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Found 6 Enz. Inhib. hit(s) with Target = 'D(1A) dopamine receptor' and Ligand = 'BDBM160875'
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataKi:  6.91nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataKi:  18.6nMAssay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataKi:  18.6nMpH: 7.4Assay Description:The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., "Di...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataKi:  18.6nMAssay Description:D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determin...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based compe...More data for this Ligand-Target Pair
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM160875(US10093655, Example 45 | US11014909, Example 45 | ...)
Affinity DataEC50:  5.30nMAssay Description:Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor ...More data for this Ligand-Target Pair