Compile Data Set for Download or QSAR
maximum 50k data
Found 9 Enz. Inhib. hit(s) with Target = 'Calcitonin gene-related peptide type 1 receptor' and Ligand = 'BDBM50254445'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0390nMAssay Description:Displacement of [125I]human CGRP from human CLR expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells coexpressing RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.280nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.280nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.620nMAssay Description:Antagonist activity at human CLR expressed in HEK293 cells coexpressing human RAMP1 assessed as inhibition of human CGRPalpha-induced cAMP production...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.620nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50254445((S)-2-(2,5-dioxo-2,4,5,6-tetrahydro-1H-imidazo[1,5...)
Affinity DataIC50:  0.620nMAssay Description:Antagonistic activity at human CGRP receptor expressed in HEK293 cells coexpressing RAMP1 assessed as inhibition of CGRP-induced cAMP production in p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed