Found 46 of ic50 for monomerid = 46858 TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Central presynaptic activity as effect on electrically evoked acetylcholine release from rat hippocampal slices (M2 model)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligandMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:Ability to displace [3H]-N-methylscopolamine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]oxotremorine-M (OXO-M); Range is 75-170More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 545nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity at 5-hydroxytryptamine 3 receptor in rat posterior cortex by [3H]-BRL 43694 displacement.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Evaluated for inhibition of binding of [3H]pirenzepine to homogenized rat cerebral cortex membranesChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Ability to displace [3H]-pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 9.15E+3nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+4nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.35E+4nMAssay Description:In vitro affinity of the compound is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]quinuclidinyl benzilate (QNB); Range is 10000-110...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.54E+4nMAssay Description:In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 2.54E+4nMAssay Description:In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.75E+4nMAssay Description:Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.80E+4nMAssay Description:Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...More data for this Ligand-Target Pair
Affinity DataIC50: 6.25E+4nMAssay Description:Compound was evaluated for its ability to displace [3H]- N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 6.50E+4nMAssay Description:In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.06E+5nMAssay Description:In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 1.16E+5nMAssay Description:Ability to displace [3H]-N-methylscopolamine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Seoul National University
Curated by ChEMBL
Seoul National University
Curated by ChEMBL
Affinity DataIC50: 1.45E+5nMAssay Description:Compound was evaluated for its ability to displace [3H]-N-methylscopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylc...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+5nMAssay Description:Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+5nMAssay Description:Displacement of [3H]Quinuclidinyl benzillate from muscarinic M1 receptor in Wistar rat cortex synaptosomal membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+5nMAssay Description:Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.28E+6nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
