Compile Data Set for Download or QSAR
maximum 50k data
Found 102 of ic50 for monomerid = 21690
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
Anshan Normal University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  36.2nMAssay Description:Antibacterial activity against Enterococcus faecalis MTCC 439 incubated overnight by broth dilution techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activityMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  122nMAssay Description:Inhibition of Escherichia coli DNA gyrase super-coiling activity using relaxed pNO1 DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Escherichia coli DNA gyrase after 1 hr by agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed PBR322 plasmid DNA as substrate incubated for 30 mins by ethidium bromide staining based agar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as supercoiled plasmid DNA formation after 30 mins by electrophoretic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  230nMAssay Description:Inhibition of Escherichia coli DNA gyrase by fluorescence based microtiter plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetDNA gyrase inhibitor()
Bugworks Research

US Patent
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  233nMAssay Description:E. coli gyrase supercoiling and its inhibition was assayed using a kit procured from Inpiralis (K0001) and the protocol (PMID: 2172086) was adapted w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A(Escherichia coli)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Escherichia coli DNA gyrase (A2B2 tetramer) using relaxed pBR322 as substrate preincubated for 30 mins followed by enzyme addition by S...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  300nMAssay Description:Inhibition of DNA gyrase supercoiling in Escherichia coli ATCC 25922More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  300nMAssay Description:Inhibition of reconstituted Escherichia coli DNA gyrase subunit AB assessed as reduction of DNA supercoiling activity using pBR322 DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against wild type Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Escherichia coli DNA gyrase A2B2 using relaxed pNO1 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  440nMAssay Description:Inhibition of Escherichia coli DNA gyrase using relaxed DNA as substrate incubated for 15 mins by ethidium bromide-based agarose gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  490nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against DNA gyrase enzyme was determined by supercoiling assay with Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  550nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  600nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activity using pBR322 as substrate incubated for 30 mins measured by gel-based assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetCholesterol side-chain cleavage enzyme, mitochondrial(Rattus norvegicus)
Anshan Normal University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  603nMAssay Description:Antibacterial activity against Enterococcus faecalis ATCC 51299 assessed as growth inhibition using fresh sample in DMSO by CLSI methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  603nMAssay Description:The inhibitory activity was measured for the supercoiling activity of DNA gyrase isolated from Escherichia coli K-12 C600.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  661nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activity using topoisomerase II treated decatenated kDNA as substrate incubated for 15 to 30 m...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  830nMAssay Description:Inhibition of Escherichia coli DNA gyrase supercoiling activity using pBR322 as substrate incubated for 30 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 2-beta(Homo sapiens (Human))
Kanebo

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  905nMAssay Description:Gyrase inhibitory activity against Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA gyrase A assessed as reduction in enzyme-mediated supercoiling of relaxed pBR322 DNA by ethidium bromid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of DNA supercoiling activity of Escherichia coli DNA gyrase gyrA A67S mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A [V210L]/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibitory effect against Escherichia coli Gyrase in Supercoiling assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of topoisomerase 4 decatenation in Staphylococcus aureus ATCC 29213More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of His tagged Escherichia coli ATCC 25922 DNA gyrase A SD-LY mutant expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence based ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 as substrate after 30 mins by agarose gel electrophoresisMore data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  4.82E+3nMAssay Description:Inhibition of Wild Type DNA gyrase Supercoiling Activity in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  5.23E+3nMAssay Description:Inhibition of Escherichia coli DNA gyrase assessed as reduction in enzyme-mediated DNA supercoiling using relaxed pBR322 substrate incubated for 60 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Bacillus subtilis)
Microbiotix

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  6.30E+3nMpH: 7.5 T: 2°CAssay Description:The 50% inhibitory concentration (IC50) is defined as the concentration of compound that inhibits the decatenation of kinetoplast DNA by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity using kDNA as substrate incubated for 10 to 20 min by ethidium bromide/...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus)
Cairo University

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  9.16E+3nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 using pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence based microtiter plate ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Redx Anti-Infectives

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  9.35E+3nMAssay Description:In vitro inhibitory concentration against DNA gyrase from Escherichia coli H560More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA helicase [35-727](Plasmodium falciparum)
International Centre For Genetic Engineering And Biotechnology

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  9.90E+3nMpH: 8.0 T: 2°CAssay Description:The hydrolysis of ATP catalyzed by PfUDN was assayed by measuring the formation of Pi from [γ-32P] ATP. The reaction mixture of 10 μl conta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetDNA gyrase subunit A(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
John Innes Centre

LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.00E+4nMAssay Description:Mycobacterium tuberculosis gyrase supercoiling, relaxation, and decatenation assays were carried out as described previously.More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling activity using pBR322 DNA as substrate after 30 mins by ethidium bromide staining based a...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University Of Sassari

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis DNA gyrase assessed as reduction in supercoiling of relaxed pBR322 DNA substrate after 30 mins by ethidium b...More data for this Ligand-Target Pair
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