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Compile Data Set for Download or QSAR

Found 10 hits of ec50 for monomerid = 476299   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
3C-like proteinase (3CL-PRO)


(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<380n/an/an/an/a



Emory University

US Patent


Assay Description
Several derivatives of EIDD-01931 have shown antiviral activity in screening against various viruses. Activity data is shown in the tables below. Nor...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 600n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.50E+3n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.50E+3n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80E+3n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.80E+3n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Genome polyprotein


(ZIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.02E+3n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.70E+4n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Structural polyprotein


(CHIKV)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>7.80E+4n/an/an/an/a



Emory University

US Patent


Assay Description
Primary cytopathic effect (CPE) reduction assay. Four-concentration CPE inhibition assays are performed. Confluent or near-confluent cell culture mon...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair
Genome polyprotein


(Hu/NV/NV/1968/US)
BDBM476299
PNG
(US10874683, Example 00106 | US10874683, Example 56...)
Show SMILES OC[C@H]1O[C@H](C(O)[C@H]1O)n1ccc(NO)nc1=O
Show InChI InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6+,7?,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>3.86E+6n/an/an/an/a



Emory University

US Patent


Assay Description
Several derivatives of EIDD-01931 have shown antiviral activity in screening against various viruses. Activity data is shown in the tables below. Nor...


US Patent US10874683 (2020)

More data for this
Ligand-Target Pair