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Compile Data Set for Download or QSAR

Found 648 hits Enz. Inhib. hit(s) with all data for entry = 432   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269150
PNG
(US9718825, Example 596)
Show SMILES CCOc1nc(cc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1
Show InChI InChI=1S/C21H20FN5O3S/c1-3-30-21-19-17(25-26-20(19)23)11-16(24-21)13-5-7-14(8-6-13)27-31(28,29)18-10-12(2)4-9-15(18)22/h4-11,27H,3H2,1-2H3,(H3,23,25,26)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269143
PNG
(US9718825, Example 589)
Show SMILES CC(C)N1CC(COc2nc(cc3[nH]nc(C)c23)-c2ccc(NS(=O)(=O)c3cc(C)ccc3F)cc2)C1
Show InChI InChI=1S/C27H30FN5O3S/c1-16(2)33-13-19(14-33)15-36-27-26-18(4)30-31-24(26)12-23(29-27)20-6-8-21(9-7-20)32-37(34,35)25-11-17(3)5-10-22(25)28/h5-12,16,19,32H,13-15H2,1-4H3,(H,30,31)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268829
PNG
(US9718825, Example 234)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1
Show InChI InChI=1S/C23H23FN6O5S/c1-33-16-6-7-18(24)19(8-16)36(31,32)30-15-4-2-14(3-5-15)20-27-21-17(9-26-29-21)22(28-20)35-13-23(10-25)11-34-12-23/h2-9,30H,10-13,25H2,1H3,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269083
PNG
(US9718825, Example 527)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncc2c(N)n[nH]c2n1
Show InChI InChI=1S/C18H15FN6O3S/c1-28-12-6-7-14(19)15(8-12)29(26,27)25-11-4-2-10(3-5-11)17-21-9-13-16(20)23-24-18(13)22-17/h2-9,25H,1H3,(H3,20,21,22,23,24)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269008
PNG
(US9718825, Example 451)
Show SMILES CCOc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1
Show InChI InChI=1S/C19H15ClF2N6O3S/c1-2-31-19-15-16(23)26-27-18(15)24-17(25-19)9-3-5-10(6-4-9)28-32(29,30)14-7-11(20)12(21)8-13(14)22/h3-8,28H,2H2,1H3,(H3,23,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268860
PNG
(US9718825, Example 265)
Show SMILES CN1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C23H22ClFN6O3S/c1-31-10-8-17(9-11-31)34-23-18-13-26-29-22(18)27-21(28-23)14-2-5-16(6-3-14)30-35(32,33)20-12-15(24)4-7-19(20)25/h2-7,12-13,17,30H,8-11H2,1H3,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268850
PNG
(US9718825, Example 255 | US9718825, Example 261)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C23H20ClF3N6O3S/c1-12-19-21(32-31-12)29-20(30-22(19)36-18-8-9-28-11-23(18,26)27)13-2-5-15(6-3-13)33-37(34,35)17-10-14(24)4-7-16(17)25/h2-7,10,18,28,33H,8-9,11H2,1H3,(H,29,30,31,32)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268828
PNG
(US9718825, Example 233)
Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCC2(CN)COC2)c2cn[nH]c2n1
Show InChI InChI=1S/C23H23ClN6O5S/c1-33-16-6-7-18(24)19(8-16)36(31,32)30-15-4-2-14(3-5-15)20-27-21-17(9-26-29-21)22(28-20)35-13-23(10-25)11-34-12-23/h2-9,30H,10-13,25H2,1H3,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268875
PNG
(US9718825, Example 300)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
Show InChI InChI=1S/C25H24FN7O3S/c1-14-3-4-17(12-27)21(11-14)37(34,35)33-18-7-5-16(6-8-18)23-29-24-22(15(2)31-32-24)25(30-23)36-20-9-10-28-13-19(20)26/h3-8,11,19-20,28,33H,9-10,13H2,1-2H3,(H,29,30,31,32)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268698
PNG
(US9718825, Example 100)
Show SMILES Cc1n[nH]c2nc(nc(NC3CCCC(O)C3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2C#N)cc1
Show InChI InChI=1S/C25H24ClN7O3S/c1-14-22-24(28-19-3-2-4-20(34)12-19)29-23(30-25(22)32-31-14)15-6-9-18(10-7-15)33-37(35,36)21-11-17(26)8-5-16(21)13-27/h5-11,19-20,33-34H,2-4,12H2,1H3,(H2,28,29,30,31,32)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269092
PNG
(US9718825, Example 537)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1ncc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C21H16Cl2N6O3S/c22-13-5-8-16(23)17(9-13)33(31,32)29-14-6-3-11(4-7-14)18-24-10-15-19(25-18)27-28-20(15)26-21(30)12-1-2-12/h3-10,12,29H,1-2H2,(H2,24,25,26,27,28,30)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268847
PNG
(US9718825, Example 252)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1
Show InChI InChI=1S/C24H23F3N6O3S/c1-13-3-8-17(25)18(11-13)37(34,35)33-16-6-4-15(5-7-16)21-29-22-20(14(2)31-32-22)23(30-21)36-19-9-10-28-12-24(19,26)27/h3-8,11,19,28,33H,9-10,12H2,1-2H3,(H,29,30,31,32)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268639
PNG
(US9718825, Example 41)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2cncn2)c2cn[nH]c2n1
Show InChI InChI=1S/C19H12Cl2N8O2S/c20-12-3-6-15(21)16(7-12)32(30,31)28-13-4-1-11(2-5-13)17-25-18-14(8-23-27-18)19(26-17)29-10-22-9-24-29/h1-10,28H,(H,23,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268644
PNG
(US9718825, Example 46)
Show SMILES NCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C20H19ClFN7O2S/c21-13-4-7-16(22)17(10-13)32(30,31)29-14-5-2-12(3-6-14)18-26-19(24-9-1-8-23)15-11-25-28-20(15)27-18/h2-7,10-11,29H,1,8-9,23H2,(H2,24,25,26,27,28)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268648
PNG
(US9718825, Example 50)
Show SMILES NCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C19H17ClFN7O2S/c20-12-3-6-15(21)16(9-12)31(29,30)28-13-4-1-11(2-5-13)17-25-18(23-8-7-22)14-10-24-27-19(14)26-17/h1-6,9-10,28H,7-8,22H2,(H2,23,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268649
PNG
(US9718825, Example 51)
Show SMILES NCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C19H17Cl2N7O2S/c20-12-3-6-15(21)16(9-12)31(29,30)28-13-4-1-11(2-5-13)17-25-18(23-8-7-22)14-10-24-27-19(14)26-17/h1-6,9-10,28H,7-8,22H2,(H2,23,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268650
PNG
(US9718825, Example 52)
Show SMILES NCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C20H19Cl2N7O2S/c21-13-4-7-16(22)17(10-13)32(30,31)29-14-5-2-12(3-6-14)18-26-19(24-9-1-8-23)15-11-25-28-20(15)27-18/h2-7,10-11,29H,1,8-9,23H2,(H2,24,25,26,27,28)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268659
PNG
(US9718825, Example 61)
Show SMILES OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C23H21Cl2N5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268660
PNG
(US9718825, Example 62)
Show SMILES NCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C20H18ClFN6O3S/c21-13-4-7-16(22)17(10-13)32(29,30)28-14-5-2-12(3-6-14)18-25-19-15(11-24-27-19)20(26-18)31-9-1-8-23/h2-7,10-11,28H,1,8-9,23H2,(H,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50043018
PNG
(CHEMBL3355028 | US9718825, Example 63)
Show SMILES NCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C20H18Cl2N6O3S/c21-13-4-7-16(22)17(10-13)32(29,30)28-14-5-2-12(3-6-14)18-25-19-15(11-24-27-19)20(26-18)31-9-1-8-23/h2-7,10-11,28H,1,8-9,23H2,(H,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268619
PNG
(US9718825, Example 15)
Show SMILES Clc1cccc(c1Cl)S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
Show InChI InChI=1S/C21H19Cl2N7O2S/c22-16-2-1-3-17(18(16)23)33(31,32)29-14-6-4-13(5-7-14)19-26-20-15(12-25-28-20)21(27-19)30-10-8-24-9-11-30/h1-7,12,24,29H,8-11H2,(H,25,26,27,28)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268620
PNG
(US9718825, Example 16)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
Show InChI InChI=1S/C21H19ClFN7O2S/c22-14-3-6-17(23)18(11-14)33(31,32)29-15-4-1-13(2-5-15)19-26-20-16(12-25-28-20)21(27-19)30-9-7-24-8-10-30/h1-6,11-12,24,29H,7-10H2,(H,25,26,27,28)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268621
PNG
(US9718825, Example 17)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(N2CCNCC2)c2cn[nH]c2n1
Show InChI InChI=1S/C21H19Cl2N7O2S/c22-14-3-6-17(23)18(11-14)33(31,32)29-15-4-1-13(2-5-15)19-26-20-16(12-25-28-20)21(27-19)30-9-7-24-8-10-30/h1-6,11-12,24,29H,7-10H2,(H,25,26,27,28)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268626
PNG
(US9718825, Example 23)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2ccncc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14ClFN6O3S/c23-14-3-6-18(24)19(11-14)34(31,32)30-15-4-1-13(2-5-15)20-27-21-17(12-26-29-21)22(28-20)33-16-7-9-25-10-8-16/h1-12,30H,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268627
PNG
(US9718825, Example 24)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2ccncc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14Cl2N6O3S/c23-14-3-6-18(24)19(11-14)34(31,32)30-15-4-1-13(2-5-15)20-27-21-17(12-26-29-21)22(28-20)33-16-7-9-25-10-8-16/h1-12,30H,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268628
PNG
(US9718825, Example 25)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-c2ccncc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14Cl2N6O2S/c23-15-3-6-18(24)19(11-15)33(31,32)30-16-4-1-14(2-5-16)21-27-20(13-7-9-25-10-8-13)17-12-26-29-22(17)28-21/h1-12,30H,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268629
PNG
(US9718825, Example 26)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2cccnc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14ClFN6O3S/c23-14-5-8-18(24)19(10-14)34(31,32)30-15-6-3-13(4-7-15)20-27-21-17(12-26-29-21)22(28-20)33-16-2-1-9-25-11-16/h1-12,30H,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268630
PNG
(US9718825, Example 27)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(Oc2cccnc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14Cl2N6O3S/c23-14-5-8-18(24)19(10-14)34(31,32)30-15-6-3-13(4-7-15)20-27-21-17(12-26-29-21)22(28-20)33-16-2-1-9-25-11-16/h1-12,30H,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50043015
PNG
(CHEMBL3355025 | US9718825, Example 1)
Show SMILES Cc1n[nH]c2nc(ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C18H13Cl2N5O2S/c1-10-14-9-21-17(22-18(14)24-23-10)11-2-5-13(6-3-11)25-28(26,27)16-8-12(19)4-7-15(16)20/h2-9,25H,1H3,(H,21,22,23,24)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50043016
PNG
(CHEMBL3355026 | US9718825, Example 3)
Show SMILES OC1CCC(CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C23H21ClFN5O4S/c24-14-3-10-19(25)20(11-14)35(32,33)30-15-4-1-13(2-5-15)21-27-22-18(12-26-29-22)23(28-21)34-17-8-6-16(31)7-9-17/h1-5,10-12,16-17,30-31H,6-9H2,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268610
PNG
(2,5-Dichloro-N-[4-(4-pyridin-3-yl-1H-pyrazolo[3,4-...)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-c2cccnc2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H14Cl2N6O2S/c23-15-5-8-18(24)19(10-15)33(31,32)30-16-6-3-13(4-7-16)21-27-20(14-2-1-9-25-11-14)17-12-26-29-22(17)28-21/h1-12,30H,(H,26,27,28,29)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268614
PNG
(US9718825, Example 10)
Show SMILES Cc1n[nH]c2nc(ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C18H13ClFN5O2S/c1-10-14-9-21-17(22-18(14)24-23-10)11-2-5-13(6-3-11)25-28(26,27)16-8-12(19)4-7-15(16)20/h2-9,25H,1H3,(H,21,22,23,24)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268638
PNG
(US9718825, Example 40)
Show SMILES Fc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2cncn2)c2cn[nH]c2n1
Show InChI InChI=1S/C19H12ClFN8O2S/c20-12-3-6-15(21)16(7-12)32(30,31)28-13-4-1-11(2-5-13)17-25-18-14(8-23-27-18)19(26-17)29-10-22-9-24-29/h1-10,28H,(H,23,25,26,27)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268637
PNG
(US9718825, Example 39)
Show SMILES Clc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(-n2ccnc2)c2cn[nH]c2n1
Show InChI InChI=1S/C20H13Cl2N7O2S/c21-13-3-6-16(22)17(9-13)32(30,31)28-14-4-1-12(2-5-14)18-25-19-15(10-24-27-19)20(26-18)29-8-7-23-11-29/h1-11,28H,(H,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268635
PNG
(US9718825, Example 36)
Show SMILES OCCCCOc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C21H19Cl2N5O4S/c22-14-5-8-17(23)18(11-14)33(30,31)28-15-6-3-13(4-7-15)19-25-20-16(12-24-27-20)21(26-19)32-10-2-1-9-29/h3-8,11-12,28-29H,1-2,9-10H2,(H,24,25,26,27)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269021
PNG
(US9718825, Example 464)
Show SMILES Cc1nc(nc2[nH]nc(N)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
Show InChI InChI=1S/C18H14Cl2N6O2S/c1-9-15-16(21)24-25-18(15)23-17(22-9)10-2-5-12(6-3-10)26-29(27,28)14-8-11(19)4-7-13(14)20/h2-8,26H,1H3,(H3,21,22,23,24,25)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268740
PNG
(US9718825, Example 142)
Show SMILES Cc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(C2CC2)c2cn[nH]c2n1
Show InChI InChI=1S/C21H18ClN5O2S/c1-12-2-9-17(22)18(10-12)30(28,29)27-15-7-5-14(6-8-15)20-24-19(13-3-4-13)16-11-23-26-21(16)25-20/h2,5-11,13,27H,3-4H2,1H3,(H,23,24,25,26)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268859
PNG
(US9718825, Example 264)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2CCCNC2)c2cn[nH]c2n1
Show InChI InChI=1S/C23H23FN6O3S/c1-14-4-9-19(24)20(11-14)34(31,32)30-16-7-5-15(6-8-16)21-27-22-18(13-26-29-22)23(28-21)33-17-3-2-10-25-12-17/h4-9,11,13,17,25,30H,2-3,10,12H2,1H3,(H,26,27,28,29)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268854
PNG
(US9718825, Example 259)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCNCC3(F)F)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
Show InChI InChI=1S/C25H23F2N7O3S/c1-14-3-4-17(12-28)19(11-14)38(35,36)34-18-7-5-16(6-8-18)22-30-23-21(15(2)32-33-23)24(31-22)37-20-9-10-29-13-25(20,26)27/h3-8,11,20,29,34H,9-10,13H2,1-2H3,(H,30,31,32,33)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269140
PNG
(US9718825, Example 586)
Show SMILES Cc1n[nH]c2cc(nc(OC3CCN(CC3)C3CC3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
Show InChI InChI=1S/C29H30N6O3S/c1-18-3-4-21(17-30)27(15-18)39(36,37)34-22-7-5-20(6-8-22)25-16-26-28(19(2)32-33-26)29(31-25)38-24-11-13-35(14-12-24)23-9-10-23/h3-8,15-16,23-24,34H,9-14H2,1-2H3,(H,32,33)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268851
PNG
(US9718825, Example 256)
Show SMILES COc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2CCNCC2(F)F)c2c(C)n[nH]c2n1
Show InChI InChI=1S/C24H23F3N6O4S/c1-13-20-22(32-31-13)29-21(30-23(20)37-19-9-10-28-12-24(19,26)27)14-3-5-15(6-4-14)33-38(34,35)18-11-16(36-2)7-8-17(18)25/h3-8,11,19,28,33H,9-10,12H2,1-2H3,(H,29,30,31,32)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268914
PNG
(US9718825, Example 339)
Show SMILES Cc1n[nH]c2nc(nc(OC3CCCNC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13-20-22(30-29-13)27-21(28-23(20)34-17-3-2-10-26-12-17)14-4-7-16(8-5-14)31-35(32,33)19-11-15(24)6-9-18(19)25/h4-9,11,17,26,31H,2-3,10,12H2,1H3,(H,27,28,29,30)
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US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268697
PNG
(US9718825, Example 99)
Show SMILES Cc1n[nH]c2nc(nc(NC3CCCC(O)C3)c12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2C#N)cc1
Show InChI InChI=1S/C26H27N7O3S/c1-15-6-7-18(14-27)22(12-15)37(35,36)33-19-10-8-17(9-11-19)24-29-25(23-16(2)31-32-26(23)30-24)28-20-4-3-5-21(34)13-20/h6-12,20-21,33-34H,3-5,13H2,1-2H3,(H2,28,29,30,31,32)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268640
PNG
(US9718825, Example 42)
Show SMILES OCCCNc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1
Show InChI InChI=1S/C20H18ClFN6O3S/c21-13-4-7-16(22)17(10-13)32(30,31)28-14-5-2-12(3-6-14)18-25-19(23-8-1-9-29)15-11-24-27-20(15)26-18/h2-7,10-11,28-29H,1,8-9H2,(H2,23,24,25,26,27)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269089
PNG
(2-Chloro-N-[2-fluoro-4-(3-methyl-1H-pyrazolo[3,4-d...)
Show SMILES COc1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(cc1F)-c1ncc2c(C)n[nH]c2n1
Show InChI InChI=1S/C19H15ClFN5O3S/c1-10-13-9-22-18(23-19(13)25-24-10)11-3-6-16(15(21)7-11)26-30(27,28)17-8-12(29-2)4-5-14(17)20/h3-9,26H,1-2H3,(H,22,23,24,25)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268717
PNG
(US9718825, Example 119)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2C[C@@H](O)C[C@@H](O)C2)c2cn[nH]c2n1
Show InChI InChI=1S/C24H24FN5O5S/c1-13-2-7-20(25)21(8-13)36(33,34)30-15-5-3-14(4-6-15)22-27-23-19(12-26-29-23)24(28-22)35-18-10-16(31)9-17(32)11-18/h2-8,12,16-18,30-32H,9-11H2,1H3,(H,26,27,28,29)/t16-,17+,18?
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268718
PNG
(US9718825, Example 120)
Show SMILES Cc1ccc(C#N)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OC2C[C@@H](O)C[C@@H](O)C2)c2cn[nH]c2n1
Show InChI InChI=1S/C25H24N6O5S/c1-14-2-3-16(12-26)22(8-14)37(34,35)31-17-6-4-15(5-7-17)23-28-24-21(13-27-30-24)25(29-23)36-20-10-18(32)9-19(33)11-20/h2-8,13,18-20,31-33H,9-11H2,1H3,(H,27,28,29,30)/t18-,19+,20?
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268719
PNG
(US9718825, Example 121 | US9718825, Example 122)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCc2cn[nH]c2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H18FN7O3S/c1-13-2-7-18(23)19(8-13)34(31,32)30-16-5-3-15(4-6-16)20-27-21-17(11-26-29-21)22(28-20)33-12-14-9-24-25-10-14/h2-11,30H,12H2,1H3,(H,24,25)(H,26,27,28,29)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM268719
PNG
(US9718825, Example 121 | US9718825, Example 122)
Show SMILES Cc1ccc(F)c(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc(OCc2cn[nH]c2)c2cn[nH]c2n1
Show InChI InChI=1S/C22H18FN7O3S/c1-13-2-7-18(23)19(8-13)34(31,32)30-16-5-3-15(4-6-16)20-27-21-17(11-26-29-21)22(28-20)33-12-14-9-24-25-10-14/h2-11,30H,12H2,1H3,(H,24,25)(H,26,27,28,29)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM269090
PNG
(2,5-Dichloro-N-[2-methoxy-4-(3-methyl-1H-pyrazolo[...)
Show SMILES COc1cc(ccc1NS(=O)(=O)c1cc(Cl)ccc1Cl)-c1ncc2c(C)n[nH]c2n1
Show InChI InChI=1S/C19H15Cl2N5O3S/c1-10-13-9-22-18(23-19(13)25-24-10)11-3-6-15(16(7-11)29-2)26-30(27,28)17-8-12(20)4-5-14(17)21/h3-9,26H,1-2H3,(H,22,23,24,25)
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SANOFI

US Patent


Assay Description
The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...


US Patent US9718825 (2017)


Article DOI: 10.1021/jm980260f
BindingDB Entry DOI: 10.7270/Q2VM4F82
More data for this
Ligand-Target Pair
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