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Found 3 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50026273'
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50026273(2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-b...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50026273(2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-b...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against Leu22-Phe mutant human Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026273(2-{4-[(2,4-Diamino-quinazolin-6-ylmethyl)-amino]-b...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of rat liver dihydrofolate reductase assayed spectrophotometrically at 340 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed