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Found 10 Enz. Inhib. hit(s) with Target = 'Dopamine beta-hydroxylase' and Ligand = 'BDBM50014968'
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataKi:  55nMpH: 4.5Assay Description:Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataKi:  55nMpH: 4.5Assay Description:Binding affinity towards Dopamine beta hydroxylase using tyramine substrate at pH 4.5 in the absence of fumarateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataKi:  344nMpH: 6.6Assay Description:Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 6.6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Rattus norvegicus)
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.57E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneallyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Homo sapiens (Human))
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.57E+3nMAssay Description:Inhibition of dopamine beta hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Homo sapiens (Human))
Molecular Simulations

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.57E+3nMAssay Description:Inhibition of dopamine beta-hydroxylase (DbetaH) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Rattus norvegicus)
University Of Illinois

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase in spontaneously hypertensive rats; Value ranges from 1.3-4.6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of Dopamine beta hydroxylase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDopamine beta-hydroxylase(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50014968(1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (1.3-4.6)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed