BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 956319 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-16(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) YYQPCYCOCBMOQX-UHFFFAOYSA-N 463147 4-Amino-5-(4-chloro-3-hydroxyphenyl)-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 1-A Guanylate cyclase soluble subunit alpha-1 Human 0.095 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463147&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144558 441572998 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956320 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-9-15(29)20(27)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-7-6-31-24(36)16(32-17)8-12-4-2-3-5-14(12)28/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) JAHIJAPKTKOVES-UHFFFAOYSA-N 463148 4-Amino-5-(4-chloro-3-fluoro-5-hydroxyphenyl)-2-{8-[(2-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 2-B Guanylate cyclase soluble subunit alpha-1 Human 0.095 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463148&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144470 441572999 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956321 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C27H19F4N7O2/c1-26(14-6-7-15(19(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)18-12-38-9-8-33-24(38)17(34-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,39H,10H2,1H3,(H3,32,35,36,37,40) MWQKDJBPUXNXJC-UHFFFAOYSA-N 463149 4-Amino-2-{8-[(2-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-[3-hydroxy-4-(trifluoromethyl)phenyl]-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 3-B Guanylate cyclase soluble subunit alpha-1 Human 0.219 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463149&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144401 441573000 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956322 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)13(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37) RYOBYWQXAXYTLE-UHFFFAOYSA-N 463150 4-Amino-5-(5-chloro-4-hydroxypyridin-2-yl)-2-{8-[(2-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 4-B Guanylate cyclase soluble subunit alpha-1 Human 0.259 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463150&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144748 441573001 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956323 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-9-15(29)20(27)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-6-5-31-24(36)16(32-17)8-12-3-2-4-14(28)7-12/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) TWUQGEOXOHPQGR-UHFFFAOYSA-N 463151 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 5-B Guanylate cyclase soluble subunit alpha-1 Human 0.091 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463151&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144571 441573002 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956324 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H17ClF3N7O2/c1-26(12-8-15(30)20(27)18(38)9-12)19-21(31)34-22(35-23(19)36-25(26)39)17-10-37-5-4-32-24(37)16(33-17)7-11-6-13(28)2-3-14(11)29/h2-6,8-10,38H,7H2,1H3,(H3,31,34,35,36,39) MDQKRTSVIMQBLN-UHFFFAOYSA-N 463152 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 6-B Guanylate cyclase soluble subunit alpha-1 Human 0.094 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463152&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156001 441573003 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956325 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H16ClF4N7O2/c1-26(11-6-13(29)19(27)17(39)7-11)18-21(32)35-22(36-23(18)37-25(26)40)16-9-38-3-2-33-24(38)15(34-16)5-10-4-12(28)8-14(30)20(10)31/h2-4,6-9,39H,5H2,1H3,(H3,32,35,36,37,40) CXVJRKICCBYWLU-UHFFFAOYSA-N 463153 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-5-methyl-2-{8- [(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]pyrimidin-6- one::US10780092, Example 7-B Guanylate cyclase soluble subunit alpha-1 Human 0.098 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463153&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144524 441573004 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956326 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-6-7-15(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) HGQKAGWUKNEYMR-UHFFFAOYSA-N 463154 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 8-A Guanylate cyclase soluble subunit alpha-1 Human 0.117 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463154&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144539 441573005 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956327 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(F)c(F)c1 InChI=1S/C26H18F3N7O2/c1-26(13-9-15(28)20(29)18(37)10-13)19-21(30)33-22(34-23(19)35-25(26)38)17-11-36-7-6-31-24(36)16(32-17)8-12-4-2-3-5-14(12)27/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) IZPXJJJLWDSELX-UHFFFAOYSA-N 463155 4-Amino-5-(3,4-difluoro-5- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 9-B Guanylate cyclase soluble subunit alpha-1 Human 0.126 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463155&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144721 441573006 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956328 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C25H17ClF2N8O2/c1-25(12-7-14(28)19(26)17(37)8-12)18-20(29)33-21(34-22(18)35-24(25)38)16-9-36-23(30-10-31-36)15(32-16)6-11-4-2-3-5-13(11)27/h2-5,7-10,37H,6H2,1H3,(H3,29,33,34,35,38) JTOJRPVESMTWFD-UHFFFAOYSA-N 463156 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 10-B Guanylate cyclase soluble subunit alpha-1 Human 0.128 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463156&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145371 441573007 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956329 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cccc(O)c1 InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-16(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-8-7-30-24(35)18(31-19)10-13-9-15(27)5-6-17(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) TURPWFPRLYAZFT-UHFFFAOYSA-N 463157 4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 11-B Guanylate cyclase soluble subunit alpha-1 Human 0.135 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463157&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144504 441573008 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956330 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H25ClFN7O2/c1-26(14-10-15(28)20(27)18(36)11-14)19-21(29)32-22(33-23(19)34-25(26)37)17-12-35-8-7-30-24(35)16(31-17)9-13-5-3-2-4-6-13/h7-8,10-13,36H,2-6,9H2,1H3,(H3,29,32,33,34,37) DEJCTJFZLQNOON-UHFFFAOYSA-N 463158 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 12-B Guanylate cyclase soluble subunit alpha-1 Human 0.153 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463158&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144750 441573009 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956331 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(F)c(O)c1 InChI=1S/C26H19F2N7O2/c1-26(14-6-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-15(13)27/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) FMHZHZLNBJXQEU-UHFFFAOYSA-N 463159 4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 13-B Guanylate cyclase soluble subunit alpha-1 Human 0.154 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463159&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144575 441573010 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956332 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H26ClN7O2/c1-26(15-7-8-16(27)19(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h7-10,12-14,35H,2-6,11H2,1H3,(H3,28,31,32,33,36) IFNHEXWLAIFQMX-UHFFFAOYSA-N 463160 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 14-A Guanylate cyclase soluble subunit alpha-1 Human 0.156 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463160&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144474 441573011 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956333 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C26H24FN9O2/c1-26(14-8-16(27)15(10-28)19(37)9-14)20-21(29)33-22(34-23(20)35-25(26)38)18-11-36-24(30-12-31-36)17(32-18)7-13-5-3-2-4-6-13/h8-9,11-13,37H,2-7H2,1H3,(H3,29,33,34,35,38) HZRIPLQQYYNXOH-UHFFFAOYSA-N 463161 4-(4-Amino-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-methyl-6-oxo-6,7-dihydro- 5H-pyrrolo[2,3-d]pyrimidin-5- yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 15-B Guanylate cyclase soluble subunit alpha-1 Human 0.158 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463161&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144531 441573012 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956334 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C26H17ClF3N7O2/c1-26(12-7-15(30)20(27)18(38)8-12)19-21(31)34-22(35-23(19)36-25(26)39)17-10-37-3-2-32-24(37)16(33-17)6-11-4-13(28)9-14(29)5-11/h2-5,7-10,38H,6H2,1H3,(H3,31,34,35,36,39) VDVKLWJLYKYHBD-UHFFFAOYSA-N 463162 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 16-B Guanylate cyclase soluble subunit alpha-1 Human 0.158 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463162&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145487 441573013 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956335 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C27H19F4N7O2/c1-26(14-5-6-16(19(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)18-12-38-8-7-33-24(38)17(34-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,39H,10H2,1H3,(H3,32,35,36,37,40) GDZUFJWEVBVZRR-UHFFFAOYSA-N 463163 4-Amino-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 17-B Guanylate cyclase soluble subunit alpha-1 Human 0.163 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463163&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156009 441573014 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956336 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C27H25FN8O2/c1-27(15-10-17(28)16(12-29)20(37)11-15)21-22(30)33-23(34-24(21)35-26(27)38)19-13-36-8-7-31-25(36)18(32-19)9-14-5-3-2-4-6-14/h7-8,10-11,13-14,37H,2-6,9H2,1H3,(H3,30,33,34,35,38) NOUXVMMDCFQWPT-UHFFFAOYSA-N 463164 4-(4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-6-oxo- 6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 18-B Guanylate cyclase soluble subunit alpha-1 Human 0.168 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463164&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144361 441573015 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956337 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-2-4-15(27)19(37)10-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)9-12-8-14(28)3-5-16(12)29/h2-8,10-11,37H,9H2,1H3,(H3,30,33,34,35,38) QLTJGWPNZNQLJF-UHFFFAOYSA-N 463165 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 19-A Guanylate cyclase soluble subunit alpha-1 Human 0.170 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463165&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144794 441573016 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956338 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)c(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-3-4-14(27)19(37)10-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)9-12-2-5-15(28)16(29)8-12/h2-8,10-11,37H,9H2,1H3,(H3,30,33,34,35,38) ZQANXJSCZDSIDX-UHFFFAOYSA-N 463166 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3,4- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 20-A Guanylate cyclase soluble subunit alpha-1 Human 0.173 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463166&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144370 441573017 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956339 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C25H24ClFN8O2/c1-25(13-8-14(27)19(26)17(36)9-13)18-20(28)32-21(33-22(18)34-24(25)37)16-10-35-23(29-11-30-35)15(31-16)7-12-5-3-2-4-6-12/h8-12,36H,2-7H2,1H3,(H3,28,32,33,34,37) NKLSIMQSRCTBLT-UHFFFAOYSA-N 463167 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 21-B Guanylate cyclase soluble subunit alpha-1 Human 0.206 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463167&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156008 441573018 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956340 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1ccc(F)c(O)c1 InChI=1S/C26H18F3N7O2/c1-26(13-3-5-15(28)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)8-12-2-4-14(27)10-16(12)29/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) NHADARDODAEHLG-UHFFFAOYSA-N 463168 4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(4-fluoro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 22-B Guanylate cyclase soluble subunit alpha-1 Human 0.214 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463168&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132150025 441573019 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956341 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C27H18F2N8O2/c1-27(14-9-17(29)15(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-7-6-32-25(37)18(33-19)8-13-4-2-3-5-16(13)28/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39) LDEXYMBXFVEUMQ-UHFFFAOYSA-N 463169 4-(4-Amino-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-6-oxo- 6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 23-B Guanylate cyclase soluble subunit alpha-1 Human 0.216 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463169&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144699 441573020 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956342 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(O)c(F)c1 InChI=1S/C26H19F2N7O2/c1-26(14-6-7-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-15(13)27/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) KCBMTXXNEMODKN-UHFFFAOYSA-N 463170 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 24-B Guanylate cyclase soluble subunit alpha-1 Human 0.241 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463170&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144518 441573021 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956343 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1 InChI=1S/C24H24ClN7O2/c1-12(2)4-7-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-6-14(25)17(33)10-13/h5-6,8-12,33H,4,7H2,1-3H3,(H3,26,29,30,31,34) PXFFNKCNLGHYKX-UHFFFAOYSA-N 463171 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 25-A Guanylate cyclase soluble subunit alpha-1 Human 0.252 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463171&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144553 441573022 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956344 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C25H18ClFN8O2/c1-25(13-4-7-15(26)18(36)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(27)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37) NZWOLOGVLNDGLG-UHFFFAOYSA-N 463172 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 26-A Guanylate cyclase soluble subunit alpha-1 Human 0.276 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463172&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155975 441573023 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956345 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C26H16F3N9O2/c1-26(12-5-16(29)15(8-30)19(39)6-12)20-21(31)35-22(36-23(20)37-25(26)40)18-9-38-24(32-10-33-38)17(34-18)4-11-2-13(27)7-14(28)3-11/h2-3,5-7,9-10,39H,4H2,1H3,(H3,31,35,36,37,40) KPBZKBYGNVHUAW-UHFFFAOYSA-N 463173 4-(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-6-oxo-6,7-dihydro- 5H-pyrrolo[2,3-d]pyrimidin-5- yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 27-B Guanylate cyclase soluble subunit alpha-1 Human 0.280 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463173&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144476 441573024 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956346 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1ccc(O)c(Cl)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-6-7-19(36)15(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-4-2-3-5-16(13)28/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) JGHXJFVHWSIDQJ-UHFFFAOYSA-N 463174 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 28-B Guanylate cyclase soluble subunit alpha-1 Human 0.283 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463174&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155973 441573025 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956347 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(F)c1 InChI=1S/C26H19F2N7O2/c1-26(14-4-7-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) FYTSZPSHBZXRKQ-UHFFFAOYSA-N 463175 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 29-B Guanylate cyclase soluble subunit alpha-1 Human 0.291 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463175&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156010 441573026 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956348 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-4-7-16(27)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(28)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) QQLSBJTXKGICBH-UHFFFAOYSA-N 463176 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 30-A Guanylate cyclase soluble subunit alpha-1 Human 0.292 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463176&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156011 441573027 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956349 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cccc(O)c1 InChI=1S/C26H20FN7O2/c1-26(15-3-2-4-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-10-9-29-24(34)18(30-19)11-14-5-7-16(27)8-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36) NZYVMBWCWGIGAC-UHFFFAOYSA-N 463177 4-Amino-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 31-B Guanylate cyclase soluble subunit alpha-1 Human 0.274 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463177&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144665 441573028 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956350 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C24H23ClFN7O2/c1-11(2)4-5-14-22-28-6-7-33(22)10-15(29-14)20-30-19(27)17-21(31-20)32-23(35)24(17,3)12-8-13(26)18(25)16(34)9-12/h6-11,34H,4-5H2,1-3H3,(H3,27,30,31,32,35) DDXMOTZDJZXWII-UHFFFAOYSA-N 463178 4-Amino-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 32-B Guanylate cyclase soluble subunit alpha-1 Human 0.306 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463178&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144638 441573029 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956351 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C27H17F6N7O2/c1-26(12-2-3-14(18(41)8-12)27(31,32)33)19-21(34)37-22(38-23(19)39-25(26)42)17-10-40-5-4-35-24(40)16(36-17)7-11-6-13(28)9-15(29)20(11)30/h2-6,8-10,41H,7H2,1H3,(H3,34,37,38,39,42) TVDDCBPPXVYGDK-UHFFFAOYSA-N 463179 4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-2-{8-[(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]pyrimidin-6- one::US10780092, Example 33-B Guanylate cyclase soluble subunit alpha-1 Human 0.312 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463179&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144547 441573030 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956352 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1cccc(O)c1 InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-16(36)10-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-8-7-30-24(35)18(31-19)9-13-5-6-15(27)11-17(13)28/h2-8,10-12,36H,9H2,1H3,(H3,29,32,33,34,37) GMTAWZMPASOYAS-UHFFFAOYSA-N 463180 4-Amino-2-{8-[(2,4- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 34-B Guanylate cyclase soluble subunit alpha-1 Human 0.317 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463180&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145012 441573031 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956353 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(O)c(Cl)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-19(36)16(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(28)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) NZCNMZFJHYPBAI-UHFFFAOYSA-N 463181 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 35-B Guanylate cyclase soluble subunit alpha-1 Human 0.333 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463181&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156069 441573032 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956354 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-2-3-16(27)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-5-4-31-24(36)17(32-18)8-12-6-14(28)10-15(29)7-12/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) BFOCAGYQXJKXNM-UHFFFAOYSA-N 463182 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 36-A Guanylate cyclase soluble subunit alpha-1 Human 0.393 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463182&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144822 441573033 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956355 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(F)c(O)c1 InChI=1S/C26H19F2N7O2/c1-26(14-4-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) WIUWJLRNQVJRQP-UHFFFAOYSA-N 463183 4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 37-B Guanylate cyclase soluble subunit alpha-1 Human 0.427 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463183&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144849 441573034 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956356 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C27H17F3N8O2/c1-27(13-7-17(30)16(10-31)20(39)8-13)21-22(32)35-23(36-24(21)37-26(27)40)19-11-38-3-2-33-25(38)18(34-19)6-12-4-14(28)9-15(29)5-12/h2-5,7-9,11,39H,6H2,1H3,(H3,32,35,36,37,40) FEIGXVQKEWGVPK-UHFFFAOYSA-N 463184 4-(4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-6- oxo-6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 38-B Guanylate cyclase soluble subunit alpha-1 Human 0.410 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463184&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144491 441573035 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956357 CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C23H21ClFN7O2/c1-3-4-5-13-21-27-6-7-32(21)10-14(28-13)19-29-18(26)16-20(30-19)31-22(34)23(16,2)11-8-12(25)17(24)15(33)9-11/h6-10,33H,3-5H2,1-2H3,(H3,26,29,30,31,34) CXXKJZLCBZIYLE-UHFFFAOYSA-N 463185 4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(4-chloro-3- fluoro-5-hydroxyphenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 39-B Guanylate cyclase soluble subunit alpha-1 Human 0.446 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463185&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156070 441573036 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956358 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)14(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-3-2-30-23(36)15(32-16)6-11-4-12(27)7-13(28)5-11/h2-5,7-10H,6H2,1H3,(H,31,37)(H3,29,33,34,35,38) VIAMPDZHUIYDDJ-UHFFFAOYSA-N 463186 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 40-B Guanylate cyclase soluble subunit alpha-1 Human 0.479 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463186&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144490 441573037 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956359 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(F)c1 InChI=1S/C25H18F2N8O2/c1-25(13-4-7-18(36)15(27)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(26)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37) DMUTYPPPCXPPTO-UHFFFAOYSA-N 463187 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 41-B Guanylate cyclase soluble subunit alpha-1 Human 0.490 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463187&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144578 441573038 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956360 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)c(F)c1 InChI=1S/C22H20ClFN8O2/c1-3-4-5-12-20-26-9-27-32(20)8-13(28-12)18-29-17(25)15-19(30-18)31-21(34)22(15,2)10-6-11(24)16(23)14(33)7-10/h6-9,33H,3-5H2,1-2H3,(H3,25,29,30,31,34) BCLQFUPUSOALKF-UHFFFAOYSA-N 463188 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(4-chloro-3-fluoro-5- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 42-B Guanylate cyclase soluble subunit alpha-1 Human 0.496 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463188&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145431 441573039 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956361 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)cc1 InChI=1S/C26H20FN7O2/c1-26(15-4-8-17(35)9-5-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-11-10-29-24(34)18(30-19)12-14-2-6-16(27)7-3-14/h2-11,13,35H,12H2,1H3,(H3,28,31,32,33,36) UNWPQKNPOZQCOP-UHFFFAOYSA-N 463189 4-Amino-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-(4- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 43-B Guanylate cyclase soluble subunit alpha-1 Human 0.457 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463189&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144566 441573040 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956362 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(Cl)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H19Cl2N7O2/c1-26(14-4-7-16(28)19(36)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(27)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) STTWWZRVHCMQND-UHFFFAOYSA-N 463190 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(4- chlorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 44-A Guanylate cyclase soluble subunit alpha-1 Human 0.507 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463190&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144113 441573041 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956363 Cc1cc(ccc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1 InChI=1S/C27H22FN7O2/c1-14-10-16(6-7-20(14)36)27(2)21-22(29)32-23(33-24(21)34-26(27)37)19-13-35-9-8-30-25(35)18(31-19)12-15-4-3-5-17(28)11-15/h3-11,13,36H,12H2,1-2H3,(H3,29,32,33,34,37) AQUZHUZOCWPQQN-UHFFFAOYSA-N 463191 4-Amino-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-(4-hydroxy-3- methylphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 45-A Guanylate cyclase soluble subunit alpha-1 Human 0.565 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463191&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145346 441573042 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956364 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C27H18F5N7O2/c1-26(13-2-3-16(19(40)9-13)27(30,31)32)20-21(33)36-22(37-23(20)38-25(26)41)18-11-39-5-4-34-24(39)17(35-18)8-12-6-14(28)10-15(29)7-12/h2-7,9-11,40H,8H2,1H3,(H3,33,36,37,38,41) UOVJAFOJELEQCF-UHFFFAOYSA-N 463192 4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(3-hydroxy- 4-(trifluoromethyl)phenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 46-B Guanylate cyclase soluble subunit alpha-1 Human 0.691 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463192&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144536 441573043 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956365 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(F)c(O)c1 InChI=1S/C24H24FN7O2/c1-12(2)4-7-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-6-14(25)17(33)10-13/h5-6,8-12,33H,4,7H2,1-3H3,(H3,26,29,30,31,34) YPYGBXXPBCRKQU-UHFFFAOYSA-N 463193 4-Amino-5-(4-fluoro-3- hydroxyphenyl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 47-B Guanylate cyclase soluble subunit alpha-1 Human 0.676 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463193&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144451 441573044 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956366 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1cccc(O)c1 InChI=1S/C26H19F2N7O2/c1-26(14-3-2-4-17(36)10-14)20-21(29)32-22(33-23(20)34-25(26)37)19-12-35-6-5-30-24(35)18(31-19)9-13-7-15(27)11-16(28)8-13/h2-8,10-12,36H,9H2,1H3,(H3,29,32,33,34,37) LJRCIOHIKASEAE-UHFFFAOYSA-N 463194 4-Amino-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 48-B Guanylate cyclase soluble subunit alpha-1 Human 0.723 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463194&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156084 441573045 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956367 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)n1 InChI=1S/C25H25ClN8O2/c1-25(17-8-7-14(26)23(35)30-17)18-19(27)31-20(32-21(18)33-24(25)36)16-12-34-10-9-28-22(34)15(29-16)11-13-5-3-2-4-6-13/h7-10,12-13H,2-6,11H2,1H3,(H,30,35)(H3,27,31,32,33,36) HQTXQKZEORRMEO-UHFFFAOYSA-N 463195 4-Amino-5-(5-chloro-6- hydroxypyridin-2-yl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 49-A Guanylate cyclase soluble subunit alpha-1 Human 0.746 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463195&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144672 441573046 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956368 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1 InChI=1S/C22H21ClN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-12(23)15(32)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33) ZYHCDPQWPGYQAM-UHFFFAOYSA-N 463196 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(4-chloro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 50-A Guanylate cyclase soluble subunit alpha-1 Human 0.775 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463196&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144447 441573047 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956369 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)14(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-6-5-29-23(35)15(31-16)8-12-3-2-4-13(27)7-12/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37) TUVDGFBHJYWIFJ-UHFFFAOYSA-N 463197 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(3- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 51-B Guanylate cyclase soluble subunit alpha-1 Human 0.874 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463197&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145960 441573048 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956370 CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1 InChI=1S/C23H22ClN7O2/c1-3-4-5-14-21-26-8-9-31(21)11-15(27-14)19-28-18(25)17-20(29-19)30-22(33)23(17,2)12-6-7-13(24)16(32)10-12/h6-11,32H,3-5H2,1-2H3,(H3,25,28,29,30,33) YFVSWNPKKHOVMV-UHFFFAOYSA-N 463198 4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(4-chloro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 52-A Guanylate cyclase soluble subunit alpha-1 Human 0.864 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463198&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144505 441573049 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956371 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(Cl)c(O)cn1 InChI=1S/C25H18ClFN8O2/c1-25(18-9-13(26)17(36)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37) PIYZXACYQVVOAD-UHFFFAOYSA-N 463199 4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 104-B::US10780092, Example 53-B Guanylate cyclase soluble subunit alpha-1 Human 1.08 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463199&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144512 441573050 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956372 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(F)c1 InChI=1S/C24H24FN7O2/c1-12(2)4-6-15-22-27-8-9-32(22)11-16(28-15)20-29-19(26)18-21(30-20)31-23(34)24(18,3)13-5-7-17(33)14(25)10-13/h5,7-12,33H,4,6H2,1-3H3,(H3,26,29,30,31,34) OKIRRPUHSUAEOS-UHFFFAOYSA-N 463200 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 54-B Guanylate cyclase soluble subunit alpha-1 Human 1.08 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463200&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144398 441573051 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956373 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCCC(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C23H19ClF3N7O2/c1-22(11-4-5-12(24)15(35)9-11)16-17(28)31-18(32-19(16)33-21(22)36)14-10-34-8-7-29-20(34)13(30-14)3-2-6-23(25,26)27/h4-5,7-10,35H,2-3,6H2,1H3,(H3,28,31,32,33,36) YZQOILTXIFFGMA-UHFFFAOYSA-N 463201 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(8- (4,4,4-trifluorobutyl)imidazo[1,2- a]pyrazin-6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 55-A Guanylate cyclase soluble subunit alpha-1 Human 1.21 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463201&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145295 441573052 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956374 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(Cl)cc2)n1)c1cccc(O)c1 InChI=1S/C26H20ClN7O2/c1-26(15-3-2-4-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-10-9-29-24(34)18(30-19)11-14-5-7-16(27)8-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36) URVUEIQZPATIPE-UHFFFAOYSA-N 463202 4-Amino-2-{8-[(4- chlorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 56-B Guanylate cyclase soluble subunit alpha-1 Human 1.24 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463202&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144494 441573053 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956375 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)cn1 InChI=1S/C23H23ClN8O2/c1-11(2)4-5-13-21-26-6-7-32(21)10-14(28-13)19-29-18(25)17-20(30-19)31-22(34)23(17,3)16-8-15(33)12(24)9-27-16/h6-11H,4-5H2,1-3H3,(H,27,33)(H3,25,29,30,31,34) PEMBXOBOPYMOGD-UHFFFAOYSA-N 463203 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 57-B Guanylate cyclase soluble subunit alpha-1 Human 1.24 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463203&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144656 441573054 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956376 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)cc1 InChI=1S/C24H25N7O2/c1-13(2)4-9-16-22-26-10-11-31(22)12-17(27-16)20-28-19(25)18-21(29-20)30-23(33)24(18,3)14-5-7-15(32)8-6-14/h5-8,10-13,32H,4,9H2,1-3H3,(H3,25,28,29,30,33) JTYXSPZZBWYRLA-UHFFFAOYSA-N 463204 4-Amino-5-(4-hydroxyphenyl)-2- (8-isopentylimidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 58-B Guanylate cyclase soluble subunit alpha-1 Human 1.54 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463204&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155977 441573055 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956377 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cccc(O)c1 InChI=1S/C24H25N7O2/c1-13(2)7-8-16-22-26-9-10-31(22)12-17(27-16)20-28-19(25)18-21(29-20)30-23(33)24(18,3)14-5-4-6-15(32)11-14/h4-6,9-13,32H,7-8H2,1-3H3,(H3,25,28,29,30,33) CWGKUGHWBIWPMC-UHFFFAOYSA-N 463205 4-Amino-5-(3-hydroxyphenyl)-2- (8-isopentylimidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 59-B Guanylate cyclase soluble subunit alpha-1 Human 1.72 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463205&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144403 441573056 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956378 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(Cl)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-4-7-19(36)16(27)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-9-8-30-24(35)17(31-18)10-13-2-5-15(28)6-3-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) GJBITWLLJLYNQR-UHFFFAOYSA-N 463206 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl]-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 60-B Guanylate cyclase soluble subunit alpha-1 Human 1.92 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463206&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155978 441573057 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956379 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C23H21F3N8O2/c1-3-4-5-13-20-28-10-29-34(20)9-14(30-13)18-31-17(27)16-19(32-18)33-21(36)22(16,2)11-6-7-12(15(35)8-11)23(24,25)26/h6-10,35H,3-5H2,1-2H3,(H3,27,31,32,33,36) OJEMQHNLVYMNSS-UHFFFAOYSA-N 463207 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 61-B Guanylate cyclase soluble subunit alpha-1 Human 2.08 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463207&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144446 441573058 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956380 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(F)c(O)c1 InChI=1S/C22H21FN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-12(23)15(32)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33) CHZNKAPRMXDMEB-UHFFFAOYSA-N 463208 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(4-fluoro-3-hydroxyphenyl)- 5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 62-B Guanylate cyclase soluble subunit alpha-1 Human 2.21 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463208&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144535 441573059 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956381 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C27H28ClN7O2/c1-27(16-8-9-17(28)20(36)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)10-7-15-5-3-2-4-6-15/h8-9,11-15,36H,2-7,10H2,1H3,(H3,29,32,33,34,37) UNKIQODOASJHJZ-UHFFFAOYSA-N 463209 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 63-A Guanylate cyclase soluble subunit alpha-1 Human 2.20 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463209&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144523 441573060 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956382 CC(C)CCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C25H24F3N7O2/c1-12(2)4-7-15-22-30-8-9-35(22)11-16(31-15)20-32-19(29)18-21(33-20)34-23(37)24(18,3)13-5-6-14(17(36)10-13)25(26,27)28/h5-6,8-12,36H,4,7H2,1-3H3,(H3,29,32,33,34,37) QWBDBYQPAZPLBL-UHFFFAOYSA-N 463210 4-Amino-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-2-(8- isopentylimidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 64-B Guanylate cyclase soluble subunit alpha-1 Human 2.22 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463210&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145458 441573061 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956383 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C23H17ClF5N7O2/c1-21(10-2-3-11(24)14(37)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38) XIMJUNZDEWHEEJ-UHFFFAOYSA-N 463211 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(8- (3,3,4,4,4- pentafluorobutyl)imidazo[1,2- a]pyrazin-6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 65-A Guanylate cyclase soluble subunit alpha-1 Human 2.26 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463211&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155937 441573062 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956384 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(Cl)c1 InChI=1S/C25H18ClFN8O2/c1-25(13-4-7-18(36)15(26)9-13)19-20(28)32-21(33-22(19)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)8-12-2-5-14(27)6-3-12/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37) IVNCGKYPWMIGJN-UHFFFAOYSA-N 463212 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 66-B Guanylate cyclase soluble subunit alpha-1 Human 2.57 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463212&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155936 441573063 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956385 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1Cl InChI=1S/C25H24Cl2N8O2/c1-25(13-7-8-14(26)19(36)18(13)27)17-20(28)32-21(33-22(17)34-24(25)37)16-10-35-23(29-11-30-35)15(31-16)9-12-5-3-2-4-6-12/h7-8,10-12,36H,2-6,9H2,1H3,(H3,28,32,33,34,37) WTDMWGJPFNOXBK-UHFFFAOYSA-N 463213 4-Amino-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(2,4-dichloro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 67-A Guanylate cyclase soluble subunit alpha-1 Human 2.65 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463213&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155984 441573064 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956386 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cccc(O)c1 InChI=1S/C22H22N8O2/c1-3-4-8-14-20-24-11-25-30(20)10-15(26-14)18-27-17(23)16-19(28-18)29-21(32)22(16,2)12-6-5-7-13(31)9-12/h5-7,9-11,31H,3-4,8H2,1-2H3,(H3,23,27,28,29,32) QVTWMPZPULLWNE-UHFFFAOYSA-N 463214 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(3-hydroxyphenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 68-B Guanylate cyclase soluble subunit alpha-1 Human 2.92 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463214&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144689 441573065 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956387 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(Cl)c(O)c1Cl InChI=1S/C26H25Cl2N7O2/c1-26(14-7-8-15(27)20(36)19(14)28)18-21(29)32-22(33-23(18)34-25(26)37)17-12-35-10-9-30-24(35)16(31-17)11-13-5-3-2-4-6-13/h7-10,12-13,36H,2-6,11H2,1H3,(H3,29,32,33,34,37) BUSJLJHSEYMWDV-UHFFFAOYSA-N 463215 4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(2,4-dichloro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 69-A Guanylate cyclase soluble subunit alpha-1 Human 3.47 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463215&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145472 441573066 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956388 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)cc1 InChI=1S/C22H22N8O2/c1-3-4-5-14-20-24-11-25-30(20)10-15(26-14)18-27-17(23)16-19(28-18)29-21(32)22(16,2)12-6-8-13(31)9-7-12/h6-11,31H,3-5H2,1-2H3,(H3,23,27,28,29,32) DAFGBMLJNRUNKN-UHFFFAOYSA-N 463216 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(4-hydroxyphenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 70-B Guanylate cyclase soluble subunit alpha-1 Human 3.96 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463216&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155981 441573067 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956389 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(F)c1 InChI=1S/C22H21FN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-15(32)12(23)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33) FAIQGVVNUKQWRR-UHFFFAOYSA-N 463217 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(3-fluoro-4-hydroxyphenyl)- 5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 71-B Guanylate cyclase soluble subunit alpha-1 Human 4.08 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463217&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145961 441573068 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956390 CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)c(Cl)cn1 InChI=1S/C22H21ClN8O2/c1-3-4-5-12-20-25-6-7-31(20)10-13(27-12)18-28-17(24)16-19(29-18)30-21(33)22(16,2)15-8-14(32)11(23)9-26-15/h6-10H,3-5H2,1-2H3,(H,26,32)(H3,24,28,29,30,33) YOGKRUNLJJIRMA-UHFFFAOYSA-N 463218 4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(5-chloro-4- hydroxypyridin-2-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 72-B Guanylate cyclase soluble subunit alpha-1 Human 4.62 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463218&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144486 441573069 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956391 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ncc(Cl)c(O)c1Cl InChI=1S/C25H16Cl2F2N8O2/c1-25(19-17(27)18(38)13(26)8-32-19)16-20(30)34-21(35-22(16)36-24(25)39)15-9-37-3-2-31-23(37)14(33-15)6-10-4-11(28)7-12(29)5-10/h2-5,7-9H,6H2,1H3,(H,32,38)(H3,30,34,35,36,39) QJPOFEHHOTZTKF-UHFFFAOYSA-N 463219 4-Amino-5-(3,5-dichloro-4- hydroxypyridin-2-yl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 73-A Guanylate cyclase soluble subunit alpha-1 Human 6.01 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463219&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144645 441573070 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956392 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(Cl)c1 InChI=1S/C22H21ClN8O2/c1-3-4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(24)16-19(29-18)30-21(33)22(16,2)11-6-7-15(32)12(23)8-11/h6-10,32H,3-5H2,1-2H3,(H3,24,28,29,30,33) OTIGUBGZMFEZBM-UHFFFAOYSA-N 463220 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-(3-chloro-4- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 74-B Guanylate cyclase soluble subunit alpha-1 Human 6.17 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463220&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144567 441573071 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956393 CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(O)c(Cl)c1 InChI=1S/C23H22ClN7O2/c1-3-4-5-14-21-26-8-9-31(21)11-15(27-14)19-28-18(25)17-20(29-19)30-22(33)23(17,2)12-6-7-16(32)13(24)10-12/h6-11,32H,3-5H2,1-2H3,(H3,25,28,29,30,33) FGRUUTQNWUFEBA-UHFFFAOYSA-N 463221 4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(3-chloro-4- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 75-B Guanylate cyclase soluble subunit alpha-1 Human 6.55 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463221&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156002 441573072 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956394 CCCCc1nc(cn2ccnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(c(O)c1)C(F)(F)F InChI=1S/C24H22F3N7O2/c1-3-4-5-14-21-29-8-9-34(21)11-15(30-14)19-31-18(28)17-20(32-19)33-22(36)23(17,2)12-6-7-13(16(35)10-12)24(25,26)27/h6-11,35H,3-5H2,1-2H3,(H3,28,31,32,33,36) BZHAFXSGQSYXBQ-UHFFFAOYSA-N 463222 4-Amino-2-(8-butylimidazo[1,2- a]pyrazin-6-yl)-5-(3-hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 76-B Guanylate cyclase soluble subunit alpha-1 Human 7.89 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463222&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145413 441573073 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956395 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)c(Cl)c1 InChI=1S/C27H28ClN7O2/c1-27(16-8-10-20(36)17(28)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)9-7-15-5-3-2-4-6-15/h8,10-15,36H,2-7,9H2,1H3,(H3,29,32,33,34,37) JGUGGOXTJCHIKZ-UHFFFAOYSA-N 463223 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 77-B Guanylate cyclase soluble subunit alpha-1 Human 8.79 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463223&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145166 441573074 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956396 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1cccc(O)c1 InChI=1S/C22H17F5N8O2/c1-20(10-3-2-4-11(36)7-10)14-15(28)32-16(33-17(14)34-19(20)37)13-8-35-18(29-9-30-35)12(31-13)5-6-21(23,24)22(25,26)27/h2-4,7-9,36H,5-6H2,1H3,(H3,28,32,33,34,37) NHZLQSHHLDJNRQ-UHFFFAOYSA-N 463224 4-Amino-5-(3-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 78-B Guanylate cyclase soluble subunit alpha-1 Human 8.88 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463224&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145091 441573075 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956397 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1cccc(O)c1 InChI=1S/C23H18F5N7O2/c1-21(11-3-2-4-12(36)9-11)15-16(29)32-17(33-18(15)34-20(21)37)14-10-35-8-7-30-19(35)13(31-14)5-6-22(24,25)23(26,27)28/h2-4,7-10,36H,5-6H2,1H3,(H3,29,32,33,34,37) VZYZDVOPVWOTTP-UHFFFAOYSA-N 463225 4-Amino-5-(3-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)imidazo[1,2- a]pyrazin-6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 79-B Guanylate cyclase soluble subunit alpha-1 Human 9.41 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463225&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144360 441573076 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956398 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)cc1 InChI=1S/C22H17F5N8O2/c1-20(10-2-4-11(36)5-3-10)14-15(28)32-16(33-17(14)34-19(20)37)13-8-35-18(29-9-30-35)12(31-13)6-7-21(23,24)22(25,26)27/h2-5,8-9,36H,6-7H2,1H3,(H3,28,32,33,34,37) OZPAIGWUZKXXMC-UHFFFAOYSA-N 463226 4-Amino-5-(4-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 80-B Guanylate cyclase soluble subunit alpha-1 Human 9.98 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463226&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156072 441573077 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956399 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)cc1 InChI=1S/C23H17ClF5N7O/c1-21(11-2-4-12(24)5-3-11)15-16(30)33-17(34-18(15)35-20(21)37)14-10-36-9-8-31-19(36)13(32-14)6-7-22(25,26)23(27,28)29/h2-5,8-10H,6-7H2,1H3,(H3,30,33,34,35,37) XUAHFEOHPUQMFY-UHFFFAOYSA-N 463227 4-Amino-5-(4-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)imidazo[1,2- a]pyrazin-6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 81-B Guanylate cyclase soluble subunit alpha-1 Human 13.9 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463227&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 118566172 441573078 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956400 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cccc(O)c1 InChI=1S/C26H27N7O2/c1-26(16-8-5-9-17(34)13-16)20-21(27)30-22(31-23(20)32-25(26)35)19-14-33-11-10-28-24(33)18(29-19)12-15-6-3-2-4-7-15/h5,8-11,13-15,34H,2-4,6-7,12H2,1H3,(H3,27,30,31,32,35) OUPDQGGPYWUJKF-UHFFFAOYSA-N 463228 4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 82-B Guanylate cyclase soluble subunit alpha-1 Human 0.402 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463228&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156075 441573079 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956401 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1cccc(O)c1 InChI=1S/C27H29N7O2/c1-27(17-8-5-9-18(35)14-17)21-22(28)31-23(32-24(21)33-26(27)36)20-15-34-13-12-29-25(34)19(30-20)11-10-16-6-3-2-4-7-16/h5,8-9,12-16,35H,2-4,6-7,10-11H2,1H3,(H3,28,31,32,33,36) HGVKHNBMVWVMLO-UHFFFAOYSA-N 463229 4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 83-B Guanylate cyclase soluble subunit alpha-1 Human 5.12 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463229&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156071 441573080 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956402 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)c(F)c1 InChI=1S/C27H28FN7O2/c1-27(16-8-10-20(36)17(28)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)9-7-15-5-3-2-4-6-15/h8,10-15,36H,2-7,9H2,1H3,(H3,29,32,33,34,37) VYOVJAQBDWSASO-UHFFFAOYSA-N 463230 4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(3-fluoro-4- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 84-B Guanylate cyclase soluble subunit alpha-1 Human 3.46 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463230&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156074 441573081 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956403 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(O)cc1 InChI=1S/C27H29N7O2/c1-27(17-8-10-18(35)11-9-17)21-22(28)31-23(32-24(21)33-26(27)36)20-15-34-14-13-29-25(34)19(30-20)12-7-16-5-3-2-4-6-16/h8-11,13-16,35H,2-7,12H2,1H3,(H3,28,31,32,33,36) BLAPHWSHBSPAGB-UHFFFAOYSA-N 463231 4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(4- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 85-B Guanylate cyclase soluble subunit alpha-1 Human 4.82 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463231&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145419 441573082 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956404 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC2CCCCC2)n1)c1ccc(F)c(O)c1 InChI=1S/C27H28FN7O2/c1-27(16-8-9-17(28)20(36)13-16)21-22(29)32-23(33-24(21)34-26(27)37)19-14-35-12-11-30-25(35)18(31-19)10-7-15-5-3-2-4-6-15/h8-9,11-15,36H,2-7,10H2,1H3,(H3,29,32,33,34,37) CLDGRZRMBJXYQW-UHFFFAOYSA-N 463232 4-Amino-2-(8-(2- cyclohexylethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(4-fluoro-3- hydroxyphenyl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 86-B Guanylate cyclase soluble subunit alpha-1 Human 2.22 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463232&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145329 441573083 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956405 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCCC(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C22H18ClF3N8O2/c1-21(10-4-5-11(23)14(35)7-10)15-16(27)31-17(32-18(15)33-20(21)36)13-8-34-19(28-9-29-34)12(30-13)3-2-6-22(24,25)26/h4-5,7-9,35H,2-3,6H2,1H3,(H3,27,31,32,33,36) TXVJQFJVHKFYIJ-UHFFFAOYSA-N 463233 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(8- (4,4,4-trifluorobutyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 87-A Guanylate cyclase soluble subunit alpha-1 Human 2.80 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463233&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144602 441573084 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956406 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C22H16ClF5N8O2/c1-20(9-2-3-10(23)13(37)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38) OAZRLCVETBRALP-UHFFFAOYSA-N 463234 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluorobutyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 88-A Guanylate cyclase soluble subunit alpha-1 Human 2.50 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463234&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144647 441573085 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956407 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1ccc(O)c(Cl)c1 InChI=1S/C26H26ClN7O2/c1-26(15-7-8-19(35)16(27)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h7-10,12-14,35H,2-6,11H2,1H3,(H3,28,31,32,33,36) SMGGDQQQNYTYLJ-UHFFFAOYSA-N 463235 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 89-B Guanylate cyclase soluble subunit alpha-1 Human 0.823 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463235&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145013 441573086 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956408 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2c(F)cccc2F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H18ClF2N7O2/c1-26(12-5-6-14(27)19(37)9-12)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-8-7-31-24(36)17(32-18)10-13-15(28)3-2-4-16(13)29/h2-9,11,37H,10H2,1H3,(H3,30,33,34,35,38) IANOGSYJNOOWSY-UHFFFAOYSA-N 463236 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,6- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 90-A Guanylate cyclase soluble subunit alpha-1 Human 2.43 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463236&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155982 441573087 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956409 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H18ClF2N7O2/c1-26(13-3-5-15(27)19(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)18-11-36-7-6-31-24(36)17(32-18)8-12-2-4-14(28)10-16(12)29/h2-7,9-11,37H,8H2,1H3,(H3,30,33,34,35,38) PJEDGLWGXAAISR-UHFFFAOYSA-N 463237 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2,4- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 91-A Guanylate cyclase soluble subunit alpha-1 Human 0.199 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463237&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144834 441573088 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956410 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H18ClFN8O2/c1-25(18-9-17(36)14(26)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-2-4-13(27)5-3-12/h2-7,9-11H,8H2,1H3,(H,30,36)(H3,28,32,33,34,37) BPWJAFPLLYITGJ-UHFFFAOYSA-N 463238 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(4- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 92-B Guanylate cyclase soluble subunit alpha-1 Human 0.729 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463238&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145239 441573089 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956411 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H25ClN8O2/c1-25(18-10-17(35)14(26)11-29-18)19-20(27)31-21(32-22(19)33-24(25)36)16-12-34-8-7-28-23(34)15(30-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,29,35)(H3,27,31,32,33,36) WXEWREZLWMZIAQ-UHFFFAOYSA-N 463239 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 93-B Guanylate cyclase soluble subunit alpha-1 Human 0.374 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463239&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144485 441573090 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956412 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)13(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-5-4-30-23(36)15(32-16)7-11-6-12(27)2-3-14(11)28/h2-6,8-10H,7H2,1H3,(H,31,37)(H3,29,33,34,35,38) QOLHVXFQSBBOFS-UHFFFAOYSA-N 463240 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 94-B Guanylate cyclase soluble subunit alpha-1 Human 0.149 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463240&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144495 441573091 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956413 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCC(F)(F)CC2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H24ClF2N7O2/c1-25(14-2-3-15(27)18(37)11-14)19-20(30)33-21(34-22(19)35-24(25)38)17-12-36-9-8-31-23(36)16(32-17)10-13-4-6-26(28,29)7-5-13/h2-3,8-9,11-13,37H,4-7,10H2,1H3,(H3,30,33,34,35,38) OBMGUEZZTPMVBK-UHFFFAOYSA-N 463241 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-(8-((4,4- difluorocyclohexyl)methyl)imidazo [1,2-a]pyrazin-6-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 95-A Guanylate cyclase soluble subunit alpha-1 Human 14.4 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463241&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144488 441573092 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956414 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1ccc(F)c(Cl)c1O InChI=1S/C26H17ClF3N7O2/c1-26(14-2-3-15(30)19(27)20(14)38)18-21(31)34-22(35-23(18)36-25(26)39)17-10-37-5-4-32-24(37)16(33-17)8-11-6-12(28)9-13(29)7-11/h2-7,9-10,38H,8H2,1H3,(H3,31,34,35,36,39) KFLYEQJKPIAZJG-UHFFFAOYSA-N 463242 4-Amino-5-(3-chloro-4-fluoro-2- hydroxyphenyl)-2-{8-[(3,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 96-B Guanylate cyclase soluble subunit alpha-1 Human 0.862 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463242&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144778 441573093 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956415 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(c(F)c1)C(F)(F)F InChI=1S/C27H25F4N7O2/c1-26(14-10-15(28)19(18(39)11-14)27(29,30)31)20-21(32)35-22(36-23(20)37-25(26)40)17-12-38-8-7-33-24(38)16(34-17)9-13-5-3-2-4-6-13/h7-8,10-13,39H,2-6,9H2,1H3,(H3,32,35,36,37,40) ABFJCTMQUFLVQI-UHFFFAOYSA-N 463243 4-Amino-2-(8- (cyclohexylmethyl)imidazo[1,2- a]pyrazin-6-yl)-5-(3-fluoro-5- hydroxy-4- (trifluoromethyl)phenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 97-B Guanylate cyclase soluble subunit alpha-1 Human 0.587 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463243&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144399 441573094 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956416 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2c(F)cccc2F)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H17ClF2N8O2/c1-25(18-8-17(37)12(26)9-31-18)19-20(29)33-21(34-22(19)35-24(25)38)16-10-36-6-5-30-23(36)15(32-16)7-11-13(27)3-2-4-14(11)28/h2-6,8-10H,7H2,1H3,(H,31,37)(H3,29,33,34,35,38) PGEBDYZSPKMMGV-UHFFFAOYSA-N 463244 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-{8-[(2,6- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 98-B Guanylate cyclase soluble subunit alpha-1 Human 8.31 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463244&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156003 441573095 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956417 Cc1cn2cc(nc(Cc3cccc(F)c3)c2n1)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1 InChI=1S/C27H21ClFN7O2/c1-13-11-36-12-19(32-18(25(36)31-13)9-14-4-3-5-16(29)8-14)23-33-22(30)21-24(34-23)35-26(38)27(21,2)15-6-7-17(28)20(37)10-15/h3-8,10-12,37H,9H2,1-2H3,(H3,30,33,34,35,38) XYCIRMPOEOXKSC-UHFFFAOYSA-N 463245 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(3- fluorophenyl)methyl]-2- methylimidazo[1,2-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 99-A Guanylate cyclase soluble subunit alpha-1 Human 0.803 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463245&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144509 441573096 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956418 Cc1cn2cc(nc(Cc3ccccc3F)c2n1)-c1nc2NC(=O)C(C)(c2c(N)n1)c1ccc(Cl)c(O)c1 InChI=1S/C27H21ClFN7O2/c1-13-11-36-12-19(32-18(25(36)31-13)9-14-5-3-4-6-17(14)29)23-33-22(30)21-24(34-23)35-26(38)27(21,2)15-7-8-16(28)20(37)10-15/h3-8,10-12,37H,9H2,1-2H3,(H3,30,33,34,35,38) FLVHMLLCOISNIK-UHFFFAOYSA-N 463246 4-Amino-5-(4-chloro-3- hydroxyphenyl)-2-{8-[(2- fluorophenyl)methyl]-2- methylimidazo[1,2-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 100-A Guanylate cyclase soluble subunit alpha-1 Human 0.544 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463246&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145118 441573097 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956419 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)ccc2F)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C27H17F3N8O2/c1-27(13-8-17(30)15(10-31)20(39)9-13)21-22(32)35-23(36-24(21)37-26(27)40)19-11-38-5-4-33-25(38)18(34-19)7-12-6-14(28)2-3-16(12)29/h2-6,8-9,11,39H,7H2,1H3,(H3,32,35,36,37,40) FBKXGAKMFNSQQV-UHFFFAOYSA-N 463247 4-(4-Amino-2-{8-[(2,5- difluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5-methyl-6- oxo-6,7-dihydro-5H-pyrrolo[2,3- d]pyrimidin-5-yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 101-B Guanylate cyclase soluble subunit alpha-1 Human 0.162 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463247&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144404 441573098 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956420 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(C#N)c(F)c1 InChI=1S/C27H16F4N8O2/c1-27(12-6-15(29)14(9-32)19(40)7-12)20-22(33)36-23(37-24(20)38-26(27)41)18-10-39-3-2-34-25(39)17(35-18)5-11-4-13(28)8-16(30)21(11)31/h2-4,6-8,10,40H,5H2,1H3,(H3,33,36,37,38,41) WZMNHSDEFOKVCC-UHFFFAOYSA-N 463248 4-(4-Amino-5-methyl-6-oxo-2- {8-[(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-6,7-dihydro- 5H-pyrro1o[2,3-d]pyrimidin-5- yl)-2-fluoro-6- hydroxybenzonitrile::US10780092, Example 102-B Guanylate cyclase soluble subunit alpha-1 Human 0.118 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463248&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144416 441573099 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956421 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2F)n1)c1cc(O)c(Cl)cn1 InChI=1S/C25H16ClF3N8O2/c1-25(17-7-16(38)12(26)8-32-17)18-20(30)34-21(35-22(18)36-24(25)39)15-9-37-3-2-31-23(37)14(33-15)5-10-4-11(27)6-13(28)19(10)29/h2-4,6-9H,5H2,1H3,(H,32,38)(H3,30,34,35,36,39) MLQAWPBUDTXLEM-UHFFFAOYSA-N 463249 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-5-methyl-2- {8-[(2,3,5- trifluorophenyl)methyl]imidazo[1, 2-a]pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]pyrimidin-6- one::US10780092, Example 103-B Guanylate cyclase soluble subunit alpha-1 Human 0.175 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463249&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156076 441573100 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956422 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(Cl)c(O)cn1 InChI=1S/C25H18ClFN8O2/c1-25(18-9-13(26)17(36)10-30-18)19-20(28)32-21(33-22(19)34-24(25)37)16-11-35-7-6-29-23(35)15(31-16)8-12-4-2-3-5-14(12)27/h2-7,9-11,36H,8H2,1H3,(H3,28,32,33,34,37) PIYZXACYQVVOAD-UHFFFAOYSA-N 463199 4-Amino-5-(4-chloro-5- hydroxypyridin-2-yl)-2-{8-[(2- fluorophenyl)methyl]imidazo[1,2- a]pyrazin-6-yl}-5-methyl-5,7- dihydro-6H-pyrrolo[2,3- d]pyrimidin-6-one::US10780092, Example 104-B::US10780092, Example 53-B Guanylate cyclase soluble subunit alpha-1 Human 1.10 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463199&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144512 441573050 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956423 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C24H24ClN9O2/c1-24(17-8-16(35)13(25)9-27-17)18-19(26)31-20(32-21(18)33-23(24)36)15-10-34-22(28-11-29-34)14(30-15)7-12-5-3-2-4-6-12/h8-12H,2-7H2,1H3,(H,27,35)(H3,26,31,32,33,36) IWEYVBJCPKBIFE-UHFFFAOYSA-N 463251 4-Amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2-(8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]pyrazin-6- yl)-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 105-B Guanylate cyclase soluble subunit alpha-1 Human 0.213 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463251&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144408 441573101 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956424 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCCCF)n1)c1ccc(Cl)c(O)c1 InChI=1S/C22H20ClFN8O2/c1-22(11-5-6-12(23)15(33)8-11)16-17(25)29-18(30-19(16)31-21(22)34)14-9-32-20(26-10-27-32)13(28-14)4-2-3-7-24/h5-6,8-10,33H,2-4,7H2,1H3,(H3,25,29,30,31,34) KASFMOLLFOHLFF-UHFFFAOYSA-N 463252 4-Amino-5-(4-chloro-3-hydroxyphenyl)-2-(8-(4-fluorobutyl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 106-A Guanylate cyclase soluble subunit alpha-1 Human 1.84 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463252&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145398 441573102 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956425 Cc1ccc(cc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1 InChI=1S/C27H22FN7O2/c1-14-6-7-16(12-20(14)36)27(2)21-22(29)32-23(33-24(21)34-26(27)37)19-13-35-9-8-30-25(35)18(31-19)11-15-4-3-5-17(28)10-15/h3-10,12-13,36H,11H2,1-2H3,(H3,29,32,33,34,37) OWSOOCMTIRAVSL-UHFFFAOYSA-N 463253 4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-(3-hydroxy-4-methylphenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 107-B Guanylate cyclase soluble subunit alpha-1 Human 0.221 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463253&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145200 441573103 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956426 CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(Cl)c(O)c2)CC1 InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-17(28)20(36)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37) QQBSQFKKQZDELG-UHFFFAOYSA-N 463254 4-Amino-5-(4-chloro-3- hydroxyphenyl)-5-methyl- 2-{8-[(4-methylcyclo- hexyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 108-AA Guanylate cyclase soluble subunit alpha-1 Human 0.924 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463254&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144424 441573104 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956427 CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(Cl)c(O)c2)CC1 InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-17(28)20(36)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37) QQBSQFKKQZDELG-UHFFFAOYSA-N 463255 4-Amino-5-(4-chloro-3-hydroxyphenyl)-5-methyl-2-{8-[(4-methylcyclohexyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 108-AB Guanylate cyclase soluble subunit alpha-1 Human 0.524 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463255&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144424 441573105 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956428 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)ccn1 InChI=1S/C24H25N9O2/c1-24(17-10-14(34)7-8-26-17)18-19(25)30-20(31-21(18)32-23(24)35)16-11-33-22(27-12-28-33)15(29-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,26,34)(H3,25,30,31,32,35) YFJFTQZJSYTWAH-UHFFFAOYSA-N 463256 4-Amino-2-(8-(cyclo- hexylmethyl)-[1,2,4]- triazolo[1,5-a]pyrazin- 6-yl)-5-(4-hydroxy- pyridin-2-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 109-A Guanylate cyclase soluble subunit alpha-1 Human 0.634 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463256&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155939 441573106 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956429 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2cccc(F)c2)n1)c1cc(O)ccn1 InChI=1S/C24H18FN9O2/c1-24(17-9-14(35)5-6-27-17)18-19(26)31-20(32-21(18)33-23(24)36)16-10-34-22(28-11-29-34)15(30-16)8-12-3-2-4-13(25)7-12/h2-7,9-11H,8H2,1H3,(H,27,35)(H3,26,31,32,33,36) OIRIXNUNDGFLBX-UHFFFAOYSA-N 463257 4-Amino-2-{8-[(3- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl}-5-(4- hydroxypyridin-2-yl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 110-B Guanylate cyclase soluble subunit alpha-1 Human 1.62 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463257&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145294 441573107 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956430 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cc(F)cc(F)c2)n1)c1nccc(O)c1Cl InChI=1S/C25H17ClF2N8O2/c1-25(19-18(26)16(37)2-3-30-19)17-20(29)33-21(34-22(17)35-24(25)38)15-10-36-5-4-31-23(36)14(32-15)8-11-6-12(27)9-13(28)7-11/h2-7,9-10H,8H2,1H3,(H,30,37)(H3,29,33,34,35,38) PJXOVGGYTDIWCO-UHFFFAOYSA-N 463258 4-Amino-5-(3-chloro-4- hydroxypyridin-2-yl)-2- {8-[(3,5-difluorophenyl)- methyl]imidazo[1,2-a]- pyrazin-6-yl}-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 111-B Guanylate cyclase soluble subunit alpha-1 Human 1.74 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463258&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144538 441573108 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956431 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(Cl)c(O)c(Cl)c1 InChI=1S/C25H24Cl2N8O2/c1-25(13-8-14(26)19(36)15(27)9-13)18-20(28)32-21(33-22(18)34-24(25)37)17-10-35-23(29-11-30-35)16(31-17)7-12-5-3-2-4-6-12/h8-12,36H,2-7H2,1H3,(H3,28,32,33,34,37) BJFKFBQBVNHRSH-UHFFFAOYSA-N 463259 4-Amino-2-(8-(cyclo- hexylmethyl)-[1,2,4]- triazolo[1,5-a]pyrazin- 6-yl)-5-(3,5-dichloro-4- hydroxyphenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 112-B Guanylate cyclase soluble subunit alpha-1 Human 1.78 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463259&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156088 441573109 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956432 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(Cl)c(O)c(Cl)c1 InChI=1S/C26H25Cl2N7O2/c1-26(14-10-15(27)20(36)16(28)11-14)19-21(29)32-22(33-23(19)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)9-13-5-3-2-4-6-13/h7-8,10-13,36H,2-6,9H2,1H3,(H3,29,32,33,34,37) QGLZGHMQKWTNQP-UHFFFAOYSA-N 463260 4-Amino-2-(8-(cyclo- hexylmethyl)imidazo- [1,2-a]pyrazin-6-yl)-5- (3,5-dichloro-4-hydroxy- phenyl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]-pyrimidin-6-one::US10780092, Example 113-A Guanylate cyclase soluble subunit alpha-1 Human 2.90 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463260&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156086 441573110 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956433 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1 InChI=1S/C22H16F6N8O2/c1-20(9-2-3-10(23)13(37)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38) FVAYFZATNABPHP-UHFFFAOYSA-N 463261 4-Amino-5-(4-fluoro-3- hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)-[1,2,4]- triazolo[1,5-a]pyrazin-6- yl)-5,7-dihydro-6H- pyrrolo(2,3-d]pyrimidin- 6-one::US10780092, Example 114-B Guanylate cyclase soluble subunit alpha-1 Human 4.95 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463261&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156087 441573111 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956434 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1 InChI=1S/C23H17F6N7O2/c1-21(10-2-3-11(24)14(37)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38) LEFIABAAHJTGKS-UHFFFAOYSA-N 463262 4-Amino-5-(4-fluoro- 3-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)- imidazo[1,2-a]pyrazin- 6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 115-B Guanylate cyclase soluble subunit alpha-1 Human 5.03 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463262&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144792 441573112 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956435 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1 InChI=1S/C22H16F6N8O2/c1-20(9-2-3-13(37)10(23)6-9)14-15(29)33-16(34-17(14)35-19(20)38)12-7-36-18(30-8-31-36)11(32-12)4-5-21(24,25)22(26,27)28/h2-3,6-8,37H,4-5H2,1H3,(H3,29,33,34,35,38) IAWCYNIHAQZTQD-UHFFFAOYSA-N 463263 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)- [1,2,4]triazolo[1,5-a] pyrazin-6-yl)-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 116-B Guanylate cyclase soluble subunit alpha-1 Human 6.38 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463263&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144544 441573113 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956436 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1 InChI=1S/C23H17F6N7O2/c1-21(10-2-3-14(37)11(24)8-10)15-16(30)33-17(34-18(15)35-20(21)38)13-9-36-7-6-31-19(36)12(32-13)4-5-22(25,26)23(27,28)29/h2-3,6-9,37H,4-5H2,1H3,(H3,30,33,34,35,38) VBOAGCHEJBFRCJ-UHFFFAOYSA-N 463264 4-Amino-5-(3-fluoro- 4-hydroxyphenyl)-5- methyl-2-(8-(3,3,4,4,4- pentafluorobutyl)- imidazo[1,2-a]pyrazin- 6-yl)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 117-B Guanylate cyclase soluble subunit alpha-1 Human 8.55 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463264&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145396 441573114 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956437 CCCCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1 InChI=1S/C21H21N9O2/c1-3-4-5-12-19-24-10-25-30(19)9-13(26-12)17-27-16(22)15-18(28-17)29-20(32)21(15,2)14-8-11(31)6-7-23-14/h6-10H,3-5H2,1-2H3,(H,23,31)(H3,22,27,28,29,32) NQJKMCSIXXPDJA-UHFFFAOYSA-N 463265 4-Amino-2-(8-butyl- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl)-5-(4- hydroxypyridin-2-yl)- 5-methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 118-B Guanylate cyclase soluble subunit alpha-1 Human 7.95 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463265&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144528 441573115 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956438 CC(C)CCc1nc(cn2ncnc12)-c1nc2NC(=O)C(C)(c2c(N)n1)c1cc(O)ccn1 InChI=1S/C22H23N9O2/c1-11(2)4-5-13-20-25-10-26-31(20)9-14(27-13)18-28-17(23)16-19(29-18)30-21(33)22(16,3)15-8-12(32)6-7-24-15/h6-11H,4-5H2,1-3H3,(H,24,32)(H3,23,28,29,30,33) XXODUAHXSYVGFA-UHFFFAOYSA-N 463266 4-Amino-5-(4- hydroxypyridin-2-yl)- 2-(8-isopentyl-[1,2,4]- triazolo[1,5-a]pyrazin- 6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 119-B Guanylate cyclase soluble subunit alpha-1 Human 2.76 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463266&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144530 441573116 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956439 CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1 InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-20(36)17(28)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37) SSSLETLXJBTJJS-UHFFFAOYSA-N 463267 4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-{8-[(4-methyl- cyclohexyl)methyl]- imidazo[1,2-a]pyrazin- 6-yl}-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 120-BA::US10780092, Example 120-BB Guanylate cyclase soluble subunit alpha-1 Human 10.9 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463267&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144660 441573117 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956440 CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1 InChI=1S/C27H28ClN7O2/c1-14-3-5-15(6-4-14)11-18-25-30-9-10-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-7-8-20(36)17(28)12-16/h7-10,12-15,36H,3-6,11H2,1-2H3,(H3,29,32,33,34,37) SSSLETLXJBTJJS-UHFFFAOYSA-N 463267 4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-{8-[(4-methyl- cyclohexyl)methyl]- imidazo[1,2-a]pyrazin- 6-yl}-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 120-BA::US10780092, Example 120-BB Guanylate cyclase soluble subunit alpha-1 Human 3.79 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463267&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144660 441573117 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956441 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cccc(O)c1 InChI=1S/C26H20FN7O2/c1-26(15-5-3-7-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-9-8-29-24(34)18(30-19)11-14-4-2-6-16(27)10-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36) KPRALRFUVJPZLT-UHFFFAOYSA-N 463269 4-Amino-2-{8-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl}-5-(3-hydroxyphenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 121-B Guanylate cyclase soluble subunit alpha-1 Human 0.382 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463269&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144427 441573118 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956442 Cc1cccc(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2cccc(O)c2)c1 InChI=1S/C27H23N7O2/c1-15-5-3-6-16(11-15)12-19-25-29-9-10-34(25)14-20(30-19)23-31-22(28)21-24(32-23)33-26(36)27(21,2)17-7-4-8-18(35)13-17/h3-11,13-14,35H,12H2,1-2H3,(H3,28,31,32,33,36) BTEJPOPMXSAION-UHFFFAOYSA-N 463270 4-Amino-5-(3-hydroxy- phenyl)-5-methyl-2-{8- [(3-methylphenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 122-B Guanylate cyclase soluble subunit alpha-1 Human 15.6 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463270&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155940 441573119 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956443 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2)n1)c1cccc(O)c1 InChI=1S/C26H21N7O2/c1-26(16-8-5-9-17(34)13-16)20-21(27)30-22(31-23(20)32-25(26)35)19-14-33-11-10-28-24(33)18(29-19)12-15-6-3-2-4-7-15/h2-11,13-14,34H,12H2,1H3,(H3,27,30,31,32,35) CULLSKISFGJVOO-UHFFFAOYSA-N 463271 4-Amino-2-(8-benzyl- imidaxol[1,2-a]pyrazin- 6-yl)-5-(3-hydroxyphenyl)- 5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 123-B Guanylate cyclase soluble subunit alpha-1 Human 0.372 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463271&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144605 441573120 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956444 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(Cl)c2)n1)c1cccc(O)c1 InChI=1S/C26H20ClN7O2/c1-26(15-5-3-7-17(35)12-15)20-21(28)31-22(32-23(20)33-25(26)36)19-13-34-9-8-29-24(34)18(30-19)11-14-4-2-6-16(27)10-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36) KORYMFJWUORIRW-UHFFFAOYSA-N 463272 4-Amino-2-{8-[(3- chlorophenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5-(3-hydroxyphenyl)- 5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 124-B Guanylate cyclase soluble subunit alpha-1 Human 2.63 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463272&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144993 441573121 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956445 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(O)c(F)c1 InChI=1S/C26H19F2N7O2/c1-26(14-5-6-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(27)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) QZXHKSVXPNQNCY-UHFFFAOYSA-N 463273 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-2-{8-[(3- fluorophenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5-methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 125-B Guanylate cyclase soluble subunit alpha-1 Human 0.508 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463273&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144520 441573122 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956446 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(Cl)c2)n1)c1ccc(O)c(F)c1 InChI=1S/C26H19ClFN7O2/c1-26(14-5-6-19(36)16(28)11-14)20-21(29)32-22(33-23(20)34-25(26)37)18-12-35-8-7-30-24(35)17(31-18)10-13-3-2-4-15(27)9-13/h2-9,11-12,36H,10H2,1H3,(H3,29,32,33,34,37) BUHMVDZFMOUDRF-UHFFFAOYSA-N 463274 4-Amino-2-{8-[(3- chlorophenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5-(3-fluoro-4-hydroxy- phenyl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 126-B Guanylate cyclase soluble subunit alpha-1 Human 1.10 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463274&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132155941 441573123 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956447 Cc1cccc(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(F)c2)c1 InChI=1S/C27H22FN7O2/c1-14-4-3-5-15(10-14)11-18-25-30-8-9-35(25)13-19(31-18)23-32-22(29)21-24(33-23)34-26(37)27(21,2)16-6-7-20(36)17(28)12-16/h3-10,12-13,36H,11H2,1-2H3,(H3,29,32,33,34,37) XHTVPDMMQQROKG-UHFFFAOYSA-N 463275 4-Amino-5-(3-fluoro-4- hydroxyphenyl)-5-methyl- 2-{8-[(3-methylphenyl)- methyl]imidazo[1,2-a]- pyrazin-6-yl}-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 127-B Guanylate cyclase soluble subunit alpha-1 Human 9.72 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463275&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144662 441573124 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956448 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2)n1)c1ccc(O)c(F)c1 InChI=1S/C26H20FN7O2/c1-26(15-7-8-19(35)16(27)12-15)20-21(28)31-22(32-23(20)33-25(26)36)18-13-34-10-9-29-24(34)17(30-18)11-14-5-3-2-4-6-14/h2-10,12-13,35H,11H2,1H3,(H3,28,31,32,33,36) MMNXROFKTLLYLM-UHFFFAOYSA-N 463276 4-Amino-2-(8-benzyl- imidazo[1,2-a]pyrazin- 6-yl)-5-(3-fluoro-4- hydroxyphenyl)-5- methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 128-B Guanylate cyclase soluble subunit alpha-1 Human 0.646 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463276&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144680 441573125 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956449 CC1(C(=O)Nc2nc(nc(N3CC(O)(C3)C(F)(F)F)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(F)c(O)c1 InChI=1S/C27H20F9N7O3/c1-23(12-2-3-13(28)16(44)8-12)17-19(41-22(23)45)39-18(40-21(17)43-10-24(46,11-43)26(31,32)33)15-9-42-7-6-37-20(42)14(38-15)4-5-25(29,30)27(34,35)36/h2-3,6-9,44,46H,4-5,10-11H2,1H3,(H,39,40,41,45) FLUOIJREICOWTO-UHFFFAOYSA-N 463277 5-(4-Fluoro-3-hydroxyphenyl)-4-(3-hydroxy-3-(trifluoromethyl)azetidin-1-yl)-5-methyl-2-(8-(3,3,4,4,4-pentafluorobutyl)imidazo[1,2-a]pyrazin-6-yl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 129-B Guanylate cyclase soluble subunit alpha-1 Human 2.00 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463277&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144510 441573126 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956450 CC1(C(=O)Nc2nc(nc(N3CC(O)(C3)C(F)(F)F)c12)-c1cn2ccnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(O)c(F)c1 InChI=1S/C27H20F9N7O3/c1-23(12-2-3-16(44)13(28)8-12)17-19(41-22(23)45)39-18(40-21(17)43-10-24(46,11-43)26(31,32)33)15-9-42-7-6-37-20(42)14(38-15)4-5-25(29,30)27(34,35)36/h2-3,6-9,44,46H,4-5,10-11H2,1H3,(H,39,40,41,45) MMSOLCGKMBISKH-UHFFFAOYSA-N 463278 5-(3-Fluoro-4-hydroxyphenyl)-4-(3-hydroxy-3-(trifluoromethyl)azetidin-1-yl)-5-methyl-2-(8-(3,3,4,4,4-pentafluorobutyl)imidazo[1,2-a]pyrazin-6-yl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 130-A Guanylate cyclase soluble subunit alpha-1 Human 7.15 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463278&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132143369 441573127 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956451 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C29H22ClF4N7O3/c1-28(15-5-6-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-8-7-35-26(41)18(37-19)10-14-3-2-4-16(31)9-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44) RWNKRYZPKPEOAZ-UHFFFAOYSA-N 463279 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(3-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-4-[(3,3,3-trifluoro- 2-hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 131-AA::US10780092, Example 131-AB Guanylate cyclase soluble subunit alpha-1 Human 0.884 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463279&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144517 441573128 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956452 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C29H22ClF4N7O3/c1-28(15-5-6-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-8-7-35-26(41)18(37-19)10-14-3-2-4-16(31)9-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44) RWNKRYZPKPEOAZ-UHFFFAOYSA-N 463279 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(3-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-4-[(3,3,3-trifluoro- 2-hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 131-AA::US10780092, Example 131-AB Guanylate cyclase soluble subunit alpha-1 Human 0.347 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463279&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144517 441573128 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956453 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C29H22ClF4N7O3/c1-28(15-4-7-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-9-8-35-26(41)18(37-19)10-14-2-5-16(31)6-3-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44) YPWMLXNQOQBFMS-UHFFFAOYSA-N 463281 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}- 5-methyl-4-[(3,3,3- trifluoro-2-hydroxy- propyl)amino]-5,7- dihydro-6H-pyrrolo- [2,3-d]-pyrimidin-6-one::US10780092, Example 132-AA::US10780092, Example 132-AB Guanylate cyclase soluble subunit alpha-1 Human 1.21 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463281&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145970 441573129 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956454 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C29H22ClF4N7O3/c1-28(15-4-7-17(30)20(42)11-15)22-24(36-12-21(43)29(32,33)34)38-23(39-25(22)40-27(28)44)19-13-41-9-8-35-26(41)18(37-19)10-14-2-5-16(31)6-3-14/h2-9,11,13,21,42-43H,10,12H2,1H3,(H2,36,38,39,40,44) YPWMLXNQOQBFMS-UHFFFAOYSA-N 463281 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}- 5-methyl-4-[(3,3,3- trifluoro-2-hydroxy- propyl)amino]-5,7- dihydro-6H-pyrrolo- [2,3-d]-pyrimidin-6-one::US10780092, Example 132-AA::US10780092, Example 132-AB Guanylate cyclase soluble subunit alpha-1 Human 1.46 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463281&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145970 441573129 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956455 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C25H19ClF8N8O3/c1-22(10-2-3-11(26)14(43)6-10)16-18(35-7-15(44)24(29,30)31)39-17(40-19(16)41-21(22)45)13-8-42-20(36-9-37-42)12(38-13)4-5-23(27,28)25(32,33)34/h2-3,6,8-9,15,43-44H,4-5,7H2,1H3,(H2,35,39,40,41,45) KYIBDNDGOPSVQG-UHFFFAOYSA-N 463283 5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- [(3,3,3-trifluoro-2- hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 133-AA::US10780092, Example 133-AB Guanylate cyclase soluble subunit alpha-1 Human 2.34 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463283&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145506 441573130 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956456 CC1(C(=O)Nc2nc(nc(NCC(O)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C25H19ClF8N8O3/c1-22(10-2-3-11(26)14(43)6-10)16-18(35-7-15(44)24(29,30)31)39-17(40-19(16)41-21(22)45)13-8-42-20(36-9-37-42)12(38-13)4-5-23(27,28)25(32,33)34/h2-3,6,8-9,15,43-44H,4-5,7H2,1H3,(H2,35,39,40,41,45) KYIBDNDGOPSVQG-UHFFFAOYSA-N 463283 5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- [(3,3,3-trifluoro-2- hydroxypropyl)amino]- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 133-AA::US10780092, Example 133-AB Guanylate cyclase soluble subunit alpha-1 Human 9.24 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463283&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145506 441573130 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956457 CN1CCN(CC1)c1nc(nc2NC(=O)C(C)(c12)c1ccc(Cl)c(O)c1)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1 InChI=1S/C31H28ClFN8O2/c1-31(19-5-8-21(32)24(42)16-19)25-27(38-30(31)43)36-26(37-29(25)40-13-11-39(2)12-14-40)23-17-41-10-9-34-28(41)22(35-23)15-18-3-6-20(33)7-4-18/h3-10,16-17,42H,11-15H2,1-2H3,(H,36,37,38,43) SOTJLJBXAWIDBJ-UHFFFAOYSA-N 463285 5-(4-Chloro-3-hydroxy- phenyl)-2-{8-[(4-fluoro- phenyl)methyl]imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-4-(4-methyl- piperazin-1-yl)-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 134-A Guanylate cyclase soluble subunit alpha-1 Human 0.592 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463285&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144534 441573131 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956458 CC1(C(=O)Nc2nc(nc(N3CCC(F)(F)CC3)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1cccc(O)c1 InChI=1S/C31H26F3N7O2/c1-30(19-3-2-4-21(42)16-19)24-26(39-29(30)43)37-25(38-28(24)40-12-9-31(33,34)10-13-40)23-17-41-14-11-35-27(41)22(36-23)15-18-5-7-20(32)8-6-18/h2-8,11,14,16-17,42H,9-10,12-13,15H2,1H3,(H,37,38,39,43) WAMBPACKCNYZTF-UHFFFAOYSA-N 463286 4-(4,4-Difluoropiperidin- 1-yl)-2-{8-[(4-fluoro- phenyl)methyl]imidazo- [1,2-a]-pyrazin-6-yl}-5- (3-hydroxyphenyl)-5- methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 135-B Guanylate cyclase soluble subunit alpha-1 Human 4.01 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463286&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145978 441573132 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956459 CC1(C(=O)Nc2nc(nc(N3CCC(F)(F)CC3)c12)-c1cn2ccnc2c(Cc2ccc(F)cc2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C31H25ClF3N7O2/c1-30(18-4-7-20(32)23(43)15-18)24-26(40-29(30)44)38-25(39-28(24)41-11-8-31(34,35)9-12-41)22-16-42-13-10-36-27(42)21(37-22)14-17-2-5-19(33)6-3-17/h2-7,10,13,15-16,43H,8-9,11-12,14H2,1H3,(H,38,39,40,44) BPNLMMSCCGACBC-UHFFFAOYSA-N 463287 5-(4-Chloro-3-hydroxy- phenyl)-4-(4,4-difluoro- piperidin-1-yl)-2-{8-[(4- fluorophenyl)methyl]- imidazo[1,2-a]pyrazin-6- yl}-5-methyl-5,7-dihydro- 6H-pyrrolo[2,3-d]- pyrimidin-6-one::US10780092, Example 136-A Guanylate cyclase soluble subunit alpha-1 Human 1.57 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463287&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145318 441573133 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956460 CC1(C(=O)Nc2nc(nc(N3CCC(CC3)C(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C28H23ClF8N8O2/c1-25(14-2-3-15(29)18(46)10-14)19-21(43-24(25)47)41-20(42-23(19)44-8-5-13(6-9-44)27(32,33)34)17-11-45-22(38-12-39-45)16(40-17)4-7-26(30,31)28(35,36)37/h2-3,10-13,46H,4-9H2,1H3,(H,41,42,43,47) KSFMEUCXGHZQGE-UHFFFAOYSA-N 463288 5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- (4-(trifluoromethyl)- piperidin-1-yl)-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 137-A Guanylate cyclase soluble subunit alpha-1 Human 2.63 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463288&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144669 441573134 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956461 CC1(C(=O)Nc2nc(nc(NCCC(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C25H19ClF8N8O2/c1-22(11-2-3-12(26)15(43)8-11)16-18(35-7-6-24(29,30)31)39-17(40-19(16)41-21(22)44)14-9-42-20(36-10-37-42)13(38-14)4-5-23(27,28)25(32,33)34/h2-3,8-10,43H,4-7H2,1H3,(H2,35,39,40,41,44) OHGAQXQQRIYABC-UHFFFAOYSA-N 463289 5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- ((3,3,3-trifluoropropyl)- amino)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 138-A Guanylate cyclase soluble subunit alpha-1 Human 4.62 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463289&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156012 441573135 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956462 CC1(C(=O)Nc2nc(nc(NCCCC(F)(F)F)c12)-c1cn2ncnc2c(CCC(F)(F)C(F)(F)F)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H21ClF8N8O2/c1-23(12-3-4-13(27)16(44)9-12)17-19(36-8-2-6-25(30,31)32)40-18(41-20(17)42-22(23)45)15-10-43-21(37-11-38-43)14(39-15)5-7-24(28,29)26(33,34)35/h3-4,9-11,44H,2,5-8H2,1H3,(H2,36,40,41,42,45) YYBGJQJKKGGQTJ-UHFFFAOYSA-N 463290 5-(4-Chloro-3-hydroxy- phenyl)-5-methyl-2-(8- (3,3,4,4,4-pentafluoro- butyl)-[1,2,4]triazolo- [1,5-a]pyrazin-6-yl)-4- ((4,4,4-trifluorobutyl)- amino)-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 139-A Guanylate cyclase soluble subunit alpha-1 Human 3.54 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463290&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144804 441573136 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956463 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2c(N)cnc2c(Cc2cccc(F)c2)n1)c1ccc(Cl)c(O)c1 InChI=1S/C26H20ClFN8O2/c1-26(13-5-6-15(27)18(37)9-13)20-21(30)33-22(34-23(20)35-25(26)38)17-11-36-19(29)10-31-24(36)16(32-17)8-12-3-2-4-14(28)7-12/h2-7,9-11,37H,8,29H2,1H3,(H3,30,33,34,35,38) RGNLRJVZTWFMLG-UHFFFAOYSA-N 463291 4-Amino-2-(3-amino-8-[(3-fluorophenyl)methyl]imidazo[1,2-a]pyrazin-6-yl)-5-(4-chloro-3-hydroxyphenyl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 140-A Guanylate cyclase soluble subunit alpha-1 Human 0.827 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463291&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144554 441573137 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956464 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCC2)n1)c1cc(O)c(Cl)cn1 InChI=1S/C24H23ClN8O2/c1-24(17-9-16(34)13(25)10-28-17)18-19(26)30-20(31-21(18)32-23(24)35)15-11-33-7-6-27-22(33)14(29-15)8-12-4-2-3-5-12/h6-7,9-12H,2-5,8H2,1H3,(H,28,34)(H3,26,30,31,32,35) IVFVQLNVPHBBCZ-UHFFFAOYSA-N 463292 4-amino-5-(5-chloro-4- hydroxypyridin-2-yl)-2- (8-(cyclopentylmethyl)- imidazo[1,2-a]pyrazin- 6-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 141-B Guanylate cyclase soluble subunit alpha-1 Human 0.706 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463292&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156013 441573138 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956465 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(Cl)c1 InChI=1S/C27H25ClN8O2/c1-27(15-10-17(28)16(12-29)20(37)11-15)21-22(30)33-23(34-24(21)35-26(27)38)19-13-36-8-7-31-25(36)18(32-19)9-14-5-3-2-4-6-14/h7-8,10-11,13-14,37H,2-6,9H2,1H3,(H3,30,33,34,35,38) NBMPJJAVCAIIES-UHFFFAOYSA-N 463293 4-(4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a]pyrazin- 6-yl}-5-methyl-6-oxo- 6,7-dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5-yl)- 2-chloro-6-hydroxy- benzonitrile::US10780092, Example 142-A Guanylate cyclase soluble subunit alpha-1 Human 1.14 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463293&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144560 441573139 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956466 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(Cl)c1 InChI=1S/C27H18ClFN8O2/c1-27(14-9-16(28)15(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-7-6-32-25(37)18(33-19)8-13-4-2-3-5-17(13)29/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39) OJXGPODKFHJLJT-UHFFFAOYSA-N 463294 4-(4-amino-2-{8-(2- fluorobenzyl)imidazo- [1,2-a]pyrazin-6-yl}- 5-methyl-6-oxo-6,7- dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5-yl)- 2-chloro-6-hydroxy- benzonitrile::US10780092, Example 143-A Guanylate cyclase soluble subunit alpha-1 Human 1.09 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463294&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144458 441573140 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956467 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(C#N)c(Cl)c1 InChI=1S/C27H18ClFN8O2/c1-27(14-9-17(28)16(11-30)20(38)10-14)21-22(31)34-23(35-24(21)36-26(27)39)19-12-37-6-5-32-25(37)18(33-19)8-13-3-2-4-15(29)7-13/h2-7,9-10,12,38H,8H2,1H3,(H3,31,34,35,36,39) DBDDDFQYAYJALJ-UHFFFAOYSA-N 463295 4-(4-amino-2-{8-(3- fluorobenzyl)imidazo- [1,2-a]pyrazin-6-yl}-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5-yl)- 2-chloro-6-hydroxy- benzonitrile::US10780092, Example 144-A Guanylate cyclase soluble subunit alpha-1 Human 0.333 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463295&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144462 441573141 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956468 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1)c1cc(O)c(cn1)C(F)(F)F InChI=1S/C26H18F4N8O2/c1-25(18-9-17(39)14(10-33-18)26(28,29)30)19-20(31)35-21(36-22(19)37-24(25)40)16-11-38-6-5-32-23(38)15(34-16)8-12-3-2-4-13(27)7-12/h2-7,9-11H,8H2,1H3,(H,33,39)(H3,31,35,36,37,40) IFAUPDJSJNTWKA-UHFFFAOYSA-N 463296 4-amino-2-(8-{3- fluorobenzyl}imidazo- [1,2-a]pyrazin-6-yl)- 5-(4-hydroxy-5- (trifluoromethyl)pyridin- 2-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 145-B Guanylate cyclase soluble subunit alpha-1 Human 0.416 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463296&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132150208 441573142 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956469 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2ccccc2F)n1)c1cc(O)c(cn1)C(F)(F)F InChI=1S/C26H18F4N8O2/c1-25(18-9-17(39)13(10-33-18)26(28,29)30)19-20(31)35-21(36-22(19)37-24(25)40)16-11-38-7-6-32-23(38)15(34-16)8-12-4-2-3-5-14(12)27/h2-7,9-11H,8H2,1H3,(H,33,39)(H3,31,35,36,37,40) QDLOQGYQYPORIM-UHFFFAOYSA-N 463297 4-amino-2-(8-{2- fluorobenzyl}imidazo- [1,2-a]pyrazin-6-yl)- 5-(4-hydroxy-5- (trifluoromethyl)- pyridin-2-yl)-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 146-B Guanylate cyclase soluble subunit alpha-1 Human 0.378 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463297&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132145533 441573143 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956470 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(CC2CCCCC2)n1)c1cc(O)c(cn1)C(F)(F)F InChI=1S/C26H25F3N8O2/c1-25(18-10-17(38)14(11-32-18)26(27,28)29)19-20(30)34-21(35-22(19)36-24(25)39)16-12-37-8-7-31-23(37)15(33-16)9-13-5-3-2-4-6-13/h7-8,10-13H,2-6,9H2,1H3,(H,32,38)(H3,30,34,35,36,39) DGXTZLOZTIAMKV-UHFFFAOYSA-N 463298 4-amino-2-{8- (cyclohexylmethyl)- imidazo[1,2-a]pyrazin- 6-yl}-5-(4-hydroxy-5- (trifluoromethyl)pyridin- 2-yl)-5-methyl-5,7- dihydro-6H-pyrrolo- [2,3-d]pyrimidin-6-one::US10780092, Example 147-B Guanylate cyclase soluble subunit alpha-1 Human 0.905 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463298&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144604 441573144 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956471 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(Cl)cn1 InChI=1S/C24H17ClFN9O2/c1-24(17-7-16(36)12(25)8-28-17)18-19(27)32-20(33-21(18)34-23(24)37)15-9-35-22(29-10-30-35)14(31-15)6-11-4-2-3-5-13(11)26/h2-5,7-10H,6H2,1H3,(H,28,36)(H3,27,32,33,34,37) SZWFXUFEKQDKFH-UHFFFAOYSA-N 463299 4-amino-5-(5-chloro- 4-hydroxypyridin-2- yl)-2-{8-(2-fluorobenzyl)- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl}-5-methyl- 5,7-dihydro-6H-pyrrolo- [2,3-c]pyrimidin-6-one::US10780092, Example 148-B Guanylate cyclase soluble subunit alpha-1 Human 0.261 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463299&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156082 441573145 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956472 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccccc2F)n1)c1cc(O)c(C#N)c(Cl)c1 InChI=1S/C26H17ClFN9O2/c1-26(13-7-15(27)14(9-29)19(38)8-13)20-21(30)34-22(35-23(20)36-25(26)39)18-10-37-24(31-11-32-37)17(33-18)6-12-4-2-3-5-16(12)28/h2-5,7-8,10-11,38H,6H2,1H3,(H3,30,34,35,36,39) IEYJPAZIVOJTHW-UHFFFAOYSA-N 463300 4-(4-amino-2-{8-(2- fluorobenzyl)-[1,2,4]- triazolo[1,5-a]pyrazin- 6-yl}-5-methyl-6-oxo- 6,7-dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5-yl)- 2-chloro-6-hydroxy- benzonitrile::US10780092, Example 149-A Guanylate cyclase soluble subunit alpha-1 Human 0.509 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463300&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156083 441573146 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956473 CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(CC2CCCCC2)n1)c1cc(O)c(C#N)c(Cl)c1 InChI=1S/C26H24ClN9O2/c1-26(14-8-16(27)15(10-28)19(37)9-14)20-21(29)33-22(34-23(20)35-25(26)38)18-11-36-24(30-12-31-36)17(32-18)7-13-5-3-2-4-6-13/h8-9,11-13,37H,2-7H2,1H3,(H3,29,33,34,35,38) LGYMEHCAJMVJFE-UHFFFAOYSA-N 463301 4-(4-amino-2-{8- (cyclohexylmethyl)- [1,2,4]triazolo[1,5-a]- pyrazin-6-yl}-5- methyl-6-oxo-6,7- dihydro-5H-pyrrolo- [2,3-d]pyrimidin-5- yl)-2-chloro-6-hydroxy- benzonitrile::US10780092, Example 150-A Guanylate cyclase soluble subunit alpha-1 Human 0.989 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463301&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132144468 441573147 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3 956474 Cc1cnc(cc1O)C1(C)C(=O)Nc2nc(nc(N)c12)-c1cn2ccnc2c(Cc2cccc(F)c2)n1 InChI=1S/C26H21FN8O2/c1-13-11-30-19(10-18(13)36)26(2)20-21(28)32-22(33-23(20)34-25(26)37)17-12-35-7-6-29-24(35)16(31-17)9-14-4-3-5-15(27)8-14/h3-8,10-12H,9H2,1-2H3,(H,30,36)(H3,28,32,33,34,37) FURKQBFBSJTMAH-UHFFFAOYSA-N 463302 4-Amino-2-{8-(3-fluorobenzyl)imidazo[1,2-a]pyrazin-6-yl}-5-(4-hydroxy-5-methylpyridin-2-yl)-5-methyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 151-A Guanylate cyclase soluble subunit alpha-1 Human 0.155 US Patent 10.7270/Q2668H8C aid1804809 US10780092 Whitehead, A; Ornoski, O; Raghavan, S; Berger, R; Garfunkle, J; Yang, Z; Ji, G; Jiang, F; Fu, J 9/22/2020 5/2/2021 Merck Sharp & Dohme Corp. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=463302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8949&target=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=463302&enzyme=Guanylate+cyclase+soluble+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132156007 441573148 1 MFCTKLKDLKITGECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRKTSRSRVYLHTLAESICKLIFPEFERLNVALQRTLAKHKIKESRKSLEREDFEKTIAEQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTNSKPCFQKKDVEDGNANFLGKASGID Guanylate cyclase soluble subunit alpha-1 GCYA1_HUMAN Q02108 D3DP19 D6RDW3 O43843 Q8TAH3