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Found 5 Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50440890'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50440890(CHEMBL2431841 | US9066954, 341)
Affinity DataKi:  9.10nM ΔG°:  -46.2kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50440890(CHEMBL2431841 | US9066954, 341)
Affinity DataKi:  74nMAssay Description:Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50440890(CHEMBL2431841 | US9066954, 341)
Affinity DataIC50:  44nMAssay Description:Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50440890(CHEMBL2431841 | US9066954, 341)
Affinity DataIC50:  69nMAssay Description:Inhibition of c-Met autophosphorylation in human NCI-H441 cells for 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50440890(CHEMBL2431841 | US9066954, 341)
Affinity DataIC50:  210nMAssay Description:Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed