BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits of ec50 for monomerid = 507046   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM507046
PNG
(2-Amino-8-(4,4-dimethyl-1H-quinazolin-2-yl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NC(C)(C)c2ccccc2N1
Show InChI InChI=1S/C27H33N5O/c1-5-13-32(14-6-2)26(33)20-15-18-11-12-19(16-23(18)29-24(28)17-20)25-30-22-10-8-7-9-21(22)27(3,4)31-25/h7-12,15-16H,5-6,13-14,17H2,1-4H3,(H2,28,29)(H,30,31)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 7n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM507046
PNG
(2-Amino-8-(4,4-dimethyl-1H-quinazolin-2-yl)-N,N-di...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NC(C)(C)c2ccccc2N1
Show InChI InChI=1S/C27H33N5O/c1-5-13-32(14-6-2)26(33)20-15-18-11-12-19(16-23(18)29-24(28)17-20)25-30-22-10-8-7-9-21(22)27(3,4)31-25/h7-12,15-16H,5-6,13-14,17H2,1-4H3,(H2,28,29)(H,30,31)
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a>1.00E+5n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair