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Found 3 Enz. Inhib. hit(s) with Target = 'Cystine/glutamate transporter' and Ligand = 'BDBM50103596'
TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  160nMAssay Description:Inhibition of xCT-mediated cystein/glutamate transporter (unknown origin) assessed as reduction in L-[14C]cyctein uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  4.50E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)
Affinity DataIC50:  4.60E+5nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank