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Compile Data Set for Download or QSAR

Found 708 hits Enz. Inhib. hit(s) with all data for entry = 6678   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145281
PNG
(US8952169, 60 | US9771376, Example 60)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)
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US Patent
n/an/a 0.300n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145285
PNG
(US8952169, 64 | US9771376, Example 64)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
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n/an/a 0.400n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47141
PNG
(US8952169, 185 | US8952169, 297)
Show SMILES Fc1cc(OCC2CCCCC2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H27FN2O4S/c21-18-12-19(27-13-14-5-2-1-3-6-14)16(15-7-8-15)11-17(18)20(24)22-28(25,26)23-9-4-10-23/h11-12,14-15H,1-10,13H2,(H,22,24)
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n/an/a 1n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145374
PNG
(US8952169, 153)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C22H26F3NO4S/c1-31(28,29)26-20(27)17-6-16(13-2-3-13)19(7-18(17)23)30-11-21-8-12-4-14(9-21)22(24,25)15(5-12)10-21/h6-7,12-15H,2-5,8-11H2,1H3,(H,26,27)
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US Patent
n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145369
PNG
(US8952169, 148 | US9771376, Example 148)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)
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US Patent
n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145281
PNG
(US8952169, 60 | US9771376, Example 60)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-21(25)18-7-17(16-2-3-16)20(8-19(18)23)28-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16H,2-6,9-12H2,1H3,(H,24,25)
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US Patent
n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47139
PNG
(US8952169, 175 | US8952169, 295)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C18H24FNO4S/c1-25(22,23)20-18(21)15-9-14(13-7-8-13)17(10-16(15)19)24-11-12-5-3-2-4-6-12/h9-10,12-13H,2-8,11H2,1H3,(H,20,21)
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n/an/a 1n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145371
PNG
(US8952169, 150 | US9771376, Example 150)
Show SMILES FC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H30F2N2O4S/c25-18-11-28(12-18)33(30,31)27-23(29)20-6-19(17-1-2-17)22(7-21(20)26)32-13-24-8-14-3-15(9-24)5-16(4-14)10-24/h6-7,14-18H,1-5,8-13H2,(H,27,29)
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n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145384
PNG
(US8952169, 163)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C23H30FNO4S/c1-2-30(27,28)25-22(26)19-8-18(17-3-4-17)21(9-20(19)24)29-13-23-10-14-5-15(11-23)7-16(6-14)12-23/h8-9,14-17H,2-7,10-13H2,1H3,(H,25,26)
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US Patent
n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145412
PNG
(US8952169, 191)
Show SMILES Fc1cc(OCC2C3CC4CC(C3)CC2C4)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-22-12-23(31-13-21-17-7-14-6-15(9-17)10-18(21)8-14)19(16-2-3-16)11-20(22)24(28)26-32(29,30)27-4-1-5-27/h11-12,14-18,21H,1-10,13H2,(H,26,28)
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US Patent
n/an/a 1n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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US Patent
n/an/a 1.31n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145369
PNG
(US8952169, 148 | US9771376, Example 148)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H30FNO4S/c25-21-9-22(30-13-24-10-14-5-15(11-24)7-16(6-14)12-24)19(17-1-2-17)8-20(21)23(27)26-31(28,29)18-3-4-18/h8-9,14-18H,1-7,10-13H2,(H,26,27)
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n/an/a 1.40n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145641
PNG
(US8952169, 446)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-17-11-18(30-12-20(21(23,24)25)8-2-1-3-9-20)15(13-4-5-13)10-16(17)19(27)26-31(28,29)14-6-7-14/h10-11,13-14H,1-9,12H2,(H,26,27)
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US Patent
n/an/a 1.60n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145576
PNG
(US8952169, 373)
Show SMILES CC1CCCCC1COc1cc(F)c(cc1C1CC1)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C21H28FNO4S/c1-13-4-2-3-5-15(13)12-27-20-11-19(22)18(10-17(20)14-6-7-14)21(24)23-28(25,26)16-8-9-16/h10-11,13-16H,2-9,12H2,1H3,(H,23,24)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145593
PNG
(US8952169, 391)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3CC3C2)cc1F
Show InChI InChI=1S/C19H24FNO4S/c1-26(23,24)21-19(22)16-8-15(12-4-5-12)18(9-17(16)20)25-10-11-2-3-13-7-14(13)6-11/h8-9,11-14H,2-7,10H2,1H3,(H,21,22)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47137
PNG
(US8952169, 270)
Show SMILES O=C(NS(=O)(=O)N1CCC1)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C23H31N3O4S/c27-21(25-31(28,29)26-4-1-5-26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,27)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145470
PNG
(US8952169, 249)
Show SMILES Fc1cc(OCC2(CCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H24F4N2O4S/c21-16-11-17(30-12-19(20(22,23)24)6-1-2-7-19)14(13-4-5-13)10-15(16)18(27)25-31(28,29)26-8-3-9-26/h10-11,13H,1-9,12H2,(H,25,27)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145485
PNG
(US8952169, 269)
Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47137
PNG
(US8952169, 270)
Show SMILES O=C(NS(=O)(=O)N1CCC1)c1cnc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C23H31N3O4S/c27-21(25-31(28,29)26-4-1-5-26)19-9-20(18-2-3-18)22(24-13-19)30-14-23-10-15-6-16(11-23)8-17(7-15)12-23/h9,13,15-18H,1-8,10-12,14H2,(H,25,27)
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n/an/a 2n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145285
PNG
(US8952169, 64 | US9771376, Example 64)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C24H31FN2O4S/c25-21-10-22(31-14-24-11-15-6-16(12-24)8-17(7-15)13-24)19(18-2-3-18)9-20(21)23(28)26-32(29,30)27-4-1-5-27/h9-10,15-18H,1-8,11-14H2,(H,26,28)
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US Patent
n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145392
PNG
(US8952169, 171 | US8952169, 267)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H17F4NO4S/c1-26(23,24)21-14(22)11-6-10(9-2-3-9)13(7-12(11)17)25-8-15(4-5-15)16(18,19)20/h6-7,9H,2-5,8H2,1H3,(H,21,22)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145623
PNG
(US8952169, 426)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H27F4NO4S/c1-21(8-6-14(7-9-21)22(24,25)26)12-31-19-11-18(23)17(10-16(19)13-2-3-13)20(28)27-32(29,30)15-4-5-15/h10-11,13-15H,2-9,12H2,1H3,(H,27,28)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145432
PNG
(US8952169, 211)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CCC1)C1CC1
Show InChI InChI=1S/C25H32FNO4S/c26-22-10-23(31-14-25-11-15-6-16(12-25)8-17(7-15)13-25)20(18-4-5-18)9-21(22)24(28)27-32(29,30)19-2-1-3-19/h9-10,15-19H,1-8,11-14H2,(H,27,28)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145379
PNG
(US8952169, 158)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3(CC3)CC2)cc1F
Show InChI InChI=1S/C20H26FNO4S/c1-27(24,25)22-19(23)16-10-15(14-2-3-14)18(11-17(16)21)26-12-13-4-6-20(7-5-13)8-9-20/h10-11,13-14H,2-9,12H2,1H3,(H,22,23)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145392
PNG
(US8952169, 171 | US8952169, 267)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H17F4NO4S/c1-26(23,24)21-14(22)11-6-10(9-2-3-9)13(7-12(11)17)25-8-15(4-5-15)16(18,19)20/h6-7,9H,2-5,8H2,1H3,(H,21,22)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145284
PNG
(US8952169, 63 | US9771376, Example 63)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H29FN2O4S/c1-24-30(27,28)25-21(26)18-7-17(16-2-3-16)20(8-19(18)23)29-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16,24H,2-6,9-12H2,1H3,(H,25,26)
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n/an/a 2.10n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145270
PNG
(US8952169, 49)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)
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n/an/a 2.20n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145594
PNG
(US8952169, 392)
Show SMILES Fc1cc(OCC2CCC3CC3C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H26FNO4S/c22-19-10-20(27-11-12-1-2-14-8-15(14)7-12)17(13-3-4-13)9-18(19)21(24)23-28(25,26)16-5-6-16/h9-10,12-16H,1-8,11H2,(H,23,24)
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n/an/a 3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145610
PNG
(US8952169, 413)
Show SMILES CC1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CC1
Show InChI InChI=1S/C21H28FNO4S/c1-13-2-4-14(5-3-13)12-27-20-11-19(22)18(10-17(20)15-6-7-15)21(24)23-28(25,26)16-8-9-16/h10-11,13-16H,2-9,12H2,1H3,(H,23,24)
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n/an/a 3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145270
PNG
(US8952169, 49)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145531
PNG
(US8952169, 327)
Show SMILES Fc1cc(OCC2(CCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C19H21F4NO4S/c20-15-9-16(28-10-18(6-1-7-18)19(21,22)23)13(11-2-3-11)8-14(15)17(25)24-29(26,27)12-4-5-12/h8-9,11-12H,1-7,10H2,(H,24,25)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145390
PNG
(US8952169, 169 | US9771376, Example 169)
Show SMILES COC1CN(C1)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H33FN2O5S/c1-32-19-12-28(13-19)34(30,31)27-24(29)21-7-20(18-2-3-18)23(8-22(21)26)33-14-25-9-15-4-16(10-25)6-17(5-15)11-25/h7-8,15-19H,2-6,9-14H2,1H3,(H,27,29)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145385
PNG
(US8952169, 164)
Show SMILES CC(C)(C)S(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H34FNO4S/c1-24(2,3)32(29,30)27-23(28)20-9-19(18-4-5-18)22(10-21(20)26)31-14-25-11-15-6-16(12-25)8-17(7-15)13-25/h9-10,15-18H,4-8,11-14H2,1-3H3,(H,27,28)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145377
PNG
(US8952169, 156)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H27F2NO4S/c1-30(27,28)25-20(26)17-5-16(15-2-3-15)19(6-18(17)23)29-12-21-7-13-4-14(8-21)10-22(24,9-13)11-21/h5-6,13-15H,2-4,7-12H2,1H3,(H,25,26)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145456
PNG
(US8952169, 235)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)CCCCC1
Show InChI InChI=1S/C21H29FN2O4S/c1-21(8-3-2-4-9-21)14-28-19-13-18(22)17(12-16(19)15-6-7-15)20(25)23-29(26,27)24-10-5-11-24/h12-13,15H,2-11,14H2,1H3,(H,23,25)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145481
PNG
(US8952169, 262)
Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145442
PNG
(US8952169, 221)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H26F4N2O4S/c22-17-12-18(31-13-20(21(23,24)25)7-2-1-3-8-20)15(14-5-6-14)11-16(17)19(28)26-32(29,30)27-9-4-10-27/h11-12,14H,1-10,13H2,(H,26,28)
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n/an/a 3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145516
PNG
(US8952169, 312 | US8952169, 430 | US8952169, 433)
Show SMILES Fc1cc(OCC23CCCCC2C3(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H24F3NO4S/c22-16-10-17(29-11-20-8-2-1-3-18(20)21(20,23)24)14(12-4-5-12)9-15(16)19(26)25-30(27,28)13-6-7-13/h9-10,12-13,18H,1-8,11H2,(H,25,26)
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n/an/a 3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145284
PNG
(US8952169, 63 | US9771376, Example 63)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H29FN2O4S/c1-24-30(27,28)25-21(26)18-7-17(16-2-3-16)20(8-19(18)23)29-12-22-9-13-4-14(10-22)6-15(5-13)11-22/h7-8,13-16,24H,2-6,9-12H2,1H3,(H,25,26)
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n/an/a 3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145609
PNG
(US8952169, 412)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3(CC3)CC2)cc1F
Show InChI InChI=1S/C21H28FNO4S/c1-2-28(25,26)23-20(24)17-11-16(15-3-4-15)19(12-18(17)22)27-13-14-5-7-21(8-6-14)9-10-21/h11-12,14-15H,2-10,13H2,1H3,(H,23,24)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145624
PNG
(US8952169, 427)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H28F4N2O4S/c1-21(7-5-15(6-8-21)22(24,25)26)13-32-19-12-18(23)17(11-16(19)14-3-4-14)20(29)27-33(30,31)28-9-2-10-28/h11-12,14-15H,2-10,13H2,1H3,(H,27,29)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145516
PNG
(US8952169, 312 | US8952169, 430 | US8952169, 433)
Show SMILES Fc1cc(OCC23CCCCC2C3(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H24F3NO4S/c22-16-10-17(29-11-20-8-2-1-3-18(20)21(20,23)24)14(12-4-5-12)9-15(16)19(26)25-30(27,28)13-6-7-13/h9-10,12-13,18H,1-8,11H2,(H,25,26)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145632
PNG
(US8952169, 435)
Show SMILES Fc1cc(OCC2CC[C@@H](CC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-18-10-19(30-11-12-1-5-14(6-2-12)21(23,24)25)16(13-3-4-13)9-17(18)20(27)26-31(28,29)15-7-8-15/h9-10,12-15H,1-8,11H2,(H,26,27)/t12?,14-
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145591
PNG
(US8952169, 389)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC2(CC2)CC1
Show InChI InChI=1S/C23H30FNO4S/c1-22(6-8-23(9-7-22)10-11-23)14-29-20-13-19(24)18(12-17(20)15-2-3-15)21(26)25-30(27,28)16-4-5-16/h12-13,15-16H,2-11,14H2,1H3,(H,25,26)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145592
PNG
(US8952169, 390)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)CCC2(CC2)CC1
Show InChI InChI=1S/C23H31FN2O4S/c1-22(5-7-23(8-6-22)9-10-23)15-30-20-14-19(24)18(13-17(20)16-3-4-16)21(27)25-31(28,29)26-11-2-12-26/h13-14,16H,2-12,15H2,1H3,(H,25,27)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145442
PNG
(US8952169, 221)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H26F4N2O4S/c22-17-12-18(31-13-20(21(23,24)25)7-2-1-3-8-20)15(14-5-6-14)11-16(17)19(28)26-32(29,30)27-9-4-10-27/h11-12,14H,1-10,13H2,(H,26,28)
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n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145411
PNG
(US8952169, 190)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-22(25)18-9-17(14-2-3-14)21(10-20(18)23)28-11-19-15-5-12-4-13(7-15)8-16(19)6-12/h9-10,12-16,19H,2-8,11H2,1H3,(H,24,25)
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n/an/a 3.10n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145276
PNG
(US8952169, 55)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC2C3CC4CC(C3)CC2C4)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-22(24)16-4-5-21(19(11-16)15-2-3-15)27-12-20-17-7-13-6-14(9-17)10-18(20)8-13/h4-5,11,13-15,17-18,20H,2-3,6-10,12H2,1H3,(H,23,24)
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n/an/a 3.10n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145641
PNG
(US8952169, 446)
Show SMILES Fc1cc(OCC2(CCCCC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-17-11-18(30-12-20(21(23,24)25)8-2-1-3-9-20)15(13-4-5-13)10-16(17)19(27)26-31(28,29)14-6-7-14/h10-11,13-14H,1-9,12H2,(H,26,27)
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n/an/a 3.10n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
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