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Found 14 of ic50 for monomerid = 50241361
TargetLactoperoxidase(Bos taurus (Bovine))TBA
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of Bos taurus (bovine) milk lactoperoxidase-catalyzed iodination of L-tyrosine substrate by reverse phase HPLC analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetLactoperoxidase(Homo sapiens (Human))
Institute Of Science

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of lactoperoxidase (unknown origin)-catalyzed iodination of L-tyrosine assessed as 3,5-diiodo-L-tyrosine formation by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLanosterol 14-alpha demethylase(Homo sapiens (Human))
Act

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50:  7.54E+5nMAssay Description:Inhibition of Dopamine beta hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Hungkuang University

Curated by ChEMBL
LigandPNGBDBM50241361(CHEMBL1515 | METHIMAZOLE | US9138393, Methimazole ...)
Affinity DataIC50:  1.43E+6nMAssay Description:Inhibition of mushroom tyrosinase-mediated L-tyrosine hydroxylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed