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Compile Data Set for Download or QSAR

Found 107 hits Enz. Inhib. hit(s) with all data for entry = 6998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164488
PNG
(US9066954, 373)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2nnc(CNc3ccnc4cc(OCCn5cncn5)cnc34)n2n1
Show InChI InChI=1S/C24H18F2N10O/c25-16-7-15(8-17(26)9-16)19-1-2-22-32-33-23(36(22)34-19)12-29-20-3-4-28-21-10-18(11-30-24(20)21)37-6-5-35-14-27-13-31-35/h1-4,7-11,13-14H,5-6,12H2,(H,28,29)
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US Patent
0.100 -57.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164473
PNG
(US9066954, 302)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cc(C)cs3)ccnc2c1
Show InChI InChI=1S/C22H17FN4O2S/c1-13-7-20(30-12-13)14-8-17(23)22-26-25-21(27(22)10-14)11-29-19-5-6-24-18-9-15(28-2)3-4-16(18)19/h3-10,12H,11H2,1-2H3
PDB
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US Patent
0.300 -54.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164486
PNG
(US9066954, 336)
Show SMILES Cc1csc(c1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H15N5S/c1-13-9-18(26-12-13)17-6-7-19-22-23-20(25(19)24-17)11-14-4-5-16-15(10-14)3-2-8-21-16/h2-10,12H,11H2,1H3
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US Patent
0.700 -52.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164420
PNG
(US9066954, 55)
Show SMILES COc1cnc2c(NCc3nnc4ncc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C20H16N8O/c1-29-14-9-16-19(23-10-14)15(7-8-21-16)22-12-18-25-26-20-24-11-17(27-28(18)20)13-5-3-2-4-6-13/h2-11H,12H2,1H3,(H,21,22)
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US Patent
0.900 -52.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164453
PNG
(US9066954, 176)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)cs3)ccnc2c1
Show InChI InChI=1S/C20H17N7OS/c1-12-7-17(29-11-12)14-3-4-18-24-25-19(27(18)26-14)10-22-15-5-6-21-16-8-13(28-2)9-23-20(15)16/h3-9,11H,10H2,1-2H3,(H,21,22)
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US Patent
1.20 -51.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24483
PNG
(5-(3-{[(7-methoxyquinolin-4-yl)oxy]methyl}-[1,2,4]...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-9-18(29-25-12)15-5-6-19-22-23-20(26(19)24-15)11-28-17-7-8-21-16-10-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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US Patent
1.60 -50.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164424
PNG
(US9066954, 62)
Show SMILES COc1cnc2c(OCc3cnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C22H14F3N5O2/c1-31-14-8-18-22(28-10-14)19(4-5-26-18)32-11-13-9-27-20-3-2-17(29-30(13)20)12-6-15(23)21(25)16(24)7-12/h2-10H,11H2,1H3
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US Patent
1.70 -50.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164475
PNG
(US9066954, 309)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc4ncsc4c3)ccnc2c1
Show InChI InChI=1S/C22H16N8OS/c1-31-14-9-18-22(25-10-14)17(6-7-23-18)24-11-21-28-27-20-5-4-15(29-30(20)21)13-2-3-16-19(8-13)32-12-26-16/h2-10,12H,11H2,1H3,(H,23,24)
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US Patent
2 -50.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164434
PNG
(US9066954, 85)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C21H16FN5O2S/c1-12-7-19(30-26-12)13-8-16(22)21-25-24-20(27(21)10-13)11-29-18-5-6-23-17-9-14(28-2)3-4-15(17)18/h3-10H,11H2,1-2H3
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US Patent
2 -50.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164430
PNG
(US9066954, 75)
Show SMILES CNC(=O)c1ccc(s1)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2c1
Show InChI InChI=1S/C23H19N5O3S/c1-24-23(29)20-7-6-19(32-20)14-3-8-21-26-27-22(28(21)12-14)13-31-18-9-10-25-17-11-15(30-2)4-5-16(17)18/h3-12H,13H2,1-2H3,(H,24,29)
PDB
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US Patent
2.20 -49.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164435
PNG
(US9066954, 86)
Show SMILES COc1ccc2c(OCc3nnc4c(F)cc(cn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C21H16FN5O2S/c1-12-24-9-19(30-12)13-7-16(22)21-26-25-20(27(21)10-13)11-29-18-5-6-23-17-8-14(28-2)3-4-15(17)18/h3-10H,11H2,1-2H3
PDB
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US Patent
2.40 -49.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164457
PNG
(US9066954, 202)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4NC(=O)CCc4c3)ccnc2c1
Show InChI InChI=1S/C25H20N6O3/c1-33-17-4-5-18-21(13-17)26-11-10-22(18)34-14-24-29-28-23-8-7-20(30-31(23)24)16-2-6-19-15(12-16)3-9-25(32)27-19/h2,4-8,10-13H,3,9,14H2,1H3,(H,27,32)
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US Patent
2.40 -49.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164441
PNG
(US9066954, 118)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)c1nnc2ccc(nn12)-c1ccccc1
Show InChI InChI=1S/C23H19N5O/c1-15(17-8-9-20-18(12-17)13-19(29-2)14-24-20)23-26-25-22-11-10-21(27-28(22)23)16-6-4-3-5-7-16/h3-15H,1-2H3/t15-/m0/s1
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US Patent
2.60 -49.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164464
PNG
(US9066954, 232)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4OCCOc4c3)ccnc2c1
Show InChI InChI=1S/C24H19N5O4/c1-30-16-3-4-17-19(13-16)25-9-8-20(17)33-14-24-27-26-23-7-5-18(28-29(23)24)15-2-6-21-22(12-15)32-11-10-31-21/h2-9,12-13H,10-11,14H2,1H3
PDB
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US Patent
2.60 -49.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50302903
PNG
(7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
Show InChI InChI=1S/C21H14F3N7O/c1-32-12-8-17-21(27-9-12)16(4-5-25-17)26-10-19-29-28-18-3-2-15(30-31(18)19)11-6-13(22)20(24)14(23)7-11/h2-9H,10H2,1H3,(H,25,26)
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US Patent
2.70 -49.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164469
PNG
(US9066954, 294)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccc4NC(=O)Cc4c3)ccnc2c1
Show InChI InChI=1S/C25H19N5O3/c1-32-18-4-5-19-21(12-18)26-9-8-22(19)33-14-24-29-28-23-7-3-16(13-30(23)24)15-2-6-20-17(10-15)11-25(31)27-20/h2-10,12-13H,11,14H2,1H3,(H,27,31)
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2.80 -49.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164446
PNG
(US9066954, 141)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4OCCc4c3)ccnc2c1
Show InChI InChI=1S/C24H19N5O3/c1-30-17-3-4-18-20(13-17)25-10-8-22(18)32-14-24-27-26-23-7-5-19(28-29(23)24)15-2-6-21-16(12-15)9-11-31-21/h2-8,10,12-13H,9,11,14H2,1H3
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2.90 -49.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50302905
PNG
(7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]t...)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)ns3)ccnc2c1
Show InChI InChI=1S/C19H16N8OS/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21)
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US Patent
3.20 -48.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164472
PNG
(US9066954, 297)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cc(C)no3)ccnc2c1
Show InChI InChI=1S/C21H17N5O3/c1-13-9-19(29-25-13)14-3-6-20-23-24-21(26(20)11-14)12-28-18-7-8-22-17-10-15(27-2)4-5-16(17)18/h3-11H,12H2,1-2H3
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3.20 -48.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164461
PNG
(US9066954, 226)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-22-10-18(29-12)15-5-6-19-23-24-20(26(19)25-15)11-28-17-7-8-21-16-9-13(27-2)3-4-14(16)17/h3-10H,11H2,1-2H3
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4.70 -47.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164455
PNG
(US9066954, 187)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc(=O)n(C)c3)ccnc2c1
Show InChI InChI=1S/C21H18N8O2/c1-28-12-13(3-6-20(28)30)15-4-5-18-25-26-19(29(18)27-15)11-23-16-7-8-22-17-9-14(31-2)10-24-21(16)17/h3-10,12H,11H2,1-2H3,(H,22,23)
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US Patent
4.90 -47.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164418
PNG
(US9066954, 52)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3ccc4C(=O)N(C)Cc4c3)ccnc2c1
Show InChI InChI=1S/C24H20N8O2/c1-31-13-15-9-14(3-4-17(15)24(31)33)18-5-6-21-28-29-22(32(21)30-18)12-26-19-7-8-25-20-10-16(34-2)11-27-23(19)20/h3-11H,12-13H2,1-2H3,(H,25,26)
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5 -47.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164445
PNG
(US9066954, 140)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4N(C)CCOc4c3)ccnc2c1
Show InChI InChI=1S/C25H22N6O3/c1-30-11-12-33-23-13-16(3-7-21(23)30)19-6-8-24-27-28-25(31(24)29-19)15-34-22-9-10-26-20-14-17(32-2)4-5-18(20)22/h3-10,13-14H,11-12,15H2,1-2H3
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5.20 -47.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164442
PNG
(US9066954, 121)
Show SMILES FC(F)(c1nnc2ccc(nn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C21H13F2N5/c22-21(23,16-8-9-17-15(13-16)7-4-12-24-17)20-26-25-19-11-10-18(27-28(19)20)14-5-2-1-3-6-14/h1-13H
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5.40 -47.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164454
PNG
(US9066954, 186)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(=O)n(C)c3)ccnc2c1
Show InChI InChI=1S/C22H18N6O3/c1-27-12-14(3-8-22(27)29)17-6-7-20-24-25-21(28(20)26-17)13-31-19-9-10-23-18-11-15(30-2)4-5-16(18)19/h3-12H,13H2,1-2H3
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6.20 -47.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164404
PNG
(US9066954, 18)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3cn(C)nn3)ccnc2c1
Show InChI InChI=1S/C20H17N7O2/c1-26-11-17(22-25-26)13-3-6-19-23-24-20(27(19)10-13)12-29-18-7-8-21-16-9-14(28-2)4-5-15(16)18/h3-11H,12H2,1-2H3
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6.60 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164419
PNG
(US9066954, 53)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnn(c3)C(C)C)ccnc2c1
Show InChI InChI=1S/C21H21N9O/c1-13(2)29-12-14(9-25-29)16-4-5-19-26-27-20(30(19)28-16)11-23-17-6-7-22-18-8-15(31-3)10-24-21(17)18/h4-10,12-13H,11H2,1-3H3,(H,22,23)
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6.70 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164463
PNG
(US9066954, 231)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4C(=O)N(C)Cc4c3)ccnc2c1
Show InChI InChI=1S/C25H20N6O3/c1-30-13-16-11-15(3-5-18(16)25(30)32)20-7-8-23-27-28-24(31(23)29-20)14-34-22-9-10-26-21-12-17(33-2)4-6-19(21)22/h3-12H,13-14H2,1-2H3
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6.70 -47.0n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24472
PNG
(4-{[6-(3-fluorophenyl)-[1,2,4]triazolo[4,3-a]pyrid...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cccc(F)c3)ccnc2c1
Show InChI InChI=1S/C22H16FN5O2/c1-29-16-5-6-17-19(12-16)24-10-9-20(17)30-13-22-26-25-21-8-7-18(27-28(21)22)14-3-2-4-15(23)11-14/h2-12H,13H2,1H3
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US Patent
7 -46.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164476
PNG
(US9066954, 311)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C19H16N8OS/c1-11-21-9-16(29-11)13-3-4-17-24-25-18(27(17)26-13)10-22-14-5-6-20-15-7-12(28-2)8-23-19(14)15/h3-9H,10H2,1-2H3,(H,20,22)
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7 -46.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164458
PNG
(US9066954, 203)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4CC(C)(C)Oc4c3)ccnc2c1
Show InChI InChI=1S/C26H23N5O3/c1-26(2)14-17-5-4-16(12-23(17)34-26)20-8-9-24-28-29-25(31(24)30-20)15-33-22-10-11-27-21-13-18(32-3)6-7-19(21)22/h4-13H,14-15H2,1-3H3
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7.5 -46.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164414
PNG
(US9066954, 40)
Show SMILES COc1cnc2ccc(Cc3nnc4ccc(nn34)-c3ccccc3)cc2c1
Show InChI InChI=1S/C22H17N5O/c1-28-18-13-17-11-15(7-8-19(17)23-14-18)12-22-25-24-21-10-9-20(26-27(21)22)16-5-3-2-4-6-16/h2-11,13-14H,12H2,1H3
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7.5 -46.7n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164438
PNG
(US9066954, 89)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)C(N)=O)ccnc2c1
Show InChI InChI=1S/C18H15N5O3/c1-25-12-3-4-13-14(8-12)20-7-6-15(13)26-10-17-22-21-16-5-2-11(18(19)24)9-23(16)17/h2-9H,10H2,1H3,(H2,19,24)
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7.90 -46.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164460
PNG
(US9066954, 209)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccncc3)ccnc2c1
Show InChI InChI=1S/C21H16N6O2/c1-28-15-2-3-16-18(12-15)23-11-8-19(16)29-13-21-25-24-20-5-4-17(26-27(20)21)14-6-9-22-10-7-14/h2-12H,13H2,1H3
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8.90 -46.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164471
PNG
(US9066954, 296)
Show SMILES COc1cnc2c(NCc3nnc4c(F)cc(cn34)-c3cnc(C)s3)ccnc2c1
Show InChI InChI=1S/C20H16FN7OS/c1-11-23-8-17(30-11)12-5-14(21)20-27-26-18(28(20)10-12)9-24-15-3-4-22-16-6-13(29-2)7-25-19(15)16/h3-8,10H,9H2,1-2H3,(H,22,24)
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8.90 -46.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50440890
PNG
(CHEMBL2431841 | US9066954, 341)
Show SMILES Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C19H15N7/c1-25-12-15(11-21-25)17-6-7-18-22-23-19(26(18)24-17)10-13-4-5-16-14(9-13)3-2-8-20-16/h2-9,11-12H,10H2,1H3
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9.10 -46.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164448
PNG
(US9066954, 148)
Show SMILES C(Oc1ccnc2ccccc12)c1nnc2ccc(nn12)-c1cccs1
Show InChI InChI=1S/C19H13N5OS/c1-2-5-14-13(4-1)16(9-10-20-14)25-12-19-22-21-18-8-7-15(23-24(18)19)17-6-3-11-26-17/h1-11H,12H2
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9.20 -46.2n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164403
PNG
(US9066954, 17)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc(-c4nc(C)no4)c(Cl)c3)ccnc2c1
Show InChI InChI=1S/C25H18ClN7O3/c1-14-28-25(36-32-14)17-5-3-15(11-19(17)26)20-7-8-23-29-30-24(33(23)31-20)13-35-22-9-10-27-21-12-16(34-2)4-6-18(21)22/h3-12H,13H2,1-2H3
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9.30 -46.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164467
PNG
(US9066954, 282)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ccccn3)ccnc2c1
Show InChI InChI=1S/C22H17N5O2/c1-28-16-6-7-17-19(12-16)24-11-9-20(17)29-14-22-26-25-21-8-5-15(13-27(21)22)18-4-2-3-10-23-18/h2-13H,14H2,1H3
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9.5 -46.1n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164416
PNG
(US9066954, 45)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc4nccn4c3)ccnc2c1
Show InChI InChI=1S/C23H17N7O2/c1-31-16-3-4-17-19(12-16)24-9-8-20(17)32-14-23-27-26-22-7-5-18(28-30(22)23)15-2-6-21-25-10-11-29(21)13-15/h2-13H,14H2,1H3
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12.1 -45.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164493
PNG
(US9066954, 447)
Show SMILES FC(F)(c1noc2ncc(cc12)-c1cc[nH]n1)c1ccc2ncccc2c1
Show InChI InChI=1S/C19H11F2N5O/c20-19(21,13-3-4-15-11(8-13)2-1-6-22-15)17-14-9-12(16-5-7-24-25-16)10-23-18(14)27-26-17/h1-10H,(H,24,25)
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12.1 -45.5n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164429
PNG
(US9066954, 73)
Show SMILES CNc1ccc(cc1)-c1ccc2nnc(COc3ccnc4cc(OC)ccc34)n2c1
Show InChI InChI=1S/C24H21N5O2/c1-25-18-6-3-16(4-7-18)17-5-10-23-27-28-24(29(23)14-17)15-31-22-11-12-26-21-13-19(30-2)8-9-20(21)22/h3-14,25H,15H2,1-2H3
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12.8 -45.4n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164411
PNG
(US9066954, 34)
Show SMILES COc1cnc2c(NCc3nnc4ccc(nn34)-c3cc(C)no3)ccnc2c1
Show InChI InChI=1S/C19H16N8O2/c1-11-7-16(29-26-11)13-3-4-17-23-24-18(27(17)25-13)10-21-14-5-6-20-15-8-12(28-2)9-22-19(14)15/h3-9H,10H2,1-2H3,(H,20,21)
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15.9 -44.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164409
PNG
(US9066954, 24)
Show SMILES COc1cnc2c(NCc3nnc4ccc(cn34)-c3ccc(F)c(Cl)c3)ccnc2c1
Show InChI InChI=1S/C22H16ClFN6O/c1-31-15-9-19-22(27-10-15)18(6-7-25-19)26-11-21-29-28-20-5-3-14(12-30(20)21)13-2-4-17(24)16(23)8-13/h2-10,12H,11H2,1H3,(H,25,26)
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17.4 -44.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24484
PNG
(4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin...)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccco3)ccnc2c1
Show InChI InChI=1S/C20H15N5O3/c1-26-13-4-5-14-16(11-13)21-9-8-17(14)28-12-20-23-22-19-7-6-15(24-25(19)20)18-3-2-10-27-18/h2-11H,12H2,1H3
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US Patent
17.6 -44.6n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164439
PNG
(US9066954, 91)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)C(O)=O)ccnc2c1
Show InChI InChI=1S/C18H14N4O4/c1-25-12-3-4-13-14(8-12)19-7-6-15(13)26-10-17-21-20-16-5-2-11(18(23)24)9-22(16)17/h2-9H,10H2,1H3,(H,23,24)
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19.2 -44.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164465
PNG
(US9066954, 279)
Show SMILES COc1ccc2c(OCc3nnc4ccc(cn34)-c3ncc(C)s3)ccnc2c1
Show InChI InChI=1S/C21H17N5O2S/c1-13-10-23-21(29-13)14-3-6-19-24-25-20(26(19)11-14)12-28-18-7-8-22-17-9-15(27-2)4-5-16(17)18/h3-11H,12H2,1-2H3
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19.7 -44.3n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164428
PNG
(US9066954, 70)
Show SMILES O=c1[nH]cnc2ccc(Cc3nnc4ccc(nn34)-c3ccccc3)cc12
Show InChI InChI=1S/C20H14N6O/c27-20-15-10-13(6-7-17(15)21-12-22-20)11-19-24-23-18-9-8-16(25-26(18)19)14-4-2-1-3-5-14/h1-10,12H,11H2,(H,21,22,27)
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22.9 -43.9n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164459
PNG
(US9066954, 208)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccc[nH]3)ccnc2c1
Show InChI InChI=1S/C20H16N6O2/c1-27-13-4-5-14-17(11-13)22-10-8-18(14)28-12-20-24-23-19-7-6-16(25-26(19)20)15-3-2-9-21-15/h2-11,21H,12H2,1H3
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23.7 -43.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM164417
PNG
(US9066954, 50)
Show SMILES COc1ccc2c(OCc3nnc4ccc(nn34)C#CC(C)(C)O)ccnc2c1
Show InChI InChI=1S/C21H19N5O3/c1-21(2,27)10-8-14-4-7-19-23-24-20(26(19)25-14)13-29-18-9-11-22-17-12-15(28-3)5-6-16(17)18/h4-7,9,11-12,27H,13H2,1-3H3
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23.8 -43.8n/an/an/an/an/a8.027



Amgen Inc.

US Patent


Assay Description
A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...


US Patent US9066954 (2015)


BindingDB Entry DOI: 10.7270/Q2N878JD
More data for this
Ligand-Target Pair
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