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Found 3 Enz. Inhib. hit(s) with Target = 'Calcitonin gene-related peptide type 1 receptor' and Ligand = 'BDBM50315405'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [125I]human CLR from human CGRP expressed in HEK293 cells coexpressing human RAMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataIC50:  0.860nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50315405(1-(((R)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP production in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed