BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 454703 CC1CN(Cc2ccc(C(F)(F)F)nc2)CC1c1nn2c(-c3ccc(F)cc3)ncc2c(=O)[nH]1 InChI=1S/C23H20F4N6O/c1-13-10-32(11-14-2-7-19(28-8-14)23(25,26)27)12-17(13)20-30-22(34)18-9-29-21(33(18)31-20)15-3-5-16(24)6-4-15/h2-9,13,17H,10-12H2,1H3,(H,30,31,34) QTAJYRZFKUSOQF-UHFFFAOYSA-N 247175 US9434733, 7-(4-fluorophenyl)-2-[4-methyl-1-[[6-(trifluoromethyl)-3-pyridyl]methyl]pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-(4-fluorophenyl)-2-[4-methyl-1-[[6-(trifluoromethyl)-3-pyridyl]methyl]pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 86 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247175&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147114 346541722 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454704 COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cn1 InChI=1S/C22H28N6O3/c1-14-11-27(12-15-3-4-19(30-2)23-9-15)13-17(14)20-25-22(29)18-10-24-21(28(18)26-20)16-5-7-31-8-6-16/h3-4,9-10,14,16-17H,5-8,11-13H2,1-2H3,(H,25,26,29) UDRZWJSXNKWGRZ-UHFFFAOYSA-N 247176 US9434733, 2-[1-[(6-methoxy-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(6-methoxy-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 67 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247176&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147115 346541723 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454705 CC1CN(Cc2ccc(C(F)(F)F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C23H26F3N5O2/c1-14-11-30(12-15-2-4-17(5-3-15)23(24,25)26)13-18(14)20-28-22(32)19-10-27-21(31(19)29-20)16-6-8-33-9-7-16/h2-5,10,14,16,18H,6-9,11-13H2,1H3,(H,28,29,32) FUIOBDQCRVPBTK-UHFFFAOYSA-N 247177 US9434733, 2-[4-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 12 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247177&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147116 346541724 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454706 CC1CN(Cc2ccccc2)CC1c1nn2c(C3=CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-18(15)20-24-22(28)19-11-23-21(27(19)25-20)17-7-9-29-10-8-17/h2-7,11,15,18H,8-10,12-14H2,1H3,(H,24,25,28) KZOJNVNGLJDSCN-UHFFFAOYSA-N 247178 US9434733, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3,6-dihydro-2H-pyran-4-yl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 281 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247178&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147117 346541725 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454707 COc1ccc(CN2CC(C)C(c3nn4c(-c5ccc(F)cc5)ncc4c(=O)[nH]3)C2)cn1 InChI=1S/C23H23FN6O2/c1-14-11-29(12-15-3-8-20(32-2)25-9-15)13-18(14)21-27-23(31)19-10-26-22(30(19)28-21)16-4-6-17(24)7-5-16/h3-10,14,18H,11-13H2,1-2H3,(H,27,28,31) ZSDYQHTXSOIATP-UHFFFAOYSA-N 247179 US9434733, 7-(4-fluorophenyl)-2-[1-[(6-methoxy-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-(4-fluorophenyl)-2-[1-[(6-methoxy-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 372 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247179&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147118 346541726 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454708 CC1CN(Cc2ccccc2)CC1c1nn2c(-c3cccnc3)ncc2c(=O)[nH]1 InChI=1S/C22H22N6O/c1-15-12-27(13-16-6-3-2-4-7-16)14-18(15)20-25-22(29)19-11-24-21(28(19)26-20)17-8-5-9-23-10-17/h2-11,15,18H,12-14H2,1H3,(H,25,26,29) QLHVOVBIRWGIOW-UHFFFAOYSA-N 247180 US9434733, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3-pyridyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(3-pyridyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 656 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247180&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147188 346541727 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454709 CC1CN(Cc2ccc(F)cc2F)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25F2N5O2/c1-13-10-28(11-15-2-3-16(23)8-18(15)24)12-17(13)20-26-22(30)19-9-25-21(29(19)27-20)14-4-6-31-7-5-14/h2-3,8-9,13-14,17H,4-7,10-12H2,1H3,(H,26,27,30) WBWZMHGREJELAI-UHFFFAOYSA-N 247181 US9434733, 2-[1-[(2,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(2,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 48 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247181&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147189 346541728 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454710 CC1CN(Cc2ccccc2)CC1c1nn2c(-c3ccc(F)cc3F)ncc2c(=O)[nH]1 InChI=1S/C23H21F2N5O/c1-14-11-29(12-15-5-3-2-4-6-15)13-18(14)21-27-23(31)20-10-26-22(30(20)28-21)17-8-7-16(24)9-19(17)25/h2-10,14,18H,11-13H2,1H3,(H,27,28,31) WJWMVEDBYNDNIU-UHFFFAOYSA-N 247182 US9434733, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(2,4-difluorophenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-(1-benzyl-4-methyl-pyrrolidin-3-yl)-7-(2,4-difluorophenyl)-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 201 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247182&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147192 346541729 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454711 CC1CN(Cc2ccc(OC(F)(F)F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C23H26F3N5O3/c1-14-11-30(12-15-2-4-17(5-3-15)34-23(24,25)26)13-18(14)20-28-22(32)19-10-27-21(31(19)29-20)16-6-8-33-9-7-16/h2-5,10,14,16,18H,6-9,11-13H2,1H3,(H,28,29,32) LJAXHJPWGMYUHE-UHFFFAOYSA-N 247183 US9434733, 2-[4-methyl-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-[[4-(trifluoromethoxy)phenyl]methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 19 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247183&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147193 346541730 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454712 COc1ccc(C2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C21H25N5O3/c1-28-17-4-2-14(3-5-17)16-11-25(12-16)13-19-23-21(27)18-10-22-20(26(18)24-19)15-6-8-29-9-7-15/h2-5,10,15-16H,6-9,11-13H2,1H3,(H,23,24,27) XZWZYGRWUHRALF-UHFFFAOYSA-N 212761 2-[[3-(4-methoxyphenyl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::BDBM247184 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 327 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=212761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=212761&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147268 376069254 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454713 COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)c(Cl)c1 InChI=1S/C23H28ClN5O3/c1-14-11-28(12-16-3-4-17(31-2)9-19(16)24)13-18(14)21-26-23(30)20-10-25-22(29(20)27-21)15-5-7-32-8-6-15/h3-4,9-10,14-15,18H,5-8,11-13H2,1-2H3,(H,26,27,30) YDFZIUUYKZFPCS-UHFFFAOYSA-N 247185 US9434733, 2-[1-[(2-chloro-4-methoxy-phenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(2-chloro-4-methoxy-phenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 41 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247185&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147271 346541732 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454714 CC1CN(Cc2ccc3nccnc3c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C24H27N7O2/c1-15-12-30(13-16-2-3-19-20(10-16)26-7-6-25-19)14-18(15)22-28-24(32)21-11-27-23(31(21)29-22)17-4-8-33-9-5-17/h2-3,6-7,10-11,15,17-18H,4-5,8-9,12-14H2,1H3,(H,28,29,32) OMZYWFZESJTRNA-UHFFFAOYSA-N 247186 US9434733, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(quinoxalin-6-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 24 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247186&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147272 346541733 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454715 O=c1[nH]c(CN2CC(c3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H22FN5O2/c21-16-3-1-13(2-4-16)15-10-25(11-15)12-18-23-20(27)17-9-22-19(26(17)24-18)14-5-7-28-8-6-14/h1-4,9,14-15H,5-8,10-12H2,(H,23,24,27) DSBCTHCYWMGWAX-UHFFFAOYSA-N 247187 US9434733, 2-[[3-(4-fluorophenyl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(4-fluorophenyl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 563 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247187&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147345 346541734 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454716 COc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O3/c1-15-12-27(13-16-3-5-18(30-2)6-4-16)14-19(15)21-25-23(29)20-11-24-22(28(20)26-21)17-7-9-31-10-8-17/h3-6,11,15,17,19H,7-10,12-14H2,1-2H3,(H,25,26,29) KURKKPDBLFUIGX-UHFFFAOYSA-N 247188 US9434733, 2-[1-[(4-methoxyphenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(4-methoxyphenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 49 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247188&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147346 346541735 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454717 CC1CN(Cc2ccncc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C21H26N6O2/c1-14-11-26(12-15-2-6-22-7-3-15)13-17(14)19-24-21(28)18-10-23-20(27(18)25-19)16-4-8-29-9-5-16/h2-3,6-7,10,14,16-17H,4-5,8-9,11-13H2,1H3,(H,24,25,28) AIVONXYKXJSCGV-UHFFFAOYSA-N 247189 US9434733, 2-[4-methyl-1-(4-pyridylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(4-pyridylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 52 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247189&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147347 346541736 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454718 O=c1[nH]c(CN2CC(Oc3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H22FN5O3/c21-14-1-3-15(4-2-14)29-16-10-25(11-16)12-18-23-20(27)17-9-22-19(26(17)24-18)13-5-7-28-8-6-13/h1-4,9,13,16H,5-8,10-12H2,(H,23,24,27) KXXMSVLXMZUNBO-UHFFFAOYSA-N 247190 US9434733, 2-[[3-(4-fluorophenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(4-fluorophenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 80 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247190&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147348 346541737 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454719 CC1CN(Cc2cncnc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C20H25N7O2/c1-13-9-26(10-14-6-21-12-22-7-14)11-16(13)18-24-20(28)17-8-23-19(27(17)25-18)15-2-4-29-5-3-15/h6-8,12-13,15-16H,2-5,9-11H2,1H3,(H,24,25,28) OYBWLFPQGJVVTE-UHFFFAOYSA-N 247191 US9434733, 2-[4-methyl-1-(pyrimidin-5-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(pyrimidin-5-ylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 135 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247191&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147349 346541738 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454720 CCN(CC)c1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C26H36N6O2/c1-4-31(5-2)21-8-6-19(7-9-21)16-30-15-18(3)22(17-30)24-28-26(33)23-14-27-25(32(23)29-24)20-10-12-34-13-11-20/h6-9,14,18,20,22H,4-5,10-13,15-17H2,1-3H3,(H,28,29,33) RXZJKRDLPPHYGF-UHFFFAOYSA-N 247192 US9434733, 2-[1-[[4-(diethylamino)phenyl]methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[[4-(diethylamino)phenyl]methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 13 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247192&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147350 346541739 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454721 CC1CN(Cc2ccco2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C20H25N5O3/c1-13-10-24(11-15-3-2-6-28-15)12-16(13)18-22-20(26)17-9-21-19(25(17)23-18)14-4-7-27-8-5-14/h2-3,6,9,13-14,16H,4-5,7-8,10-12H2,1H3,(H,22,23,26) STGSJKIOOHTCDY-UHFFFAOYSA-N 247193 US9434733, 2-[1-(2-furylmethyl)-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-(2-furylmethyl)-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 25 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247193&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147433 346541740 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454722 C[C@@H]1CN(Cc2ncccn2)C[C@H]1c1nn2c(-c3ccc(F)cc3)ncc2c(=O)[nH]1 InChI=1S/C21H20FN7O/c1-13-10-28(12-18-23-7-2-8-24-18)11-16(13)19-26-21(30)17-9-25-20(29(17)27-19)14-3-5-15(22)6-4-14/h2-9,13,16H,10-12H2,1H3,(H,26,27,30) SJGBDDNPEAVYTF-UHFFFAOYSA-N 247194 US9434733, 7-(4-fluorophenyl)-2-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-(4-fluorophenyl)-2-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 341 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247194&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 131635529 346541741 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454723 CC1CN(Cc2ccc(F)cc2Cl)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25ClFN5O2/c1-13-10-28(11-15-2-3-16(24)8-18(15)23)12-17(13)20-26-22(30)19-9-25-21(29(19)27-20)14-4-6-31-7-5-14/h2-3,8-9,13-14,17H,4-7,10-12H2,1H3,(H,26,27,30) LDKKRBUDFCLKNM-UHFFFAOYSA-N 247195 US9434733, 2-[1-[(2-chloro-4-fluoro-phenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(2-chloro-4-fluoro-phenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 21 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247195&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147436 346541742 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454724 CC1CN(Cc2ccc(N(C)C)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C24H32N6O2/c1-16-13-29(14-17-4-6-19(7-5-17)28(2)3)15-20(16)22-26-24(31)21-12-25-23(30(21)27-22)18-8-10-32-11-9-18/h4-7,12,16,18,20H,8-11,13-15H2,1-3H3,(H,26,27,31) YKQLNRBWAXAMCE-UHFFFAOYSA-N 247196 US9434733, 2-[1-[(4-dimethylaminophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(4-dimethylaminophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 27 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247196&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147437 346541743 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454725 Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O2/c1-15-3-5-17(6-4-15)13-27-12-16(2)19(14-27)21-25-23(29)20-11-24-22(28(20)26-21)18-7-9-30-10-8-18/h3-6,11,16,18-19H,7-10,12-14H2,1-2H3,(H,25,26,29) DEYHKEDGDQQMMT-UHFFFAOYSA-N 247197 US9434733, 2-[4-methyl-1-(p-tolylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(p-tolylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 47 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247197&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147512 346541744 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454726 O=c1[nH]c(COCc2ccccc2)nn2c(C3CCOCC3)ncc12 InChI=1S/C18H20N4O3/c23-18-15-10-19-17(14-6-8-24-9-7-14)22(15)21-16(20-18)12-25-11-13-4-2-1-3-5-13/h1-5,10,14H,6-9,11-12H2,(H,20,21,23) VMVFYPHPPVZXMU-UHFFFAOYSA-N 247198 US9434733, 2-(benzyloxymethyl)-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-(benzyloxymethyl)-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 384 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247198&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147513 346541745 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454727 O=c1[nH]c(CN2CC(Oc3c(F)cccc3F)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H21F2N5O3/c21-14-2-1-3-15(22)18(14)30-13-9-26(10-13)11-17-24-20(28)16-8-23-19(27(16)25-17)12-4-6-29-7-5-12/h1-3,8,12-13H,4-7,9-11H2,(H,24,25,28) XXZNQXDAFQSBNF-UHFFFAOYSA-N 247199 US9434733, 2-[[3-(2,6-difluorophenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(2,6-difluorophenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 155 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247199&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147514 346541746 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454728 CC1CN(CC2CCCCC2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H33N5O2/c1-15-12-26(13-16-5-3-2-4-6-16)14-18(15)20-24-22(28)19-11-23-21(27(19)25-20)17-7-9-29-10-8-17/h11,15-18H,2-10,12-14H2,1H3,(H,24,25,28) ZSUJPDOSWCXSCU-UHFFFAOYSA-N 247200 US9434733, 2-[1-(cyclohexylmethyl)-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-(cyclohexylmethyl)-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 409 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247200&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147515 346541747 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454729 O=c1[nH]c(CN2CC(Oc3ccc(OC(F)(F)F)cc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C21H22F3N5O4/c22-21(23,24)33-15-3-1-14(2-4-15)32-16-10-28(11-16)12-18-26-20(30)17-9-25-19(29(17)27-18)13-5-7-31-8-6-13/h1-4,9,13,16H,5-8,10-12H2,(H,26,27,30) IZNUDVDZMZHEKO-UHFFFAOYSA-N 247201 US9434733, 7-tetrahydropyran-4-yl-2-[[3-[4-(trifluoromethoxy)phenoxy]azetidin-1-yl]methyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-tetrahydropyran-4-yl-2-[[3-[4-(trifluoromethoxy)phenoxy]azetidin-1-yl]methyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 158 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247201&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147516 346541748 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454730 CN(C)c1ccc(C2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H28N6O2/c1-26(2)18-5-3-15(4-6-18)17-12-27(13-17)14-20-24-22(29)19-11-23-21(28(19)25-20)16-7-9-30-10-8-16/h3-6,11,16-17H,7-10,12-14H2,1-2H3,(H,24,25,29) LKFBTVQBUMZDDA-UHFFFAOYSA-N 247202 US9434733, 2-[[3-(4-dimethylaminophenyl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(4-dimethylaminophenyl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 86 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247202&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147517 346541749 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454731 CC1CN(Cc2cccnc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C21H26N6O2/c1-14-11-26(12-15-3-2-6-22-9-15)13-17(14)19-24-21(28)18-10-23-20(27(18)25-19)16-4-7-29-8-5-16/h2-3,6,9-10,14,16-17H,4-5,7-8,11-13H2,1H3,(H,24,25,28) VSTBHVRNMRPFGX-UHFFFAOYSA-N 247203 US9434733, 2-[4-methyl-1-(3-pyridylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-(3-pyridylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 37 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247203&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147585 346541750 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454732 CC1CN(Cc2c(F)cccc2F)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25F2N5O2/c1-13-10-28(12-16-17(23)3-2-4-18(16)24)11-15(13)20-26-22(30)19-9-25-21(29(19)27-20)14-5-7-31-8-6-14/h2-4,9,13-15H,5-8,10-12H2,1H3,(H,26,27,30) NUTHQDRLIDEIHP-UHFFFAOYSA-N 247204 US9434733, 2-[1-[(2,6-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(2,6-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 62 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247204&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147586 346541751 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454733 O=c1[nH]c(CN2CC(Oc3ccccc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H23N5O3/c26-20-17-10-21-19(14-6-8-27-9-7-14)25(17)23-18(22-20)13-24-11-16(12-24)28-15-4-2-1-3-5-15/h1-5,10,14,16H,6-9,11-13H2,(H,22,23,26) BCLAFGSWRBSLAN-UHFFFAOYSA-N 247205 US9434733, 2-[(3-phenoxyazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(3-phenoxyazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 153 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247205&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147587 346541752 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454734 O=c1[nH]c(CN2CC(OCc3ccc(F)cc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C21H24FN5O3/c22-16-3-1-14(2-4-16)13-30-17-10-26(11-17)12-19-24-21(28)18-9-23-20(27(18)25-19)15-5-7-29-8-6-15/h1-4,9,15,17H,5-8,10-13H2,(H,24,25,28) QEJJXMNBAFWGJK-UHFFFAOYSA-N 247206 US9434733, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-[(4-fluorophenyl)methoxy]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US10513524, Compound (P4)::US11608342, Compound (P4)::US20250019381, Compound (P4) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 10 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247206&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147589 346541753 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454735 COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O3/c1-14(26-12-17(13-26)15-3-5-18(29-2)6-4-15)20-24-22(28)19-11-23-21(27(19)25-20)16-7-9-30-10-8-16/h3-6,11,14,16-17H,7-10,12-13H2,1-2H3,(H,24,25,28) ZREJPXVTFHAYCJ-UHFFFAOYSA-N 247207 US9434733, 2-[1-[3-(4-methoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-methoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 47 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247207&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147590 346541754 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454736 Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)o1 InChI=1S/C21H27N5O3/c1-13-10-25(11-16-4-3-14(2)29-16)12-17(13)19-23-21(27)18-9-22-20(26(18)24-19)15-5-7-28-8-6-15/h3-4,9,13,15,17H,5-8,10-12H2,1-2H3,(H,23,24,27) XICIHBUBEUWHBA-UHFFFAOYSA-N 247208 US9434733, 2-[4-methyl-1-[(5-methyl-2-furyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-[(5-methyl-2-furyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 28 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247208&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147655 346541755 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454737 CC1CN(Cc2ccc(Cl)o2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C20H24ClN5O3/c1-12-9-25(10-14-2-3-17(21)29-14)11-15(12)18-23-20(27)16-8-22-19(26(16)24-18)13-4-6-28-7-5-13/h2-3,8,12-13,15H,4-7,9-11H2,1H3,(H,23,24,27) ZSTHLCRVPMHGFU-UHFFFAOYSA-N 247209 US9434733, 2-[1-[(5-chloro-2-furyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(5-chloro-2-furyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 63 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247209&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147656 346541756 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454738 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(F)cc2)C1 InChI=1S/C21H24FN5O2/c1-13(26-11-16(12-26)14-2-4-17(22)5-3-14)19-24-21(28)18-10-23-20(27(18)25-19)15-6-8-29-9-7-15/h2-5,10,13,15-16H,6-9,11-12H2,1H3,(H,24,25,28) ZICYIWODUOLSGV-UHFFFAOYSA-N 247210 US9434733, 2-[1-[3-(4-fluorophenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-fluorophenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 128 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247210&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147658 346541757 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454739 O=c1[nH]c(CN2CC(c3ccccc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H23N5O2/c26-20-17-10-21-19(15-6-8-27-9-7-15)25(17)23-18(22-20)13-24-11-16(12-24)14-4-2-1-3-5-14/h1-5,10,15-16H,6-9,11-13H2,(H,22,23,26) QQDIKKJPVFMTIQ-UHFFFAOYSA-N 247211 US9434733, 2-[(3-phenylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(3-phenylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 208 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247211&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147657 346541758 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454740 Cc1ccc(OC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C21H25N5O3/c1-14-2-4-16(5-3-14)29-17-11-25(12-17)13-19-23-21(27)18-10-22-20(26(18)24-19)15-6-8-28-9-7-15/h2-5,10,15,17H,6-9,11-13H2,1H3,(H,23,24,27) GOZJBFXAXWXYJB-UHFFFAOYSA-N 247212 US9434733, 2-[[3-(4-methylphenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(4-methylphenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 91 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247212&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147659 346541759 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454741 CC1CN(Cc2cncc(F)c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C21H25FN6O2/c1-13-10-27(11-14-6-16(22)8-23-7-14)12-17(13)19-25-21(29)18-9-24-20(28(18)26-19)15-2-4-30-5-3-15/h6-9,13,15,17H,2-5,10-12H2,1H3,(H,25,26,29) AUYUYYDAEJBNSE-UHFFFAOYSA-N 247213 US9434733, 2-[1-[(5-fluoro-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(5-fluoro-3-pyridyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 25 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247213&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147723 346541760 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454742 CC(C)c1ccc(OC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O3/c1-15(2)16-3-5-18(6-4-16)31-19-12-27(13-19)14-21-25-23(29)20-11-24-22(28(20)26-21)17-7-9-30-10-8-17/h3-6,11,15,17,19H,7-10,12-14H2,1-2H3,(H,25,26,29) DRSMGLKHXGBEGS-UHFFFAOYSA-N 247214 US9434733, 2-[[3-(4-isopropylphenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(4-isopropylphenoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 134 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247214&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147726 346541761 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454743 CC1CN(Cc2ccc(F)c(F)c2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25F2N5O2/c1-13-10-28(11-14-2-3-17(23)18(24)8-14)12-16(13)20-26-22(30)19-9-25-21(29(19)27-20)15-4-6-31-7-5-15/h2-3,8-9,13,15-16H,4-7,10-12H2,1H3,(H,26,27,30) BECBIXJSTIGKCD-UHFFFAOYSA-N 247215 US9434733, 2-[1-[(3,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(3,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 23 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247215&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147725 346541762 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454744 CC1CN(Cc2ccc(Cl)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H26ClN5O2/c1-14-11-27(12-15-2-4-17(23)5-3-15)13-18(14)20-25-22(29)19-10-24-21(28(19)26-20)16-6-8-30-9-7-16/h2-5,10,14,16,18H,6-9,11-13H2,1H3,(H,25,26,29) MFVLKKRBSDNESU-UHFFFAOYSA-N 247216 US9434733, 2-[1-[(4-chlorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(4-chlorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 32 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247216&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147727 346541763 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454745 CC1CN(Cc2ccc(N(C)C)nc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C23H31N7O2/c1-15-12-29(13-16-4-5-20(24-10-16)28(2)3)14-18(15)21-26-23(31)19-11-25-22(30(19)27-21)17-6-8-32-9-7-17/h4-5,10-11,15,17-18H,6-9,12-14H2,1-3H3,(H,26,27,31) DRHKCEUMFIJJEQ-UHFFFAOYSA-N 247217 US9434733, 2-[1-[[6-(dimethylamino)-3-pyridyl]methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[[6-(dimethylamino)-3-pyridyl]methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 36 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247217&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147783 346541764 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454746 COC(=O)c1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)s1 InChI=1S/C22H27N5O4S/c1-13-10-26(11-15-3-4-18(32-15)22(29)30-2)12-16(13)19-24-21(28)17-9-23-20(27(17)25-19)14-5-7-31-8-6-14/h3-4,9,13-14,16H,5-8,10-12H2,1-2H3,(H,24,25,28) ZGEBBGQCOLCUSL-UHFFFAOYSA-N 247218 US9434733, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]methyl]thiophene-2-carboxylate::US9533992, methyl 5-[[3-methyl-4-(4-oxo-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-2-yl)pyrrolidin-1-yl]methyl]thiophene-2-carboxylate High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 8 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247218&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78138539 346541765 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454747 O=c1[nH]c(CN2CC(c3ccc(C(F)(F)F)cn3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C20H21F3N6O2/c21-20(22,23)14-1-2-15(24-7-14)13-9-28(10-13)11-17-26-19(30)16-8-25-18(29(16)27-17)12-3-5-31-6-4-12/h1-2,7-8,12-13H,3-6,9-11H2,(H,26,27,30) HMCYSUZCPUZNSN-UHFFFAOYSA-N 247219 US9434733, 7-tetrahydropyran-4-yl-2-[[3-[5-(trifluoromethyl)-2-pyridyl]azetidin-1-yl]methyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-tetrahydropyran-4-yl-2-[[3-[5-(trifluoromethyl)-2-pyridyl]azetidin-1-yl]methyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 560 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247219&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147784 346541766 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454748 O=c1[nH]c(CN2CC(Oc3cccnc3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C19H22N6O3/c26-19-16-9-21-18(13-3-6-27-7-4-13)25(16)23-17(22-19)12-24-10-15(11-24)28-14-2-1-5-20-8-14/h1-2,5,8-9,13,15H,3-4,6-7,10-12H2,(H,22,23,26) QYWRANXKUULQSK-UHFFFAOYSA-N 247220 US9434733, 2-[[3-(3-pyridyloxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(3-pyridyloxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US10513524, Compound (P2) High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 350 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247220&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147785 346541767 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454749 C[C@H]1CN(Cc2ccc(F)cc2F)C[C@@H]1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H25F2N5O2/c1-13-10-28(11-15-2-3-16(23)8-18(15)24)12-17(13)20-26-22(30)19-9-25-21(29(19)27-20)14-4-6-31-7-5-14/h2-3,8-9,13-14,17H,4-7,10-12H2,1H3,(H,26,27,30) WBWZMHGREJELAI-UHFFFAOYSA-N 247221 US9434733, 2-[(3R,4R)-1-[(2,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(3R,4R)-1-[(2,4-difluorophenyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 47 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247221&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 131635530 346541768 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454750 COc1ccc(C2CN([C@H](C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O3/c1-14(26-12-17(13-26)15-3-5-18(29-2)6-4-15)20-24-22(28)19-11-23-21(27(19)25-20)16-7-9-30-10-8-16/h3-6,11,14,16-17H,7-10,12-13H2,1-2H3,(H,24,25,28) ZREJPXVTFHAYCJ-UHFFFAOYSA-N 247222 US9434733, 2-[(1R)-1-[3-(4-methoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(1R)-1-[3-(4-methoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 22 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247222&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 131635531 346541769 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454751 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(Oc2ccc(F)cc2)C1 InChI=1S/C21H24FN5O3/c1-13(26-11-17(12-26)30-16-4-2-15(22)3-5-16)19-24-21(28)18-10-23-20(27(18)25-19)14-6-8-29-9-7-14/h2-5,10,13-14,17H,6-9,11-12H2,1H3,(H,24,25,28) KZLPXQILQVHILX-UHFFFAOYSA-N 247223 US9434733, 2-[1-[3-(4-fluorophenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-fluorophenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 57 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247223&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147838 346541770 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454752 Cc1ccc(CN2CC(C)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)s1 InChI=1S/C21H27N5O2S/c1-13-10-25(11-16-4-3-14(2)29-16)12-17(13)19-23-21(27)18-9-22-20(26(18)24-19)15-5-7-28-8-6-15/h3-4,9,13,15,17H,5-8,10-12H2,1-2H3,(H,23,24,27) UDGAOQCWPFCSNL-UHFFFAOYSA-N 247224 US9434733, 2-[4-methyl-1-[(5-methyl-2-thienyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-[(5-methyl-2-thienyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 22 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247224&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147786 346541771 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454753 CC1CN(Cc2ccc(Cl)s2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C20H24ClN5O2S/c1-12-9-25(10-14-2-3-17(21)29-14)11-15(12)18-23-20(27)16-8-22-19(26(16)24-18)13-4-6-28-7-5-13/h2-3,8,12-13,15H,4-7,9-11H2,1H3,(H,23,24,27) GZSRRVIDDJGCHN-UHFFFAOYSA-N 247225 US9434733, 2-[1-[(5-chloro-2-thienyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(5-chloro-2-thienyl)methyl]-4-methyl-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 13 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247225&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147839 346541772 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454754 CC1CN(Cc2ccc(N3CCCC3)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C26H34N6O2/c1-18-15-30(16-19-4-6-21(7-5-19)31-10-2-3-11-31)17-22(18)24-28-26(33)23-14-27-25(32(23)29-24)20-8-12-34-13-9-20/h4-7,14,18,20,22H,2-3,8-13,15-17H2,1H3,(H,28,29,33) HMHSVENRNQOZMK-UHFFFAOYSA-N 247226 US9434733, 2-[4-methyl-1-[(4-pyrrolidin-1-ylphenyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methyl-1-[(4-pyrrolidin-1-ylphenyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 61 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247226&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147840 346541773 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454755 COC1CN(Cc2ccccc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H27N5O3/c1-29-19-14-26(12-15-5-3-2-4-6-15)13-17(19)20-24-22(28)18-11-23-21(27(18)25-20)16-7-9-30-10-8-16/h2-6,11,16-17,19H,7-10,12-14H2,1H3,(H,24,25,28) AUXNBCWBZMTPRX-UHFFFAOYSA-N 247227 US9434733, 2-(1-benzyl-4-methoxy-pyrrolidin-3-yl)-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-(1-benzyl-4-methoxy-pyrrolidin-3-yl)-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 54 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247227&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147841 346541774 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454756 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(O)cc2)C1 InChI=1S/C21H25N5O3/c1-13(25-11-16(12-25)14-2-4-17(27)5-3-14)19-23-21(28)18-10-22-20(26(18)24-19)15-6-8-29-9-7-15/h2-5,10,13,15-16,27H,6-9,11-12H2,1H3,(H,23,24,28) URMMQAZEDQVFPP-UHFFFAOYSA-N 247228 US9434733, 2-[1-[3-(4-hydroxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-hydroxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 120 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247228&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147843 346541775 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454757 COC1CN(Cc2ccc(F)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C22H26FN5O3/c1-30-19-13-27(11-14-2-4-16(23)5-3-14)12-17(19)20-25-22(29)18-10-24-21(28(18)26-20)15-6-8-31-9-7-15/h2-5,10,15,17,19H,6-9,11-13H2,1H3,(H,25,26,29) FTTKKIPKPPYNRE-UHFFFAOYSA-N 247229 US9434733, 2-[1-[(4-fluorophenyl)methyl]-4-methoxy-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[(4-fluorophenyl)methyl]-4-methoxy-pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 94 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247229&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147911 346541776 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454758 COC1CN(Cc2ccc(C)cc2)CC1c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1 InChI=1S/C23H29N5O3/c1-15-3-5-16(6-4-15)12-27-13-18(20(14-27)30-2)21-25-23(29)19-11-24-22(28(19)26-21)17-7-9-31-10-8-17/h3-6,11,17-18,20H,7-10,12-14H2,1-2H3,(H,25,26,29) JZDLEPJVERNDNL-UHFFFAOYSA-N 247230 US9434733, 2-[4-methoxy-1-(p-tolylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methoxy-1-(p-tolylmethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 90 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247230&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147912 346541777 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454759 Cc1ccc(COC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O3/c1-15-2-4-16(5-3-15)14-30-18-11-26(12-18)13-20-24-22(28)19-10-23-21(27(19)25-20)17-6-8-29-9-7-17/h2-5,10,17-18H,6-9,11-14H2,1H3,(H,24,25,28) FFAUIZNHVTZFHW-UHFFFAOYSA-N 247231 US9434733, 2-[[3-(p-tolylmethoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(p-tolylmethoxy)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 150 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247231&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147913 346541778 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454760 Cc1ccc(OC2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O3/c1-14-3-5-17(6-4-14)30-18-12-26(13-18)15(2)20-24-22(28)19-11-23-21(27(19)25-20)16-7-9-29-10-8-16/h3-6,11,15-16,18H,7-10,12-13H2,1-2H3,(H,24,25,28) JCLOSJGDOIJPMS-UHFFFAOYSA-N 247232 US9434733, 2-[1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 110 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247232&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147915 346541779 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454761 COc1ccc(OCC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O4/c1-29-17-2-4-18(5-3-17)31-14-15-11-26(12-15)13-20-24-22(28)19-10-23-21(27(19)25-20)16-6-8-30-9-7-16/h2-5,10,15-16H,6-9,11-14H2,1H3,(H,24,25,28) OTVJVRRODPXHPJ-UHFFFAOYSA-N 247233 US9434733, 2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 82 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247233&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147978 346541780 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454762 O=c1[nH]c(CN2CC(c3ncccn3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C18H21N7O2/c26-18-14-8-21-17(12-2-6-27-7-3-12)25(14)23-15(22-18)11-24-9-13(10-24)16-19-4-1-5-20-16/h1,4-5,8,12-13H,2-3,6-7,9-11H2,(H,22,23,26) XEFLPTQXULEBHZ-UHFFFAOYSA-N 247234 US9434733, 2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 3400 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247234&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147979 346541781 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454763 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(N3CCCC3)cc2)C1 InChI=1S/C25H32N6O2/c1-17(30-15-20(16-30)18-4-6-21(7-5-18)29-10-2-3-11-29)23-27-25(32)22-14-26-24(31(22)28-23)19-8-12-33-13-9-19/h4-7,14,17,19-20H,2-3,8-13,15-16H2,1H3,(H,27,28,32) FSNXFDJNCMPDLS-UHFFFAOYSA-N 247235 US9434733, 2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 110 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247235&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147980 346541782 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454764 O=c1[nH]c(C2CN(Cc3ccccc3)CC2C(F)(F)F)nn2c(C3CCOCC3)ncc12 InChI=1S/C22H24F3N5O2/c23-22(24,25)17-13-29(11-14-4-2-1-3-5-14)12-16(17)19-27-21(31)18-10-26-20(30(18)28-19)15-6-8-32-9-7-15/h1-5,10,15-17H,6-9,11-13H2,(H,27,28,31) BYOLYWQLPISLQI-UHFFFAOYSA-N 247236 US9434733, 2-[1-benzyl-4-(trifluoromethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-benzyl-4-(trifluoromethyl)pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 50 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247236&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147981 346541783 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454765 O=c1[nH]c(CN2CC(c3ncc(N4CCCC4)cn3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C22H28N8O2/c31-22-18-11-25-21(15-3-7-32-8-4-15)30(18)27-19(26-22)14-28-12-16(13-28)20-23-9-17(10-24-20)29-5-1-2-6-29/h9-11,15-16H,1-8,12-14H2,(H,26,27,31) LYJILQJPMLZUDD-UHFFFAOYSA-N 247237 US9434733, 2-[[3-(5-pyrrolidin-1-ylpyrimidin-2-yl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-(5-pyrrolidin-1-ylpyrimidin-2-yl)azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 120 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247237&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147982 346541784 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454766 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(N(C)C)cc2)C1 InChI=1S/C23H30N6O2/c1-15(28-13-18(14-28)16-4-6-19(7-5-16)27(2)3)21-25-23(30)20-12-24-22(29(20)26-21)17-8-10-31-11-9-17/h4-7,12,15,17-18H,8-11,13-14H2,1-3H3,(H,25,26,30) QBUPOLYZNAIZLK-UHFFFAOYSA-N 247238 US9434733, 2-[1-[3-(4-dimethylaminophenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-dimethylaminophenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 86 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247238&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147983 346541785 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454767 COc1ccc(CN2CC(OC)C(c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O4/c1-30-17-5-3-15(4-6-17)12-27-13-18(20(14-27)31-2)21-25-23(29)19-11-24-22(28(19)26-21)16-7-9-32-10-8-16/h3-6,11,16,18,20H,7-10,12-14H2,1-2H3,(H,25,26,29) ZHTJCCAIYWCLJD-UHFFFAOYSA-N 247239 US9434733, 2-[4-methoxy-1-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[4-methoxy-1-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 83 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247239&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146923 346541786 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454768 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccccc2)C1 InChI=1S/C21H25N5O2/c1-14(25-12-17(13-25)15-5-3-2-4-6-15)19-23-21(27)18-11-22-20(26(18)24-19)16-7-9-28-10-8-16/h2-6,11,14,16-17H,7-10,12-13H2,1H3,(H,23,24,27) FZUKRPWMHZXLKZ-UHFFFAOYSA-N 247240 US9434733, 2-[1-(3-phenylazetidin-1-yl)ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-(3-phenylazetidin-1-yl)ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 360 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247240&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146924 346541787 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454769 COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1F InChI=1S/C22H26FN5O3/c1-13(27-11-16(12-27)15-3-4-19(30-2)17(23)9-15)20-25-22(29)18-10-24-21(28(18)26-20)14-5-7-31-8-6-14/h3-4,9-10,13-14,16H,5-8,11-12H2,1-2H3,(H,25,26,29) LTAJEFJIXFLORZ-UHFFFAOYSA-N 247241 US9434733, 2-[1-[3-(3-fluoro-4-methoxy-phenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(3-fluoro-4-methoxy-phenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 240 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247241&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146925 346541788 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454770 COc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)c(F)c1 InChI=1S/C22H26FN5O3/c1-13(27-11-15(12-27)17-4-3-16(30-2)9-18(17)23)20-25-22(29)19-10-24-21(28(19)26-20)14-5-7-31-8-6-14/h3-4,9-10,13-15H,5-8,11-12H2,1-2H3,(H,25,26,29) WZRIDMZAWURLIK-UHFFFAOYSA-N 247242 US9434733, 2-[1-[3-(2-fluoro-4-methoxy-phenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(2-fluoro-4-methoxy-phenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 300 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247242&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146926 346541789 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454771 CCOc1ccc(C2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O3/c1-3-31-19-6-4-16(5-7-19)18-13-27(14-18)15(2)21-25-23(29)20-12-24-22(28(20)26-21)17-8-10-30-11-9-17/h4-7,12,15,17-18H,3,8-11,13-14H2,1-2H3,(H,25,26,29) OVJMVQAGLLBCOU-UHFFFAOYSA-N 247243 US9434733, 2-[1-[3-(4-ethoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-ethoxyphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 290 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247243&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146927 346541790 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454772 COc1ccc(CC2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C23H29N5O3/c1-15(27-13-17(14-27)11-16-3-5-19(30-2)6-4-16)21-25-23(29)20-12-24-22(28(20)26-21)18-7-9-31-10-8-18/h3-6,12,15,17-18H,7-11,13-14H2,1-2H3,(H,25,26,29) KOOOVKDNLYYFCF-UHFFFAOYSA-N 247244 US9434733, 2-[1-[3-[(4-methoxyphenyl)methyl]azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-[(4-methoxyphenyl)methyl]azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 68 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247244&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146928 346541791 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454773 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(OC(F)(F)F)cc2)C1 InChI=1S/C22H24F3N5O3/c1-13(29-11-16(12-29)14-2-4-17(5-3-14)33-22(23,24)25)19-27-21(31)18-10-26-20(30(18)28-19)15-6-8-32-9-7-15/h2-5,10,13,15-16H,6-9,11-12H2,1H3,(H,27,28,31) HRPJUVMZFQZVSR-UHFFFAOYSA-N 247245 US9434733, 7-tetrahydropyran-4-yl-2-[1-[3-[4-(trifluoromethoxy)phenyl]azetidin-1-yl]ethyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 7-tetrahydropyran-4-yl-2-[1-[3-[4-(trifluoromethoxy)phenyl]azetidin-1-yl]ethyl]-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 210 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247245&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78146998 346541792 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454774 Cc1ccc(OC2CN(C(C)c3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O3/c1-14-3-5-17(6-4-14)30-18-12-26(13-18)15(2)20-24-22(28)19-11-23-21(27(19)25-20)16-7-9-29-10-8-16/h3-6,11,15-16,18H,7-10,12-13H2,1-2H3,(H,24,25,28) JCLOSJGDOIJPMS-UHFFFAOYSA-N 247232 US9434733, 2-[1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-methylphenoxy)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 110 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247232&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147915 346541779 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454775 COc1ccc(OCC2CN(Cc3nn4c(C5CCOCC5)ncc4c(=O)[nH]3)C2)cc1 InChI=1S/C22H27N5O4/c1-29-17-2-4-18(5-3-17)31-14-15-11-26(12-15)13-20-24-22(28)19-10-23-21(27(19)25-20)16-6-8-30-9-7-16/h2-5,10,15-16H,6-9,11-14H2,1H3,(H,24,25,28) OTVJVRRODPXHPJ-UHFFFAOYSA-N 247233 US9434733, 2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[[3-[(4-methoxyphenoxy)methyl]azetidin-1-yl]methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 82 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247233&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147978 346541780 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454776 O=c1[nH]c(CN2CC(c3ncccn3)C2)nn2c(C3CCOCC3)ncc12 InChI=1S/C18H21N7O2/c26-18-14-8-21-17(12-2-6-27-7-3-12)25(14)23-15(22-18)11-24-9-13(10-24)16-19-4-1-5-20-16/h1,4-5,8,12-13H,2-3,6-7,9-11H2,(H,22,23,26) XEFLPTQXULEBHZ-UHFFFAOYSA-N 247234 US9434733, 2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[(3-pyrimidin-2-ylazetidin-1-yl)methyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 3400 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247234&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147979 346541781 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 454777 CC(c1nn2c(C3CCOCC3)ncc2c(=O)[nH]1)N1CC(c2ccc(N3CCCC3)cc2)C1 InChI=1S/C25H32N6O2/c1-17(30-15-20(16-30)18-4-6-21(7-5-18)29-10-2-3-11-29)23-27-25(32)22-14-26-24(31(22)28-23)19-8-12-33-13-9-19/h4-7,14,17,19-20H,2-3,8-13,15-16H2,1H3,(H,27,28,32) FSNXFDJNCMPDLS-UHFFFAOYSA-N 247235 US9434733, 2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one::US9533992, 2-[1-[3-(4-pyrrolidin-1-ylphenyl)azetidin-1-yl]ethyl]-7-tetrahydropyran-4-yl-3H-imidazo[5,1-f][1,2,4]triazin-4-one High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 110 7.6000 25.00 C US Patent 10.7270/Q2QZ28XZ aid1803690 US9533992 Svenstrup, N; Simonsen, KB; Rasmussen, LK; Juhl, K; Langgard, M; Wen, K; Wang, Y 1/3/2017 12/4/2017 H. Lundbeck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=247235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=247235&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 78147980 346541782 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0