Found 3 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1' and Ligand = 'BDBM50134989' TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer Healthcare
Curated by ChEMBL
Bayer Healthcare
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer Healthcare
Curated by ChEMBL
Bayer Healthcare
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Bayer Healthcare
Curated by ChEMBL
Bayer Healthcare
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
