N 260477 US9527851, 48::US9527851, 121::US9527851, example 48::US10428074, Example 121 Tyrosine-protein kinase JAK1 Homo sapiens 1 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260477&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89663982 350085161 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454048 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1cnc(C)s1)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H23N7OS/c1-11-21-7-16(28-11)24-19(27)26-8-12-5-14(6-13(12)9-26)25(2)18-15-3-4-20-17(15)22-10-23-18/h3-4,7,10,12-14H,5-6,8-9H2,1-2H3,(H,24,27)(H,20,22,23) AVKQKMUOFLVZST-UHFFFAOYSA-N 260512 US9527851, 124::US9527851, example 124::US10428074, Example 124 Tyrosine-protein kinase JAK1 Homo sapiens 119 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260512&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 89664057 350085195 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454049 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK1 Homo sapiens 0.2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454050 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r| InChI=1S/C16H20FN5O2/c1-21(16-14-12(17)4-18-15(14)19-8-20-16)11-2-9-5-22(13(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20) RIJLZDQWJHPXCL-UHFFFAOYSA-N 260514 US9527851, 128::US9527851, example 128 Tyrosine-protein kinase JAK1 Homo sapiens 13 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260514&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621433 350085196 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454051 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]c(F)cc12 |r| InChI=1S/C16H20FN5O2/c1-21(16-12-4-13(17)20-15(12)18-8-19-16)11-2-9-5-22(14(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20) SBFNBKVGMWHRJC-UHFFFAOYSA-N 260515 US9527851, 129::US9527851, example 129::US10428074, Example 129 Tyrosine-protein kinase JAK1 Homo sapiens 36 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260515&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622029 350085197 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454052 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK1 Homo sapiens 1 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454053 CN(c1ncnc2[nH]ccc12)C1CC2CNC(=O)CC2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260520 US9527851, 148::US9527851, example 148 Tyrosine-protein kinase JAK1 Homo sapiens 8 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260520&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 78137542 350085201 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454054 CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8OS/c1-25(16-14-2-4-19-15(14)20-9-21-16)13-6-11-3-5-26(8-12(11)7-13)18(27)23-17-24-22-10-28-17/h2,4,9-13H,3,5-8H2,1H3,(H,19,20,21)(H,23,24,27) VSMVCHIPOZPGRW-UHFFFAOYSA-N 260521 US9527851, 150::US9527851, example 150::US10428074, Example 150 Tyrosine-protein kinase JAK1 Homo sapiens 40 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260521&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664622 350085202 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454055 CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H27N5O/c1-12(2)19(25)24-7-5-13-8-15(9-14(13)10-24)23(3)18-16-4-6-20-17(16)21-11-22-18/h4,6,11-15H,5,7-10H2,1-3H3,(H,20,21,22) XNZFHURSGUMHJP-UHFFFAOYSA-N 260522 US9527851, 151::US9527851, example 151::US10428074, Example 151 Tyrosine-protein kinase JAK1 Homo sapiens 106 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260522&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 117664709 350085203 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454056 COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)17(27)22-16-23-24-18(28-2)29-16/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,27) ZAZOCQNHEOUPIF-UHFFFAOYSA-N 260523 US9527851, 155::US9527851, example 155 Tyrosine-protein kinase JAK1 Homo sapiens 4 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260523&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621752 350085204 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454057 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(O)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8O2S/c1-24(14-12-2-3-18-13(12)19-8-20-14)11-4-9-6-25(7-10(9)5-11)17(27)22-16-21-15(26)23-28-16/h2-3,8-11H,4-7H2,1H3,(H,18,19,20)(H2,21,22,23,26,27) UOPZLJPIFNKDDV-UHFFFAOYSA-N 260524 US9527851, 156::US9527851, example 156 Tyrosine-protein kinase JAK1 Homo sapiens 171 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803680 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4917&target=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260524&enzyme=Tyrosine-protein+kinase+JAK1&column=ki&startPg=0&Increment=50&submit=Search 71621886 350085205 1 MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 5L04,5IXI,5IXD,6SMB,6SM8,6ELR,8S85,6RSH,6RSE,6RSD,6RSC,6RSB,6N7D,6N7C,6N7B,6N7A,6N79,6N78,6N77,6HZU,5WO4,5HX8,4K77,4K6Z,4IVD,4IVC,4IVB,4I5C,4FK6,4EI4,4EHZ,4E5W,4E4N,4E4L,6GGH,6TPF,6TPE,6AAH,5E1E,3EYH,3EYG Tyrosine-protein kinase JAK1 JAK1_HUMAN P23458 Q59GQ2 Q9UD26 454058 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H21N5O2/c1-20(16-13-2-3-17-15(13)18-9-19-16)12-4-10-6-21(14(23)8-22)7-11(10)5-12/h2-3,9-12,22H,4-8H2,1H3,(H,17,18,19) CLHWMUKWBSGCJU-UHFFFAOYSA-N 260453 US9527851, 6::US9527851, example 112::US10428074, Example 6 Tyrosine-protein kinase JAK2 Homo sapiens 45 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260453&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71598725 350085137 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454059 C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260459 US9527851, 17::US9527851, example 17::US10428074, Example 17 Tyrosine-protein kinase JAK2 Homo sapiens 3 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260459&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622168 350085143 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454060 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-4-6-20-17(15)21-11-22-18)14-7-12-9-24(10-13(12)8-14)16(25)3-2-5-19/h4,6,11-14H,2-3,7-10H2,1H3,(H,20,21,22) AVTGDSQGKFZTQR-UHFFFAOYSA-N 260463 US9527851, 22::US9527851, example 22::US10428074, Example 22 Tyrosine-protein kinase JAK2 Homo sapiens 54 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260463&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71623000 350085147 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454061 COC(=O)CN1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(17-14-3-4-18-16(14)19-10-20-17)13-5-11-7-22(8-12(11)6-13)9-15(23)24-2/h3-4,10-13H,5-9H2,1-2H3,(H,18,19,20) OEZLLEKHYIIGCT-UHFFFAOYSA-N 260465 US9527851, 24::US9527851, example 24::US10428074, Example 24 Tyrosine-protein kinase JAK2 Homo sapiens 77 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260465&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89664090 350085149 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454062 COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27) DNBCBAXDWNDRNO-UHFFFAOYSA-N 260469 US9527851, 34::US9527851, example 34::US10428074, Example 34 Tyrosine-protein kinase JAK2 Homo sapiens 5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260469 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260469&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622431 350085153 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454063 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(C)=O)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O/c1-11(23)22-6-4-12-7-14(8-13(12)9-22)21(2)17-15-3-5-18-16(15)19-10-20-17/h3,5,10,12-14H,4,6-9H2,1-2H3,(H,18,19,20) HAFYTSOEALROHE-UHFFFAOYSA-N 260470 US9527851, 35::US10428074, Example 35 Tyrosine-protein kinase JAK2 Homo sapiens 16 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260470 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260470&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622432 350085154 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454064 COC(=O)N1CC[C@H]2CC(C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(16-14-3-5-18-15(14)19-10-20-16)13-7-11-4-6-22(17(23)24-2)9-12(11)8-13/h3,5,10-13H,4,6-9H2,1-2H3,(H,18,19,20) QCBFFVVAONXLHM-UHFFFAOYSA-N 260471 US9527851, 36::US10428074, Example 36 Tyrosine-protein kinase JAK2 Homo sapiens 75 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260471 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260471&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664377 350085155 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454065 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-21(17-14-2-4-18-16(14)19-10-20-17)13-6-11-3-5-22(15(24)9-23)8-12(11)7-13/h2,4,10-13,23H,3,5-9H2,1H3,(H,18,19,20) VOFSAPSQHCBZQQ-UHFFFAOYSA-N 260472 US9527851, 37::US9527851, example 37::US10428074, Example 37 Tyrosine-protein kinase JAK2 Homo sapiens 72 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260472&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89664002 350085156 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454066 COc1nsc(NC(=O)N2CC[C@H]3CC(N(C)c4ncnc5[nH]ccc45)C[C@H]3C2)n1 InChI=1S/C19H24N8O2S/c1-26(16-14-3-5-20-15(14)21-10-22-16)13-7-11-4-6-27(9-12(11)8-13)19(28)24-18-23-17(29-2)25-30-18/h3,5,10-13H,4,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) MYAXCRKJBHAHBC-UHFFFAOYSA-N 260473 US9527851, 38::US9527851, example 38::US10428074, Example 38 Tyrosine-protein kinase JAK2 Homo sapiens 7 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260473 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260473&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622433 350085157 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454067 CN(C1C[C@@H]2CCN(C[C@@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-3-6-20-17(15)21-11-22-18)14-8-12-4-7-24(10-13(12)9-14)16(25)2-5-19/h3,6,11-14H,2,4,7-10H2,1H3,(H,20,21,22) NRMPNHBYSBGAQE-UHFFFAOYSA-N 260474 US9527851, 39::US9527851, example 39::US10428074, Example 39 Tyrosine-protein kinase JAK2 Homo sapiens 113 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260474 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260474&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89663971 350085158 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454068 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK2 Homo sapiens 23 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454069 CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) DUPYAJLEYKVLNZ-UHFFFAOYSA-N 260477 US9527851, 48::US9527851, 121::US9527851, example 48::US10428074, Example 121 Tyrosine-protein kinase JAK2 Homo sapiens 31 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260477&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89663982 350085161 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454070 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK2 Homo sapiens 14 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454071 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8O2S/c1-25(16-13-2-3-19-15(13)20-9-21-16)12-4-10-6-26(7-11(10)5-12)18(28)23-17-22-14(8-27)24-29-17/h2-3,9-12,27H,4-8H2,1H3,(H,19,20,21)(H,22,23,24,28) XLPLHVMZOYBIBG-UHFFFAOYSA-N 260479 US9527851, 50 Tyrosine-protein kinase JAK2 Homo sapiens 7 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260479 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260479&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622575 350085163 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454072 CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20F3N5/c1-23(15-13-2-3-20-14(13)21-9-22-15)12-4-10-6-24(7-11(10)5-12)8-16(17,18)19/h2-3,9-12H,4-8H2,1H3,(H,20,21,22) GMUIAVNHQPVDNZ-UHFFFAOYSA-N 260481 US9527851, 56::US9527851, example 56::US10428074, Example 56 Tyrosine-protein kinase JAK2 Homo sapiens 32 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260481 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260481&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622854 350085165 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454073 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)c1nc(C)no1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H21N7O/c1-10-21-17(25-22-10)24-7-11-5-13(6-12(11)8-24)23(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9,11-13H,5-8H2,1-2H3,(H,18,19,20) RVEKSRYFIDXWBN-UHFFFAOYSA-N 260482 US9527851, 61::US9527851, example 61::US10428074, Example 61 Tyrosine-protein kinase JAK2 Homo sapiens 25 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260482 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260482&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622858 350085166 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454074 CN(C1C[C@H]2CN(C[C@H]2C1)c1nc(C)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H21N7S/c1-10-21-17(25-22-10)24-7-11-5-13(6-12(11)8-24)23(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9,11-13H,5-8H2,1-2H3,(H,18,19,20) ZZEBVMRIKZWBTE-UHFFFAOYSA-N 260483 US9527851, 65 Tyrosine-protein kinase JAK2 Homo sapiens 179 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260483 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260483&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622859 350085167 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454075 CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H22N6/c1-22(17-15-3-5-19-16(15)20-11-21-17)14-7-12-9-23(6-2-4-18)10-13(12)8-14/h3,5,11-14H,2,6-10H2,1H3,(H,19,20,21) XPIZAVXMVAKCMR-UHFFFAOYSA-N 260484 US9527851, 68::US9527851, example 68::US10428074, Example 68 Tyrosine-protein kinase JAK2 Homo sapiens 18 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260484 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260484&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89663968 350085168 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454076 CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20) VNVPUFSPTOLWEW-UHFFFAOYSA-N 260485 US9527851, 69::US9527851, example 69::US10428074, Example 69 Tyrosine-protein kinase JAK2 Homo sapiens 4 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260485 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260485&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622028 350085169 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454077 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8OS/c1-24(15-13-2-3-18-14(13)19-8-20-15)12-4-10-6-25(7-11(10)5-12)17(26)22-16-23-21-9-27-16/h2-3,8-12H,4-7H2,1H3,(H,18,19,20)(H,22,23,26) XXMRXZSCYMAWAX-UHFFFAOYSA-N 260488 US9527851, 73::US9527851, example 73::US10428074, Example 73 Tyrosine-protein kinase JAK2 Homo sapiens 47 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260488 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260488&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71620801 350085172 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454078 COc1nsc(NC(=O)N2C[C@@H]3C[C@@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)18(27)23-17-22-16(28-2)24-29-17/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,24,27) DNBCBAXDWNDRNO-UHFFFAOYSA-N 260489 US9527851, 74::US9527851, example 74::US10428074, Example 74 Tyrosine-protein kinase JAK2 Homo sapiens 56 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260489 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260489&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622431 350085173 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454079 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CCC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N6O/c1-23(18-15-4-6-20-17(15)21-11-22-18)14-7-12-9-24(10-13(12)8-14)16(25)3-2-5-19/h4,6,11-14H,2-3,7-10H2,1H3,(H,20,21,22) AVTGDSQGKFZTQR-UHFFFAOYSA-N 260490 US9527851, 75::US9527851, example 75::US10428074, Example 75 Tyrosine-protein kinase JAK2 Homo sapiens 156 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260490 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260490&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71623000 350085174 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454080 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8OS/c1-24(15-13-2-3-18-14(13)19-8-20-15)12-4-10-6-25(7-11(10)5-12)17(26)22-16-23-21-9-27-16/h2-3,8-12H,4-7H2,1H3,(H,18,19,20)(H,22,23,26) XXMRXZSCYMAWAX-UHFFFAOYSA-N 260497 US9527851, 86::US9527851, example 86::US10428074, Example 86 Tyrosine-protein kinase JAK2 Homo sapiens 52 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260497&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71620801 350085181 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454081 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)[C@H](O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O3/c1-21(16-13-2-3-18-15(13)19-9-20-16)12-4-10-6-22(7-11(10)5-12)17(25)14(24)8-23/h2-3,9-12,14,23-24H,4-8H2,1H3,(H,18,19,20) OZSJWTSKFVWRDI-UHFFFAOYSA-N 260498 US9527851, 92::US9527851, example 92::US10428074, Example 92 Tyrosine-protein kinase JAK2 Homo sapiens 203 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260498&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664374 350085182 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454082 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C21H28N8O3S/c1-21(2,31)10-32-18-25-19(33-27-18)26-20(30)29-8-12-6-14(7-13(12)9-29)28(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,31H,6-10H2,1-3H3,(H,22,23,24)(H,25,26,27,30) NFXSQEWDYUCEGU-UHFFFAOYSA-N 260502 US9527851, 99 Tyrosine-protein kinase JAK2 Homo sapiens 5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260502&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71621112 350085186 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454083 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20F3N5O2/c1-24(15-13-2-3-21-14(13)22-9-23-15)12-4-10-6-25(7-11(10)5-12)16(26)27-8-17(18,19)20/h2-3,9-12H,4-8H2,1H3,(H,21,22,23) IBQMTPXNTWEHOG-UHFFFAOYSA-N 260505 US9527851, 111::US9527851, example 111::US10428074, Example 111 Tyrosine-protein kinase JAK2 Homo sapiens 146 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260505&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664504 350085189 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454084 COc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ccnc3[nH]ccc23)n1 |r| InChI=1S/C19H23N7O2S/c1-25(15-4-6-21-16-14(15)3-5-20-16)13-7-11-9-26(10-12(11)8-13)19(27)23-18-22-17(28-2)24-29-18/h3-6,11-13H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27) QZZCHXWNBVIWLJ-UHFFFAOYSA-N 260507 US9527851, 113::US9527851, example 113 Tyrosine-protein kinase JAK2 Homo sapiens 178 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260507&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664531 350085191 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454085 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(C)ns1)c1ccnc2[nH]ccc12 |r| InChI=1S/C19H23N7OS/c1-11-22-18(28-24-11)23-19(27)26-9-12-7-14(8-13(12)10-26)25(2)16-4-6-21-17-15(16)3-5-20-17/h3-6,12-14H,7-10H2,1-2H3,(H,20,21)(H,22,23,24,27) WWBABDLTQYBIOH-UHFFFAOYSA-N 260508 US9527851, 114::US9527851, example 114::US10428074, Example 114 Tyrosine-protein kinase JAK2 Homo sapiens 140 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260508&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664651 350085192 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454086 CCc1nsc(NC(=O)N2C[C@@H]3C[C@H](C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)n1 |r| InChI=1S/C19H24N8OS/c1-3-15-23-18(29-25-15)24-19(28)27-8-11-6-13(7-12(11)9-27)26(2)17-14-4-5-20-16(14)21-10-22-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) DUPYAJLEYKVLNZ-UHFFFAOYSA-N 260477 US9527851, 48::US9527851, 121::US9527851, example 48::US10428074, Example 121 Tyrosine-protein kinase JAK2 Homo sapiens 31 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260477&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 89663982 350085161 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454087 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK2 Homo sapiens 14 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454088 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r| InChI=1S/C16H20FN5O2/c1-21(16-14-12(17)4-18-15(14)19-8-20-16)11-2-9-5-22(13(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20) RIJLZDQWJHPXCL-UHFFFAOYSA-N 260514 US9527851, 128::US9527851, example 128 Tyrosine-protein kinase JAK2 Homo sapiens 196 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260514&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71621433 350085196 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454089 COC(=O)CN1C[C@H]2[C@H](CN(C)c3ncnc4[nH]ccc34)[C@H]2C1 |r| InChI=1S/C16H21N5O2/c1-20(16-10-3-4-17-15(10)18-9-19-16)5-11-12-6-21(7-13(11)12)8-14(22)23-2/h3-4,9,11-13H,5-8H2,1-2H3,(H,17,18,19) RHXOALWZLULAHC-UHFFFAOYSA-N 260517 US9527851, 134::US9527851, example 134::US10428074, Example 134 Tyrosine-protein kinase JAK2 Homo sapiens 60 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260517&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664627 350085199 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454090 CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H21N5O/c1-21(16-11-4-5-18-15(11)19-9-20-16)6-12-13-7-22(8-14(12)13)17(23)10-2-3-10/h4-5,9-10,12-14H,2-3,6-8H2,1H3,(H,18,19,20) LEGXQCPXWHJLGW-UHFFFAOYSA-N 260518 US9527851, 135::US9527851, example 135::US10428074, Example 135 Tyrosine-protein kinase JAK2 Homo sapiens 2 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260518&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71621587 350085200 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454091 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK2 Homo sapiens 5 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454092 CN(c1ncnc2[nH]ccc12)C1CC2CNC(=O)CC2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260520 US9527851, 148::US9527851, example 148 Tyrosine-protein kinase JAK2 Homo sapiens 23 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260520&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 78137542 350085201 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454093 CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8OS/c1-25(16-14-2-4-19-15(14)20-9-21-16)13-6-11-3-5-26(8-12(11)7-13)18(27)23-17-24-22-10-28-17/h2,4,9-13H,3,5-8H2,1H3,(H,19,20,21)(H,23,24,27) VSMVCHIPOZPGRW-UHFFFAOYSA-N 260521 US9527851, 150::US9527851, example 150::US10428074, Example 150 Tyrosine-protein kinase JAK2 Homo sapiens 23 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260521&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664622 350085202 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454094 CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H27N5O/c1-12(2)19(25)24-7-5-13-8-15(9-14(13)10-24)23(3)18-16-4-6-20-17(16)21-11-22-18/h4,6,11-15H,5,7-10H2,1-3H3,(H,20,21,22) XNZFHURSGUMHJP-UHFFFAOYSA-N 260522 US9527851, 151::US9527851, example 151::US10428074, Example 151 Tyrosine-protein kinase JAK2 Homo sapiens 127 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260522&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 117664709 350085203 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454095 COc1nnc(NC(=O)N2C[C@@H]3CC(C[C@@H]3C2)N(C)c2ncnc3[nH]ccc23)s1 |r| InChI=1S/C18H22N8O2S/c1-25(15-13-3-4-19-14(13)20-9-21-15)12-5-10-7-26(8-11(10)6-12)17(27)22-16-23-24-18(28-2)29-16/h3-4,9-12H,5-8H2,1-2H3,(H,19,20,21)(H,22,23,27) ZAZOCQNHEOUPIF-UHFFFAOYSA-N 260523 US9527851, 155::US9527851, example 155 Tyrosine-protein kinase JAK2 Homo sapiens 41 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803681 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4918&target=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260523&enzyme=Tyrosine-protein+kinase+JAK2&column=ki&startPg=0&Increment=50&submit=Search 71621752 350085204 1 MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6E2Q,6E2P,4JIA,4JI9,4IVA,4HGE,6WTQ,6WTP,6WTO,6WTN,4AQC,5AEP,4D1S,4D0X,4D0W,3RVG,3TJD,3TJC,7REE,7LL4,5CF6,5CF5,5CF4,4ZIM,5CF8,3Q32,3LPB,3KRR,7LL5,6VSN,6VS3,6VNM,6VNL,6VNK,6VNJ,6VNI,6VNH,6VNG,6VNF,6VNE,6VNC,6VNB,6VN8,6VGL,6DRW,5USY,3E64,3E63,3E62,4P7E,3FUP,2B7A,3KCK,3IOK,3IO7,4YTI,4YTH,4YTF,4YTC,7UYW,3JY9,7F7W Tyrosine-protein kinase JAK2 JAK2_HUMAN O60674 O14636 O75297 454096 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H21N5O2/c1-20(16-13-2-3-17-15(13)18-9-19-16)12-4-10-6-21(14(23)8-22)7-11(10)5-12/h2-3,9-12,22H,4-8H2,1H3,(H,17,18,19) CLHWMUKWBSGCJU-UHFFFAOYSA-N 260453 US9527851, 6::US9527851, example 112::US10428074, Example 6 Tyrosine-protein kinase JAK3 Homo sapiens 11 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260453&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71598725 350085137 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454097 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CC#N)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N6O/c1-22(17-14-3-5-19-16(14)20-10-21-17)13-6-11-8-23(9-12(11)7-13)15(24)2-4-18/h3,5,10-13H,2,6-9H2,1H3,(H,19,20,21) UNUNDLREFQLZKK-UHFFFAOYSA-N 260454 US9527851, 8::US9527851, example 8::US10428074, Example 8 Tyrosine-protein kinase JAK3 Homo sapiens 67 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260454&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 89663998 350085138 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454098 C[C@H](O)C(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O2/c1-10(23)17(24)22-7-11-5-13(6-12(11)8-22)21(2)16-14-3-4-18-15(14)19-9-20-16/h3-4,9-13,23H,5-8H2,1-2H3,(H,18,19,20) IJKKBQHULDYNJO-UHFFFAOYSA-N 260459 US9527851, 17::US9527851, example 17::US10428074, Example 17 Tyrosine-protein kinase JAK3 Homo sapiens 0.3 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260459&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622168 350085143 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454099 CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)CO)c1ncnc2[nH]ccc12 |r| InChI=1S/C15H19N5O2/c1-19(15-9-2-3-16-14(9)17-8-18-15)4-10-11-5-20(6-12(10)11)13(22)7-21/h2-3,8,10-12,21H,4-7H2,1H3,(H,16,17,18) SENRPZGAPAUSPH-UHFFFAOYSA-N 260468 US9527851, 31::US9527851, example 31::US10428074, Example 31 Tyrosine-protein kinase JAK3 Homo sapiens 93 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260468 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260468&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 89663973 350085152 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454100 COc1nsc(NC(=O)N2CC[C@H]3CC(N(C)c4ncnc5[nH]ccc45)C[C@H]3C2)n1 InChI=1S/C19H24N8O2S/c1-26(16-14-3-5-20-15(14)21-10-22-16)13-7-11-4-6-27(9-12(11)8-13)19(28)24-18-23-17(29-2)25-30-18/h3,5,10-13H,4,6-9H2,1-2H3,(H,20,21,22)(H,23,24,25,28) MYAXCRKJBHAHBC-UHFFFAOYSA-N 260473 US9527851, 38::US9527851, example 38::US10428074, Example 38 Tyrosine-protein kinase JAK3 Homo sapiens 40 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260473 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260473&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622433 350085157 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454101 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK3 Homo sapiens 71 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454102 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK3 Homo sapiens 39 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454103 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(CO)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8O2S/c1-25(16-13-2-3-19-15(13)20-9-21-16)12-4-10-6-26(7-11(10)5-12)18(28)23-17-22-14(8-27)24-29-17/h2-3,9-12,27H,4-8H2,1H3,(H,19,20,21)(H,22,23,24,28) XLPLHVMZOYBIBG-UHFFFAOYSA-N 260479 US9527851, 50 Tyrosine-protein kinase JAK3 Homo sapiens 201 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260479 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260479&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622575 350085163 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454104 CN([C@@H]1C[C@H]2CN(CC(F)(F)F)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20F3N5/c1-23(15-13-2-3-20-14(13)21-9-22-15)12-4-10-6-24(7-11(10)5-12)8-16(17,18)19/h2-3,9-12H,4-8H2,1H3,(H,20,21,22) GMUIAVNHQPVDNZ-UHFFFAOYSA-N 260481 US9527851, 56::US9527851, example 56::US10428074, Example 56 Tyrosine-protein kinase JAK3 Homo sapiens 75 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260481 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260481&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622854 350085165 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454105 CN([C@H]1C[C@H]2CN(CCC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H22N6/c1-22(17-15-3-5-19-16(15)20-11-21-17)14-7-12-9-23(6-2-4-18)10-13(12)8-14/h3,5,11-14H,2,6-10H2,1H3,(H,19,20,21) XPIZAVXMVAKCMR-UHFFFAOYSA-N 260484 US9527851, 68::US9527851, example 68::US10428074, Example 68 Tyrosine-protein kinase JAK3 Homo sapiens 43 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260484 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260484&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 89663968 350085168 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454106 CN([C@H]1C[C@H]2CN(CC#N)C[C@H]2C1)c1ncnc2[nH]ccc12 |r| InChI=1S/C16H20N6/c1-21(16-14-2-4-18-15(14)19-10-20-16)13-6-11-8-22(5-3-17)9-12(11)7-13/h2,4,10-13H,5-9H2,1H3,(H,18,19,20) VNVPUFSPTOLWEW-UHFFFAOYSA-N 260485 US9527851, 69::US9527851, example 69::US10428074, Example 69 Tyrosine-protein kinase JAK3 Homo sapiens 20 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260485 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260485&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622028 350085169 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454107 CN([C@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20N8OS/c1-24(15-13-2-3-18-14(13)19-8-20-15)12-4-10-6-25(7-11(10)5-12)17(26)22-16-23-21-9-27-16/h2-3,8-12H,4-7H2,1H3,(H,18,19,20)(H,22,23,26) XXMRXZSCYMAWAX-UHFFFAOYSA-N 260488 US9527851, 73::US9527851, example 73::US10428074, Example 73 Tyrosine-protein kinase JAK3 Homo sapiens 191 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260488 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260488&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71620801 350085172 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454108 CCC(=O)N1C[C@@H]2C[C@H](C[C@@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H23N5O/c1-3-15(23)22-8-11-6-13(7-12(11)9-22)21(2)17-14-4-5-18-16(14)19-10-20-17/h4-5,10-13H,3,6-9H2,1-2H3,(H,18,19,20) MNUAUENNCLYYAM-UHFFFAOYSA-N 260495 US9527851, 84::US9527851, example 84::US10428074, Example 84 Tyrosine-protein kinase JAK3 Homo sapiens 70 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260495&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 89664107 350085179 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454109 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)C(O)C(F)(F)F)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20F3N5O2/c1-24(15-12-2-3-21-14(12)22-8-23-15)11-4-9-6-25(7-10(9)5-11)16(27)13(26)17(18,19)20/h2-3,8-11,13,26H,4-7H2,1H3,(H,21,22,23) VHEXBZQPDPLHEY-UHFFFAOYSA-N 260501 US9527851, 97::US9527851, example 97::US10428074, Example 97 Tyrosine-protein kinase JAK3 Homo sapiens 110 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260501&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71621110 350085185 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454110 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(OCC(C)(C)O)ns1)c1ncnc2[nH]ccc12 |r| InChI=1S/C21H28N8O3S/c1-21(2,31)10-32-18-25-19(33-27-18)26-20(30)29-8-12-6-14(7-13(12)9-29)28(3)17-15-4-5-22-16(15)23-11-24-17/h4-5,11-14,31H,6-10H2,1-3H3,(H,22,23,24)(H,25,26,27,30) NFXSQEWDYUCEGU-UHFFFAOYSA-N 260502 US9527851, 99 Tyrosine-protein kinase JAK3 Homo sapiens 110 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260502&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71621112 350085186 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454111 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)OCC(F)(F)F)c1ncnc2[nH]ccc12 |r| InChI=1S/C17H20F3N5O2/c1-24(15-13-2-3-21-14(13)22-9-23-15)12-4-10-6-25(7-11(10)5-12)16(26)27-8-17(18,19)20/h2-3,9-12H,4-8H2,1H3,(H,21,22,23) IBQMTPXNTWEHOG-UHFFFAOYSA-N 260505 US9527851, 111::US9527851, example 111::US10428074, Example 111 Tyrosine-protein kinase JAK3 Homo sapiens 101 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260505&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 117664504 350085189 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454112 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)Nc1nc(ns1)C1CC1)c1ncnc2[nH]ccc12 |r| InChI=1S/C20H24N8OS/c1-27(18-15-4-5-21-17(15)22-10-23-18)14-6-12-8-28(9-13(12)7-14)20(29)25-19-24-16(26-30-19)11-2-3-11/h4-5,10-14H,2-3,6-9H2,1H3,(H,21,22,23)(H,24,25,26,29) XOBSBAMFSLQBJI-UHFFFAOYSA-N 260478 US9527851, 49::US9527851, 125::US9527851, example 125::US10428074, Example 125 Tyrosine-protein kinase JAK3 Homo sapiens 39 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260478 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260478&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622574 350085162 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454113 CN(C1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]cc(F)c12 |r| InChI=1S/C16H20FN5O2/c1-21(16-14-12(17)4-18-15(14)19-8-20-16)11-2-9-5-22(13(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20) RIJLZDQWJHPXCL-UHFFFAOYSA-N 260514 US9527851, 128::US9527851, example 128 Tyrosine-protein kinase JAK3 Homo sapiens 4 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260514&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71621433 350085196 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454114 CN([C@@H]1C[C@H]2CN(C[C@H]2C1)C(=O)CO)c1ncnc2[nH]c(F)cc12 |r| InChI=1S/C16H20FN5O2/c1-21(16-12-4-13(17)20-15(12)18-8-19-16)11-2-9-5-22(14(24)7-23)6-10(9)3-11/h4,8-11,23H,2-3,5-7H2,1H3,(H,18,19,20) SBFNBKVGMWHRJC-UHFFFAOYSA-N 260515 US9527851, 129::US9527851, example 129::US10428074, Example 129 Tyrosine-protein kinase JAK3 Homo sapiens 17 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260515&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622029 350085197 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454115 CN(C[C@H]1[C@@H]2CN(C[C@H]12)C(=O)OC(C)(C)C)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H25N5O2/c1-18(2,3)25-17(24)23-8-13-12(14(13)9-23)7-22(4)16-11-5-6-19-15(11)20-10-21-16/h5-6,10,12-14H,7-9H2,1-4H3,(H,19,20,21) HTKKIFXNLVVISD-UHFFFAOYSA-N 260516 US9527851, 133::US9527851, example 133::US10428074, Example 133 Tyrosine-protein kinase JAK3 Homo sapiens 90 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260516 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260516&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71621586 350085198 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454116 COC(=O)CN1C[C@H]2[C@H](CN(C)c3ncnc4[nH]ccc34)[C@H]2C1 |r| InChI=1S/C16H21N5O2/c1-20(16-10-3-4-17-15(10)18-9-19-16)5-11-12-6-21(7-13(11)12)8-14(22)23-2/h3-4,9,11-13H,5-8H2,1-2H3,(H,17,18,19) RHXOALWZLULAHC-UHFFFAOYSA-N 260517 US9527851, 134::US9527851, example 134::US10428074, Example 134 Tyrosine-protein kinase JAK3 Homo sapiens 164 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260517&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 117664627 350085199 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454117 CN(c1ncnc2[nH]ccc12)[C@H]1C[C@H]2CNC(=O)C[C@H]2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260475 US9527851, 40::US9527851, 147::US9527851, example 147::US10428074, Example 147 Tyrosine-protein kinase JAK3 Homo sapiens 31 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260475&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 71622434 350085159 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454118 CN(c1ncnc2[nH]ccc12)C1CC2CNC(=O)CC2C1 InChI=1S/C15H19N5O/c1-20(15-12-2-3-16-14(12)18-8-19-15)11-4-9-6-13(21)17-7-10(9)5-11/h2-3,8-11H,4-7H2,1H3,(H,17,21)(H,16,18,19) PJQRHTCLLFABDO-UHFFFAOYSA-N 260520 US9527851, 148::US9527851, example 148 Tyrosine-protein kinase JAK3 Homo sapiens 71 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260520&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 78137542 350085201 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454119 CN([C@@H]1C[C@@H]2CCN(C[C@@H]2C1)C(=O)Nc1nncs1)c1ncnc2[nH]ccc12 |r| InChI=1S/C18H22N8OS/c1-25(16-14-2-4-19-15(14)20-9-21-16)13-6-11-3-5-26(8-12(11)7-13)18(27)23-17-24-22-10-28-17/h2,4,9-13H,3,5-8H2,1H3,(H,19,20,21)(H,23,24,27) VSMVCHIPOZPGRW-UHFFFAOYSA-N 260521 US9527851, 150::US9527851, example 150::US10428074, Example 150 Tyrosine-protein kinase JAK3 Homo sapiens 148 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260521&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 117664622 350085202 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7 454120 CC(C)C(=O)N1CC[C@H]2C[C@H](C[C@H]2C1)N(C)c1ncnc2[nH]ccc12 |r| InChI=1S/C19H27N5O/c1-12(2)19(25)24-7-5-13-8-15(9-14(13)10-24)23(3)18-16-4-6-20-17(16)21-11-22-18/h4,6,11-15H,5,7-10H2,1-3H3,(H,20,21,22) XNZFHURSGUMHJP-UHFFFAOYSA-N 260522 US9527851, 151::US9527851, example 151::US10428074, Example 151 Tyrosine-protein kinase JAK3 Homo sapiens 203 7.3000 27.00 C US Patent 10.7270/Q2HD7TM2 aid1803682 US9527851 Zhang, X; Dong, Q; Liu, B; Zhu, Y; Li, X; Lan, J 12/27/2016 12/4/2017 Jiangsu Hengrui Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260522&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search 117664709 350085203 1 MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS 7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ Tyrosine-protein kinase JAK3 JAK3_HUMAN P52333 Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2 N/A A0A024R7M7