Compile Data Set for Download or QSAR
maximum 50k data
Found 27 of ic50 for monomerid = 50142887
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Src (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  0.5nMT: 2°CAssay Description:Kinase activity (Src-family kinases, Hck, Lyn, Fyn, and c-Src) and the effect of the molecules were determined by ProFluor Src-Family Kinase Assay Ki...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56lck autophosphorylationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HckChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  6nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  6nMAssay Description:The ADP-Glo™ Kinase Assay is specifically designed to quantify kinase activity by measuring the ADP produced in the reaction The reaction buffer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Ankara University

LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  19nMAssay Description:Inhibition of RIP2 in the presence of 100uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Lck in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Src in the presence of 50uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  36.6nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  36.6nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  41nMAssay Description:Inhibition of CK1delta in the presence of 20uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  50nMAssay Description:Inhibition cSRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  172nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Washington Through Its Center For Commercialization

US Patent
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  172nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  480nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
University Of Delhi

LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:The kinase reaction was initiated with the incubation of the 2.5 µL of the reaction cocktail (0.7 nM of His6-Src kinase domain in kinase buffer)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  500nMAssay Description:Inhibition of His6-tagged c-Src kinase domain using AEEEIYGEFEAKKKK as substrate pre-incubated for 10 mins before substrate addition measured after 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of c-Src after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of GST-tagged c-Src preincubated for 30 mins measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Indo-Soviet Friendship College Of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of GST-fussed c-SRC after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Korea Institute Of Science & Technology (Kist School)

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  4.23E+3nMAssay Description:Inhibition of p38 alpha (unknown origin) using Ser/Thr 15 as substrate incubated for 1 hr in presence of ATP by Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Protana

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50:  5.20E+4nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50: >5.00E+7nMAssay Description:Inhibition of JAK2Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50142887(1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[...)
Affinity DataIC50: >1.00E+8nMAssay Description:Inhibition of ZAP70Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed