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Found 6 of ic50 for monomerid = 35226
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant NET expressed in HEK293 cells assessed as inhibition of [3H]NE reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTransporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of norepinephrine uptake at NET in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Theravance

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human recombinant CYP2D6 by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of serotonin uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of dopamine uptake at cloned DAT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed