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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor(L858R)' and Ligand = 'BDBM504405'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor(L858R)


(Homo sapiens (Human))
BDBM504405
PNG
(US11040984, Compound 4)
Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3OC)c2cc1N1CC2(CCN(C)CC2)OC1=O
Show InChI InChI=1S/C24H26ClN5O4/c1-29-9-7-24(8-10-29)13-30(23(31)34-24)19-11-15-18(12-20(19)32-2)26-14-27-22(15)28-17-6-4-5-16(25)21(17)33-3/h4-6,11-12,14H,7-10,13H2,1-3H3,(H,26,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 30.1n/an/an/an/an/an/a



MEDSHINE DISCOVERY INC.

US Patent


Assay Description
Buffer formulation: a buffer consisted of 50 mM HEPES (pH 7.5), 0.01% BSA, 5 mM MgCl2, 0.1 mM Orthovanadate. After the buffer was formulated, an enzy...


US Patent US11040984 (2021)

More data for this
Ligand-Target Pair