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Compile Data Set for Download or QSAR

Found 63 hits Enz. Inhib. hit(s) with all data for entry = 8147   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234579
PNG
(US9353093, 1)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-16-6-5-8-20(14-16)27-24(30)26-19-12-10-17(11-13-19)22-15-18-7-3-4-9-21(18)28(22)23(25)29/h3-15H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234580
PNG
(US9353093, 2)
Show SMILES COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1
Show InChI InChI=1S/C25H22N4O4/c1-15-4-3-5-20(12-15)28-25(32)27-19-10-8-16(9-11-19)21-13-17-6-7-18(23(30)33-2)14-22(17)29(21)24(26)31/h3-14H,1-2H3,(H2,26,31)(H2,27,28,32)
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n/an/a 5n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234581
PNG
(US9353093, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-15-5-4-7-19(13-15)26-23(29)25-18-11-9-16(10-12-18)21-14-17-6-2-3-8-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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n/an/a 6n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234582
PNG
(US9353093, 4)
Show SMILES CC(C)c1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C25H24N4O2/c1-16(2)18-7-5-8-21(14-18)28-25(31)27-20-12-10-17(11-13-20)23-15-19-6-3-4-9-22(19)29(23)24(26)30/h3-16H,1-2H3,(H2,26,30)(H2,27,28,31)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234583
PNG
(US9353093, 5)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(9-10-18(17)24)27-22(30)26-15-7-5-13(6-8-15)20-11-14-3-1-2-4-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
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n/an/a 8n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234584
PNG
(US9353093, 6)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-5-3-6-18(13-16)29-22(32)28-17-10-8-14(9-11-17)20-12-15-4-1-2-7-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
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n/an/a 9n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234585
PNG
(US9353093, 7)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-11-18(24)19(12-14)27-23(30)26-17-9-7-15(8-10-17)21-13-16-4-2-3-5-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234579
PNG
(US9353093, 1)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-16-6-5-8-20(14-16)27-24(30)26-19-12-10-17(11-13-19)22-15-18-7-3-4-9-21(18)28(22)23(25)29/h3-15H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 10n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234580
PNG
(US9353093, 2)
Show SMILES COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1
Show InChI InChI=1S/C25H22N4O4/c1-15-4-3-5-20(12-15)28-25(32)27-19-10-8-16(9-11-19)21-13-17-6-7-18(23(30)33-2)14-22(17)29(21)24(26)31/h3-14H,1-2H3,(H2,26,31)(H2,27,28,32)
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n/an/a 10n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234586
PNG
(US9353093, 8)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O3/c1-30-19-7-4-6-18(14-19)26-23(29)25-17-11-9-15(10-12-17)21-13-16-5-2-3-8-20(16)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234587
PNG
(US9353093, 9)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H16F4N4O2/c24-17-10-7-15(23(25,26)27)12-18(17)30-22(33)29-16-8-5-13(6-9-16)20-11-14-3-1-2-4-19(14)31(20)21(28)32/h1-12H,(H2,28,32)(H2,29,30,33)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234580
PNG
(US9353093, 2)
Show SMILES COC(=O)c1ccc2cc(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)n(C(N)=O)c2c1
Show InChI InChI=1S/C25H22N4O4/c1-15-4-3-5-20(12-15)28-25(32)27-19-10-8-16(9-11-19)21-13-17-6-7-18(23(30)33-2)14-22(17)29(21)24(26)31/h3-14H,1-2H3,(H2,26,31)(H2,27,28,32)
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n/an/a 11n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234589
PNG
(US9353093, 11)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)cc1
Show InChI InChI=1S/C23H20N4O2/c1-15-6-10-18(11-7-15)25-23(29)26-19-12-8-16(9-13-19)21-14-17-4-2-3-5-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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n/an/a 11n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234586
PNG
(US9353093, 8)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O3/c1-30-19-7-4-6-18(14-19)26-23(29)25-17-11-9-15(10-12-17)21-13-16-5-2-3-8-20(16)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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n/an/a 12n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234579
PNG
(US9353093, 1)
Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-16-6-5-8-20(14-16)27-24(30)26-19-12-10-17(11-13-19)22-15-18-7-3-4-9-21(18)28(22)23(25)29/h3-15H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 13n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234581
PNG
(US9353093, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-15-5-4-7-19(13-15)26-23(29)25-18-11-9-16(10-12-18)21-14-17-6-2-3-8-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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n/an/a 14n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234582
PNG
(US9353093, 4)
Show SMILES CC(C)c1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C25H24N4O2/c1-16(2)18-7-5-8-21(14-18)28-25(31)27-20-12-10-17(11-13-20)23-15-19-6-3-4-9-22(19)29(23)24(26)30/h3-16H,1-2H3,(H2,26,30)(H2,27,28,31)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234582
PNG
(US9353093, 4)
Show SMILES CC(C)c1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C25H24N4O2/c1-16(2)18-7-5-8-21(14-18)28-25(31)27-20-12-10-17(11-13-20)23-15-19-6-3-4-9-22(19)29(23)24(26)30/h3-16H,1-2H3,(H2,26,30)(H2,27,28,31)
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n/an/a 16n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234581
PNG
(US9353093, 3)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-15-5-4-7-19(13-15)26-23(29)25-18-11-9-16(10-12-18)21-14-17-6-2-3-8-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234583
PNG
(US9353093, 5)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(9-10-18(17)24)27-22(30)26-15-7-5-13(6-8-15)20-11-14-3-1-2-4-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234585
PNG
(US9353093, 7)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-11-18(24)19(12-14)27-23(30)26-17-9-7-15(8-10-17)21-13-16-4-2-3-5-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 20n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234588
PNG
(US9353093, 10)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C22H18N4O2/c23-21(27)26-19-9-5-4-6-16(19)14-20(26)15-10-12-18(13-11-15)25-22(28)24-17-7-2-1-3-8-17/h1-14H,(H2,23,27)(H2,24,25,28)
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n/an/a 22n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234588
PNG
(US9353093, 10)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C22H18N4O2/c23-21(27)26-19-9-5-4-6-16(19)14-20(26)15-10-12-18(13-11-15)25-22(28)24-17-7-2-1-3-8-17/h1-14H,(H2,23,27)(H2,24,25,28)
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n/an/a 23n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234589
PNG
(US9353093, 11)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)cc1
Show InChI InChI=1S/C23H20N4O2/c1-15-6-10-18(11-7-15)25-23(29)26-19-12-8-16(9-13-19)21-14-17-4-2-3-5-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234584
PNG
(US9353093, 6)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-5-3-6-18(13-16)29-22(32)28-17-10-8-14(9-11-17)20-12-15-4-1-2-7-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
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n/an/a 28n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234585
PNG
(US9353093, 7)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-11-18(24)19(12-14)27-23(30)26-17-9-7-15(8-10-17)21-13-16-4-2-3-5-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234586
PNG
(US9353093, 8)
Show SMILES COc1cccc(NC(=O)Nc2ccc(cc2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O3/c1-30-19-7-4-6-18(14-19)26-23(29)25-17-11-9-15(10-12-17)21-13-16-5-2-3-8-20(16)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234587
PNG
(US9353093, 9)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H16F4N4O2/c24-17-10-7-15(23(25,26)27)12-18(17)30-22(33)29-16-8-5-13(6-9-16)20-11-14-3-1-2-4-19(14)31(20)21(28)32/h1-12H,(H2,28,32)(H2,29,30,33)
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n/an/a 55n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234584
PNG
(US9353093, 6)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-5-3-6-18(13-16)29-22(32)28-17-10-8-14(9-11-17)20-12-15-4-1-2-7-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
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n/an/a 58n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234599
PNG
(US9353093, 28)
Show SMILES CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C22H20N4O2S/c1-2-14-6-5-8-16(10-14)24-22(28)25-17-12-20(29-13-17)19-11-15-7-3-4-9-18(15)26(19)21(23)27/h3-13H,2H2,1H3,(H2,23,27)(H2,24,25,28)
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n/an/a 60n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234597
PNG
(US9353093, 26)
Show SMILES Cc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H18N4O2S/c1-13-5-4-7-15(9-13)23-21(27)24-16-11-19(28-12-16)18-10-14-6-2-3-8-17(14)25(18)20(22)26/h2-12H,1H3,(H2,22,26)(H2,23,24,27)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234601
PNG
(US9353093, 30)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(F)c(Cl)c2)cs1
Show InChI InChI=1S/C20H14ClFN4O2S/c21-14-8-12(5-6-15(14)22)24-20(28)25-13-9-18(29-10-13)17-7-11-3-1-2-4-16(11)26(17)19(23)27/h1-10H,(H2,23,27)(H2,24,25,28)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234598
PNG
(US9353093, 27)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H15F3N4O2S/c22-21(23,24)13-5-3-6-14(9-13)26-20(30)27-15-10-18(31-11-15)17-8-12-4-1-2-7-16(12)28(17)19(25)29/h1-11H,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234600
PNG
(US9353093, 29)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H17FN4O2S/c1-12-6-7-15(22)16(8-12)25-21(28)24-14-10-19(29-11-14)18-9-13-4-2-3-5-17(13)26(18)20(23)27/h2-11H,1H3,(H2,23,27)(H2,24,25,28)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234583
PNG
(US9353093, 5)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccc(F)c(Cl)c2)cc1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(9-10-18(17)24)27-22(30)26-15-7-5-13(6-8-15)20-11-14-3-1-2-4-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234590
PNG
(US9353093, 12)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cc2ccccc2n1C(N)=O
Show InChI InChI=1S/C23H20N4O2/c1-15-6-2-4-8-19(15)26-23(29)25-18-12-10-16(11-13-18)21-14-17-7-3-5-9-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234587
PNG
(US9353093, 9)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1
Show InChI InChI=1S/C23H16F4N4O2/c24-17-10-7-15(23(25,26)27)12-18(17)30-22(33)29-16-8-5-13(6-9-16)20-11-14-3-1-2-4-19(14)31(20)21(28)32/h1-12H,(H2,28,32)(H2,29,30,33)
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n/an/a 139n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234588
PNG
(US9353093, 10)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1ccc(NC(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C22H18N4O2/c23-21(27)26-19-9-5-4-6-16(19)14-20(26)15-10-12-18(13-11-15)25-22(28)24-17-7-2-1-3-8-17/h1-14H,(H2,23,27)(H2,24,25,28)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
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n/an/a 151n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234598
PNG
(US9353093, 27)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H15F3N4O2S/c22-21(23,24)13-5-3-6-14(9-13)26-20(30)27-15-10-18(31-11-15)17-8-12-4-1-2-7-16(12)28(17)19(25)29/h1-11H,(H2,25,29)(H2,26,27,30)
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Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234590
PNG
(US9353093, 12)
Show SMILES Cc1ccccc1NC(=O)Nc1ccc(cc1)-c1cc2ccccc2n1C(N)=O
Show InChI InChI=1S/C23H20N4O2/c1-15-6-2-4-8-19(15)26-23(29)25-18-12-10-16(11-13-18)21-14-17-7-3-5-9-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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US Patent
n/an/a 174n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234592
PNG
(US9353093, 20)
Show SMILES CCc1cccc(NC(=O)Nc2cccc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C24H22N4O2/c1-2-16-7-5-10-19(13-16)26-24(30)27-20-11-6-9-17(14-20)22-15-18-8-3-4-12-21(18)28(22)23(25)29/h3-15H,2H2,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 240n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234594
PNG
(US9353093, 22)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cccc(NC(=O)Nc2ccc(F)c(Cl)c2)c1
Show InChI InChI=1S/C22H16ClFN4O2/c23-17-12-16(8-9-18(17)24)27-22(30)26-15-6-3-5-13(10-15)20-11-14-4-1-2-7-19(14)28(20)21(25)29/h1-12H,(H2,25,29)(H2,26,27,30)
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n/an/a 249n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234593
PNG
(US9353093, 21)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)16-7-4-9-18(13-16)29-22(32)28-17-8-3-6-14(11-17)20-12-15-5-1-2-10-19(15)30(20)21(27)31/h1-13H,(H2,27,31)(H2,28,29,32)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234599
PNG
(US9353093, 28)
Show SMILES CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C22H20N4O2S/c1-2-14-6-5-8-16(10-14)24-22(28)25-17-12-20(29-13-17)19-11-15-7-3-4-9-18(15)26(19)21(23)27/h3-13H,2H2,1H3,(H2,23,27)(H2,24,25,28)
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US Patent
n/an/a 264n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234591
PNG
(US9353093, 19)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H20N4O2/c1-15-6-4-9-18(12-15)25-23(29)26-19-10-5-8-16(13-19)21-14-17-7-2-3-11-20(17)27(21)22(24)28/h2-14H,1H3,(H2,24,28)(H2,25,26,29)
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Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234595
PNG
(US9353093, 23)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2cccc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C23H19FN4O2/c1-14-9-10-18(24)19(11-14)27-23(30)26-17-7-4-6-15(12-17)21-13-16-5-2-3-8-20(16)28(21)22(25)29/h2-13H,1H3,(H2,25,29)(H2,26,27,30)
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n/an/a 334n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234597
PNG
(US9353093, 26)
Show SMILES Cc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H18N4O2S/c1-13-5-4-7-15(9-13)23-21(27)24-16-11-19(28-12-16)18-10-14-6-2-3-8-17(14)25(18)20(22)26/h2-12H,1H3,(H2,22,26)(H2,23,24,27)
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Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234597
PNG
(US9353093, 26)
Show SMILES Cc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C21H18N4O2S/c1-13-5-4-7-15(9-13)23-21(27)24-16-11-19(28-12-16)18-10-14-6-2-3-8-17(14)25(18)20(22)26/h2-12H,1H3,(H2,22,26)(H2,23,24,27)
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US Patent
n/an/a 1.14E+3n/an/an/an/a7.4n/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
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