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Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with all data for entry = 50007628   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065562
PNG
(CHEMBL96279 | [2-(6-Fluoro-2,2-dimethyl-chroman-8-...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCC(C)(C)Oc23)cc1
Show InChI InChI=1S/C24H32FNO3/c1-24(2)12-11-19-16-20(25)17-22(23(19)29-24)28-15-14-26-13-5-4-6-18-7-9-21(27-3)10-8-18/h7-10,16-17,26H,4-6,11-15H2,1-3H3
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0.149n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065578
PNG
(CHEMBL419147 | [2-(6-Fluoro-2H-chromen-8-yloxy)-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C=CCOc23)cc1
Show InChI InChI=1S/C22H26FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h4,6-10,15-16,24H,2-3,5,11-14H2,1H3
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0.159n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065555
PNG
(CHEMBL96578 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C21H26FNO3/c1-15-3-6-17-13-18(22)14-20(21(17)26-15)25-12-11-23-10-9-16-4-7-19(24-2)8-5-16/h4-5,7-8,13-15,23H,3,6,9-12H2,1-2H3
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0.188n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50057436
PNG
(CHEMBL25213 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl]...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCCOc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h7-10,15-16,24H,2-6,11-14H2,1H3
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0.221n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50057436
PNG
(CHEMBL25213 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl]...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCCOc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h7-10,15-16,24H,2-6,11-14H2,1H3
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0.259n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065573
PNG
(CHEMBL96222 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C23H30FNO3/c1-17-6-9-19-15-20(24)16-22(23(19)28-17)27-14-13-25-12-4-3-5-18-7-10-21(26-2)11-8-18/h7-8,10-11,15-17,25H,3-6,9,12-14H2,1-2H3
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0.270n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065578
PNG
(CHEMBL419147 | [2-(6-Fluoro-2H-chromen-8-yloxy)-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C=CCOc23)cc1
Show InChI InChI=1S/C22H26FNO3/c1-25-20-9-7-17(8-10-20)5-2-3-11-24-12-14-26-21-16-19(23)15-18-6-4-13-27-22(18)21/h4,6-10,15-16,24H,2-3,5,11-14H2,1H3
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0.288n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065573
PNG
(CHEMBL96222 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C23H30FNO3/c1-17-6-9-19-15-20(24)16-22(23(19)28-17)27-14-13-25-12-4-3-5-18-7-10-21(26-2)11-8-18/h7-8,10-11,15-17,25H,3-6,9,12-14H2,1-2H3
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0.312n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065562
PNG
(CHEMBL96279 | [2-(6-Fluoro-2,2-dimethyl-chroman-8-...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3CCC(C)(C)Oc23)cc1
Show InChI InChI=1S/C24H32FNO3/c1-24(2)12-11-19-16-20(25)17-22(23(19)29-24)28-15-14-26-13-5-4-6-18-7-9-21(27-3)10-8-18/h7-10,16-17,26H,4-6,11-15H2,1-3H3
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0.435n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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0.590n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity of the compound was evaluated against Dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand; ND = Not determined


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065563
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C22H28FNO4/c1-26-18-7-5-16(6-8-18)4-2-3-10-24-11-13-27-21-15-17(23)14-19-20(25)9-12-28-22(19)21/h5-8,14-15,20,24-25H,2-4,9-13H2,1H3
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0.716n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065563
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C22H28FNO4/c1-26-18-7-5-16(6-8-18)4-2-3-10-24-11-13-27-21-15-17(23)14-19-20(25)9-12-28-22(19)21/h5-8,14-15,20,24-25H,2-4,9-13H2,1H3
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2.10n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065561
PNG
(CHEMBL96546 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C25H34FNO3/c1-19-8-11-21-17-22(26)18-24(25(21)30-19)29-16-15-27-14-6-4-3-5-7-20-9-12-23(28-2)13-10-20/h9-10,12-13,17-19,27H,3-8,11,14-16H2,1-2H3
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2.31n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065582
PNG
(6-Fluoro-8-{2-[2-(4-methoxy-phenyl)-ethylamino]-et...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C20H24FNO4/c1-24-16-4-2-14(3-5-16)6-8-22-9-11-25-19-13-15(21)12-17-18(23)7-10-26-20(17)19/h2-5,12-13,18,22-23H,6-11H2,1H3
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2.34n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065576
PNG
(8-{2-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-butyla...)
Show SMILES Fc1cc(OCCNCCCCc2ccc3OCCOc3c2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C23H26FNO5/c24-17-14-18-19(26)6-9-30-23(18)22(15-17)27-10-8-25-7-2-1-3-16-4-5-20-21(13-16)29-12-11-28-20/h4-5,13-15,25H,1-3,6-12H2
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2.60n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065557
PNG
(8-[2-(4-Benzo[1,3]dioxol-5-yl-butylamino)-ethoxy]-...)
Show SMILES Fc1cc(OCCNCCCCc2ccc3OCOc3c2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C22H24FNO5/c23-16-12-17-18(25)6-9-27-22(17)21(13-16)26-10-8-24-7-2-1-3-15-4-5-19-20(11-15)29-14-28-19/h4-5,11-13,24H,1-3,6-10,14H2
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2.67n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065582
PNG
(6-Fluoro-8-{2-[2-(4-methoxy-phenyl)-ethylamino]-et...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C20H24FNO4/c1-24-16-4-2-14(3-5-16)6-8-22-9-11-25-19-13-15(21)12-17-18(23)7-10-26-20(17)19/h2-5,12-13,18,22-23H,6-11H2,1H3
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2.99n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065560
PNG
(CHEMBL95044 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C24H32FNO3/c1-18-7-10-20-16-21(25)17-23(24(20)29-18)28-15-14-26-13-5-3-4-6-19-8-11-22(27-2)12-9-19/h8-9,11-12,16-18,26H,3-7,10,13-15H2,1-2H3
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3.02n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065568
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C22H26FNO4/c1-26-18-7-5-16(6-8-18)4-2-3-10-24-11-13-27-21-15-17(23)14-19-20(25)9-12-28-22(19)21/h5-8,14-15,24H,2-4,9-13H2,1H3
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3.07n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065569
PNG
(6-Fluoro-8-{2-[2-(4-methoxy-phenyl)-ethylamino]-et...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C20H22FNO4/c1-24-16-4-2-14(3-5-16)6-8-22-9-11-25-19-13-15(21)12-17-18(23)7-10-26-20(17)19/h2-5,12-13,22H,6-11H2,1H3
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4.04n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065563
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C22H28FNO4/c1-26-18-7-5-16(6-8-18)4-2-3-10-24-11-13-27-21-15-17(23)14-19-20(25)9-12-28-22(19)21/h5-8,14-15,20,24-25H,2-4,9-13H2,1H3
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4.10n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065563
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(O)CCOc23)cc1
Show InChI InChI=1S/C22H28FNO4/c1-26-18-7-5-16(6-8-18)4-2-3-10-24-11-13-27-21-15-17(23)14-19-20(25)9-12-28-22(19)21/h5-8,14-15,20,24-25H,2-4,9-13H2,1H3
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4.11n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065558
PNG
(8-{2-[4-(2,3-Dihydro-benzofuran-5-yl)-butylamino]-...)
Show SMILES Fc1cc(OCCNCCCCc2ccc3OCCc3c2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C23H26FNO4/c24-18-14-19-20(26)7-11-29-23(19)22(15-18)28-12-9-25-8-2-1-3-16-4-5-21-17(13-16)6-10-27-21/h4-5,13-15,25H,1-3,6-12H2
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4.19n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065565
PNG
(CHEMBL92651 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-16-5-8-18-14-19(23)15-21(22(18)27-16)26-13-12-24-11-3-4-17-6-9-20(25-2)10-7-17/h6-7,9-10,14-16,24H,3-5,8,11-13H2,1-2H3
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4.98n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065560
PNG
(CHEMBL95044 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C24H32FNO3/c1-18-7-10-20-16-21(25)17-23(24(20)29-18)28-15-14-26-13-5-3-4-6-19-8-11-22(27-2)12-9-19/h8-9,11-12,16-18,26H,3-7,10,13-15H2,1-2H3
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7.33n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065555
PNG
(CHEMBL96578 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C21H26FNO3/c1-15-3-6-17-13-18(22)14-20(21(17)26-15)25-12-11-23-10-9-16-4-7-19(24-2)8-5-16/h4-5,7-8,13-15,23H,3,6,9-12H2,1-2H3
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8.13n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065561
PNG
(CHEMBL96546 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCCCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C25H34FNO3/c1-19-8-11-21-17-22(26)18-24(25(21)30-19)29-16-15-27-14-6-4-3-5-7-20-9-12-23(28-2)13-10-20/h9-10,12-13,17-19,27H,3-8,11,14-16H2,1-2H3
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8.99n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065571
PNG
(CHEMBL318418 | [2-(6-Fluoro-4-methoxy-chroman-8-yl...)
Show SMILES COC1CCOc2c(OCCNCCCCc3ccc(OC)cc3)cc(F)cc12
Show InChI InChI=1S/C23H30FNO4/c1-26-19-8-6-17(7-9-19)5-3-4-11-25-12-14-28-22-16-18(24)15-20-21(27-2)10-13-29-23(20)22/h6-9,15-16,21,25H,3-5,10-14H2,1-2H3
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9.07n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065565
PNG
(CHEMBL92651 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...)
Show SMILES COc1ccc(CCCNCCOc2cc(F)cc3CCC(C)Oc23)cc1
Show InChI InChI=1S/C22H28FNO3/c1-16-5-8-18-14-19(23)15-21(22(18)27-16)26-13-12-24-11-3-4-17-6-9-20(25-2)10-7-17/h6-7,9-10,14-16,24H,3-5,8,11-13H2,1-2H3
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9.53n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065579
PNG
(4-{4-[2-(6-Fluoro-4-oxo-chroman-8-yloxy)-ethylamin...)
Show SMILES Fc1cc(OCCNCCCCc2ccc(cc2)C#N)c2OCCC(=O)c2c1
Show InChI InChI=1S/C22H23FN2O3/c23-18-13-19-20(26)8-11-28-22(19)21(14-18)27-12-10-25-9-2-1-3-16-4-6-17(15-24)7-5-16/h4-7,13-14,25H,1-3,8-12H2
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11n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065580
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(CCOc23)N=O)cc1
Show InChI InChI=1S/C22H27FN2O4/c1-27-18-7-5-16(6-8-18)4-2-3-10-24-11-13-28-21-15-17(23)14-19-20(25-26)9-12-29-22(19)21/h5-8,14-15,20,24H,2-4,9-13H2,1H3
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11.7n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065554
PNG
(8-{2-[4-(4-Ethoxy-phenyl)-butylamino]-ethoxy}-6-fl...)
Show SMILES CCOc1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C23H28FNO4/c1-2-27-19-8-6-17(7-9-19)5-3-4-11-25-12-14-28-22-16-18(24)15-20-21(26)10-13-29-23(20)22/h6-9,15-16,25H,2-5,10-14H2,1H3
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18n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065571
PNG
(CHEMBL318418 | [2-(6-Fluoro-4-methoxy-chroman-8-yl...)
Show SMILES COC1CCOc2c(OCCNCCCCc3ccc(OC)cc3)cc(F)cc12
Show InChI InChI=1S/C23H30FNO4/c1-26-19-8-6-17(7-9-19)5-3-4-11-25-12-14-28-22-16-18(24)15-20-21(27-2)10-13-29-23(20)22/h6-9,15-16,21,25H,3-5,10-14H2,1-2H3
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18.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065556
PNG
(6-Fluoro-8-{2-[4-(4-methylsulfanyl-phenyl)-butylam...)
Show SMILES CSc1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C22H26FNO3S/c1-28-18-7-5-16(6-8-18)4-2-3-10-24-11-13-26-21-15-17(23)14-19-20(25)9-12-27-22(19)21/h5-8,14-15,24H,2-4,9-13H2,1H3
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18.4n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065581
PNG
(8-{2-[4-(4-Chloro-phenyl)-butylamino]-ethoxy}-6-fl...)
Show SMILES Fc1cc(OCCNCCCCc2ccc(Cl)cc2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C21H23ClFNO3/c22-16-6-4-15(5-7-16)3-1-2-9-24-10-12-26-20-14-17(23)13-18-19(25)8-11-27-21(18)20/h4-7,13-14,24H,1-3,8-12H2
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19n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065572
PNG
(6-Fluoro-8-{2-[4-(4-nitro-phenyl)-butylamino]-etho...)
Show SMILES [O-][N+](=O)c1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C21H23FN2O5/c22-16-13-18-19(25)8-11-29-21(18)20(14-16)28-12-10-23-9-2-1-3-15-4-6-17(7-5-15)24(26)27/h4-7,13-14,23H,1-3,8-12H2
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19.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065566
PNG
(6-Fluoro-8-{2-[4-(4-hydroxy-phenyl)-butylamino]-et...)
Show SMILES Oc1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C21H24FNO4/c22-16-13-18-19(25)8-11-27-21(18)20(14-16)26-12-10-23-9-2-1-3-15-4-6-17(24)7-5-15/h4-7,13-14,23-24H,1-3,8-12H2
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23.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065570
PNG
(6-Fluoro-8-{2-[4-(2-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccccc1CCCCNCCOc1cc(F)cc2C(=O)CCOc12
Show InChI InChI=1S/C22H26FNO4/c1-26-20-8-3-2-6-16(20)7-4-5-10-24-11-13-27-21-15-17(23)14-18-19(25)9-12-28-22(18)21/h2-3,6,8,14-15,24H,4-5,7,9-13H2,1H3
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23.7n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065570
PNG
(6-Fluoro-8-{2-[4-(2-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccccc1CCCCNCCOc1cc(F)cc2C(=O)CCOc12
Show InChI InChI=1S/C22H26FNO4/c1-26-20-8-3-2-6-16(20)7-4-5-10-24-11-13-27-21-15-17(23)14-18-19(25)9-12-28-22(18)21/h2-3,6,8,14-15,24H,4-5,7,9-13H2,1H3
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24n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065576
PNG
(8-{2-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-butyla...)
Show SMILES Fc1cc(OCCNCCCCc2ccc3OCCOc3c2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C23H26FNO5/c24-17-14-18-19(26)6-9-30-23(18)22(15-17)27-10-8-25-7-2-1-3-16-4-5-20-21(13-16)29-12-11-28-20/h4-5,13-15,25H,1-3,6-12H2
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25.1n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065580
PNG
(6-Fluoro-8-{2-[4-(4-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1ccc(CCCCNCCOc2cc(F)cc3C(CCOc23)N=O)cc1
Show InChI InChI=1S/C22H27FN2O4/c1-27-18-7-5-16(6-8-18)4-2-3-10-24-11-13-28-21-15-17(23)14-19-20(25-26)9-12-29-22(19)21/h5-8,14-15,20,24H,2-4,9-13H2,1H3
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27.7n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065559
PNG
(8-{2-[4-(4-Dimethylamino-phenyl)-butylamino]-ethox...)
Show SMILES CN(C)c1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C23H29FN2O3/c1-26(2)19-8-6-17(7-9-19)5-3-4-11-25-12-14-28-22-16-18(24)15-20-21(27)10-13-29-23(20)22/h6-9,15-16,25H,3-5,10-14H2,1-2H3
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28.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065581
PNG
(8-{2-[4-(4-Chloro-phenyl)-butylamino]-ethoxy}-6-fl...)
Show SMILES Fc1cc(OCCNCCCCc2ccc(Cl)cc2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C21H23ClFNO3/c22-16-6-4-15(5-7-16)3-1-2-9-24-10-12-26-20-14-17(23)13-18-19(25)8-11-27-21(18)20/h4-7,13-14,24H,1-3,8-12H2
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32.3n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065559
PNG
(8-{2-[4-(4-Dimethylamino-phenyl)-butylamino]-ethox...)
Show SMILES CN(C)c1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C23H29FN2O3/c1-26(2)19-8-6-17(7-9-19)5-3-4-11-25-12-14-28-22-16-18(24)15-20-21(27)10-13-29-23(20)22/h6-9,15-16,25H,3-5,10-14H2,1-2H3
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34.6n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065569
PNG
(6-Fluoro-8-{2-[2-(4-methoxy-phenyl)-ethylamino]-et...)
Show SMILES COc1ccc(CCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C20H22FNO4/c1-24-16-4-2-14(3-5-16)6-8-22-9-11-25-19-13-15(21)12-17-18(23)7-10-26-20(17)19/h2-5,12-13,22H,6-11H2,1H3
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38n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065556
PNG
(6-Fluoro-8-{2-[4-(4-methylsulfanyl-phenyl)-butylam...)
Show SMILES CSc1ccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)cc1
Show InChI InChI=1S/C22H26FNO3S/c1-28-18-7-5-16(6-8-18)4-2-3-10-24-11-13-26-21-15-17(23)14-19-20(25)9-12-27-22(19)21/h5-8,14-15,24H,2-4,9-13H2,1H3
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38.8n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065575
PNG
(6-Fluoro-8-[2-(4-phenyl-butylamino)-ethoxy]-chroma...)
Show SMILES Fc1cc(OCCNCCCCc2ccccc2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C21H24FNO3/c22-17-14-18-19(24)9-12-26-21(18)20(15-17)25-13-11-23-10-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,14-15,23H,4-5,8-13H2
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41.8n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065557
PNG
(8-[2-(4-Benzo[1,3]dioxol-5-yl-butylamino)-ethoxy]-...)
Show SMILES Fc1cc(OCCNCCCCc2ccc3OCOc3c2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C22H24FNO5/c23-16-12-17-18(25)6-9-27-22(17)21(13-16)26-10-8-24-7-2-1-3-15-4-5-19-20(11-15)29-14-28-19/h4-5,11-13,24H,1-3,6-10,14H2
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42.1n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50065583
PNG
(6-Fluoro-8-{2-[4-(3-methoxy-phenyl)-butylamino]-et...)
Show SMILES COc1cccc(CCCCNCCOc2cc(F)cc3C(=O)CCOc23)c1
Show InChI InChI=1S/C22H26FNO4/c1-26-18-7-4-6-16(13-18)5-2-3-9-24-10-12-27-21-15-17(23)14-19-20(25)8-11-28-22(19)21/h4,6-7,13-15,24H,2-3,5,8-12H2,1H3
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43.4n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50065575
PNG
(6-Fluoro-8-[2-(4-phenyl-butylamino)-ethoxy]-chroma...)
Show SMILES Fc1cc(OCCNCCCCc2ccccc2)c2OCCC(=O)c2c1
Show InChI InChI=1S/C21H24FNO3/c22-17-14-18-19(24)9-12-26-21(18)20(15-17)25-13-11-23-10-5-4-8-16-6-2-1-3-7-16/h1-3,6-7,14-15,23H,4-5,8-13H2
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43.9n/an/an/an/an/an/an/an/a



Yamanouchi Pharmaceutical Company, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity against dopamine receptor D2 on rat striatum using [3H]-spiperone as radioligand.


J Med Chem 41: 2765-78 (1998)


Article DOI: 10.1021/jm9707840
BindingDB Entry DOI: 10.7270/Q2K073CQ
More data for this
Ligand-Target Pair
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