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Found 12 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM3532'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  0.310nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  1.26nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Epidermal growth factor receptor tyrosine kinase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Mus musculus)
Novartis

Curated by ChEMBL
LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50: <100nMAssay Description:Inhibition of EGF-dependent mouse keratinocyte MK cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Epidermal growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  900nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed