Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with Target = 'Advanced glycosylation end product-specific receptor' and Ligand = 'BDBM50249580'
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of biotinylated human RAGE/amyloid beta interaction incubated for 120 mins by ELISA assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant human RAGE assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  500nMAssay Description:Inhibition of amyloid beta (1 to 42) binding to RAGE domain V (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdvanced glycosylation end product-specific receptor(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50249580(Azeliragon | PF-04494700 | TTP448 | US11524942, Co...)
Affinity DataKd:  12.7nMAssay Description:The binding affinity of COMPOUND I and compounds of the invention to human sRAGE (the soluble extracellular domain of the human receptor for advanced...More data for this Ligand-Target Pair
In DepthDetails US Patent