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Found 5 Enz. Inhib. hit(s) with Target = 'Dipeptidyl peptidase 4' and Ligand = 'BDBM123781'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM123781(3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenyl...)
Affinity DataIC50:  360nMAssay Description:The HypoGen module in DS2.5 was employed to produce pharmaphores with the training set compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM123781(3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenyl...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human DPP4 isolated from from human CaCo2 cells incubated for 15 mins using Gly-Pro-pNA.Tos substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
China Pharmaceutical University

LigandPNGBDBM123781(3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenyl...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123781(3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenyl...)
Affinity DataIC50:  550nMAssay Description:Inhibition of DPP4 in rat plasma incubated for 60 mins using H-lys-Ala-pNA.2HCl substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123781(3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenyl...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of DPP4 in rat spleen incubated for 60 mins using H-lys-Ala-pNA.2HCl substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed