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Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with all data for entry = 50037246   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A1


(Homo sapiens (human))
BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
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6.40n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement.


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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11n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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12n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement.


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50370303
PNG
(CHEMBL605486)
Show SMILES Nc1nc(N=NNC(=O)Nc2cccc(Cl)c2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H18ClN9O5/c18-7-2-1-3-8(4-7)21-17(31)25-26-24-16-22-13(19)10-14(23-16)27(6-20-10)15-12(30)11(29)9(5-28)32-15/h1-4,6,9,11-12,15,28-30H,5H2,(H4,19,21,22,23,24,25,31)/t9-,11-,12-,15?/m1/s1
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15n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
In vitro binding affinity towards human adenosine A1 receptor by [3H]DPCPX displacement.


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50370303
PNG
(CHEMBL605486)
Show SMILES Nc1nc(N=NNC(=O)Nc2cccc(Cl)c2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H18ClN9O5/c18-7-2-1-3-8(4-7)21-17(31)25-26-24-16-22-13(19)10-14(23-16)27(6-20-10)15-12(30)11(29)9(5-28)32-15/h1-4,6,9,11-12,15,28-30H,5H2,(H4,19,21,22,23,24,25,31)/t9-,11-,12-,15?/m1/s1
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59n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Binding affinity for human Adenosine A3 receptor using [125 I]-IABMECA


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (human))
BDBM21220
PNG
((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Show SMILES CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
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60n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Tested for binding affinity towards human adenosine A2A receptor using [3H]ZM-241385 as radioligand


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Adenosine receptor A3


(Homo sapiens (human))
BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
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281n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A3


(Homo sapiens (human))
BDBM50370311
PNG
(CHEMBL603394)
Show SMILES Nc1nc(NN=NC(=O)Oc2ccccc2)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H18N8O6/c18-13-10-14(25(7-19-10)15-12(28)11(27)9(6-26)31-15)21-16(20-13)22-24-23-17(29)30-8-4-2-1-3-5-8/h1-5,7,9,11-12,15,26-28H,6H2,(H3,18,20,21,22,23,29)/t9-,11-,12-,15?/m1/s1
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577n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of [125 I]-IABMECA binding to human adenosine A3 receptor


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A2


(Homo sapiens (human))
BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
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639n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Tested for binding affinity towards human adenosine A2A receptor using [3H]ZM-241385 as radioligand


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Homo sapiens (human))
BDBM50085658
PNG
((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NC3CCCC3)nc(Cl)nc12
Show InChI InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptor


J Med Chem 46: 1492-503 (2003)


Article DOI: 10.1021/jm021074j
BindingDB Entry DOI: 10.7270/Q2MG7Q7H
More data for this
Ligand-Target Pair