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Compile Data Set for Download or QSAR

Found 71 hits Enz. Inhib. hit(s) with all data for entry = 50033298   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343025
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-N2-neopenty...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)(C)C)c1
Show InChI InChI=1S/C15H27N5/c1-15(2,3)10-18-14-8-12(7-13(16)19-14)20-6-5-11(9-20)17-4/h7-8,11,17H,5-6,9-10H2,1-4H3,(H3,16,18,19)/t11-/m1/s1
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0.0400n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343021
PNG
((R)-N2-isobutyl-4-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)c1
Show InChI InChI=1S/C14H25N5/c1-10(2)8-17-14-7-12(6-13(15)18-14)19-5-4-11(9-19)16-3/h6-7,10-11,16H,4-5,8-9H2,1-3H3,(H3,15,17,18)/t11-/m1/s1
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0.200n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343018
PNG
(4-(4-methylpiperazin-1-yl)-N2-neopentylpyridine-2,...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NCC(C)(C)C)c1
Show InChI InChI=1S/C15H27N5/c1-15(2,3)11-17-14-10-12(9-13(16)18-14)20-7-5-19(4)6-8-20/h9-10H,5-8,11H2,1-4H3,(H3,16,17,18)
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0.300n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343023
PNG
((R)-N2-cyclopentyl-4-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-17-12-6-7-20(10-12)13-8-14(16)19-15(9-13)18-11-4-2-3-5-11/h8-9,11-12,17H,2-7,10H2,1H3,(H3,16,18,19)/t12-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342990
PNG
(CHEMBL1771001 | N4-cyclopentyl-6-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-19-6-8-20(9-7-19)13-10-12(17-14(15)18-13)16-11-4-2-3-5-11/h10-11H,2-9H2,1H3,(H3,15,16,17,18)
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1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343007
PNG
((R)-N2-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCC(C)C)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-13-17-11(14)6-12(18-13)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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1n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343014
PNG
(CHEMBL1770964 | N2-isobutyl-4-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(cc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C14H25N5/c1-11(2)10-16-14-9-12(8-13(15)17-14)19-6-4-18(3)5-7-19/h8-9,11H,4-7,10H2,1-3H3,(H3,15,16,17)
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2n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342989
PNG
(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-11-8-12(17-13(14)16-11)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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2n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343019
PNG
((R)-N2-isopropyl-4-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)c1
Show InChI InChI=1S/C13H23N5/c1-9(2)16-13-7-11(6-12(14)17-13)18-5-4-10(8-18)15-3/h6-7,9-10,15H,4-5,8H2,1-3H3,(H3,14,16,17)/t10-/m1/s1
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342987
PNG
(CHEMBL1770998 | N4-isopropyl-6-(4-methylpiperazin-...)
Show SMILES CC(C)Nc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C12H22N6/c1-9(2)14-10-8-11(16-12(13)15-10)18-6-4-17(3)5-7-18/h8-9H,4-7H2,1-3H3,(H3,13,14,15,16)
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343016
PNG
(CHEMBL1770966 | N2-cyclopentyl-4-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-19-6-8-20(9-7-19)13-10-14(16)18-15(11-13)17-12-4-2-3-5-12/h10-12H,2-9H2,1H3,(H3,16,17,18)
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342992
PNG
((R)-N4-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC(C)C)nc(N)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-10-6-11(17-12(13)16-10)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342994
PNG
((R)-N4-isobutyl-6-(3-(methylamino)pyrrolidin-1-yl)...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCC(C)C)nc(N)n1
Show InChI InChI=1S/C13H24N6/c1-9(2)7-16-11-6-12(18-13(14)17-11)19-5-4-10(8-19)15-3/h6,9-10,15H,4-5,7-8H2,1-3H3,(H3,14,16,17,18)/t10-/m1/s1
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4n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342982
PNG
(4-(4-Methylpiperazin-1-yl)-6-pyrrolidin-1-ylpyrimi...)
Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-17-6-8-19(9-7-17)12-10-11(15-13(14)16-12)18-4-2-3-5-18/h10H,2-9H2,1H3,(H2,14,15,16)
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6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343005
PNG
((R)-N2-isopropyl-6-(3-(methylamino)pyrrolidin-1-yl...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC(C)C)n1
Show InChI InChI=1S/C12H22N6/c1-8(2)15-12-16-10(13)6-11(17-12)18-5-4-9(7-18)14-3/h6,8-9,14H,4-5,7H2,1-3H3,(H3,13,15,16,17)/t9-/m1/s1
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6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343009
PNG
((R)-N2-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NC2CCCC2)n1
Show InChI InChI=1S/C14H24N6/c1-16-11-6-7-20(9-11)13-8-12(15)18-14(19-13)17-10-4-2-3-5-10/h8,10-11,16H,2-7,9H2,1H3,(H3,15,17,18,19)/t11-/m1/s1
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6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342981
PNG
(4-(piperazin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-...)
Show SMILES Nc1nc(cc(n1)N1CCNCC1)N1CCCC1
Show InChI InChI=1S/C12H20N6/c13-12-15-10(17-5-1-2-6-17)9-11(16-12)18-7-3-14-4-8-18/h9,14H,1-8H2,(H2,13,15,16)
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8n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342995
PNG
((R)-N4-cyclopentyl-6-(3-(methylamino)pyrrolidin-1-...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NC2CCCC2)nc(N)n1
Show InChI InChI=1S/C14H24N6/c1-16-11-6-7-20(9-11)13-8-12(18-14(15)19-13)17-10-4-2-3-5-10/h8,10-11,16H,2-7,9H2,1H3,(H3,15,17,18,19)/t11-/m1/s1
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9n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343002
PNG
(CHEMBL1770987 | N2-cyclopentyl-6-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)n1
Show InChI InChI=1S/C14H24N6/c1-19-6-8-20(9-7-19)13-10-12(15)17-14(18-13)16-11-4-2-3-5-11/h10-11H,2-9H2,1H3,(H3,15,16,17,18)
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10n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343000
PNG
(CHEMBL1770985 | N2-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1nc(N)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-13-16-11(14)8-12(17-13)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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15n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304527
PNG
(CHEMBL492677 | N4-Benzyl-6-(4-methylpiperazin-1-yl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2)nc(N)n1
Show InChI InChI=1S/C16H22N6/c1-21-7-9-22(10-8-21)15-11-14(19-16(17)20-15)18-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H3,17,18,19,20)
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20n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342988
PNG
(CHEMBL1770999 | N4-isopropyl-N4-methyl-6-(4-methyl...)
Show SMILES CC(C)N(C)c1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)18(4)11-9-12(16-13(14)15-11)19-7-5-17(3)6-8-19/h9-10H,5-8H2,1-4H3,(H2,14,15,16)
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24n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342991
PNG
(2-(2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-y...)
Show SMILES CN1CCN(CC1)c1cc(NCCO)nc(N)n1
Show InChI InChI=1S/C11H20N6O/c1-16-3-5-17(6-4-16)10-8-9(13-2-7-18)14-11(12)15-10/h8,18H,2-7H2,1H3,(H3,12,13,14,15)
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25n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50179335
PNG
((5-Chloro-1H-benzoimidazol-2-yl)-(4-methyl-piperaz...)
Show SMILES CN1CCN(CC1)C(=O)c1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C13H15ClN4O/c1-17-4-6-18(7-5-17)13(19)12-15-10-3-2-9(14)8-11(10)16-12/h2-3,8H,4-7H2,1H3,(H,15,16)
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26n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343012
PNG
(CHEMBL1770962 | N2-isopropyl-4-(4-methylpiperazin-...)
Show SMILES CC(C)Nc1cc(cc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H23N5/c1-10(2)15-13-9-11(8-12(14)16-13)18-6-4-17(3)5-7-18/h8-10H,4-7H2,1-3H3,(H3,14,15,16)
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28n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343020
PNG
((R)-N2-isopropyl-N2-methyl-4-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(c1)N(C)C(C)C
Show InChI InChI=1S/C14H25N5/c1-10(2)18(4)14-8-12(7-13(15)17-14)19-6-5-11(9-19)16-3/h7-8,10-11,16H,5-6,9H2,1-4H3,(H2,15,17)/t11-/m1/s1
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29n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342984
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-15-10-4-7-19(9-10)12-8-11(16-13(14)17-12)18-5-2-3-6-18/h8,10,15H,2-7,9H2,1H3,(H2,14,16,17)/t10-/m1/s1
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36n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342986
PNG
(CHEMBL1770997 | rac-4-(pyrrolidin-1-yl)-6-(tetrahy...)
Show SMILES Nc1nc(cc(n1)N1CC2CCCNC2C1)N1CCCC1
Show InChI InChI=1S/C15H24N6/c16-15-18-13(20-6-1-2-7-20)8-14(19-15)21-9-11-4-3-5-17-12(11)10-21/h8,11-12,17H,1-7,9-10H2,(H2,16,18,19)
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40n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342997
PNG
((R)-2-(2-amino-6-(3-(methylamino)pyrrolidin-1-yl)p...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCCO)nc(N)n1
Show InChI InChI=1S/C11H20N6O/c1-13-8-2-4-17(7-8)10-6-9(14-3-5-18)15-11(12)16-10/h6,8,13,18H,2-5,7H2,1H3,(H3,12,14,15,16)/t8-/m1/s1
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44n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343024
PNG
((R)-N2-benzyl-4-(3-(methylamino)pyrrolidin-1-yl)py...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCc2ccccc2)c1
Show InChI InChI=1S/C17H23N5/c1-19-14-7-8-22(12-14)15-9-16(18)21-17(10-15)20-11-13-5-3-2-4-6-13/h2-6,9-10,14,19H,7-8,11-12H2,1H3,(H3,18,20,21)/t14-/m1/s1
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50n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342993
PNG
((R)-N4-isopropyl-N4-methyl-6-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(nc(N)n1)N(C)C(C)C
Show InChI InChI=1S/C13H24N6/c1-9(2)18(4)11-7-12(17-13(14)16-11)19-6-5-10(8-19)15-3/h7,9-10,15H,5-6,8H2,1-4H3,(H2,14,16,17)/t10-/m1/s1
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51n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342996
PNG
((R)-N4-benzyl-6-(3-(methylamino)pyrrolidin-1-yl)py...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(NCc2ccccc2)nc(N)n1
Show InChI InChI=1S/C16H22N6/c1-18-13-7-8-22(11-13)15-9-14(20-16(17)21-15)19-10-12-5-3-2-4-6-12/h2-6,9,13,18H,7-8,10-11H2,1H3,(H3,17,19,20,21)/t13-/m1/s1
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58n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342983
PNG
((R)-4-(3-aminopyrrolidin-1-yl)-6-(pyrrolidin-1-yl)...)
Show SMILES N[C@@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C12H20N6/c13-9-3-6-18(8-9)11-7-10(15-12(14)16-11)17-4-1-2-5-17/h7,9H,1-6,8,13H2,(H2,14,15,16)/t9-/m1/s1
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64n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343010
PNG
((R)-N2-benzyl-6-(3-(methylamino)pyrrolidin-1-yl)py...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCc2ccccc2)n1
Show InChI InChI=1S/C16H22N6/c1-18-13-7-8-22(11-13)15-9-14(17)20-16(21-15)19-10-12-5-3-2-4-6-12/h2-6,9,13,18H,7-8,10-11H2,1H3,(H3,17,19,20,21)/t13-/m1/s1
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69n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343022
PNG
((R)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-16-11-4-7-19(10-11)12-8-13(15)17-14(9-12)18-5-2-3-6-18/h8-9,11,16H,2-7,10H2,1H3,(H2,15,17)/t11-/m1/s1
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77n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342985
PNG
((S)-4-(3-(methylamino)pyrrolidin-1-yl)-6-(pyrrolid...)
Show SMILES CN[C@H]1CCN(C1)c1cc(nc(N)n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-15-10-4-7-19(9-10)12-8-11(16-13(14)17-12)18-5-2-3-6-18/h8,10,15H,2-7,9H2,1H3,(H2,14,16,17)/t10-/m0/s1
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83n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343015
PNG
(4-(4-methylpiperazin-1-yl)-6-(pyrrolidin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(c1)N1CCCC1
Show InChI InChI=1S/C14H23N5/c1-17-6-8-18(9-7-17)12-10-13(15)16-14(11-12)19-4-2-3-5-19/h10-11H,2-9H2,1H3,(H2,15,16)
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100n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343008
PNG
((R)-6-(3-(methylamino)pyrrolidin-1-yl)-2-(pyrrolid...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-15-10-4-7-19(9-10)12-8-11(14)16-13(17-12)18-5-2-3-6-18/h8,10,15H,2-7,9H2,1H3,(H2,14,16,17)/t10-/m1/s1
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127n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343001
PNG
(6-(4-methylpiperazin-1-yl)-2-(pyrrolidin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(n1)N1CCCC1
Show InChI InChI=1S/C13H22N6/c1-17-6-8-18(9-7-17)12-10-11(14)15-13(16-12)19-4-2-3-5-19/h10H,2-9H2,1H3,(H2,14,15,16)
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132n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343006
PNG
((R)-N2-isopropyl-N2-methyl-6-(3-(methylamino)pyrro...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(n1)N(C)C(C)C
Show InChI InChI=1S/C13H24N6/c1-9(2)18(4)13-16-11(14)7-12(17-13)19-6-5-10(8-19)15-3/h7,9-10,15H,5-6,8H2,1-4H3,(H2,14,16,17)/t10-/m1/s1
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140n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343017
PNG
(CHEMBL1770967 | N2-benzyl-4-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NCc2ccccc2)c1
Show InChI InChI=1S/C17H23N5/c1-21-7-9-22(10-8-21)15-11-16(18)20-17(12-15)19-13-14-5-3-2-4-6-14/h2-6,11-12H,7-10,13H2,1H3,(H3,18,19,20)
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148n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342998
PNG
(CHEMBL1770983 | N2-isopropyl-6-(4-methylpiperazin-...)
Show SMILES CC(C)Nc1nc(N)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C12H22N6/c1-9(2)14-12-15-10(13)8-11(16-12)18-6-4-17(3)5-7-18/h8-9H,4-7H2,1-3H3,(H3,13,14,15,16)
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162n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343013
PNG
(CHEMBL1770963 | N2-isopropyl-N2-methyl-4-(4-methyl...)
Show SMILES CC(C)N(C)c1cc(cc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C14H25N5/c1-11(2)18(4)14-10-12(9-13(15)16-14)19-7-5-17(3)6-8-19/h9-11H,5-8H2,1-4H3,(H2,15,16)
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189n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343011
PNG
((R)-2-(4-amino-6-(3-(methylamino)pyrrolidin-1-yl)p...)
Show SMILES CN[C@@H]1CCN(C1)c1cc(N)nc(NCCO)n1
Show InChI InChI=1S/C11H20N6O/c1-13-8-2-4-17(7-8)10-6-9(12)15-11(16-10)14-3-5-18/h6,8,13,18H,2-5,7H2,1H3,(H3,12,14,15,16)/t8-/m1/s1
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255n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342999
PNG
(CHEMBL1770984 | N2-isopropyl-N2-methyl-6-(4-methyl...)
Show SMILES CC(C)N(C)c1nc(N)cc(n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)18(4)13-15-11(14)9-12(16-13)19-7-5-17(3)6-8-19/h9-10H,5-8H2,1-4H3,(H2,14,15,16)
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853n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343003
PNG
(CHEMBL1770988 | N2-benzyl-6-(4-methylpiperazin-1-y...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NCc2ccccc2)n1
Show InChI InChI=1S/C16H22N6/c1-21-7-9-22(10-8-21)15-11-14(17)19-16(20-15)18-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H3,17,18,19,20)
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1.08E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50343004
PNG
(2-(4-amino-6-(4-methylpiperazin-1-yl)pyrimidin-2-y...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NCCO)n1
Show InChI InChI=1S/C11H20N6O/c1-16-3-5-17(6-4-16)10-8-9(12)14-11(15-10)13-2-7-18/h8,18H,2-7H2,1H3,(H3,12,13,14,15)
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1.16E+3n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342988
PNG
(CHEMBL1770999 | N4-isopropyl-N4-methyl-6-(4-methyl...)
Show SMILES CC(C)N(C)c1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)18(4)11-9-12(16-13(14)15-11)19-7-5-17(3)6-8-19/h9-10H,5-8H2,1-4H3,(H2,14,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50342989
PNG
(CHEMBL1771000 | N4-isobutyl-6-(4-methylpiperazin-1...)
Show SMILES CC(C)CNc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C13H24N6/c1-10(2)9-15-11-8-12(17-13(14)16-11)19-6-4-18(3)5-7-19/h8,10H,4-7,9H2,1-3H3,(H3,14,15,16,17)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.017
BindingDB Entry DOI: 10.7270/Q24X5845
More data for this
Ligand-Target Pair
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