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Found 5 Enz. Inhib. hit(s) with Target = 'Bifunctional epoxide hydrolase 2' and Ligand = 'BDBM50100520'
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataKi:  0.310nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataKi:  0.310nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by FRET-based ACPU displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataKi:  0.660nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Rattus norvegicus)
University Of California Davis

Curated by ChEMBL
LigandPNGBDBM50100520(CHEMBL3327077 | US10377744, Compound No. 2422 | US...)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed