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Found 4 Enz. Inhib. hit(s) with Target = 'Beta-secretase 1' and Ligand = 'BDBM50358930'
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358930(CHEMBL1923754)
Affinity DataKi:  17nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by Michaelis menton equationChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358930(CHEMBL1923754)
Affinity DataIC50:  18nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by FRET analysisChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358930(CHEMBL1923754)
Affinity DataEC50:  37nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP Swedish K595N and M596L double mutant assessed as inhibition of amyloid beta (1 to 42) productio...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358930(CHEMBL1923754)
Affinity DataEC50:  37nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP Swedish K595N and M596L double mutant assessed as inhibition of amyloid beta (1 to 40) productio...Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed