BindingDB PrimarySearch

Found 38 Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 2' and Ligand = 'BDBM10886'

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nM ΔG°: -45.2kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibitory activity of compound against human carbonic anhydrase IIMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibitory activity against human carbonic anhydrase IIMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Ki value against human carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Binding affinity towards human cloned carbonic anhydrase IIMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Ki value against human carbonic anhydrase IIMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow hydration assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Homo sapiens (Human))
Kochi Medical School

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 9nMAssay Description:Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Carbonic anhydrase 2(Mycobacterium tuberculosis)
Universit?? Degli Studi Di Firenze

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 460nM ΔG°: -36.2kJ/molepH: 8.3 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair

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Carbonic anhydrase 2(Mycobacterium tuberculosis)
Universit?? Degli Studi Di Firenze

BDBM10886(2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | ...)

Ki: 467nMAssay Description:Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair

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Filter my 38 hits

Targets 1▿
- Carbonic anhydrase 2 38
Publications 36▿
- Bioorg Med Chem Lett 19: 6649-54 (2009) 2
- Bioorg Med Chem Lett 26: 4184-90 (2016) 2
- Bioorg Med Chem 17: 1158-63 (2009) 1
- Bioorg Med Chem Lett 14: 5775-80 (2004) 1
- Bioorg Med Chem 25: 3555-3561 (2017) 1
- J Med Chem 56: 1761-71 (2013) 1
- Bioorg Med Chem 21: 1534-8 (2013) 1
- Bioorg Med Chem 23: 2303-9 (2015) 1
- Bioorg Med Chem 24: 1115-20 (2016) 1
- Bioorg Med Chem Lett 27: 490-495 (2017) 1
- J Enzyme Inhib Med Chem 19: 269-73 (2004) 1
- Bioorg Med Chem 22: 2939-46 (2014) 1
- Bioorg Med Chem Lett 15: 971-6 (2005) 1
- Bioorg Med Chem 19: 1172-8 (2011) 1
- J Med Chem 50: 381-8 (2007) 1
- J Med Chem 55: 3513-20 (2012) 1
- J Enzyme Inhib Med Chem 28: 384-7 (2013) 1
- Bioorg Med Chem Lett 16: 2182-8 (2006) 1
- Bioorg Med Chem Lett 13: 2867-73 (2003) 1
- Bioorg Med Chem Lett 15: 963-9 (2005) 1
- Bioorg Med Chem 23: 1728-34 (2015) 1
- Bioorg Med Chem 19: 5023-30 (2011) 1
- Bioorg Med Chem 20: 1403-10 (2012) 1
- Bioorg Med Chem Lett 14: 2357-61 (2004) 1
- J Med Chem 48: 7860-6 (2005) 1
- Bioorg Med Chem 23: 526-31 (2015) 1
- J Med Chem 49: 2117-26 (2006) 1
- Bioorg Med Chem Lett 26: 1821-6 (2016) 1
- Bioorg Med Chem Lett 25: 3550-5 (2015) 1
- Bioorg Med Chem Lett 26: 401-5 (2016) 1
- Bioorg Med Chem Lett 26: 1253-9 (2016) 1
- Bioorg Med Chem 19: 1847-51 (2011) 1
- Bioorg Med Chem 17: 5054-8 (2009) 1
- Bioorg Med Chem Lett 21: 710-4 (2011) 1
- Bioorg Med Chem Lett 25: 5485-9 (2015) 1
- Bioorg Med Chem 22: 4537-43 (2014) 1
Institutions 15▿
- Universit£ 16
- Kochi Medical School 6
- University Of Tampere And Tampere University Hospital 2
- Centre Scientifique De Monaco 2
- Cnr 2
- Bruker-Axs 1
- Recep Tayyip Erdogan University 1
- Union Life Sciences 1
- University Of Montpellier 1
- Slovak Academy Of Sciences 1
- Universit?? Degli Studi Di Firenze 1
- UniversitÀ Degli Studi Di Firenze 1
- Balikesir University 1
- Istituto Di Bioscienze E Biorisorse 1
- Istituto Di Biochimica Delle Proteine-Cnr 1
Affinity: 9 to 4.7E+2 nM▿
- Ki 38
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1