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Found 5 Enz. Inhib. hit(s) with Target = 'Complement factor B' and Ligand = 'BDBM160036'
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160036(US10093663, Example 21a | US9682968, Example-21a)
Affinity DataIC50:  0.0200nMAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160036(US10093663, Example 21a | US9682968, Example-21a)
Affinity DataIC50:  18nMAssay Description:Inhibition of human serine protease factor B by TR-FRET based competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160036(US10093663, Example 21a | US9682968, Example-21a)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor B(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM160036(US10093663, Example 21a | US9682968, Example-21a)
Affinity DataIC50:  150nMAssay Description:Inhibition of serine protease factor B in 50% mouse serum assessed as reduction in C3b deposition pre-incubated for 15 mins before activated zymosan ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement factor B(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM160036(US10093663, Example 21a | US9682968, Example-21a)
Affinity DataIC50:  180nMAssay Description:Inhibition of serine protease factor B in 50% human whole blood assessed as reduction in alternative pathway-mediated membrane attack complex formati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed