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Found 3 Enz. Inhib. hit(s) with Target = 'Hematopoietic prostaglandin D synthase' and Ligand = 'BDBM50526485'
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) using PGH2 as substrate measured after 90 to 120 secs by R...More data for this Ligand-Target Pair
TargetHematopoietic prostaglandin D synthase(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataIC50:  100nMAssay Description:Inhibition of HPGDS in RBL cells assessed as reduction in A23187-induced PGD2 production preincubated for 30 mins followed by A23187 addition and mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50526485(CHEMBL4473072)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to full-length human His6-tagged HPGDS expressed in Escherichia coli BL21 (DE3) by tryptophan fluorescence quenching assayMore data for this Ligand-Target Pair