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Found
1
Enz. Inhib. hit(s) with Target = 'Coagulation factor XII' and Ligand = 'BDBM498915'
Target
Coagulation factor XII
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM498915
(N-{(3S,4R)-1-[N~2~- cyclohexyl-N~6~- (methylsulfon...)
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Affinity Data
IC50: 52.4nM
Assay Description:
Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...
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Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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