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Found 4 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM33395'
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  1.90E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.90E+3nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  1.02E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM33395(2,4-diaminofuro[2,3-d]pyrimidine, 1b | Z-isomer)
Affinity DataIC50:  3.00E+4nMAssay Description:Standard DHFR assays were conducted at 37 deg C with continuous recording of change of OD at 340 nm. All determinations of IC50 were made by fitting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed