Compile Data Set for Download or QSAR
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Found 9 of ec50 for monomerid = 20182
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  20nMAssay Description:Activity at 6His-tagged human RORgamma LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of biotinylated...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  20nMAssay Description:Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  20nMAssay Description:In vivo luteinising hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)More data for this Ligand-Target Pair
TargetAlpha-crystallin B chain(Homo sapiens)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  320nMAssay Description:Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced intracellular protein aggregation expressed in human HeLa cells or HLE-B3 cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  630nMAssay Description:Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase repor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Dartmouth College

LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  1.16E+3nMpH: 7.5 T: 2°CAssay Description:The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50:  3.30E+3nMAssay Description:Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2A receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Sage Therapeutics

Curated by ChEMBL
LigandPNGBDBM20182((1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-me...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of recombinant human GluN1/GluN2B receptor stably expressed in HEK293 cells assessed as increase in glycine/L-glutamat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed