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Compile Data Set for Download or QSAR

Found 40 hits Enz. Inhib. hit(s) with all data for entry = 50041768   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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23n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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25n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415135
PNG
(CHEMBL571314)
Show SMILES CC(OC1=NCCN1)c1ccccc1
Show InChI InChI=1S/C11H14N2O/c1-9(10-5-3-2-4-6-10)14-11-12-7-8-13-11/h2-6,9H,7-8H2,1H3,(H,12,13)
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27n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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35n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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49n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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50n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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58n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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59n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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79n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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85n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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148n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415135
PNG
(CHEMBL571314)
Show SMILES CC(OC1=NCCN1)c1ccccc1
Show InChI InChI=1S/C11H14N2O/c1-9(10-5-3-2-4-6-10)14-11-12-7-8-13-11/h2-6,9H,7-8H2,1H3,(H,12,13)
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166n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415135
PNG
(CHEMBL571314)
Show SMILES CC(OC1=NCCN1)c1ccccc1
Show InChI InChI=1S/C11H14N2O/c1-9(10-5-3-2-4-6-10)14-11-12-7-8-13-11/h2-6,9H,7-8H2,1H3,(H,12,13)
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263n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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269n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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269n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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309n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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339n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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398n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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490n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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501n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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525n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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537n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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550n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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550n/an/an/an/an/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 794n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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n/an/an/an/a 398n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 50n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor


(Homo sapiens (Human))
BDBM50029051
PNG
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)
Show SMILES NC[C@H](O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
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n/an/an/an/a 372n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2A adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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n/an/an/an/a 63n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415137
PNG
(CHEMBL570863)
Show SMILES CC(OC1=NCCN1)c1ccccc1C
Show InChI InChI=1S/C12H16N2O/c1-9-5-3-4-6-11(9)10(2)15-12-13-7-8-14-12/h3-6,10H,7-8H2,1-2H3,(H,13,14)
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n/an/an/an/a 5.01E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415136
PNG
(CHEMBL570973)
Show SMILES CC(OC1=NCCN1)c1ccccc1CC=C
Show InChI InChI=1S/C14H18N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h3-5,7-8,11H,1,6,9-10H2,2H3,(H,15,16)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 40n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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n/an/an/an/a 155n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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n/an/an/an/a 25n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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n/an/an/an/a 2.88E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415141
PNG
(CHEMBL576819)
Show SMILES Cc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C11H14N2O/c1-9-4-2-3-5-10(9)8-14-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)
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n/an/an/an/a 2.51E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415139
PNG
(CHEMBL576623)
Show SMILES CC(OC1=NCCN1)c1ccccc1C1CC1
Show InChI InChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415140
PNG
(CHEMBL569933)
Show SMILES CCCc1ccccc1COC1=NCCN1
Show InChI InChI=1S/C13H18N2O/c1-2-5-11-6-3-4-7-12(11)10-16-13-14-8-9-15-13/h3-4,6-7H,2,5,8-10H2,1H3,(H,14,15)
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n/an/an/an/a 62n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair
Alpha-2B adrenergic receptor


(Homo sapiens (Human))
BDBM50415138
PNG
(CHEMBL576078)
Show SMILES CCCc1ccccc1C(C)OC1=NCCN1
Show InChI InChI=1S/C14H20N2O/c1-3-6-12-7-4-5-8-13(12)11(2)17-14-15-9-10-16-14/h4-5,7-8,11H,3,6,9-10H2,1-2H3,(H,15,16)
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n/an/an/an/a 3.16E+3n/an/an/an/a



Universita degli Studi di Camerino

Curated by ChEMBL


Assay Description
Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry


J Med Chem 52: 7319-22 (2009)


Article DOI: 10.1021/jm901262f
BindingDB Entry DOI: 10.7270/Q2J104DZ
More data for this
Ligand-Target Pair