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Found 8 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50103251'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  95nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataKi:  95nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50:  1.30nMAssay Description:Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50:  16nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50:  67nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50:  107nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103251(5-(3,5-Dichloro-phenyl)-10-methoxy-2,2,4-trimethyl...)
Affinity DataIC50:  139nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed