TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.00800nMAssay Description:Inhibition of CHO-K1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0210nMAssay Description:Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMAssay Description:In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0280nMAssay Description:In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0450nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0540nMAssay Description:Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0730nMAssay Description:Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity measured after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.More data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in co-transfected CV-1 cell lines.More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at progesterone receptor assessed as progesterone-induced alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphataseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Antagonist activity against PR beta-mediated transactivation of MMTV luciferase reporter gene in BacMam transduced progesterone-stimulated CV1 cellsMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.298nMAssay Description:Antagonist activity against glucocorticoid receptor (unknown origin) expressed in HEK293 cells by GRE-dependent luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity at human PRB expressed in African green monkey CV1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against progesterone induced PRE-luciferase activity in CV-cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against the Progesterone Receptor (PR)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Antagonist activity against progesterone receptor (PR) using PRE-luciferase plasmid co-transfected CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phosphatase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human PR expressed in CHO-K1 cells assessed as reduction in progesterone-induced response incubated for 20 hrs by luciferase r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at human progesterone receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase rep...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at cloned glucocorticoid receptor-ligand binding domain expressed in african green monkey COS7 cells by GAL4 luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Displacement of [3H]R5020 from human PR in human T47D cells by whole cell assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human GR ligand binding domain expressed in african green monkey COS7 cells in presence of Dexamethasone by Gal4 hybrid assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human progesterone receptor B expressed in african green monkey CV1 cells co-transfected with MMTV-Luc assessed as effect on p...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at glucocorticoid receptor ligand binding domain by two hybrid assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at glucocorticoid receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.640nMAssay Description:Antagonist activity at glucocorticoid receptor in human HeLa cells assessed as reduction in dexamethasone-induced luciferase activity by dual-Glo luc...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of antagonist activity towards glucocorticoid receptorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibitory activity against human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human GR assessed as reduction in dexamethasone-induced transactivationMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity against the Glucocorticoid Receptor (GR)More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter ...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human androgen receptor expressed in african green monkey CV1 cells co-transfected with MMTV-Luc by luciferase reporter gene a...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]dexamethasone from human Glucocorticoid receptor (GR)More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 1.10nM EC50: 4.80nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Dexamethasone binding to Glucocorticoid receptorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of [3H]dexamethasone binding to human glucocorticoid receptorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
The Pennsylvania State University
Curated by ChEMBL
The Pennsylvania State University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to human GRMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activityMore data for this Ligand-Target Pair