Compile Data Set for Download or QSAR

Found 38 hits Enz. Inhib. hit(s) with all data for entry = 7231   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182716 (US9145402, 23 | US9145402, 36) Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C15H17F3N4O3S/c1-8-5-10(11(25-3)6-12(8)26(4,23)24)21-14-20-7-9(15(16,17)18)13(19-2)22-14/h5-7H,1-4H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182713 (US9145402, 20) Show SMILES CNc1nc(Nc2cc(Cl)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C14H14ClF3N4O3S/c1-19-12-7(14(16,17)18)6-20-13(22-12)21-9-4-8(15)11(26(3,23)24)5-10(9)25-2/h4-6H,1-3H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM60652 (US9145402, 1) Show SMILES CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C14H15F3N4O3S/c1-18-12-9(14(15,16)17)7-19-13(21-12)20-10-5-4-8(25(3,22)23)6-11(10)24-2/h4-7H,1-3H3,(H2,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM60653 (US9145402, 2) Show SMILES CNc1nc(Nc2ccc(cc2OC)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C13H15ClN4O3S/c1-15-12-9(14)7-16-13(18-12)17-10-5-4-8(22(3,19)20)6-11(10)21-2/h4-7H,1-3H3,(H2,15,16,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182715 (US9145402, 22) Show SMILES CCNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F Show InChI InChI=1S/C20H24F5N5O2/c1-2-26-18-14(20(23,24)25)11-27-19(29-18)28-16-10-15(22)13(9-17(16)32-6-3-21)12-30-4-7-31-8-5-30/h9-11H,2-8,12H2,1H3,(H2,26,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182712 (US9145402, 19) Show SMILES CNc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C15H16F4N4O3S/c1-20-13-10(15(17,18)19)8-21-14(23-13)22-11-4-3-9(27(2,24)25)7-12(11)26-6-5-16/h3-4,7-8H,5-6H2,1-2H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182716 (US9145402, 23 | US9145402, 36) Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C15H17F3N4O3S/c1-8-5-10(11(25-3)6-12(8)26(4,23)24)21-14-20-7-9(15(16,17)18)13(19-2)22-14/h5-7H,1-4H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182728 (US9145402, 35) Show SMILES CCS(=O)(=O)c1cc(OC)c(Nc2ncc(c(NC)n2)C(F)(F)F)cc1C Show InChI InChI=1S/C16H19F3N4O3S/c1-5-27(24,25)13-7-12(26-4)11(6-9(13)2)22-15-21-8-10(16(17,18)19)14(20-3)23-15/h6-8H,5H2,1-4H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182727 (US9145402, 34) Show SMILES CCNc1nc(Nc2cc(C)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C16H19F3N4O3S/c1-5-20-14-10(16(17,18)19)8-21-15(23-14)22-11-6-9(2)13(27(4,24)25)7-12(11)26-3/h6-8H,5H2,1-4H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182726 (US9145402, 33) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)C2COC2)ncc1C(F)(F)F Show InChI InChI=1S/C16H16F4N4O2/c1-21-14-10(16(18,19)20)5-22-15(24-14)23-12-4-11(17)9(3-13(12)25-2)8-6-26-7-8/h3-5,8H,6-7H2,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182724 (US9145402, 31) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)N2CCOCC2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H17F4N5O3/c1-22-15-9(17(19,20)21)7-23-16(25-15)24-11-5-10(18)12(6-13(11)28-2)26-3-4-29-8-14(26)27/h5-7H,3-4,8H2,1-2H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182723 (US9145402, 30) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)N2CCCC2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H17F4N5O2/c1-22-15-9(17(19,20)21)8-23-16(25-15)24-11-6-10(18)12(7-13(11)28-2)26-5-3-4-14(26)27/h6-8H,3-5H2,1-2H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182731 (US9145402, 38) Show SMILES CCNc1nc(Nc2ccc(c3OCCOc23)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C16H17F3N4O4S/c1-3-20-14-9(16(17,18)19)8-21-15(23-14)22-10-4-5-11(28(2,24)25)13-12(10)26-6-7-27-13/h4-5,8H,3,6-7H2,1-2H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM50398665 (CHEMBL2178137 | US9145402, 15) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C14H14F4N4O3S/c1-19-12-7(14(16,17)18)6-20-13(22-12)21-9-4-8(15)11(26(3,23)24)5-10(9)25-2/h4-6H,1-3H3,(H2,19,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182703 (US9145402, 9) Show SMILES CNc1nc(Nc2ccc(CN3CCOCC3)cc2OC)ncc1C(F)(F)F Show InChI InChI=1S/C18H22F3N5O2/c1-22-16-13(18(19,20)21)10-23-17(25-16)24-14-4-3-12(9-15(14)27-2)11-26-5-7-28-8-6-26/h3-4,9-10H,5-8,11H2,1-2H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182714 (US9145402, 21) Show SMILES CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OCCF)ncc1C(F)(F)F Show InChI InChI=1S/C19H22F5N5O2/c1-25-17-13(19(22,23)24)10-26-18(28-17)27-15-9-14(21)12(8-16(15)31-5-2-20)11-29-3-6-30-7-4-29/h8-10H,2-7,11H2,1H3,(H2,25,26,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182725 (US9145402, 32) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)N2CCCCC2=O)ncc1C(F)(F)F Show InChI InChI=1S/C18H19F4N5O2/c1-23-16-10(18(20,21)22)9-24-17(26-16)25-12-7-11(19)13(8-14(12)29-2)27-6-4-3-5-15(27)28/h7-9H,3-6H2,1-2H3,(H2,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	5.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182718 (US9145402, 25) Show SMILES CNc1nc(Nc2ccc(cc2OC)C(O)=O)ncc1Cl Show InChI InChI=1S/C13H13ClN4O3/c1-15-11-8(14)6-16-13(18-11)17-9-4-3-7(12(19)20)5-10(9)21-2/h3-6H,1-2H3,(H,19,20)(H2,15,16,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase PC cid PC sid UniChem Similars	US Patent	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182701 (US9145402, 7) Show SMILES CNc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C13H12ClF3N4O2S/c1-18-11-8(13(15,16)17)6-19-12(21-11)20-10-4-3-7(5-9(10)14)24(2,22)23/h3-6H,1-2H3,(H2,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182702 (US9145402, 8) Show SMILES CNc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C12H12Cl2N4O2S/c1-15-11-9(14)6-16-12(18-11)17-10-4-3-7(5-8(10)13)21(2,19)20/h3-6H,1-2H3,(H2,15,16,17,18)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM60657 (US9145402, 5) Show SMILES CNc1nc(Nc2ccc(cc2OC)C#N)ncc1Cl Show InChI InChI=1S/C13H12ClN5O/c1-16-12-9(14)7-17-13(19-12)18-10-4-3-8(6-15)5-11(10)20-2/h3-5,7H,1-2H3,(H2,16,17,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM60656 (US9145402, 4) Show SMILES CNc1nc(Nc2c(OC)cc(cc2C(F)(F)F)C#N)ncc1C(F)(F)F Show InChI InChI=1S/C15H11F6N5O/c1-23-12-9(15(19,20)21)6-24-13(26-12)25-11-8(14(16,17)18)3-7(5-22)4-10(11)27-2/h3-4,6H,1-2H3,(H2,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182708 (US9145402, 14) Show SMILES CNc1nc(Nc2ccc(CN3CCOCC3)cc2OCCF)ncc1Cl Show InChI InChI=1S/C18H23ClFN5O2/c1-21-17-14(19)11-22-18(24-17)23-15-3-2-13(10-16(15)27-7-4-20)12-25-5-8-26-9-6-25/h2-3,10-11H,4-9,12H2,1H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182717 (US9145402, 24) Show SMILES CNc1nc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl Show InChI InChI=1S/C16H20ClN5O2/c1-18-15-12(17)10-19-16(21-15)20-13-4-3-11(9-14(13)23-2)22-5-7-24-8-6-22/h3-4,9-10H,5-8H2,1-2H3,(H2,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182711 (US9145402, 18) Show SMILES COc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C14H15ClFN3O4S/c1-22-13-10(15)8-17-14(19-13)18-11-4-3-9(24(2,20)21)7-12(11)23-6-5-16/h3-4,7-8H,5-6H2,1-2H3,(H,17,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182710 (US9145402, 17) Show SMILES CNc1nc(Nc2ccc(cc2OCCF)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C14H16ClFN4O3S/c1-17-13-10(15)8-18-14(20-13)19-11-4-3-9(24(2,21)22)7-12(11)23-6-5-16/h3-4,7-8H,5-6H2,1-2H3,(H2,17,18,19,20)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182707 (US9145402, 13) Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)C#N)ncc1C(F)(F)F Show InChI InChI=1S/C15H14F3N5O/c1-8-4-11(12(24-3)5-9(8)6-19)22-14-21-7-10(15(16,17)18)13(20-2)23-14/h4-5,7H,1-3H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182706 (US9145402, 12) Show SMILES CCNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N Show InChI InChI=1S/C19H23FN6O2/c1-3-22-18-14(10-21)11-23-19(25-18)24-16-9-15(20)13(8-17(16)27-2)12-26-4-6-28-7-5-26/h8-9,11H,3-7,12H2,1-2H3,(H2,22,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182709 (US9145402, 16) Show SMILES CNc1nc(Nc2ccc(cc2OC(C)C)S(C)(=O)=O)ncc1C(F)(F)F Show InChI InChI=1S/C16H19F3N4O3S/c1-9(2)26-13-7-10(27(4,24)25)5-6-12(13)22-15-21-8-11(16(17,18)19)14(20-3)23-15/h5-9H,1-4H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM60654 (US9145402, 3) Show SMILES CNc1nc(Nc2cc(F)c(cc2OC)C#N)ncc1C(F)(F)F Show InChI InChI=1S/C14H11F4N5O/c1-20-12-8(14(16,17)18)6-21-13(23-12)22-10-4-9(15)7(5-19)3-11(10)24-2/h3-4,6H,1-2H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182720 (US9145402, 27) Show SMILES CNc1nc(Nc2ccc(cc2OC)C(F)(F)F)ncc1C(F)(F)F Show InChI InChI=1S/C14H12F6N4O/c1-21-11-8(14(18,19)20)6-22-12(24-11)23-9-4-3-7(13(15,16)17)5-10(9)25-2/h3-6H,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182705 (US9145402, 11) Show SMILES CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C#N Show InChI InChI=1S/C18H21FN6O2/c1-21-17-13(9-20)10-22-18(24-17)23-15-8-14(19)12(7-16(15)26-2)11-25-3-5-27-6-4-25/h7-8,10H,3-6,11H2,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182721 (US9145402, 28) Show SMILES CNc1nc(Nc2ccc(cc2OC)C(F)(F)F)ncc1Cl Show InChI InChI=1S/C13H12ClF3N4O/c1-18-11-8(14)6-19-12(21-11)20-9-4-3-7(13(15,16)17)5-10(9)22-2/h3-6H,1-2H3,(H2,18,19,20,21)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182722 (US9145402, 29) Show SMILES CNc1nc(Nc2cc(Cl)c(cc2OC)C(O)=O)ncc1Cl Show InChI InChI=1S/C13H12Cl2N4O3/c1-16-11-8(15)5-17-13(19-11)18-9-4-7(14)6(12(20)21)3-10(9)22-2/h3-5H,1-2H3,(H,20,21)(H2,16,17,18,19)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase PC cid PC sid UniChem Similars	US Patent	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182704 (US9145402, 10) Show SMILES CNc1nc(Nc2cc(C)c(cc2Cl)C#N)ncc1C(F)(F)F Show InChI InChI=1S/C14H11ClF3N5/c1-7-3-11(10(15)4-8(7)5-19)22-13-21-6-9(14(16,17)18)12(20-2)23-13/h3-4,6H,1-2H3,(H2,20,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182719 (US9145402, 26) Show SMILES CNc1nc(Nc2ccc(cc2OC)S(=O)(=O)N2CCOCC2)ncc1C(F)(F)F Show InChI InChI=1S/C17H20F3N5O4S/c1-21-15-12(17(18,19)20)10-22-16(24-15)23-13-4-3-11(9-14(13)28-2)30(26,27)25-5-7-29-8-6-25/h3-4,9-10H,5-8H2,1-2H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182730 (US9145402, 37) Show SMILES CNc1nc(Nc2cc(F)c(CN3CCOCC3)cc2OC)ncc1C(F)(F)F Show InChI InChI=1S/C18H21F4N5O2/c1-23-16-12(18(20,21)22)9-24-17(26-16)25-14-8-13(19)11(7-15(14)28-2)10-27-3-5-29-6-4-27/h7-9H,3-6,10H2,1-2H3,(H2,23,24,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	US Patent	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (Homo sapiens (Human))	BDBM182700 (US9145402, 6) Show SMILES COc1nc(Nc2ccc(cc2Cl)S(C)(=O)=O)ncc1Cl Show InChI InChI=1S/C12H11Cl2N3O3S/c1-20-11-9(14)6-15-12(17-11)16-10-4-3-7(5-8(10)13)21(2,18)19/h3-6H,1-2H3,(H,15,16,17)	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description his assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 38...				US Patent US9145402 (2015) BindingDB Entry DOI: 10.7270/Q2J67FQ3
					More data for this Ligand-Target Pair