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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Chymase' and Ligand = 'BDBM50098886'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Chymase


(Homo sapiens (Human))
BDBM50098886
PNG
(4-[2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-ac...)
Show SMILES Nc1cnc(-c2ccccc2)n(CC(=O)NC(Cc2ccccc2)C(=O)C(F)(F)C(=O)NCc2ccccc2)c1=O
Show InChI InChI=1/C30H27F2N5O4/c31-30(32,29(41)35-17-21-12-6-2-7-13-21)26(39)24(16-20-10-4-1-5-11-20)36-25(38)19-37-27(22-14-8-3-9-15-22)34-18-23(33)28(37)40/h1-15,18,24H,16-17,19,33H2,(H,35,41)(H,36,38)
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Similars

Article
PubMed
32.5n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
In vitro inhibitory activity was determined against human heart chymase


J Med Chem 44: 1297-304 (2001)


Article DOI: 10.1021/jm000497n
BindingDB Entry DOI: 10.7270/Q22R3SCD
More data for this
Ligand-Target Pair