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Found 3 Enz. Inhib. hit(s) with Target = 'Apolipoprotein L1' and Ligand = 'BDBM50547876'
TargetApolipoprotein L1(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50: <250nMAssay Description:Inhibition of APOL1 (unknown origin) in HEK293 cells assessed as thallium influx incubated for 30 mins by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApolipoprotein L1(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50:  600nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApolipoprotein L1(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50:  600nMAssay Description:Briefly, the AlamarBlue active compound, the resazurin, a blue, water soluble, non-toxic and cell permeable molecule, which can be followed by absorb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent