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Compile Data Set for Download or QSAR

Found 29 hits Enz. Inhib. hit(s) with all data for entry = 6632   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107727
PNG
(US8933095, 11)
Show SMILES COc1cccc(Cn2cc3C[C@H](N)C(=O)N(O)c3n2)c1
Show InChI InChI=1S/C14H16N4O3/c1-21-11-4-2-3-9(5-11)7-17-8-10-6-12(15)14(19)18(20)13(10)16-17/h2-5,8,12,20H,6-7,15H2,1H3/t12-/m0/s1
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US Patent
n/an/a 8.93n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107721
PNG
(US8933095, 3)
Show SMILES Cn1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1ccccc1
Show InChI InChI=1S/C14H16N4O2/c1-17-12(7-9-5-3-2-4-6-9)10-8-11(15)14(19)18(20)13(10)16-17/h2-6,11,20H,7-8,15H2,1H3/t11-/m0/s1
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US Patent
n/an/a 11.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107747
PNG
(CHEMBL2347115 | US8933095, 4)
Show SMILES N[C@H]1Cc2c(cnn2Cc2ccccc2)N(O)C1=O
Show InChI InChI=1S/C13H14N4O2/c14-10-6-11-12(17(19)13(10)18)7-15-16(11)8-9-4-2-1-3-5-9/h1-5,7,10,19H,6,8,14H2/t10-/m0/s1
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n/an/a 22.5n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107739
PNG
(US8933095, 23)
Show SMILES CCn1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1ccccc1
Show InChI InChI=1S/C15H18N4O2/c1-2-18-13(8-10-6-4-3-5-7-10)11-9-12(16)15(20)19(21)14(11)17-18/h3-7,12,21H,2,8-9,16H2,1H3/t12-/m0/s1
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n/an/a 24.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107730
PNG
(CHEMBL2347108 | US8933095, 14)
Show SMILES N[C@H]1Cc2cn(nc2N(O)C1=O)-c1ccccc1
Show InChI InChI=1S/C12H12N4O2/c13-10-6-8-7-15(9-4-2-1-3-5-9)14-11(8)16(18)12(10)17/h1-5,7,10,18H,6,13H2/t10-/m0/s1
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n/an/a 24.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107731
PNG
(US8933095, 15)
Show SMILES COc1ccc(Cn2cc3C[C@H](N)C(=O)N(O)c3n2)cc1
Show InChI InChI=1S/C14H16N4O3/c1-21-11-4-2-9(3-5-11)7-17-8-10-6-12(15)14(19)18(20)13(10)16-17/h2-5,8,12,20H,6-7,15H2,1H3/t12-/m0/s1
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n/an/a 28.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107745
PNG
(US8933095, 29)
Show SMILES N[C@H]1Cc2cn(nc2N(O)C1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N4O2/c14-13(15,16)8-1-3-9(4-2-8)19-6-7-5-10(17)12(21)20(22)11(7)18-19/h1-4,6,10,22H,5,17H2/t10-/m0/s1
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n/an/a 31.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107724
PNG
(US8933095, 8)
Show SMILES N[C@H]1Cc2cn(Cc3cccc4ccccc34)nc2N(O)C1=O
Show InChI InChI=1S/C17H16N4O2/c18-15-8-13-10-20(19-16(13)21(23)17(15)22)9-12-6-3-5-11-4-1-2-7-14(11)12/h1-7,10,15,23H,8-9,18H2/t15-/m0/s1
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n/an/a 36n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107743
PNG
(US8933095, 27)
Show SMILES Cn1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O2/c1-21-12(6-8-2-4-9(5-3-8)15(16,17)18)10-7-11(19)14(23)22(24)13(10)20-21/h2-5,11,24H,6-7,19H2,1H3/t11-/m0/s1
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n/an/a 37n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107744
PNG
(US8933095, 28)
Show SMILES N[C@H]1Cc2cn(nc2N(O)C1=O)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C13H11F3N4O2/c14-13(15,16)8-3-1-2-4-10(8)19-6-7-5-9(17)12(21)20(22)11(7)18-19/h1-4,6,9,22H,5,17H2/t9-/m0/s1
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n/an/a 38.8n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107742
PNG
(US8933095, 26)
Show SMILES Cn1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O2/c1-21-12(6-8-4-2-3-5-10(8)15(16,17)18)9-7-11(19)14(23)22(24)13(9)20-21/h2-5,11,24H,6-7,19H2,1H3/t11-/m0/s1
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US Patent
n/an/a 40.7n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107741
PNG
(US8933095, 25)
Show SMILES Cn1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O2/c1-21-12(6-8-3-2-4-9(5-8)15(16,17)18)10-7-11(19)14(23)22(24)13(10)20-21/h2-5,11,24H,6-7,19H2,1H3/t11-/m0/s1
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n/an/a 42.2n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107722
PNG
(CHEMBL2347114 | US8933095, 5)
Show SMILES N[C@H]1Cc2c(N(O)C1=O)c(nn2Cc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2/c15-14(16,17)12-11-10(6-9(18)13(22)21(11)23)20(19-12)7-8-4-2-1-3-5-8/h1-5,9,23H,6-7,18H2/t9-/m0/s1
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n/an/a 42.7n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107723
PNG
(US8933095, 6)
Show SMILES N[C@H]1Cc2cn(Cc3ccc(OC(F)(F)F)cc3)nc2N(O)C1=O
Show InChI InChI=1S/C14H13F3N4O3/c15-14(16,17)24-10-3-1-8(2-4-10)6-20-7-9-5-11(18)13(22)21(23)12(9)19-20/h1-4,7,11,23H,5-6,18H2/t11-/m0/s1
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n/an/a 43.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107726
PNG
(US8933095, 10)
Show SMILES COc1ccccc1Cn1cc2C[C@H](N)C(=O)N(O)c2n1
Show InChI InChI=1S/C14H16N4O3/c1-21-12-5-3-2-4-9(12)7-17-8-10-6-11(15)14(19)18(20)13(10)16-17/h2-5,8,11,20H,6-7,15H2,1H3/t11-/m0/s1
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n/an/a 50.2n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107746
PNG
(CHEMBL2347107 | US8933095, 1)
Show SMILES N[C@H]1Cc2cn(Cc3ccccc3)nc2N(O)C1=O
Show InChI InChI=1S/C13H14N4O2/c14-11-6-10-8-16(7-9-4-2-1-3-5-9)15-12(10)17(19)13(11)18/h1-5,8,11,19H,6-7,14H2/t11-/m0/s1
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n/an/a 59.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107740
PNG
(US8933095, 24)
Show SMILES CC(C)n1nc2N(O)C(=O)[C@@H](N)Cc2c1Cc1ccccc1
Show InChI InChI=1S/C16H20N4O2/c1-10(2)19-14(8-11-6-4-3-5-7-11)12-9-13(17)16(21)20(22)15(12)18-19/h3-7,10,13,22H,8-9,17H2,1-2H3/t13-/m0/s1
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n/an/a 63n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM142233
PNG
(US8933095, 2)
Show SMILES Cn1nc2N(O)C(=O)[C@H](N)Cc2c1Cc1ccccc1
Show InChI InChI=1S/C14H16N4O2/c1-17-12(7-9-5-3-2-4-6-9)10-8-11(15)14(19)18(20)13(10)16-17/h2-6,11,20H,7-8,15H2,1H3/t11-/m1/s1
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n/an/a 63.7n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107738
PNG
(CHEMBL2347113 | US8933095, 22)
Show SMILES COc1cccc(Cc2nn(C)c3N(O)C(=O)[C@@H](N)Cc23)c1
Show InChI InChI=1S/C15H18N4O3/c1-18-14-11(8-12(16)15(20)19(14)21)13(17-18)7-9-4-3-5-10(6-9)22-2/h3-6,12,21H,7-8,16H2,1-2H3/t12-/m0/s1
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n/an/a 65.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107748
PNG
(US8933095, 7)
Show SMILES N[C@H]1Cc2cn(nc2N(O)C1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C13H11F3N4O2/c14-13(15,16)8-2-1-3-9(5-8)19-6-7-4-10(17)12(21)20(22)11(7)18-19/h1-3,5-6,10,22H,4,17H2/t10-/m0/s1
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n/an/a 74.7n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107735
PNG
(US8933095, 19)
Show SMILES N[C@H]1Cc2cn(nc2N(O)C1=O)C1CCC1
Show InChI InChI=1S/C10H14N4O2/c11-8-4-6-5-13(7-2-1-3-7)12-9(6)14(16)10(8)15/h5,7-8,16H,1-4,11H2/t8-/m0/s1
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n/an/a 81.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107728
PNG
(US8933095, 12)
Show SMILES Cc1c2C[C@H](N)C(=O)N(O)c2nn1Cc1ccccc1
Show InChI InChI=1S/C14H16N4O2/c1-9-11-7-12(15)14(19)18(20)13(11)16-17(9)8-10-5-3-2-4-6-10/h2-6,12,20H,7-8,15H2,1H3/t12-/m0/s1
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n/an/a 81.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM50432200
PNG
(CHEMBL2347109 | US8933095, 16)
Show SMILES N[C@H]1Cc2nn(cc2N(O)C1=O)-c1ccccc1
Show InChI InChI=1S/C12H12N4O2/c13-9-6-10-11(16(18)12(9)17)7-15(14-10)8-4-2-1-3-5-8/h1-5,7,9,18H,6,13H2/t9-/m0/s1
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n/an/a 85n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107725
PNG
(US8933095, 9)
Show SMILES N[C@H]1Cc2cn(Cc3ccc4ccccc4c3)nc2N(O)C1=O
Show InChI InChI=1S/C17H16N4O2/c18-15-8-14-10-20(19-16(14)21(23)17(15)22)9-11-5-6-12-3-1-2-4-13(12)7-11/h1-7,10,15,23H,8-9,18H2/t15-/m0/s1
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n/an/a 117n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107736
PNG
(US8933095, 20)
Show SMILES CC(C)n1cc2C[C@H](N)C(=O)N(O)c2n1
Show InChI InChI=1S/C9H14N4O2/c1-5(2)12-4-6-3-7(10)9(14)13(15)8(6)11-12/h4-5,7,15H,3,10H2,1-2H3/t7-/m0/s1
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n/an/a 153n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107729
PNG
(US8933095, 13)
Show SMILES N[C@H]1Cc2nn(Cc3ccccc3)cc2N(O)C1=O
Show InChI InChI=1S/C13H14N4O2/c14-10-6-11-12(17(19)13(10)18)8-16(15-11)7-9-4-2-1-3-5-9/h1-5,8,10,19H,6-7,14H2/t10-/m0/s1
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n/an/a 182n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107734
PNG
(CHEMBL2347111 | US8933095, 18)
Show SMILES Cn1ncc2C[C@H](N)C(=O)N(O)c12
Show InChI InChI=1S/C7H10N4O2/c1-10-6-4(3-9-10)2-5(8)7(12)11(6)13/h3,5,13H,2,8H2,1H3/t5-/m0/s1
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n/an/a 329n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107737
PNG
(US8933095, 21)
Show SMILES COc1ccc(Cc2nn(C)c3N(O)C(=O)[C@@H](N)Cc23)cc1
Show InChI InChI=1S/C15H18N4O3/c1-18-14-11(8-12(16)15(20)19(14)21)13(17-18)7-9-3-5-10(22-2)6-4-9/h3-6,12,21H,7-8,16H2,1-2H3/t12-/m0/s1
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n/an/a 440n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial


(Homo sapiens (Human))
BDBM107733
PNG
(US8933095, 17)
Show SMILES Cc1c2N(O)C(=O)[C@@H](N)Cc2nn1-c1ccccc1
Show InChI InChI=1S/C13H14N4O2/c1-8-12-11(7-10(14)13(18)17(12)19)15-16(8)9-5-3-2-4-6-9/h2-6,10,19H,7,14H2,1H3/t10-/m0/s1
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n/an/a 2.01E+3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
Formation of kynurenic acid (KYNA) is indirectly assessed by a decrease in light absorbance at 370 nm (OD370) as the L-kynurenine (KYN) substrate is ...


US Patent US8933095 (2015)


BindingDB Entry DOI: 10.7270/Q2J9653C
More data for this
Ligand-Target Pair